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The map label for this gene is bioA [H]

Identifier: 238893819

GI number: 238893819

Start: 1691558

End: 1692865

Strand: Reverse

Name: bioA [H]

Synonym: KP1_1749

Alternate gene names: 238893819

Gene position: 1692865-1691558 (Counterclockwise)

Preceding gene: 238893824

Following gene: 238893818

Centisome position: 32.25

GC content: 62.54

Gene sequence:

>1308_bases
ATGGTTTACAAGTCGCTTATGACACTGGACGATCTCGCTTTCGATCGGCGCCACATCTGGCACCCCTACACCTCTATGAC
TTCCCCCCTGCCGGTCTACCCGGTGGTGTCCGCCCACGGTTGCGAGCTGTCCCTCGCCGGCGGCGAACAGTTGGTTGACG
GTATGTCTTCCTGGTGGGCGGCGATCCACGGCTACAATCACCCACGCCTCAATGCGGCGCTGAAGGGGCAAATTGACCAA
ATGTCGCACGTGATGTTCGGCGGGATCACCCATCCGCCGGCAGTTGCGCTATGCCGTCAGCTGGTGGCGATGACCCCGGC
CTCGCTGGAGTGCGTTTTCCTCGCCGACTCCGGTTCAGTGGCGGTAGAGGTGGCGATGAAAATGGCGCTGCAGTACTGGC
AGGCTAAAGGCGAACCACGTCGTCGTTTTCTGACCTTCCGCAACGGCTATCACGGGGATACCTTCGGAGCGATGTCGGTC
TGCGATCCGCAGAACTCGATGCACAGCCTGTGGCAGGGCTACCTGCCGGATAACCTGTTCGCCCCCGCGCCGCAAAGCCG
CTTTGACGGCGAGTGGGACGAGATGGATATGGTACCGTTTGCCCGCCTGATGGCCGCGCATCGTCACGAAATCGCCGCGG
TGATCCTCGAACCTATCGTCCAGGGGGCGGGCGGCATGCGGATGTACCATCCGGAGTGGCTGAAGCGGGTGCGTAAAATG
TGCGACCGGGAAGGGATACTGCTGATCGCCGATGAGATTGCCACCGGCTTTGGCCGCACCGGCAAGCTGTTCGCTTGTGA
ACACGCCGGGATTACCGCCGACATTCTGTGTCTGGGCAAAGCGCTGACCGGCGGCACCATGACCCTTTCCGCCGCCATCA
CCACCCGAACGGTTGCTGAAACCATTAGCAATGGCGAAGCCGGTTGCTTTATGCACGGCCCCACCTTTATGGGCAATCCG
CTGGCCTGCGCGGTGGCCGGCGAAAGCCTGCGCCTGCTGGAGAGCGGCGAATGGCAGCCGCAGGTGGCGGCGATTGAAGC
CCAGCTGCAGGCCGAGCTGGCCCCGGCGCGGGGATCCGCGCTGGTCGCAGACGTCCGCGTGCTGGGCGCTATTGGCGTGG
TTGAAACCCGTCGCCCGGTCAACATGGCCGCCCTGCAGCGCTTTTTCGTCGAGCAGGGAGTCTGGATCCGTCCGTTTGGC
CGGCTGATTTATCTGATGCCGCCGTACATCATCACGCCCGAGCAGCTGACCCGCCTGACCCGTGCGGTCAACCAAGCAGT
GCAGGACGAAACATTTTTTAGCGAATAA

Upstream 100 bases:

>100_bases
GGATGTTCTCGCTTGCCGCCTCGATGCTGCGCGAAATATTTTGTGTACGTTTCATTGTAAGTAAGTTCAGTGTAGACTTG
TAAACCTAAATGTTTTCAAA

Downstream 100 bases:

>100_bases
ATAGCGGAATTGCGTCGTCGGGAAGGCTACACTTCTTTGTTAATCAGCGCATTATCAATGAGGATGAAGCATGAAACTGA
TCAGTCACGATATCCAGGAC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MVYKSLMTLDDLAFDRRHIWHPYTSMTSPLPVYPVVSAHGCELSLAGGEQLVDGMSSWWAAIHGYNHPRLNAALKGQIDQ
MSHVMFGGITHPPAVALCRQLVAMTPASLECVFLADSGSVAVEVAMKMALQYWQAKGEPRRRFLTFRNGYHGDTFGAMSV
CDPQNSMHSLWQGYLPDNLFAPAPQSRFDGEWDEMDMVPFARLMAAHRHEIAAVILEPIVQGAGGMRMYHPEWLKRVRKM
CDREGILLIADEIATGFGRTGKLFACEHAGITADILCLGKALTGGTMTLSAAITTRTVAETISNGEAGCFMHGPTFMGNP
LACAVAGESLRLLESGEWQPQVAAIEAQLQAELAPARGSALVADVRVLGAIGVVETRRPVNMAALQRFFVEQGVWIRPFG
RLIYLMPPYIITPEQLTRLTRAVNQAVQDETFFSE

Sequences:

