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The map label for this gene is yceE [H]

Identifier: 238894103

GI number: 238894103

Start: 2003645

End: 2004871

Strand: Reverse

Name: yceE [H]

Synonym: KP1_2054

Alternate gene names: 238894103

Gene position: 2004871-2003645 (Counterclockwise)

Preceding gene: 238894104

Following gene: 238894102

Centisome position: 38.2

GC content: 58.35

Gene sequence:

>1227_bases
ATGTCGTCTGCTGAAACCCCCATTAACTGGAAACGAAACCTGACCGTGACCTGGCTTGGCTGCTTTTTAACCGGCGCCGC
CTTCAGCCTGGTCATGCCCTTTCTGCCACTCTACGTCGAACAGCTCGGCGTCACCGGGCATAGCGCCCTGAACATGTGGT
CCGGGCTGGTCTTTAGTATTACCTTTCTTTTCTCCGCCATCGCCTCGCCGTTCTGGGGGGGGCTTGCTGATCGCAAGGGG
AGAAAAATCATGCTGCTGCGTTCCGCCCTCGGGATGGCCATCGTGATGATGCTGATGGGAATGGCGCAGAATATCTGGCA
GTTTCTGCTGCTGCGCGCATTGCTCGGCCTGCTGGGCGGTTTTATTCCTAACGCCAACGCCCTGATCGCCACCCAGATCC
CGCGCCATAAAAGCGGCTGGGCGCTGGGGACACTGTCTACCGGCGCGGTAAGCGGCGCCCTGCTCGGCCCGCTGGCAGGT
GGCTTCCTGGCCGACCACTGGGGATTGCGCACCGTCTTCTTTATGACCGCGGCGGTACTATTTATCTGTTTCTTGTTTAC
CCTGTTTTTAATCCGCGAAAATTTTGTGCCGATCGCCAGGAAAGAGATGCTCAGTGCCAGAGAGGTGTTCTCCTCGCTGC
AGAATCCCAAACTGGTGCTCAGCCTGTTTGTGACCTCGCTGATAATCCAGGTGGCCACCGGTTCCATTGCGCCGATCCTG
ACGCTTTATGTACGCGATCTCGCGGGCAACGTCAGTTACATCGCCTTTATCAGCGGAATGATCGCCTCGGTGCCGGGCAT
TGCCGCGCTGATGAGCGCCCCGCGGCTGGGCAAACTGGGGGATCGCATCGGGCCGGAAAAAATCCTCATCGTGGCGCTGA
TTATCTCGGTGCTACTCCTGATCCCGATGTCGTTCGTTCAGACCCCGCTGCAGTTAGGTATCCTGCGATTCCTGCTCGGC
GCCGCGGACGGCGCGCTGCTGCCGGCGGTGCAAACCCTGCTGGTGTACAACTCCACCAGTCAGATCTCCGGGCGAATCTT
CAGCTATAACCAGTCGTTCCGCGATATTGGCAACGTTACCGGCCCCCTGATTGGCGCGTCGGTTTCCGCTAACTATGGCT
TCCGCGCTGTATTTCTGGTCACCGCAGGGGTGGTATTGTTTAATGCGATCTACTCCACCCTCAGCCTGCGTCGGCCAGCC
GCGGATACTTCGCATTCAGTAAATTAA

Upstream 100 bases:

>100_bases
TAAAAGCTCTCCTCCATTGCGGCATCTATTTCTCAGGCGCATAATTAGCAGGCTCATATTTTCTCTTAATTTGACCTGCC
GCGCAGGCCAGTGGAACCCT

Downstream 100 bases:

>100_bases
CGTCGAGAGTGGCTCTGTCCCTTGACGCCGTGCGTACCGCCTTCTATAGATTGAATCGTGTTCAATTCATATTCTTCTCA
GGAGATTCGCTATGCCAAAG

Product: drug efflux system protein MdtG

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSSAETPINWKRNLTVTWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKG
RKIMLLRSALGMAIVMMLMGMAQNIWQFLLLRALLGLLGGFIPNANALIATQIPRHKSGWALGTLSTGAVSGALLGPLAG
GFLADHWGLRTVFFMTAAVLFICFLFTLFLIRENFVPIARKEMLSAREVFSSLQNPKLVLSLFVTSLIIQVATGSIAPIL
TLYVRDLAGNVSYIAFISGMIASVPGIAALMSAPRLGKLGDRIGPEKILIVALIISVLLLIPMSFVQTPLQLGILRFLLG
AADGALLPAVQTLLVYNSTSQISGRIFSYNQSFRDIGNVTGPLIGASVSANYGFRAVFLVTAGVVLFNAIYSTLSLRRPA
ADTSHSVN

Sequences:

>Translated_408_residues
MSSAETPINWKRNLTVTWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKG
RKIMLLRSALGMAIVMMLMGMAQNIWQFLLLRALLGLLGGFIPNANALIATQIPRHKSGWALGTLSTGAVSGALLGPLAG
GFLADHWGLRTVFFMTAAVLFICFLFTLFLIRENFVPIARKEMLSAREVFSSLQNPKLVLSLFVTSLIIQVATGSIAPIL
TLYVRDLAGNVSYIAFISGMIASVPGIAALMSAPRLGKLGDRIGPEKILIVALIISVLLLIPMSFVQTPLQLGILRFLLG
AADGALLPAVQTLLVYNSTSQISGRIFSYNQSFRDIGNVTGPLIGASVSANYGFRAVFLVTAGVVLFNAIYSTLSLRRPA
ADTSHSVN
>Mature_407_residues
SSAETPINWKRNLTVTWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGR
KIMLLRSALGMAIVMMLMGMAQNIWQFLLLRALLGLLGGFIPNANALIATQIPRHKSGWALGTLSTGAVSGALLGPLAGG
FLADHWGLRTVFFMTAAVLFICFLFTLFLIRENFVPIARKEMLSAREVFSSLQNPKLVLSLFVTSLIIQVATGSIAPILT
LYVRDLAGNVSYIAFISGMIASVPGIAALMSAPRLGKLGDRIGPEKILIVALIISVLLLIPMSFVQTPLQLGILRFLLGA
ADGALLPAVQTLLVYNSTSQISGRIFSYNQSFRDIGNVTGPLIGASVSANYGFRAVFLVTAGVVLFNAIYSTLSLRRPAA
DTSHSVN

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=394, Percent_Identity=86.5482233502538, Blast_Score=662, Evalue=0.0,
Organism=Escherichia coli, GI87082404, Length=299, Percent_Identity=24.7491638795987, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319871, Length=153, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43763; Mature: 43632

Theoretical pI: Translated: 10.91; Mature: 10.91

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAETPINWKRNLTVTWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TFLFSAIASPFWGGLADRKGRKIMLLRSALGMAIVMMLMGMAQNIWQFLLLRALLGLLGG
HHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FIPNANALIATQIPRHKSGWALGTLSTGAVSGALLGPLAGGFLADHWGLRTVFFMTAAVL
CCCCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FICFLFTLFLIRENFVPIARKEMLSAREVFSSLQNPKLVLSLFVTSLIIQVATGSIAPIL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHH
TLYVRDLAGNVSYIAFISGMIASVPGIAALMSAPRLGKLGDRIGPEKILIVALIISVLLL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHH
IPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSTSQISGRIFSYNQSFRDIGNVT
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHCCHHEECCHHHHHHHCCC
GPLIGASVSANYGFRAVFLVTAGVVLFNAIYSTLSLRRPAADTSHSVN
CCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SSAETPINWKRNLTVTWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TFLFSAIASPFWGGLADRKGRKIMLLRSALGMAIVMMLMGMAQNIWQFLLLRALLGLLGG
HHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FIPNANALIATQIPRHKSGWALGTLSTGAVSGALLGPLAGGFLADHWGLRTVFFMTAAVL
CCCCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FICFLFTLFLIRENFVPIARKEMLSAREVFSSLQNPKLVLSLFVTSLIIQVATGSIAPIL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHH
TLYVRDLAGNVSYIAFISGMIASVPGIAALMSAPRLGKLGDRIGPEKILIVALIISVLLL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHH
IPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSTSQISGRIFSYNQSFRDIGNVT
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHCCHHEECCHHHHHHHCCC
GPLIGASVSANYGFRAVFLVTAGVVLFNAIYSTLSLRRPAADTSHSVN
CCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA