Click here to switch to the map view.

The map label for this gene is tpx [H]

Identifier: 238894370

GI number: 238894370

Start: 2262910

End: 2263416

Strand: Reverse

Name: tpx [H]

Synonym: KP1_2352

Alternate gene names: 238894370

Gene position: 2263416-2262910 (Counterclockwise)

Preceding gene: 238894372

Following gene: 238894366

Centisome position: 43.12

GC content: 60.75

Gene sequence:

>507_bases
ATGTCACAAACCGTGCATTTCCAGGGCAACCCCGTTTCTGTTCAGGGCACCATTCCGCAGGCAGGCGCTAAAGCGCAGCC
GTTTACGCTGGTCGCCAAAGATCTCTCTGACGTCGCGCTGAGCCAGTACGCCGGCAAACGTAAAGTACTGAATATTTTCC
CGAGCATTGATACCGGCGTGTGTGCCGCATCAGTGCGTAAATTCAACCAGCTGGCCGCTGAACTGGACAACACCGTAGTG
CTGTGCATTTCCGCTGACCTGCCGTTCGCCCAGTCCCGCTTCTGCGGCGCGGAAGGCCTGAGCAATGTGGTCACCCTGTC
CACGCTGCGCGGCGCGTCCTTCCTCGCTGACTACGGCGTCGCCATCGCCACCGGTCCGCTGGCTGGCCTGGCTGCCCGTG
CGGTGGTCGTTATCGATGAAAACGATCAGGTCGTCTACAGCCAGCTGGTGAACGAAATCACCGAAGAGCCGGACTACGAC
GCCGCGCTGGCCGCCCTGAAAGCCTGA

Upstream 100 bases:

>100_bases
CCTTGTCCTCTCTGGTAAATGTTAAATAGGGTTTGCCGTGTAGCTGGCGGATGTCATACACTACTCGCGACGTTAACTAT
ATGTAAACAGGAAGATAACC

Downstream 100 bases:

>100_bases
TAACAGATTGCCCGGGCGCATCGCGCTCGCGGACATTCGATCTGCCCAGCCCTCGCTCTGCGAGGGCTTTTTATTGCCGC
GGCGCATAGCGGGAGATAGC

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: Scavengase P20 [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MSQTVHFQGNPVSVQGTIPQAGAKAQPFTLVAKDLSDVALSQYAGKRKVLNIFPSIDTGVCAASVRKFNQLAAELDNTVV
LCISADLPFAQSRFCGAEGLSNVVTLSTLRGASFLADYGVAIATGPLAGLAARAVVVIDENDQVVYSQLVNEITEEPDYD
AALAALKA

Sequences:

>Translated_168_residues
MSQTVHFQGNPVSVQGTIPQAGAKAQPFTLVAKDLSDVALSQYAGKRKVLNIFPSIDTGVCAASVRKFNQLAAELDNTVV
LCISADLPFAQSRFCGAEGLSNVVTLSTLRGASFLADYGVAIATGPLAGLAARAVVVIDENDQVVYSQLVNEITEEPDYD
AALAALKA
>Mature_167_residues
SQTVHFQGNPVSVQGTIPQAGAKAQPFTLVAKDLSDVALSQYAGKRKVLNIFPSIDTGVCAASVRKFNQLAAELDNTVVL
CISADLPFAQSRFCGAEGLSNVVTLSTLRGASFLADYGVAIATGPLAGLAARAVVVIDENDQVVYSQLVNEITEEPDYDA
ALAALKA

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) within the catalase- and peroxidase-deficient periplasmic space [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=168, Percent_Identity=83.9285714285714, Blast_Score=291, Evalue=2e-80,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 17544; Mature: 17413

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTVHFQGNPVSVQGTIPQAGAKAQPFTLVAKDLSDVALSQYAGKRKVLNIFPSIDTGV
CCCEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
CAASVRKFNQLAAELDNTVVLCISADLPFAQSRFCGAEGLSNVVTLSTLRGASFLADYGV
HHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCCCCCCCCEEEHHHHCCHHHHHHCCH
AIATGPLAGLAARAVVVIDENDQVVYSQLVNEITEEPDYDAALAALKA
HEECCCHHHHHCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
SQTVHFQGNPVSVQGTIPQAGAKAQPFTLVAKDLSDVALSQYAGKRKVLNIFPSIDTGV
CCEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
CAASVRKFNQLAAELDNTVVLCISADLPFAQSRFCGAEGLSNVVTLSTLRGASFLADYGV
HHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCCCCCCCCEEEHHHHCCHHHHHHCCH
AIATGPLAGLAARAVVVIDENDQVVYSQLVNEITEEPDYDAALAALKA
HEECCCHHHHHCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]