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The map label for this gene is bioF [H]

Identifier: 238893821

GI number: 238893821

Start: 1694098

End: 1695255

Strand: Direct

Name: bioF [H]

Synonym: KP1_1751

Alternate gene names: 238893821

Gene position: 1694098-1695255 (Clockwise)

Preceding gene: 238893820

Following gene: 238893822

Centisome position: 32.28

GC content: 67.96

Gene sequence:

>1158_bases
ATGAGCTGGCAGCAGCGAATCGATCGGGCGCTGGACGAGCGGCGGGCGGCGGAAGCTTTTCGCCGCCGCCTGCCGGTGAC
GCACGGCGCCGGGCGCTGGCTGGAGCGGGAAGGGGAGCGCTGGCTTAACTTCTCCAGCAATGACTATCTGGGCCTGAGTC
AGCATCCGGCGATTATCGCCGCCTGGCAACAGGGGGCCACGCGCTATGGCGTCGGCGCCGGCGGCTCGGGCCACGTGAGC
GGCTATAGCGAAGCCCACCGCGCGCTGGAAGAGGCGCTCGCCGACTGGCTGGGCTATCCGCGCGCATTGCTGTTTATCTC
CGGCTTTGCCGCGAATCAGGCGCTGATCGCCGCCCTGGTGGAGAAAGACGATCGGATTGTCGCCGACCGCCTGAGCCACG
CCTCTCTGCTGGAGGCGGCGAGCCTCAGCCCGGCGCAGCTGCGGCGCTTTACCCACAACGATCCGCAGCAGCTCGCGCAA
CTGCTGGCTAAGCCGCTGGCGGGCGAACAGTTGGCGGTCACTGAAGGCATTTTCAGCATGGACGGCGACAGCGCGCCGCT
GGCGGCCATTCACGCCGCGACGCAGGCCGCAGGGGCAGTGTTGCTGGTGGATGACGCCCATGGTGTTGGCGTGCTCGGCG
ACGAAGGACGCGGGAGCTGCGCCGCGCAGGCGGTGCGCCCTGAGCTGCTGGTGGTTACCTTCGGCAAGGCCTTCGGCGTC
AGCGGCGCGGCGGTGCTGTGCGACGAAGCAATGGCCGATTATCTGCTGCAGTTTGCCCGTCATCTGATCTACAGCACCGC
GATGCCGCCCGCCCAGGCGGTGGCGCTGAGGGCTGCTCTGGGGATCATTCGCAGCGATGAAGGGCAGCAGCGTCGCGACA
TCCTGGCCGCCCGCATCCGTCAGTTCCGTGAGGGGATGGGCGAGGTGTCGCTGGGGTTGACCGACTCCGTCAGCGCGATC
CAGCCGCTGATCGTCGGCGACAACGCCCGGGCGCTGAACCTGGCCTGCCGTCTACGCGACGCGGGCTGCTGGGCAACGGC
GATCCGTCCGCCGACGGTGCCGGTCGGCAGCGCGCGTTTGCGCCTGACCCTGACAGCCGCCCATCATGCTGAAGACATTA
ACCGTTTACTGGAGGTGCTGCATGGCCACAGTGAATAA

Upstream 100 bases:

>100_bases
AGCAGACGGCGGTGCTGGAAGGCGACAATGAGCAGCAGCAGCGTCTGGAGCAGGCCTTACTCACCCCGGACACTGAGGAA
TATTACAACGCGGCGGCGCT

Downstream 100 bases:

>100_bases
GCAGGCGGTGGCCGCGGCGTTTGGCCGGGCGGCCAGCGGCTATACGCAACATGATGAACTGCAGCGGCGCTGCGCCGATC
TATTGCTGCGCCAGCTGGCG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MSWQQRIDRALDERRAAEAFRRRLPVTHGAGRWLEREGERWLNFSSNDYLGLSQHPAIIAAWQQGATRYGVGAGGSGHVS
GYSEAHRALEEALADWLGYPRALLFISGFAANQALIAALVEKDDRIVADRLSHASLLEAASLSPAQLRRFTHNDPQQLAQ
LLAKPLAGEQLAVTEGIFSMDGDSAPLAAIHAATQAAGAVLLVDDAHGVGVLGDEGRGSCAAQAVRPELLVVTFGKAFGV
SGAAVLCDEAMADYLLQFARHLIYSTAMPPAQAVALRAALGIIRSDEGQQRRDILAARIRQFREGMGEVSLGLTDSVSAI
QPLIVGDNARALNLACRLRDAGCWATAIRPPTVPVGSARLRLTLTAAHHAEDINRLLEVLHGHSE

Sequences:

>Translated_385_residues
MSWQQRIDRALDERRAAEAFRRRLPVTHGAGRWLEREGERWLNFSSNDYLGLSQHPAIIAAWQQGATRYGVGAGGSGHVS
GYSEAHRALEEALADWLGYPRALLFISGFAANQALIAALVEKDDRIVADRLSHASLLEAASLSPAQLRRFTHNDPQQLAQ
LLAKPLAGEQLAVTEGIFSMDGDSAPLAAIHAATQAAGAVLLVDDAHGVGVLGDEGRGSCAAQAVRPELLVVTFGKAFGV
SGAAVLCDEAMADYLLQFARHLIYSTAMPPAQAVALRAALGIIRSDEGQQRRDILAARIRQFREGMGEVSLGLTDSVSAI
QPLIVGDNARALNLACRLRDAGCWATAIRPPTVPVGSARLRLTLTAAHHAEDINRLLEVLHGHSE
>Mature_384_residues
SWQQRIDRALDERRAAEAFRRRLPVTHGAGRWLEREGERWLNFSSNDYLGLSQHPAIIAAWQQGATRYGVGAGGSGHVSG
YSEAHRALEEALADWLGYPRALLFISGFAANQALIAALVEKDDRIVADRLSHASLLEAASLSPAQLRRFTHNDPQQLAQL
LAKPLAGEQLAVTEGIFSMDGDSAPLAAIHAATQAAGAVLLVDDAHGVGVLGDEGRGSCAAQAVRPELLVVTFGKAFGVS
GAAVLCDEAMADYLLQFARHLIYSTAMPPAQAVALRAALGIIRSDEGQQRRDILAARIRQFREGMGEVSLGLTDSVSAIQ
PLIVGDNARALNLACRLRDAGCWATAIRPPTVPVGSARLRLTLTAAHHAEDINRLLEVLHGHSE

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=346, Percent_Identity=32.0809248554913, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI284448556, Length=346, Percent_Identity=32.0809248554913, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI83977444, Length=345, Percent_Identity=31.304347826087, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI83977442, Length=345, Percent_Identity=31.304347826087, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI83977440, Length=345, Percent_Identity=31.304347826087, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI4502025, Length=395, Percent_Identity=29.1139240506329, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI40316939, Length=395, Percent_Identity=29.1139240506329, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=29.6195652173913, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI4758668, Length=361, Percent_Identity=29.9168975069252, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI5454084, Length=192, Percent_Identity=27.6041666666667, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786993, Length=383, Percent_Identity=71.5404699738903, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1790046, Length=386, Percent_Identity=33.9378238341969, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71994529, Length=345, Percent_Identity=32.463768115942, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI32566772, Length=360, Percent_Identity=30, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17560914, Length=385, Percent_Identity=29.3506493506493, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17560912, Length=385, Percent_Identity=29.3506493506493, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=261, Percent_Identity=25.2873563218391, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71982625, Length=261, Percent_Identity=25.2873563218391, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320438, Length=418, Percent_Identity=27.2727272727273, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320267, Length=375, Percent_Identity=26.6666666666667, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6323954, Length=268, Percent_Identity=27.6119402985075, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24662918, Length=367, Percent_Identity=30.2452316076294, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17137420, Length=355, Percent_Identity=30.4225352112676, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI17136286, Length=363, Percent_Identity=27.5482093663912, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653280, Length=326, Percent_Identity=24.2331288343558, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24653276, Length=326, Percent_Identity=24.2331288343558, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24653278, Length=326, Percent_Identity=24.2331288343558, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 41237; Mature: 41106

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWQQRIDRALDERRAAEAFRRRLPVTHGAGRWLEREGERWLNFSSNDYLGLSQHPAIIA
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHCCCCCCCCCCCCCCCCEEE
AWQQGATRYGVGAGGSGHVSGYSEAHRALEEALADWLGYPRALLFISGFAANQALIAALV
EECCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHH
EKDDRIVADRLSHASLLEAASLSPAQLRRFTHNDPQQLAQLLAKPLAGEQLAVTEGIFSM
HCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCEEHHHCHHCC
DGDSAPLAAIHAATQAAGAVLLVDDAHGVGVLGDEGRGSCAAQAVRPELLVVTFGKAFGV
CCCCCCHHHHHHHHHHCCEEEEEECCCCCEEECCCCCCCHHHHHCCCEEEEEEECHHHCC
SGAAVLCDEAMADYLLQFARHLIYSTAMPPAQAVALRAALGIIRSDEGQQRRDILAARIR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
QFREGMGEVSLGLTDSVSAIQPLIVGDNARALNLACRLRDAGCWATAIRPPTVPVGSARL
HHHHCCCCEECCCCCCHHHHCCEEECCCCCEEEEEEEEECCCCEEECCCCCCCCCCCCEE
RLTLTAAHHAEDINRLLEVLHGHSE
EEEEEHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SWQQRIDRALDERRAAEAFRRRLPVTHGAGRWLEREGERWLNFSSNDYLGLSQHPAIIA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHCCCCCCCCCCCCCCCCEEE
AWQQGATRYGVGAGGSGHVSGYSEAHRALEEALADWLGYPRALLFISGFAANQALIAALV
EECCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHH
EKDDRIVADRLSHASLLEAASLSPAQLRRFTHNDPQQLAQLLAKPLAGEQLAVTEGIFSM
HCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCEEHHHCHHCC
DGDSAPLAAIHAATQAAGAVLLVDDAHGVGVLGDEGRGSCAAQAVRPELLVVTFGKAFGV
CCCCCCHHHHHHHHHHCCEEEEEECCCCCEEECCCCCCCHHHHHCCCEEEEEEECHHHCC
SGAAVLCDEAMADYLLQFARHLIYSTAMPPAQAVALRAALGIIRSDEGQQRRDILAARIR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
QFREGMGEVSLGLTDSVSAIQPLIVGDNARALNLACRLRDAGCWATAIRPPTVPVGSARL
HHHHCCCCEECCCCCCHHHHCCEEECCCCCEEEEEEEEECCCCEEECCCCCCCCCCCCEE
RLTLTAAHHAEDINRLLEVLHGHSE
EEEEEHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA