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The map label for this gene is exuT2 [H]

Identifier: 238893879

GI number: 238893879

Start: 1751561

End: 1752862

Strand: Reverse

Name: exuT2 [H]

Synonym: KP1_1812

Alternate gene names: 238893879

Gene position: 1752862-1751561 (Counterclockwise)

Preceding gene: 238893881

Following gene: 238893878

Centisome position: 33.4

GC content: 58.6

Gene sequence:

>1302_bases
ATGAGTCAAGGCCTCAACAATGATATCGCCGTCAGCAAAACGCGCCGGGTAGTGAAAAACCTGCGCTGGTGGGTGCTGGT
CCTGTTTTTACTTGGCGTTACCGTCAACTACATCACACGCAACTCGCTGGGAATTATCGCGCCGGAACTGAAAGCGACCC
TCGGCATTACTACCGAACAATACTCGTGGATCGTCGGCGCGTTTCAGCTGGCTTACACGATTTTCCAGCCGCTGTGCGGC
TGGCTTATCGACGTCATCGGCCTGAAGCTTGGCTTTATGATCTGCGCCACCCTGTGGGCGCTGGCCTGTATCGCCCACGC
CGGGGCCGGTAGCTGGCTGCACCTGGCTATTTTGCGCTTCTTTATGGGTGGGGCCGAGGCGGCCGCTACTCCGGCCAACG
CCAAAACCATCGGCGAATGGTTTCCGAAATCTGAACGCCCGATTGCCGCCGGCTGGGCTGGCGTTGGGTTCTCCATCGGC
GCGATGCTGGCCCCGCCGATCATCTACTTCGCCCACGCCTCCTTCGGCTGGCAAGGGGCGTTTATGTTTACCGGCGCGCT
GGCGCTACTGTGGGTAGTACTATGGTGGGCCTTCTATCAGACCCCGGAAAAGCACCCCAATCTCAGCAAAAGCGAGCTGG
AGTACATCAAACAGGATAACGAAGCCCCGCCGGTAAAACAGCCCTTCTTTACCGCGCTCAAAACCGTCTCGAAAAATAAA
CGTTTCTACGGGATCGCCATTCCCGCCTTTATGGCCGAGCCCGCCTGGGCGGTGCTGAGTTTCTGGGTGCCGCTGTACCT
GGCGAAAGAGCACGGCATGGATTTGAAGCAGATCGCCATGTTTGCCTGGCTGCCGTTTCTCGCCGCCGATCTCGGCAGCG
TGGTCAGCGGCTACCTCACCCGCCTGTATGTTCGCTGGTTCGGCTGTACGCGAGTGAACTCGGTGATCGCCAGCTCGGTA
ACCGGCGCGTTCCTGATGCTCTCCCTGGCCCTCGTCGCCATCACCCGCGATCCCTATATCACCATCATCCTGATCTCCAT
TGGCGGCTTCGGCCATCAGATCATCTCCTGCATGCTCAGCGCGCTGGTGGTGGAGTCTTTCGACAAGGGACAAATGGCGA
CGGTCAACGGTATGCGCGGCTCCGCAGCGTGGATCGCCAGCTTCTTGTTCTCGTTATTAATCGGGGTGACCGCCGACAAA
ATCGGCTTCAACCCGCTATTTATCGCCATGGGTTTCTTTGACCTGATTGGCGCCGTTTTCCTGGTGGCATTTATTGCTGA
ACGTCGCGCCAAGCGCGCCTGA

Upstream 100 bases:

>100_bases
GAGATAAAAAATAGACTATTCAAATAGTTAATAAATCTACGTGACCACTCAGGGAGTGAGACCGTCACTTTCCCCCTACA
AACGTCTTGTGGAGTGTGCT

Downstream 100 bases:

>100_bases
GAGTGGATGTAAGATATGAAGACGCTGAAACACTGGAGTTTGCATCAACAGCTGGAGCATCACGTTGAACTGACGGTCGA
TGGCCAGCACACCCTGTGCC

Product: hexuronate transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MSQGLNNDIAVSKTRRVVKNLRWWVLVLFLLGVTVNYITRNSLGIIAPELKATLGITTEQYSWIVGAFQLAYTIFQPLCG
WLIDVIGLKLGFMICATLWALACIAHAGAGSWLHLAILRFFMGGAEAAATPANAKTIGEWFPKSERPIAAGWAGVGFSIG
AMLAPPIIYFAHASFGWQGAFMFTGALALLWVVLWWAFYQTPEKHPNLSKSELEYIKQDNEAPPVKQPFFTALKTVSKNK
RFYGIAIPAFMAEPAWAVLSFWVPLYLAKEHGMDLKQIAMFAWLPFLAADLGSVVSGYLTRLYVRWFGCTRVNSVIASSV
TGAFLMLSLALVAITRDPYITIILISIGGFGHQIISCMLSALVVESFDKGQMATVNGMRGSAAWIASFLFSLLIGVTADK
IGFNPLFIAMGFFDLIGAVFLVAFIAERRAKRA

Sequences:

>Translated_433_residues
MSQGLNNDIAVSKTRRVVKNLRWWVLVLFLLGVTVNYITRNSLGIIAPELKATLGITTEQYSWIVGAFQLAYTIFQPLCG
WLIDVIGLKLGFMICATLWALACIAHAGAGSWLHLAILRFFMGGAEAAATPANAKTIGEWFPKSERPIAAGWAGVGFSIG
AMLAPPIIYFAHASFGWQGAFMFTGALALLWVVLWWAFYQTPEKHPNLSKSELEYIKQDNEAPPVKQPFFTALKTVSKNK
RFYGIAIPAFMAEPAWAVLSFWVPLYLAKEHGMDLKQIAMFAWLPFLAADLGSVVSGYLTRLYVRWFGCTRVNSVIASSV
TGAFLMLSLALVAITRDPYITIILISIGGFGHQIISCMLSALVVESFDKGQMATVNGMRGSAAWIASFLFSLLIGVTADK
IGFNPLFIAMGFFDLIGAVFLVAFIAERRAKRA
>Mature_432_residues
SQGLNNDIAVSKTRRVVKNLRWWVLVLFLLGVTVNYITRNSLGIIAPELKATLGITTEQYSWIVGAFQLAYTIFQPLCGW
LIDVIGLKLGFMICATLWALACIAHAGAGSWLHLAILRFFMGGAEAAATPANAKTIGEWFPKSERPIAAGWAGVGFSIGA
MLAPPIIYFAHASFGWQGAFMFTGALALLWVVLWWAFYQTPEKHPNLSKSELEYIKQDNEAPPVKQPFFTALKTVSKNKR
FYGIAIPAFMAEPAWAVLSFWVPLYLAKEHGMDLKQIAMFAWLPFLAADLGSVVSGYLTRLYVRWFGCTRVNSVIASSVT
GAFLMLSLALVAITRDPYITIILISIGGFGHQIISCMLSALVVESFDKGQMATVNGMRGSAAWIASFLFSLLIGVTADKI
GFNPLFIAMGFFDLIGAVFLVAFIAERRAKRA

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI6912666, Length=248, Percent_Identity=27.8225806451613, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI2367193, Length=416, Percent_Identity=43.2692307692308, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI87082320, Length=422, Percent_Identity=26.303317535545, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1789152, Length=312, Percent_Identity=27.2435897435897, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI2367379, Length=339, Percent_Identity=25.6637168141593, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1789515, Length=361, Percent_Identity=24.3767313019391, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17554148, Length=259, Percent_Identity=26.6409266409266, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573299, Length=305, Percent_Identity=24.5901639344262, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573708, Length=328, Percent_Identity=24.6951219512195, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28573707, Length=328, Percent_Identity=24.6951219512195, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24584153, Length=403, Percent_Identity=22.5806451612903, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24658658, Length=431, Percent_Identity=20.8816705336427, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639764, Length=330, Percent_Identity=21.8181818181818, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45550460, Length=312, Percent_Identity=22.4358974358974, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24648416, Length=368, Percent_Identity=24.1847826086957, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356189, Length=368, Percent_Identity=24.1847826086957, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550495, Length=442, Percent_Identity=24.4343891402715, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24654215, Length=301, Percent_Identity=25.5813953488372, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922400, Length=301, Percent_Identity=25.5813953488372, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24655255, Length=250, Percent_Identity=23.2, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24583789, Length=359, Percent_Identity=22.8412256267409, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47523; Mature: 47391

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCC
>Mature Secondary Structure 
SQGLNNDIAVSKTRRVVKNLRWWVLVLFLLGVTVNYITRNSLGIIAPELKATLGITTEQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHCCCHHH
YSWIVGAFQLAYTIFQPLCGWLIDVIGLKLGFMICATLWALACIAHAGAGSWLHLAILRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FMGGAEAAATPANAKTIGEWFPKSERPIAAGWAGVGFSIGAMLAPPIIYFAHASFGWQGA
HHCCCHHCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHCCCCCCCCHH
FMFTGALALLWVVLWWAFYQTPEKHPNLSKSELEYIKQDNEAPPVKQPFFTALKTVSKNK
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
RFYGIAIPAFMAEPAWAVLSFWVPLYLAKEHGMDLKQIAMFAWLPFLAADLGSVVSGYLT
CEEEEECHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RLYVRWFGCTRVNSVIASSVTGAFLMLSLALVAITRDPYITIILISIGGFGHQIISCMLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHH
ALVVESFDKGQMATVNGMRGSAAWIASFLFSLLIGVTADKIGFNPLFIAMGFFDLIGAVF
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LVAFIAERRAKRA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]