Click here to switch to the map view.

The map label for this gene is uvrB [H]

Identifier: 238893826

GI number: 238893826

Start: 1698084

End: 1700105

Strand: Direct

Name: uvrB [H]

Synonym: KP1_1756

Alternate gene names: 238893826

Gene position: 1698084-1700105 (Clockwise)

Preceding gene: 238893823

Following gene: 238893832

Centisome position: 32.35

GC content: 60.48

Gene sequence:

>2022_bases
ATGAGTAAATCGTTTGTACTGCATTCCGCCTTTCGCCCCTCCGGAGACCAACCGGAAGCCATCCGCCGCCTGGAAGAGGG
GCTGGAGGATGGGCTTGCGCATCAGACGCTACTGGGGGTTACCGGCTCCGGTAAAACCTTTACCATCGCCAACGTGATTG
CCGACCTGCAGCGGCCGACGATGGTGCTGGCGCCAAACAAAACCCTGGCGGCTCAGCTCTACGGCGAGATGAAAGAGTTT
TTCCCGGAGAATGCCGTCGAGTATTTCGTCTCCTACTACGATTACTATCAGCCGGAAGCCTACGTTCCCAGCTCAGATAC
CTTCATTGAGAAGGACGCCTCGGTTAACGAACATATTGAGCAGATGCGTCTGTCGGCCACCAAAGCGCTGCTCGAGCGGC
GCGACGTAGTGGTGGTGGCGTCAGTCTCGGCGATCTACGGCCTCGGCGACCCGGACCTGTATCTGAAAATGATGTTGCAT
CTGACGGTCGGTATGCTGATTGACCAGCGGGCGATCCTGCGTCGTCTGGCCGAACTGCAGTATACCCGCAACGATCAGGC
CTTCCAGCGCGGCACTTTTCGCGTGCGCGGCGAGGTGATCGACGTCTTCCCGGCGGAATCCGACGATATCGCCCTGCGCA
TTGAGCTTTTTGACGAAGAGGTCGAGCGTCTGTCGCTGTTCGACCCGCTCACCGGCCACGTCGAAGGGACGGTGCCGCGC
TATACCATTTATCCCAAGACCCACTATGTGACGCCGCGGGAGCGCATCGTCCAGGCGATGGAAGAGATCAAGCTGGAGCT
GGCGGAGCGGCGCAAGGTGCTGCTGGCCAACAACAAGCTGCTGGAAGAGCAGCGCTTAACCCAGCGTACCCAGTTTGACC
TCGAAATGATGAACGAGCTGGGTTACTGCTCGGGCATTGAAAACTACTCGCGCTTTCTCTCCGGGCGCGGGCCCGGCGAG
CCGCCGCCGACCCTGTTCGACTATCTGCCGGCGGATGGCCTGTTGGTGATTGACGAATCCCACGTCACGGTGCCGCAGAT
CGGCGGTATGTACCGGGGCGACCGGGCGCGCAAAGAGACGCTGGTGGAATACGGTTTCCGCCTGCCGTCGGCGCTGGATA
ACCGGCCGATGAAGTTTGAAGAATTCGAAGCGCTGGCGCCGCAAACCATCTATGTGTCGGCGACCCCGGGCGCCTATGAG
CTGGATAAATCCGGCGGCGAGGTAGTGGATCAGGTGGTGCGGCCGACCGGTCTGCTTGACCCAATCATCGAAGTGCGCCC
GGTGGCGACTCAGGTCGACGATCTGCTGTCAGAGATCCGCCTGCGCACGGCCATCAACGAGCGCGTGCTGGTCACCACTC
TCACCAAGCGGATGGCGGAGGACTTAACCGAGTATCTTGAGGAGCACGGCGAGCGCGTGCGCTATCTGCACTCGGATATC
GACACCGTCGAGCGCATGGAAATCATCCGCGACCTGCGTCTTGGCGAGTTTGACGTGCTGGTGGGGATCAACCTGCTGCG
TGAGGGGCTGGATATGCCTGAGGTGTCGTTGGTGGCGATCCTGGATGCGGATAAAGAGGGCTTCCTGCGTTCTGAACGCT
CGCTGATCCAGACTATCGGCCGCGCGGCGCGCAACGTCAACGGCAAGGCCATCCTCTACGGCGATAAGATCACCCCCTCC
ATGGCCAAAGCCATTGGCGAGACCGAGCGTCGACGGGAGAAACAGCAGCGCTACAACGAAGAGCACGGCATCGTGCCGCA
GGGGCTCAATAAGAAAGTGGTGGATATCCTGCAGCTGGGCCAGGGCCTGGCGAAAACCAAAGCCAAAGGGCGCGGTAAAG
CGAAGGTCGTTGAGCCTGCCGGGCTTAGCGCTGTGGATATGACGCCAAAAGCGCTGCAGCAGAAAATCCACGAGCTGGAA
GGGCAGATGATGCAGCACGCGCAGAACCTCGAGTTTGAGGAGGCGGCGCAAATACGCGACCAGCTGCATCAGCTGCGCGA
GCTGTTTATCGCCGCCTCCTGA

Upstream 100 bases:

>100_bases
GTACGTACTGTTTAAATATCCAGTGTAATTTATTGGCAAAAAACGGTCCGGGGGGTAGAATTAAACACCGGCCGCTAATT
CTTTTTTCAGGTTCTGATTG

Downstream 100 bases:

>100_bases
TTCTGGGCGCAGACTGGCGGAGTGGACGTGCGGGGTATAGTGAAGGCGCGCTTCTCTTATCGTCCTGCTTGCCAGATAAC
AAACATTTGAGAAGAAAAAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MSKSFVLHSAFRPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEF
FPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLH
LTVGMLIDQRAILRRLAELQYTRNDQAFQRGTFRVRGEVIDVFPAESDDIALRIELFDEEVERLSLFDPLTGHVEGTVPR
YTIYPKTHYVTPRERIVQAMEEIKLELAERRKVLLANNKLLEEQRLTQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGE
PPPTLFDYLPADGLLVIDESHVTVPQIGGMYRGDRARKETLVEYGFRLPSALDNRPMKFEEFEALAPQTIYVSATPGAYE
LDKSGGEVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRLRTAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
DTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPS
MAKAIGETERRREKQQRYNEEHGIVPQGLNKKVVDILQLGQGLAKTKAKGRGKAKVVEPAGLSAVDMTPKALQQKIHELE
GQMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS

Sequences:

>Translated_673_residues
MSKSFVLHSAFRPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEF
FPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLH
LTVGMLIDQRAILRRLAELQYTRNDQAFQRGTFRVRGEVIDVFPAESDDIALRIELFDEEVERLSLFDPLTGHVEGTVPR
YTIYPKTHYVTPRERIVQAMEEIKLELAERRKVLLANNKLLEEQRLTQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGE
PPPTLFDYLPADGLLVIDESHVTVPQIGGMYRGDRARKETLVEYGFRLPSALDNRPMKFEEFEALAPQTIYVSATPGAYE
LDKSGGEVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRLRTAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
DTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPS
MAKAIGETERRREKQQRYNEEHGIVPQGLNKKVVDILQLGQGLAKTKAKGRGKAKVVEPAGLSAVDMTPKALQQKIHELE
GQMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS
>Mature_672_residues
SKSFVLHSAFRPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFF
PENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHL
TVGMLIDQRAILRRLAELQYTRNDQAFQRGTFRVRGEVIDVFPAESDDIALRIELFDEEVERLSLFDPLTGHVEGTVPRY
TIYPKTHYVTPRERIVQAMEEIKLELAERRKVLLANNKLLEEQRLTQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGEP
PPTLFDYLPADGLLVIDESHVTVPQIGGMYRGDRARKETLVEYGFRLPSALDNRPMKFEEFEALAPQTIYVSATPGAYEL
DKSGGEVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRLRTAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDID
TVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPSM
AKAIGETERRREKQQRYNEEHGIVPQGLNKKVVDILQLGQGLAKTKAKGRGKAKVVEPAGLSAVDMTPKALQQKIHELEG
QMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=674, Percent_Identity=93.620178041543, Blast_Score=1265, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76064; Mature: 75933

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSFVLHSAFRPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPT
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHCHHHHHHEEECCCCCEEEHHHHHHHHCCCE
MVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIE
EEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
QMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMLIDQRAILRRLAELQ
HHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTRNDQAFQRGTFRVRGEVIDVFPAESDDIALRIELFDEEVERLSLFDPLTGHVEGTVPR
HCCCCHHHHCCCEEEECEEEEEECCCCCCEEEEEEEHHHHHHHHHHCCCCCCCCCCCCCC
YTIYPKTHYVTPRERIVQAMEEIKLELAERRKVLLANNKLLEEQRLTQRTQFDLEMMNEL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEHHCCHHHHHHHHHHHHHHHHHHHHHC
GYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVIDESHVTVPQIGGMYRGDRARKET
CCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
LVEYGFRLPSALDNRPMKFEEFEALAPQTIYVSATPGAYELDKSGGEVVDQVVRPTGLLD
HHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCEECCCCHHHHHHHHCCCCCCC
PIIEVRPVATQVDDLLSEIRLRTAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNVNGKAILYGDKITPSMAKAIGETERRREKQQRYNEEHGIVPQGLNKKVVDILQLG
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHC
QGLAKTKAKGRGKAKVVEPAGLSAVDMTPKALQQKIHELEGQMMQHAQNLEFEEAAQIRD
CHHHHHHHCCCCCEEEECCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QLHQLRELFIAAS
HHHHHHHHHHCCC
>Mature Secondary Structure 
SKSFVLHSAFRPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPT
CCCEEEEECCCCCCCCHHHHHHHHHHHHHCHHHHHHEEECCCCCEEEHHHHHHHHCCCE
MVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIE
EEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
QMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMLIDQRAILRRLAELQ
HHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTRNDQAFQRGTFRVRGEVIDVFPAESDDIALRIELFDEEVERLSLFDPLTGHVEGTVPR
HCCCCHHHHCCCEEEECEEEEEECCCCCCEEEEEEEHHHHHHHHHHCCCCCCCCCCCCCC
YTIYPKTHYVTPRERIVQAMEEIKLELAERRKVLLANNKLLEEQRLTQRTQFDLEMMNEL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEHHCCHHHHHHHHHHHHHHHHHHHHHC
GYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVIDESHVTVPQIGGMYRGDRARKET
CCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
LVEYGFRLPSALDNRPMKFEEFEALAPQTIYVSATPGAYELDKSGGEVVDQVVRPTGLLD
HHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCEECCCCHHHHHHHHCCCCCCC
PIIEVRPVATQVDDLLSEIRLRTAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNVNGKAILYGDKITPSMAKAIGETERRREKQQRYNEEHGIVPQGLNKKVVDILQLG
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHC
QGLAKTKAKGRGKAKVVEPAGLSAVDMTPKALQQKIHELEGQMMQHAQNLEFEEAAQIRD
CHHHHHHHCCCCCEEEECCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QLHQLRELFIAAS
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA