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The map label for this gene is lrp [C]

Identifier: 238893988

GI number: 238893988

Start: 1882700

End: 1883161

Strand: Reverse

Name: lrp [C]

Synonym: KP1_1932

Alternate gene names: 238893988

Gene position: 1883161-1882700 (Counterclockwise)

Preceding gene: 238893993

Following gene: 238893987

Centisome position: 35.88

GC content: 48.92

Gene sequence:

>462_bases
ATGAAACTTGACGCATGGGATAAAAAAATTCTTACGCTCTTGCAGCGTAATAATCGCTTGTCGCAACGGGAGATCGCCGA
TCGGATCAGCCTGTCTCCTTCGGCAGTCAATCGGCGTATCGCTGCACTGGAGGATGCAGGAGTGATTAAACGCAGTGTTA
GCTTAGTGGACGCCAGTAAAGTGGGAAGACCAATCACCATTATGGTGCAGGTGACCATTGAGAATGAACGTCTCGATCTG
CTTGAGGAGGATAAACAGCGTTTCGTAACCTGTCCGCAAGTGCAGCAGGTCTACTATGTCACTGGCGACTTCGATTTCCT
GCTCGTGATCAACGTCCGTGATATGGCGGAATACGAAGCGCTAACCCGTGAACTCTTTTTTGCCTCGGGAAATATCAAGT
CTTTCCGGACCATCGTGTCGATGCAAAATGCGAAGCAGGAAATGACGGTCATTATCGAGTAA

Upstream 100 bases:

>100_bases
AGTTGCCCATCGCGCCGCAATTTTCACTCTGTTTTATCATTCTCACGCAACAACGTTGCATTAGTGAGGTTGATCACAGG
CTTGCAGGACGAGATATATG

Downstream 100 bases:

>100_bases
GTCGTGTAAAAGTCGACATGGGGAGCCAAAGAACGCCCCGGAGGTGTATTTATTTCCGAAATCCACCCTTCCCTGTGCGA
AATCTACTTGTCTGATGGAA

Product: regulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MKLDAWDKKILTLLQRNNRLSQREIADRISLSPSAVNRRIAALEDAGVIKRSVSLVDASKVGRPITIMVQVTIENERLDL
LEEDKQRFVTCPQVQQVYYVTGDFDFLLVINVRDMAEYEALTRELFFASGNIKSFRTIVSMQNAKQEMTVIIE

Sequences:

>Translated_153_residues
MKLDAWDKKILTLLQRNNRLSQREIADRISLSPSAVNRRIAALEDAGVIKRSVSLVDASKVGRPITIMVQVTIENERLDL
LEEDKQRFVTCPQVQQVYYVTGDFDFLLVINVRDMAEYEALTRELFFASGNIKSFRTIVSMQNAKQEMTVIIE
>Mature_153_residues
MKLDAWDKKILTLLQRNNRLSQREIADRISLSPSAVNRRIAALEDAGVIKRSVSLVDASKVGRPITIMVQVTIENERLDL
LEEDKQRFVTCPQVQQVYYVTGDFDFLLVINVRDMAEYEALTRELFFASGNIKSFRTIVSMQNAKQEMTVIIE

Specific function: Mediates A Global Response To Leucine. Exogenous Leucine Affects The Expression Of A Number Of Different Operons; Lrp Mediates This Effect For At Least Some Of These Operons. For Example It Is Regulator Of The Branched-Chain Amino Acid Transport Genes. [

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=151, Percent_Identity=29.8013245033113, Blast_Score=81, Evalue=3e-17,
Organism=Escherichia coli, GI87081742, Length=155, Percent_Identity=27.741935483871, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR013196
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg; PF08279 HTH_11 [H]

EC number: NA

Molecular weight: Translated: 17552; Mature: 17552

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDAWDKKILTLLQRNNRLSQREIADRISLSPSAVNRRIAALEDAGVIKRSVSLVDASK
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VGRPITIMVQVTIENERLDLLEEDKQRFVTCPQVQQVYYVTGDFDFLLVINVRDMAEYEA
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEEEHHHHHHHH
LTRELFFASGNIKSFRTIVSMQNAKQEMTVIIE
HHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEC
>Mature Secondary Structure
MKLDAWDKKILTLLQRNNRLSQREIADRISLSPSAVNRRIAALEDAGVIKRSVSLVDASK
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VGRPITIMVQVTIENERLDLLEEDKQRFVTCPQVQQVYYVTGDFDFLLVINVRDMAEYEA
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEEEHHHHHHHH
LTRELFFASGNIKSFRTIVSMQNAKQEMTVIIE
HHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]