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The map label for this gene is gdhA [H]

Identifier: 238894265

GI number: 238894265

Start: 2155015

End: 2156358

Strand: Reverse

Name: gdhA [H]

Synonym: KP1_2238

Alternate gene names: 238894265

Gene position: 2156358-2155015 (Counterclockwise)

Preceding gene: 238894266

Following gene: 238894261

Centisome position: 41.09

GC content: 61.09

Gene sequence:

>1344_bases
ATGGATCAGACGTGCACTCTGGAAGGCTTTCTCACCCGCGTTCAACAGCGCGATCCTCATCAAACCGAATTTGCTCAAGC
CGTCCGGGAGGTGATGACCACCCTGTGGCCTTTCCTTGAGGAAAATCCGCGCTATCGTCAGCTTGCTTTGCTGGAACGTC
TGGTGGAACCGGAGCGCGTGATCCAGTTCCGCGTGGTGTGGGTGGACGACCGCAATCAGGTCCAGGTCAACCGCGCTTGG
CGCGTGCAGTTCAACTCGGCCATCGGCCCGTATAAAGGCGGGATGCGTTTTCACCCGTCGGTTAACCTGTCGATTCTCAA
ATTCCTTGGCTTCGAGCAGACCTTCAAAAACGCCCTGACCACTCTGCCGATGGGCGGCGGGAAAGGCGGCAGCGATTTCG
ACCCTAAAGGCAAGAGCGATGGCGAAGTGATGCGTTTCTGCCAGGCGCTGATGACCGAACTCTATCGCCACCTTGGCCCG
GATACCGACGTACCGGCGGGCGATATCGGCGTCGGCGGTCGCGAAGTCGGCTTTATGGCCGGAATGATGCGCAAGCTCTC
CAACAACAGCGCCTGCGTCTTCACCGGTAAAGGACTCTCCTTTGGCGGCAGCTTGATCCGTCCGGAAGCCACTGGTTACG
GCCTGATCTACTTCACCGAAGCGATGCTCAAACGTCACGGCCTCGGCTTCGAAGGCGCTCGCGTGGCGGTTTCCGGCTCC
GGCAACGTCGCGCAATACGCCATTGAGAAAGCGATGGAGCTTGGCGCGCGGGTGGTGACGGCCTCCGACTCCAACGGCAC
CGTCGTTGACGAAGCGGGCTTCACCAAAGAAAAACTGGCCCACCTGATCGACATTAAAGAGCGTGCCCACGGCCGCGTGG
CCGATTACGCCCGCGAATTTGGCCTCACCTATCTTGAAGGCCAGCAGCCGTGGTCAGTGCCGGTGGATATTGCCCTGCCT
TGCGCGACCCAGAACGAACTGGACGTCGATGCCGCCCGCCAGCTGATTGCCAATGGCGTCAAGGCCGTGGCGGAAGGCGC
CAACATGCCGACCACCATCGCCGCAACCGACCTGTTCCTGGAAGCTGGCGTGCTGTTTGCCCCGGGCAAAGCGGCCAACG
CCGGCGGCGTGGCGACTTCCGGTCTGGAGATGGCGCAGAACGCCGCGCGCATGGGCTGGAAAGCGGAAAAAGTGGATGCC
CGTCTGCATCACATCATGCTGGATATCCACCACGCTTGCGTGCAGTACGGCGGCGAAGCGAAGCAGACCAACTACGTGCG
CGGCGCGAATATCGCCGGTTTCGTGAAGGTTGCGGATGCCATGCTGGCCCAGGGCGTGATTTAA

Upstream 100 bases:

>100_bases
TGCCTAAGGATTAGCGGTGTTATAGTCGGAAAATCGGTTTTTTCAAGGACCGAATCATAATAAATACATGCAACCACAAC
CATAAGGGGAACTGATATCT

Downstream 100 bases:

>100_bases
CCACCCCTAACTCCATCCCGGCGGCAGCCCGCCGGGATGCGTCTCACGACGTCATCGTGATCACAACTTTCCCCAGATGC
TGACCACTGTCCAGACAGGC

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MDQTCTLEGFLTRVQQRDPHQTEFAQAVREVMTTLWPFLEENPRYRQLALLERLVEPERVIQFRVVWVDDRNQVQVNRAW
RVQFNSAIGPYKGGMRFHPSVNLSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSDGEVMRFCQALMTELYRHLGP
DTDVPAGDIGVGGREVGFMAGMMRKLSNNSACVFTGKGLSFGGSLIRPEATGYGLIYFTEAMLKRHGLGFEGARVAVSGS
GNVAQYAIEKAMELGARVVTASDSNGTVVDEAGFTKEKLAHLIDIKERAHGRVADYAREFGLTYLEGQQPWSVPVDIALP
CATQNELDVDAARQLIANGVKAVAEGANMPTTIAATDLFLEAGVLFAPGKAANAGGVATSGLEMAQNAARMGWKAEKVDA
RLHHIMLDIHHACVQYGGEAKQTNYVRGANIAGFVKVADAMLAQGVI

Sequences:

>Translated_447_residues
MDQTCTLEGFLTRVQQRDPHQTEFAQAVREVMTTLWPFLEENPRYRQLALLERLVEPERVIQFRVVWVDDRNQVQVNRAW
RVQFNSAIGPYKGGMRFHPSVNLSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSDGEVMRFCQALMTELYRHLGP
DTDVPAGDIGVGGREVGFMAGMMRKLSNNSACVFTGKGLSFGGSLIRPEATGYGLIYFTEAMLKRHGLGFEGARVAVSGS
GNVAQYAIEKAMELGARVVTASDSNGTVVDEAGFTKEKLAHLIDIKERAHGRVADYAREFGLTYLEGQQPWSVPVDIALP
CATQNELDVDAARQLIANGVKAVAEGANMPTTIAATDLFLEAGVLFAPGKAANAGGVATSGLEMAQNAARMGWKAEKVDA
RLHHIMLDIHHACVQYGGEAKQTNYVRGANIAGFVKVADAMLAQGVI
>Mature_447_residues
MDQTCTLEGFLTRVQQRDPHQTEFAQAVREVMTTLWPFLEENPRYRQLALLERLVEPERVIQFRVVWVDDRNQVQVNRAW
RVQFNSAIGPYKGGMRFHPSVNLSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSDGEVMRFCQALMTELYRHLGP
DTDVPAGDIGVGGREVGFMAGMMRKLSNNSACVFTGKGLSFGGSLIRPEATGYGLIYFTEAMLKRHGLGFEGARVAVSGS
GNVAQYAIEKAMELGARVVTASDSNGTVVDEAGFTKEKLAHLIDIKERAHGRVADYAREFGLTYLEGQQPWSVPVDIALP
CATQNELDVDAARQLIANGVKAVAEGANMPTTIAATDLFLEAGVLFAPGKAANAGGVATSGLEMAQNAARMGWKAEKVDA
RLHHIMLDIHHACVQYGGEAKQTNYVRGANIAGFVKVADAMLAQGVI

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=396, Percent_Identity=29.7979797979798, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4885281, Length=390, Percent_Identity=29.7435897435897, Blast_Score=138, Evalue=9e-33,
Organism=Escherichia coli, GI1788059, Length=447, Percent_Identity=89.9328859060403, Blast_Score=847, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17544676, Length=342, Percent_Identity=30.1169590643275, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319256, Length=453, Percent_Identity=53.2008830022075, Blast_Score=426, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6324951, Length=451, Percent_Identity=51.219512195122, Blast_Score=422, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24649283, Length=318, Percent_Identity=31.7610062893082, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45553475, Length=358, Percent_Identity=28.7709497206704, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI45549226, Length=357, Percent_Identity=28.2913165266106, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24649460, Length=297, Percent_Identity=29.6296296296296, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 48516; Mature: 48516

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQTCTLEGFLTRVQQRDPHQTEFAQAVREVMTTLWPFLEENPRYRQLALLERLVEPERV
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCE
IQFRVVWVDDRNQVQVNRAWRVQFNSAIGPYKGGMRFHPSVNLSILKFLGFEQTFKNALT
EEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCEEECCCCCHHHHHHHCHHHHHHHHHH
TLPMGGGKGGSDFDPKGKSDGEVMRFCQALMTELYRHLGPDTDVPAGDIGVGGREVGFMA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
GMMRKLSNNSACVFTGKGLSFGGSLIRPEATGYGLIYFTEAMLKRHGLGFEGARVAVSGS
HHHHHHCCCCEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECC
GNVAQYAIEKAMELGARVVTASDSNGTVVDEAGFTKEKLAHLIDIKERAHGRVADYAREF
CCHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
GLTYLEGQQPWSVPVDIALPCATQNELDVDAARQLIANGVKAVAEGANMPTTIAATDLFL
CCEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
EAGVLFAPGKAANAGGVATSGLEMAQNAARMGWKAEKVDARLHHIMLDIHHACVQYGGEA
HCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
KQTNYVRGANIAGFVKVADAMLAQGVI
CCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDQTCTLEGFLTRVQQRDPHQTEFAQAVREVMTTLWPFLEENPRYRQLALLERLVEPERV
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCE
IQFRVVWVDDRNQVQVNRAWRVQFNSAIGPYKGGMRFHPSVNLSILKFLGFEQTFKNALT
EEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCEEECCCCCHHHHHHHCHHHHHHHHHH
TLPMGGGKGGSDFDPKGKSDGEVMRFCQALMTELYRHLGPDTDVPAGDIGVGGREVGFMA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
GMMRKLSNNSACVFTGKGLSFGGSLIRPEATGYGLIYFTEAMLKRHGLGFEGARVAVSGS
HHHHHHCCCCEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECC
GNVAQYAIEKAMELGARVVTASDSNGTVVDEAGFTKEKLAHLIDIKERAHGRVADYAREF
CCHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
GLTYLEGQQPWSVPVDIALPCATQNELDVDAARQLIANGVKAVAEGANMPTTIAATDLFL
CCEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
EAGVLFAPGKAANAGGVATSGLEMAQNAARMGWKAEKVDARLHHIMLDIHHACVQYGGEA
HCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
KQTNYVRGANIAGFVKVADAMLAQGVI
CCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6308576; 6373501; 9097039; 9278503; 9298646 [H]