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The map label for this gene is moaA [H]

Identifier: 238893832

GI number: 238893832

Start: 1705036

End: 1706100

Strand: Direct

Name: moaA [H]

Synonym: KP1_1764

Alternate gene names: 238893832

Gene position: 1705036-1706100 (Clockwise)

Preceding gene: 238893826

Following gene: 238893833

Centisome position: 32.49

GC content: 59.91

Gene sequence:

>1065_bases
TTGGCCGCGACGCCGCCGGTTGTCGCCAGGGCGTGGAAAGAAATGACCGCGTCTCCCGTATTTGGAAAGGTGTATATGGC
CTCACAGCTTACCGATGCATACGCGCGTAAGTTTTATTACCTGCGTCTGTCGATTACCGATGTGTGCAACTTCCGTTGCA
CCTACTGCCTGCCGAACGGTTACAAACCCGGCGCCGTCAATAACAATGGCTTTCTCAGCGTAGACGAAGTACGCCGGGTT
ACGCGCGCTTTCTCTGCGCTGGGCACCGAAAAAGTTCGCCTCACCGGTGGGGAACCCTCCCTGCGCCGCGACTTCACCGA
GATCATTGCCGCCGTGCGTGAAAACCCGGCGATCCGTCAGATTGCGGTCACTACCAACGGTTACCGCCTGGCGCGCGATG
TCGAACGCTGGCGCGATGCCGGCCTGACGGCGATTAACGTCAGCGTTGATAGCCTCGACGCCCGCCAGTTCCATGCCATC
ACCGGCCAGGACAAGTTCCACCAGGTGATGGACGGCATTGACGCCGCCTTCGCCGCCGGCTTTGACAAGGTGAAGGTGAA
TACCGTGCTGATGCGTGATGTTAACCATCACCAGCTCGATACCTTCCTCGCGTGGATCCAACCCCGTCGTATCCAGCTGC
GCTTTATTGAGCTGATGGAAACCGGTGAAGGCAGCGACCTGTTCCGCCGTCACCATCTCTCCGGCATGGTGCTGCGCGAT
GAACTGCTGCGCCGCGGCTGGATCCATCAGATCCGCCAGCGCAGCGATGGCCCGGCGCAGGTCTTTTGTCACCCGGACTA
CGCCGGCGAGATCGGCCTCATCATGCCGTATGAAAAAGACTTCTGCGCCACCTGCAATCGGCTGCGCGTCTCGTCCGTTG
GCAAACTGCACCTGTGCCTGTTTGGCGAAGGCGGCGTCGACCTGCGCGACCTGATGGCCGAAGACCAGCAGCAGGCCGCG
CTGGAGGCGCGGATCGCCGAAGCCTTAACCCATAAAAAGCAGACCCATTTCCTGCATCAGGGCAACACCGGTATTACGCA
GAACCTGTCCTATATTGGCGGTTAA

Upstream 100 bases:

>100_bases
ATAGCGAAATCGCCAATGGCGAAACTGCCTGTAACGCGCTACTATCGACATAACCTGTTAACACTCTAGCCTCTTCGCCT
GTGTCAAAAGATATGGCGAT

Downstream 100 bases:

>100_bases
TCGTTTTCGAAAGGAGCATTCAGATGAGCCAGGCTAGCGCTGAGTTTATCCCGACCCGTATTGCTATTCTTACCGTTTCC
AGCCGTCGCGGCGAAGAGGA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MAATPPVVARAWKEMTASPVFGKVYMASQLTDAYARKFYYLRLSITDVCNFRCTYCLPNGYKPGAVNNNGFLSVDEVRRV
TRAFSALGTEKVRLTGGEPSLRRDFTEIIAAVRENPAIRQIAVTTNGYRLARDVERWRDAGLTAINVSVDSLDARQFHAI
TGQDKFHQVMDGIDAAFAAGFDKVKVNTVLMRDVNHHQLDTFLAWIQPRRIQLRFIELMETGEGSDLFRRHHLSGMVLRD
ELLRRGWIHQIRQRSDGPAQVFCHPDYAGEIGLIMPYEKDFCATCNRLRVSSVGKLHLCLFGEGGVDLRDLMAEDQQQAA
LEARIAEALTHKKQTHFLHQGNTGITQNLSYIGG

Sequences:

