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The map label for this gene is ycdW [H]

Identifier: 238894092

GI number: 238894092

Start: 1993087

End: 1994025

Strand: Direct

Name: ycdW [H]

Synonym: KP1_2043

Alternate gene names: 238894092

Gene position: 1993087-1994025 (Clockwise)

Preceding gene: 238894091

Following gene: 238894093

Centisome position: 37.97

GC content: 62.62

Gene sequence:

>939_bases
ATGGAGATTATTTTTTACCATCCGACCTTTGATACCCAATACTGGATCTGTGAGCTGGAAAAGCAGTTACCCGGCGCGCG
GGTGCGCGAGTGGAAAGCGGGCGATAACCGGCCGGCGGACTACGCCCTGGTCTGGCATCCGCCGGTAGAGATGCTGCAGG
GCCGGGCGCTGAAGGCCGTGTTCGCCCTCGGGGCAGGGGTGGACTCTATTCTCAGCAAGCTGCGTGACCATCCGGATATG
CTGCCGCTGTCGATTCCGCTGTTTCGTCTCGAAGATACCGGTATGGGACGGCAGATGCAGGAGTATGCCGTGAGCCAGGT
GCTCCACTGGTTCCGCCGCTTTGATGACTATCAGGCGCTGAAGCTGGCGTCCCGCTGGCAGCCGCTGCCCGAGTACCGCG
CCGACGAATTCACCGTCGGGATTATGGGCGCCGGCGTGCTGGGGGCGAAGGTTGCGGAAAGTCTGCAACCCTGGGGGTTC
CCGCTTCGCGTCTGGAGCCGTAGCCGCAAATCCTGGCCGCAGGTGCAGAGCTTCGCCGGCCAGGCCGAGCTGGGCGAATT
CCTGCAGGGCACTCGCGTGCTGATCAACCTGCTGCCGAATACCGCCGAAACCGCCGGCATTATTAACCAGACGCTGCTGG
CGCAGTTGCCGGATGAGAGCTATGTCCTCAACCTTGCTCGCGGCGTGCATGTCGTTGAAGAGGATCTGCTGGCGGCGCTG
AACAGCGGTAAGCTCAAAGGGGCGATGCTCGATGTCTTCAGTCGCGAACCGCTGCCGCAGGAGAGCCCGCTATGGGCGCA
TCCGCGGGTGGCCATGACCCCCCATGTGGCGGCAGTGACCCGTCCAATGGAAGCTATCACCTACATTGCGGAGACCATTA
GCCGGCTTGAGCGAGGGGAGCCGGTAAGCGGTCAGGTCGACCGCCAGCGCGGTTATTAA

Upstream 100 bases:

>100_bases
CTCGGGGGAAATTTGTTATGCTGGCAAACCAATAGAAAACAATGAGTAAAATAAGACGCCAGCGTTAATCGGCCAAAGGC
GTCTGCTATCAGGAGCCCCT

Downstream 100 bases:

>100_bases
GACGAGAGAACCCCGCCACGGCGGGGTTTTTGCTAATCAATAGCCCGGTTTCCTGCTATTCTTGCGGCAAACAGAAGAGG
AGAATGTGATGTATCCCGTT

Product: 2-ketoacid reductase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MEIIFYHPTFDTQYWICELEKQLPGARVREWKAGDNRPADYALVWHPPVEMLQGRALKAVFALGAGVDSILSKLRDHPDM
LPLSIPLFRLEDTGMGRQMQEYAVSQVLHWFRRFDDYQALKLASRWQPLPEYRADEFTVGIMGAGVLGAKVAESLQPWGF
PLRVWSRSRKSWPQVQSFAGQAELGEFLQGTRVLINLLPNTAETAGIINQTLLAQLPDESYVLNLARGVHVVEEDLLAAL
NSGKLKGAMLDVFSREPLPQESPLWAHPRVAMTPHVAAVTRPMEAITYIAETISRLERGEPVSGQVDRQRGY

Sequences:

>Translated_312_residues
MEIIFYHPTFDTQYWICELEKQLPGARVREWKAGDNRPADYALVWHPPVEMLQGRALKAVFALGAGVDSILSKLRDHPDM
LPLSIPLFRLEDTGMGRQMQEYAVSQVLHWFRRFDDYQALKLASRWQPLPEYRADEFTVGIMGAGVLGAKVAESLQPWGF
PLRVWSRSRKSWPQVQSFAGQAELGEFLQGTRVLINLLPNTAETAGIINQTLLAQLPDESYVLNLARGVHVVEEDLLAAL
NSGKLKGAMLDVFSREPLPQESPLWAHPRVAMTPHVAAVTRPMEAITYIAETISRLERGEPVSGQVDRQRGY
>Mature_312_residues
MEIIFYHPTFDTQYWICELEKQLPGARVREWKAGDNRPADYALVWHPPVEMLQGRALKAVFALGAGVDSILSKLRDHPDM
LPLSIPLFRLEDTGMGRQMQEYAVSQVLHWFRRFDDYQALKLASRWQPLPEYRADEFTVGIMGAGVLGAKVAESLQPWGF
PLRVWSRSRKSWPQVQSFAGQAELGEFLQGTRVLINLLPNTAETAGIINQTLLAQLPDESYVLNLARGVHVVEEDLLAAL
NSGKLKGAMLDVFSREPLPQESPLWAHPRVAMTPHVAAVTRPMEAITYIAETISRLERGEPVSGQVDRQRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=218, Percent_Identity=30.2752293577982, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI23308577, Length=268, Percent_Identity=27.9850746268657, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI87081824, Length=312, Percent_Identity=75.6410256410256, Blast_Score=492, Evalue=1e-140,
Organism=Escherichia coli, GI87082289, Length=146, Percent_Identity=30.8219178082192, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=264, Percent_Identity=28.4090909090909, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=176, Percent_Identity=27.8409090909091, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574286, Length=258, Percent_Identity=26.7441860465116, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45552429, Length=258, Percent_Identity=24.8062015503876, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585514, Length=258, Percent_Identity=24.8062015503876, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574282, Length=258, Percent_Identity=24.8062015503876, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551003, Length=258, Percent_Identity=24.8062015503876, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574284, Length=258, Percent_Identity=24.8062015503876, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 35170; Mature: 35170

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIFYHPTFDTQYWICELEKQLPGARVREWKAGDNRPADYALVWHPPVEMLQGRALKAV
CEEEEECCCCCCCCCEEEHHHHCCCCHHHHCCCCCCCCCCEEEEECCCHHHHCCHHHHHH
FALGAGVDSILSKLRDHPDMLPLSIPLFRLEDTGMGRQMQEYAVSQVLHWFRRFDDYQAL
HHHHCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
KLASRWQPLPEYRADEFTVGIMGAGVLGAKVAESLQPWGFPLRVWSRSRKSWPQVQSFAG
HHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHCC
QAELGEFLQGTRVLINLLPNTAETAGIINQTLLAQLPDESYVLNLARGVHVVEEDLLAAL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
NSGKLKGAMLDVFSREPLPQESPLWAHPRVAMTPHVAAVTRPMEAITYIAETISRLERGE
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PVSGQVDRQRGY
CCCCCCCCCCCC
>Mature Secondary Structure
MEIIFYHPTFDTQYWICELEKQLPGARVREWKAGDNRPADYALVWHPPVEMLQGRALKAV
CEEEEECCCCCCCCCEEEHHHHCCCCHHHHCCCCCCCCCCEEEEECCCHHHHCCHHHHHH
FALGAGVDSILSKLRDHPDMLPLSIPLFRLEDTGMGRQMQEYAVSQVLHWFRRFDDYQAL
HHHHCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
KLASRWQPLPEYRADEFTVGIMGAGVLGAKVAESLQPWGFPLRVWSRSRKSWPQVQSFAG
HHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHCC
QAELGEFLQGTRVLINLLPNTAETAGIINQTLLAQLPDESYVLNLARGVHVVEEDLLAAL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
NSGKLKGAMLDVFSREPLPQESPLWAHPRVAMTPHVAAVTRPMEAITYIAETISRLERGE
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PVSGQVDRQRGY
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA