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The map label for this gene is nudG [H]

Identifier: 238894266

GI number: 238894266

Start: 2156541

End: 2156951

Strand: Reverse

Name: nudG [H]

Synonym: KP1_2239

Alternate gene names: 238894266

Gene position: 2156951-2156541 (Counterclockwise)

Preceding gene: 238894268

Following gene: 238894265

Centisome position: 41.1

GC content: 64.48

Gene sequence:

>411_bases
ATGCTAAAAATGATTGATGTTGTCGCCGCCATTATTGAACAGGATGGCCAGATTCTGCTGGCGCAGCGTCCGCCCCACGC
CGACCAGCCGGGGATGTGGGAGTTCGCCGGCGGCAAAGTGGAGCCGGGTGAAAACCAGCCGCAGGCGCTGGCCCGCGAAC
TGCAGGAGGAGATGGGCATCATCGCCCGCCCAGCTTGCTATATCGCTAGCCATCAGCGGGAGGTCTCCGGCCGCCGGATC
CATCTGCACGCCTGGTGGGTGCCGCACTTTCAGGGCACGCCGCTGGCCCACTATCACACTCAGCTGCGCTGGTGCCTTCC
CACAGAAGCGCTGGCCCTCGATCTCGCCCCGGCCGATATTCCTCTGCTGCACGCCTTTATCGCCCAGCGCCCCACCCTTT
CCGTCCGCTGA

Upstream 100 bases:

>100_bases
TGGCTATCAAGCATGAAGGTCTCCAGCAGGGTTGGCGGTTGTCAGTTACGGTCTATGGCGGTGATAATAGGCCATATTCG
TCTTATTAACCTTGATGCTT

Downstream 100 bases:

>100_bases
TCCGCCCGCCGCCTCGTCATCGCTTTTAGTTATGACGAGCGGGCAATTATAAATTTTGTTGTCGGCTCAATTTTTCCTTG
CTTGCCTAAGGATTAGCGGT

Product: pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MLKMIDVVAAIIEQDGQILLAQRPPHADQPGMWEFAGGKVEPGENQPQALARELQEEMGIIARPACYIASHQREVSGRRI
HLHAWWVPHFQGTPLAHYHTQLRWCLPTEALALDLAPADIPLLHAFIAQRPTLSVR

Sequences:

>Translated_136_residues
MLKMIDVVAAIIEQDGQILLAQRPPHADQPGMWEFAGGKVEPGENQPQALARELQEEMGIIARPACYIASHQREVSGRRI
HLHAWWVPHFQGTPLAHYHTQLRWCLPTEALALDLAPADIPLLHAFIAQRPTLSVR
>Mature_136_residues
MLKMIDVVAAIIEQDGQILLAQRPPHADQPGMWEFAGGKVEPGENQPQALARELQEEMGIIARPACYIASHQREVSGRRI
HLHAWWVPHFQGTPLAHYHTQLRWCLPTEALALDLAPADIPLLHAFIAQRPTLSVR

Specific function: Specific for pyrimidine substrates. Acts on 5-methyl- dCTP, CTP and dCTP in decreasing order [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=129, Percent_Identity=69.7674418604651, Blast_Score=175, Evalue=1e-45,
Organism=Escherichia coli, GI1786288, Length=123, Percent_Identity=31.7073170731707, Blast_Score=61, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 15273; Mature: 15273

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKMIDVVAAIIEQDGQILLAQRPPHADQPGMWEFAGGKVEPGENQPQALARELQEEMGI
CCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCEECCCCCCHHHHHHHHHHHCCC
IARPACYIASHQREVSGRRIHLHAWWVPHFQGTPLAHYHTQLRWCLPTEALALDLAPADI
CCCCHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHCEEEEECCCCCEEEECCCCCH
PLLHAFIAQRPTLSVR
HHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLKMIDVVAAIIEQDGQILLAQRPPHADQPGMWEFAGGKVEPGENQPQALARELQEEMGI
CCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCEECCCCCCHHHHHHHHHHHCCC
IARPACYIASHQREVSGRRIHLHAWWVPHFQGTPLAHYHTQLRWCLPTEALALDLAPADI
CCCCHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHCEEEEECCCCCEEEECCCCCH
PLLHAFIAQRPTLSVR
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 11053429 [H]