>Translated_354_residues
MAATPPVVARAWKEMTASPVFGKVYMASQLTDAYARKFYYLRLSITDVCNFRCTYCLPNGYKPGAVNNNGFLSVDEVRRV
TRAFSALGTEKVRLTGGEPSLRRDFTEIIAAVRENPAIRQIAVTTNGYRLARDVERWRDAGLTAINVSVDSLDARQFHAI
TGQDKFHQVMDGIDAAFAAGFDKVKVNTVLMRDVNHHQLDTFLAWIQPRRIQLRFIELMETGEGSDLFRRHHLSGMVLRD
ELLRRGWIHQIRQRSDGPAQVFCHPDYAGEIGLIMPYEKDFCATCNRLRVSSVGKLHLCLFGEGGVDLRDLMAEDQQQAA
LEARIAEALTHKKQTHFLHQGNTGITQNLSYIGG
>Mature_353_residues
AATPPVVARAWKEMTASPVFGKVYMASQLTDAYARKFYYLRLSITDVCNFRCTYCLPNGYKPGAVNNNGFLSVDEVRRVT
RAFSALGTEKVRLTGGEPSLRRDFTEIIAAVRENPAIRQIAVTTNGYRLARDVERWRDAGLTAINVSVDSLDARQFHAIT
GQDKFHQVMDGIDAAFAAGFDKVKVNTVLMRDVNHHQLDTFLAWIQPRRIQLRFIELMETGEGSDLFRRHHLSGMVLRDE
LLRRGWIHQIRQRSDGPAQVFCHPDYAGEIGLIMPYEKDFCATCNRLRVSSVGKLHLCLFGEGGVDLRDLMAEDQQQAAL
EARIAEALTHKKQTHFLHQGNTGITQNLSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=312, Percent_Identity=37.5, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI22027536, Length=312, Percent_Identity=37.5, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1786999, Length=329, Percent_Identity=87.8419452887538, Blast_Score=610, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI32566331, Length=308, Percent_Identity=35.7142857142857, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI32566329, Length=308, Percent_Identity=35.7142857142857, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17561210, Length=308, Percent_Identity=36.3636363636364, Blast_Score=197, Evalue=5e-51,
Organism=Drosophila melanogaster, GI28574488, Length=313, Percent_Identity=35.7827476038339, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI28574490, Length=313, Percent_Identity=35.7827476038339, Blast_Score=197, Evalue=9e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 39874; Mature: 39743

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATPPVVARAWKEMTASPVFGKVYMASQLTDAYARKFYYLRLSITDVCNFRCTYCLPNG
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEEEEEEEHHCCCEEEEECCCC
YKPGAVNNNGFLSVDEVRRVTRAFSALGTEKVRLTGGEPSLRRDFTEIIAAVRENPAIRQ
CCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEE
IAVTTNGYRLARDVERWRDAGLTAINVSVDSLDARQFHAITGQDKFHQVMDGIDAAFAAG
EEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHEEEECCCHHHHHHHHHHHHHHHCC
FDKVKVNTVLMRDVNHHQLDTFLAWIQPRRIQLRFIELMETGEGSDLFRRHHLSGMVLRD
CCCEEEEEEEEECCCHHHHHHHHHHHCCCHHHEEEEEHHHCCCCHHHHHHHHCCCHHHHH
ELLRRGWIHQIRQRSDGPAQVFCHPDYAGEIGLIMPYEKDFCATCNRLRVSSVGKLHLCL
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEE
FGEGGVDLRDLMAEDQQQAALEARIAEALTHKKQTHFLHQGNTGITQNLSYIGG
ECCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCC
>Mature Secondary Structure 
AATPPVVARAWKEMTASPVFGKVYMASQLTDAYARKFYYLRLSITDVCNFRCTYCLPNG
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEEEEEEEHHCCCEEEEECCCC
YKPGAVNNNGFLSVDEVRRVTRAFSALGTEKVRLTGGEPSLRRDFTEIIAAVRENPAIRQ
CCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEE
IAVTTNGYRLARDVERWRDAGLTAINVSVDSLDARQFHAITGQDKFHQVMDGIDAAFAAG
EEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHEEEECCCHHHHHHHHHHHHHHHCC
FDKVKVNTVLMRDVNHHQLDTFLAWIQPRRIQLRFIELMETGEGSDLFRRHHLSGMVLRD
CCCEEEEEEEEECCCHHHHHHHHHHHCCCHHHEEEEEHHHCCCCHHHHHHHHCCCHHHHH
ELLRRGWIHQIRQRSDGPAQVFCHPDYAGEIGLIMPYEKDFCATCNRLRVSSVGKLHLCL
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEE
FGEGGVDLRDLMAEDQQQAALEARIAEALTHKKQTHFLHQGNTGITQNLSYIGG
ECCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA