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The map label for this gene is lpxK [H]

Identifier: 238893971

GI number: 238893971

Start: 1862087

End: 1863067

Strand: Direct

Name: lpxK [H]

Synonym: KP1_1915

Alternate gene names: 238893971

Gene position: 1862087-1863067 (Clockwise)

Preceding gene: 238893970

Following gene: 238893972

Centisome position: 35.48

GC content: 63.81

Gene sequence:

>981_bases
ATGATCGCGCGCATCTGGTCCGGGGAATCGCCGCTGTGGCGCCTGCTGCTGCCGCTCTCCTGGCTGTATGGCCTGGTGAG
CGGGGTGATTCGCCTCAGCTATCAGCTGGGGTGGCAAAAAGCCTGGCGCGCGCCGGTGCCGGTGGTGGTGGTTGGTAACC
TGACCGCCGGCGGCAATGGCAAAACGCCGGTGGTGATCTGGCTGGTGGAGCAGCTGCAGCAGCGCGGTATTCGCGTTGGC
GTCGTGTCTCGCGGCTACGGCGGTAAAGCCGACCGCTATCCGCTGGTGTTGGACGACAGAACCAGTACGGCGCTGGCGGG
TGATGAACCGGTGTTGATCCATCAGCGTACCGGTGCCCCGGTCGCTGTCGCTCCGCTACGCAGCGACGCGGTAAAAGCAT
TGCTCAGCGCGCACGATCTGCAGATGATTGTGACCGACGACGGGTTGCAGCACTATAAGCTCGCGCGGGACAGAGAAATT
GTCGTTATTGACGGCGTGCGCCGCTTTGGCAACGGCTGGTGGCTGCCTGCCGGGCCGATGCGCGAGCGGGCGTCGCGCTT
GCAAAGCGTTGATGCGGTTATCGTTAACGGCGGCGTGGCGCGTCCGGGTGAGATCCCGATGCGGTTGCGCCCAGGGATGG
CGGTTAACCTGCTTACCGGCGAACGTCGCGATGTCTCCACCTTCACGAACGTAGTGGCGATGGCCGGCATCGGCCATCCG
CCGCGCTTCTTCGCCACCCTCGAAAGCTGCGGCGTCCAGCCGGTCAAAACCGTGGCGCTGGCGGACCATCAGGCGCTGAG
CCAGGATGATGTCGCCGCCCTGGTGACCGCCGATCAGACGCTGCTGATGACCGAGAAAGATGCCGTGAAATGTCGCGATT
TCGCCGCTGCAAACTGGTGGTATTTACCGGTCGACGCCATAATGGCCGATGAACGCGCACAGCGGTTGCTTGCGGACTTA
GCGACGTTGGCGCAACGTTAA

Upstream 100 bases:

>100_bases
TGGTGGTTGAAGACGGGCGGATCGTGGAGCGCGGAACGCACCATGACCTGCTGGAGCATAAGGGCGTGTACGCCCAGCTG
CATAAGATGCAATTCGGCGA

Downstream 100 bases:

>100_bases
CTGACGCGCCGGCTTTGCTCGCCGCTGTGCTGGAATTCCTGACGGAGAACCTGCATGTCGGTATTGCAACTATCGCTTAA
CGAGGCGCGCCACCTCCATC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MIARIWSGESPLWRLLLPLSWLYGLVSGVIRLSYQLGWQKAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEQLQQRGIRVG
VVSRGYGGKADRYPLVLDDRTSTALAGDEPVLIHQRTGAPVAVAPLRSDAVKALLSAHDLQMIVTDDGLQHYKLARDREI
VVIDGVRRFGNGWWLPAGPMRERASRLQSVDAVIVNGGVARPGEIPMRLRPGMAVNLLTGERRDVSTFTNVVAMAGIGHP
PRFFATLESCGVQPVKTVALADHQALSQDDVAALVTADQTLLMTEKDAVKCRDFAAANWWYLPVDAIMADERAQRLLADL
ATLAQR

Sequences:

>Translated_326_residues
MIARIWSGESPLWRLLLPLSWLYGLVSGVIRLSYQLGWQKAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEQLQQRGIRVG
VVSRGYGGKADRYPLVLDDRTSTALAGDEPVLIHQRTGAPVAVAPLRSDAVKALLSAHDLQMIVTDDGLQHYKLARDREI
VVIDGVRRFGNGWWLPAGPMRERASRLQSVDAVIVNGGVARPGEIPMRLRPGMAVNLLTGERRDVSTFTNVVAMAGIGHP
PRFFATLESCGVQPVKTVALADHQALSQDDVAALVTADQTLLMTEKDAVKCRDFAAANWWYLPVDAIMADERAQRLLADL
ATLAQR
>Mature_326_residues
MIARIWSGESPLWRLLLPLSWLYGLVSGVIRLSYQLGWQKAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEQLQQRGIRVG
VVSRGYGGKADRYPLVLDDRTSTALAGDEPVLIHQRTGAPVAVAPLRSDAVKALLSAHDLQMIVTDDGLQHYKLARDREI
VVIDGVRRFGNGWWLPAGPMRERASRLQSVDAVIVNGGVARPGEIPMRLRPGMAVNLLTGERRDVSTFTNVVAMAGIGHP
PRFFATLESCGVQPVKTVALADHQALSQDDVAALVTADQTLLMTEKDAVKCRDFAAANWWYLPVDAIMADERAQRLLADL
ATLAQR

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=325, Percent_Identity=77.2307692307692, Blast_Score=505, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 35586; Mature: 35586

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARIWSGESPLWRLLLPLSWLYGLVSGVIRLSYQLGWQKAWRAPVPVVVVGNLTAGGNG
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEEEECEECCCCC
KTPVVIWLVEQLQQRGIRVGVVSRGYGGKADRYPLVLDDRTSTALAGDEPVLIHQRTGAP
CCCEEEEEHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCEECCCCCEEEEECCCCC
VAVAPLRSDAVKALLSAHDLQMIVTDDGLQHYKLARDREIVVIDGVRRFGNGWWLPAGPM
EEEECCCHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCEEEEEECHHHHCCCCCCCCCHH
RERASRLQSVDAVIVNGGVARPGEIPMRLRPGMAVNLLTGERRDVSTFTNVVAMAGIGHP
HHHHHHHHHCCEEEEECCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
PRFFATLESCGVQPVKTVALADHQALSQDDVAALVTADQTLLMTEKDAVKCRDFAAANWW
HHHHHHHHHCCCCHHHHEEHHHHHHCCCCCEEEEEECCCEEEEECCCHHHHHHHCCCCEE
YLPVDAIMADERAQRLLADLATLAQR
EEEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIARIWSGESPLWRLLLPLSWLYGLVSGVIRLSYQLGWQKAWRAPVPVVVVGNLTAGGNG
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEEEECEECCCCC
KTPVVIWLVEQLQQRGIRVGVVSRGYGGKADRYPLVLDDRTSTALAGDEPVLIHQRTGAP
CCCEEEEEHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCEECCCCCEEEEECCCCC
VAVAPLRSDAVKALLSAHDLQMIVTDDGLQHYKLARDREIVVIDGVRRFGNGWWLPAGPM
EEEECCCHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCEEEEEECHHHHCCCCCCCCCHH
RERASRLQSVDAVIVNGGVARPGEIPMRLRPGMAVNLLTGERRDVSTFTNVVAMAGIGHP
HHHHHHHHHCCEEEEECCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
PRFFATLESCGVQPVKTVALADHQALSQDDVAALVTADQTLLMTEKDAVKCRDFAAANWW
HHHHHHHHHCCCCHHHHEEHHHHHHCCCCCEEEEEECCCEEEEECCCHHHHHHHCCCCEE
YLPVDAIMADERAQRLLADLATLAQR
EEEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA