| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is ytbE [H]
Identifier: 238894391
GI number: 238894391
Start: 2276665
End: 2277534
Strand: Direct
Name: ytbE [H]
Synonym: KP1_2374
Alternate gene names: 238894391
Gene position: 2276665-2277534 (Clockwise)
Preceding gene: 238894390
Following gene: 238894399
Centisome position: 43.38
GC content: 52.87
Gene sequence:
>870_bases GTGGAATATTCAGTATTAAGTAACGCTCGCAAAATGCCGATGCTGGGTTTCGGCGTTTTCAAGGTGACCGATAAAGCGGA GTGTAAGCAGGCGGTGTTGAACGCCATTCGCATCGGTTATCGCCTCATCGATACCGCTGCCGTCTACGATAATGAAGATG CGGTGGGTGAGGCCGTGCGCGAAGCCATCGCCGAAGGTCTGTGTACCCGCGAGGCGCTGTTTATTACCTCCAAACTGTGG GTCCAGGACATGGCCAACACCGGGATGGCGAAAGCCGGGATTGCCGCGTCATTAAAAAAATCGGGCCTGGAATACTTTGA TCTTTATTTGCTACATCAGGCGATGGGCGATTATTTCAGCGCCTGGCGTGCGCTGGAAGAGGCCTATGAGGCCGGTACCC TGAAAGCGATCGGCGTCTCCAATTTTTACCCCCATGTGTTAGCTAACTTCTGCGAAACTGTCAGAATTAAACCAATGGTG AACCAGGTTGAACTGCATCCTTATTTCGCGCAGCCCGCGGCGCTGGAAGCCATGAAGCATTATCACGTTCAGCCTGAAGC GTGGGCGCCGTTAGGCGGTGGCAGACATAATCCGTATCAAGATGCATTGCTTCGGGGGATCGCCGATGCGCACCAGAAAA CCATTGCGCAGGTTGTTCTGCGGTGGAACGTGCAGCGTGGCGTCACGGTGATCCCTAAATCCACCCGCCAGGAGCGCATT GAAGAAAATTTTGCTATCTGGGATTTCGTATTAACAGATAACGAAATGGCGCAAATCAGCGCCCTGGATTTAGGCTATGT TGGCGAAGCGGTAAAACACTTCAACCCTGAGTTCGTTCGCGGATGTCTGGGGGTGAAAATCCACGACTGA
Upstream 100 bases:
>100_bases GATTAATGAATTGAATGCATAAGTCAAATCAGGAATGACAGGCTAATCGTGACCGCGTTCCTGTCTTACCATGGTGTTTT AACATGAGGGGAGCTTCACC
Downstream 100 bases:
>100_bases CCGCGGCACCGATTGGCTCCATCTTCATCTCCCCGCCTGCGCCGCGGCGACGGGCTCGGTATGCTGGTTAGCACCCACGT GTTTGCCGCGACGGTTGTCA
Product: putative aldo/keto reductase family
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 289; Mature: 289
Protein sequence:
>289_residues MEYSVLSNARKMPMLGFGVFKVTDKAECKQAVLNAIRIGYRLIDTAAVYDNEDAVGEAVREAIAEGLCTREALFITSKLW VQDMANTGMAKAGIAASLKKSGLEYFDLYLLHQAMGDYFSAWRALEEAYEAGTLKAIGVSNFYPHVLANFCETVRIKPMV NQVELHPYFAQPAALEAMKHYHVQPEAWAPLGGGRHNPYQDALLRGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERI EENFAIWDFVLTDNEMAQISALDLGYVGEAVKHFNPEFVRGCLGVKIHD
Sequences:
>Translated_289_residues MEYSVLSNARKMPMLGFGVFKVTDKAECKQAVLNAIRIGYRLIDTAAVYDNEDAVGEAVREAIAEGLCTREALFITSKLW VQDMANTGMAKAGIAASLKKSGLEYFDLYLLHQAMGDYFSAWRALEEAYEAGTLKAIGVSNFYPHVLANFCETVRIKPMV NQVELHPYFAQPAALEAMKHYHVQPEAWAPLGGGRHNPYQDALLRGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERI EENFAIWDFVLTDNEMAQISALDLGYVGEAVKHFNPEFVRGCLGVKIHD >Mature_289_residues MEYSVLSNARKMPMLGFGVFKVTDKAECKQAVLNAIRIGYRLIDTAAVYDNEDAVGEAVREAIAEGLCTREALFITSKLW VQDMANTGMAKAGIAASLKKSGLEYFDLYLLHQAMGDYFSAWRALEEAYEAGTLKAIGVSNFYPHVLANFCETVRIKPMV NQVELHPYFAQPAALEAMKHYHVQPEAWAPLGGGRHNPYQDALLRGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERI EENFAIWDFVLTDNEMAQISALDLGYVGEAVKHFNPEFVRGCLGVKIHD
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI5174695, Length=294, Percent_Identity=39.4557823129252, Blast_Score=191, Evalue=6e-49, Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=38.2671480144404, Blast_Score=172, Evalue=2e-43, Organism=Homo sapiens, GI223468663, Length=292, Percent_Identity=36.3013698630137, Blast_Score=171, Evalue=5e-43, Organism=Homo sapiens, GI310109922, Length=271, Percent_Identity=36.5313653136531, Blast_Score=169, Evalue=3e-42, Organism=Homo sapiens, GI45446745, Length=292, Percent_Identity=34.9315068493151, Blast_Score=168, Evalue=6e-42, Organism=Homo sapiens, GI4503285, Length=292, Percent_Identity=34.9315068493151, Blast_Score=168, Evalue=6e-42, Organism=Homo sapiens, GI310109920, Length=292, Percent_Identity=34.5890410958904, Blast_Score=167, Evalue=7e-42, Organism=Homo sapiens, GI300116271, Length=271, Percent_Identity=38.3763837638376, Blast_Score=167, Evalue=1e-41, Organism=Homo sapiens, GI5453543, Length=292, Percent_Identity=34.5890410958904, Blast_Score=166, Evalue=2e-41, Organism=Homo sapiens, GI24497583, Length=292, Percent_Identity=34.2465753424658, Blast_Score=165, Evalue=5e-41, Organism=Homo sapiens, GI24497577, Length=293, Percent_Identity=34.4709897610922, Blast_Score=164, Evalue=9e-41, Organism=Homo sapiens, GI5174391, Length=293, Percent_Identity=34.4709897610922, Blast_Score=164, Evalue=9e-41, Organism=Homo sapiens, GI24497585, Length=295, Percent_Identity=34.2372881355932, Blast_Score=162, Evalue=3e-40, Organism=Homo sapiens, GI291291012, Length=281, Percent_Identity=34.8754448398576, Blast_Score=155, Evalue=5e-38, Organism=Homo sapiens, GI4502049, Length=287, Percent_Identity=34.8432055749129, Blast_Score=154, Evalue=1e-37, Organism=Homo sapiens, GI93277124, Length=296, Percent_Identity=31.7567567567568, Blast_Score=146, Evalue=2e-35, Organism=Homo sapiens, GI310109924, Length=150, Percent_Identity=36, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI207028673, Length=109, Percent_Identity=41.2844036697248, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI310109926, Length=109, Percent_Identity=40.3669724770642, Blast_Score=82, Evalue=4e-16, Organism=Escherichia coli, GI87082198, Length=264, Percent_Identity=40.530303030303, Blast_Score=198, Evalue=4e-52, Organism=Escherichia coli, GI1786400, Length=257, Percent_Identity=32.6848249027237, Blast_Score=130, Evalue=1e-31, Organism=Escherichia coli, GI1788081, Length=272, Percent_Identity=29.0441176470588, Blast_Score=73, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17550248, Length=283, Percent_Identity=38.5159010600707, Blast_Score=178, Evalue=3e-45, Organism=Caenorhabditis elegans, GI17537077, Length=288, Percent_Identity=35.4166666666667, Blast_Score=164, Evalue=4e-41, Organism=Caenorhabditis elegans, GI17564128, Length=306, Percent_Identity=34.3137254901961, Blast_Score=163, Evalue=1e-40, Organism=Caenorhabditis elegans, GI17537075, Length=291, Percent_Identity=34.7079037800687, Blast_Score=159, Evalue=1e-39, Organism=Caenorhabditis elegans, GI17566692, Length=287, Percent_Identity=34.8432055749129, Blast_Score=157, Evalue=7e-39, Organism=Caenorhabditis elegans, GI71998625, Length=269, Percent_Identity=33.0855018587361, Blast_Score=143, Evalue=1e-34, Organism=Caenorhabditis elegans, GI17561298, Length=274, Percent_Identity=30.6569343065693, Blast_Score=137, Evalue=5e-33, Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=28.6764705882353, Blast_Score=130, Evalue=6e-31, Organism=Caenorhabditis elegans, GI17552492, Length=270, Percent_Identity=28.5185185185185, Blast_Score=122, Evalue=2e-28, Organism=Caenorhabditis elegans, GI17537079, Length=297, Percent_Identity=26.5993265993266, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17562292, Length=275, Percent_Identity=26.1818181818182, Blast_Score=116, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17561300, Length=273, Percent_Identity=28.2051282051282, Blast_Score=107, Evalue=7e-24, Organism=Caenorhabditis elegans, GI17550246, Length=75, Percent_Identity=46.6666666666667, Blast_Score=73, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6321896, Length=304, Percent_Identity=33.8815789473684, Blast_Score=176, Evalue=4e-45, Organism=Saccharomyces cerevisiae, GI6320576, Length=288, Percent_Identity=30.2083333333333, Blast_Score=140, Evalue=2e-34, Organism=Saccharomyces cerevisiae, GI6324694, Length=281, Percent_Identity=30.6049822064057, Blast_Score=137, Evalue=2e-33, Organism=Saccharomyces cerevisiae, GI6322556, Length=267, Percent_Identity=33.3333333333333, Blast_Score=136, Evalue=5e-33, Organism=Saccharomyces cerevisiae, GI6319625, Length=319, Percent_Identity=31.3479623824451, Blast_Score=135, Evalue=7e-33, Organism=Saccharomyces cerevisiae, GI6320079, Length=289, Percent_Identity=28.719723183391, Blast_Score=111, Evalue=2e-25, Organism=Drosophila melanogaster, GI24662789, Length=292, Percent_Identity=35.2739726027397, Blast_Score=177, Evalue=5e-45, Organism=Drosophila melanogaster, GI24657054, Length=289, Percent_Identity=38.4083044982699, Blast_Score=177, Evalue=9e-45, Organism=Drosophila melanogaster, GI21356425, Length=295, Percent_Identity=35.2542372881356, Blast_Score=172, Evalue=2e-43, Organism=Drosophila melanogaster, GI20129731, Length=306, Percent_Identity=35.2941176470588, Blast_Score=171, Evalue=6e-43, Organism=Drosophila melanogaster, GI24663317, Length=299, Percent_Identity=37.123745819398, Blast_Score=170, Evalue=8e-43, Organism=Drosophila melanogaster, GI45553081, Length=288, Percent_Identity=32.6388888888889, Blast_Score=162, Evalue=3e-40, Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=33, Blast_Score=154, Evalue=7e-38, Organism=Drosophila melanogaster, GI24662781, Length=277, Percent_Identity=36.4620938628159, Blast_Score=151, Evalue=5e-37, Organism=Drosophila melanogaster, GI24662785, Length=278, Percent_Identity=36.6906474820144, Blast_Score=151, Evalue=5e-37, Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=30.9375, Blast_Score=146, Evalue=1e-35, Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=32.03125, Blast_Score=138, Evalue=5e-33,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 32268; Mature: 32268
Theoretical pI: Translated: 6.42; Mature: 6.42
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 3.1 %Met (Translated Protein) 4.5 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 4.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEYSVLSNARKMPMLGFGVFKVTDKAECKQAVLNAIRIGYRLIDTAAVYDNEDAVGEAVR CCCCHHHCCCCCCEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH EAIAEGLCTREALFITSKLWVQDMANTGMAKAGIAASLKKSGLEYFDLYLLHQAMGDYFS HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH AWRALEEAYEAGTLKAIGVSNFYPHVLANFCETVRIKPMVNQVELHPYFAQPAALEAMKH HHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCCHHHEEECCCCCCHHHHHHHHH YHVQPEAWAPLGGGRHNPYQDALLRGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERI CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHH EENFAIWDFVLTDNEMAQISALDLGYVGEAVKHFNPEFVRGCLGVKIHD HCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEECC >Mature Secondary Structure MEYSVLSNARKMPMLGFGVFKVTDKAECKQAVLNAIRIGYRLIDTAAVYDNEDAVGEAVR CCCCHHHCCCCCCEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH EAIAEGLCTREALFITSKLWVQDMANTGMAKAGIAASLKKSGLEYFDLYLLHQAMGDYFS HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH AWRALEEAYEAGTLKAIGVSNFYPHVLANFCETVRIKPMVNQVELHPYFAQPAALEAMKH HHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCCHHHEEECCCCCCHHHHHHHHH YHVQPEAWAPLGGGRHNPYQDALLRGIADAHQKTIAQVVLRWNVQRGVTVIPKSTRQERI CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHH EENFAIWDFVLTDNEMAQISALDLGYVGEAVKHFNPEFVRGCLGVKIHD HCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]