>Translated_435_residues
MVYKSLMTLDDLAFDRRHIWHPYTSMTSPLPVYPVVSAHGCELSLAGGEQLVDGMSSWWAAIHGYNHPRLNAALKGQIDQ
MSHVMFGGITHPPAVALCRQLVAMTPASLECVFLADSGSVAVEVAMKMALQYWQAKGEPRRRFLTFRNGYHGDTFGAMSV
CDPQNSMHSLWQGYLPDNLFAPAPQSRFDGEWDEMDMVPFARLMAAHRHEIAAVILEPIVQGAGGMRMYHPEWLKRVRKM
CDREGILLIADEIATGFGRTGKLFACEHAGITADILCLGKALTGGTMTLSAAITTRTVAETISNGEAGCFMHGPTFMGNP
LACAVAGESLRLLESGEWQPQVAAIEAQLQAELAPARGSALVADVRVLGAIGVVETRRPVNMAALQRFFVEQGVWIRPFG
RLIYLMPPYIITPEQLTRLTRAVNQAVQDETFFSE
>Mature_435_residues
MVYKSLMTLDDLAFDRRHIWHPYTSMTSPLPVYPVVSAHGCELSLAGGEQLVDGMSSWWAAIHGYNHPRLNAALKGQIDQ
MSHVMFGGITHPPAVALCRQLVAMTPASLECVFLADSGSVAVEVAMKMALQYWQAKGEPRRRFLTFRNGYHGDTFGAMSV
CDPQNSMHSLWQGYLPDNLFAPAPQSRFDGEWDEMDMVPFARLMAAHRHEIAAVILEPIVQGAGGMRMYHPEWLKRVRKM
CDREGILLIADEIATGFGRTGKLFACEHAGITADILCLGKALTGGTMTLSAAITTRTVAETISNGEAGCFMHGPTFMGNP
LACAVAGESLRLLESGEWQPQVAAIEAQLQAELAPARGSALVADVRVLGAIGVVETRRPVNMAALQRFFVEQGVWIRPFG
RLIYLMPPYIITPEQLTRLTRAVNQAVQDETFFSE

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=437, Percent_Identity=29.5194508009153, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=31.1728395061728, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI13994255, Length=380, Percent_Identity=27.6315789473684, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI37574042, Length=459, Percent_Identity=24.8366013071895, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI226442705, Length=458, Percent_Identity=24.8908296943231, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI226442709, Length=405, Percent_Identity=25.1851851851852, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1786991, Length=429, Percent_Identity=85.5477855477856, Blast_Score=759, Evalue=0.0,
Organism=Escherichia coli, GI145693181, Length=401, Percent_Identity=30.6733167082294, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789759, Length=336, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789016, Length=350, Percent_Identity=28.8571428571429, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788044, Length=311, Percent_Identity=32.7974276527331, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787560, Length=408, Percent_Identity=27.2058823529412, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1786349, Length=323, Percent_Identity=27.2445820433437, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI25144271, Length=422, Percent_Identity=27.0142180094787, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=237, Percent_Identity=31.6455696202532, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=431, Percent_Identity=24.8259860788863, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324386, Length=460, Percent_Identity=48.2608695652174, Blast_Score=434, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6323470, Length=428, Percent_Identity=27.3364485981308, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=316, Percent_Identity=28.7974683544304, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21357415, Length=415, Percent_Identity=27.710843373494, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI28574759, Length=400, Percent_Identity=27.75, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI161085790, Length=416, Percent_Identity=26.6826923076923, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI281366494, Length=281, Percent_Identity=27.0462633451957, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24667139, Length=281, Percent_Identity=27.0462633451957, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24667143, Length=281, Percent_Identity=27.0462633451957, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47793; Mature: 47793

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYKSLMTLDDLAFDRRHIWHPYTSMTSPLPVYPVVSAHGCELSLAGGEQLVDGMSSWWA
CCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEECCCCCCEEEECCCHHHHHHHHHHHH
AIHGYNHPRLNAALKGQIDQMSHVMFGGITHPPAVALCRQLVAMTPASLECVFLADSGSV
HHCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCH
AVEVAMKMALQYWQAKGEPRRRFLTFRNGYHGDTFGAMSVCDPQNSMHSLWQGYLPDNLF
HHHHHHHHHHHHHHCCCCCHHHEEEECCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCC
APAPQSRFDGEWDEMDMVPFARLMAAHRHEIAAVILEPIVQGAGGMRMYHPEWLKRVRKM
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHH
CDREGILLIADEIATGFGRTGKLFACEHAGITADILCLGKALTGGTMTLSAAITTRTVAE
HCCCCEEEEEHHHHHCCCCCCCEEEEECCCCEEEHHHHHHHCCCCCEEEEHHHHHHHHHH
TISNGEAGCFMHGPTFMGNPLACAVAGESLRLLESGEWQPQVAAIEAQLQAELAPARGSA
HHCCCCCCEEEECCCCCCCCEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
LVADVRVLGAIGVVETRRPVNMAALQRFFVEQGVWIRPFGRLIYLMPPYIITPEQLTRLT
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEECCCCEEEECCCEEECHHHHHHHH
RAVNQAVQDETFFSE
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MVYKSLMTLDDLAFDRRHIWHPYTSMTSPLPVYPVVSAHGCELSLAGGEQLVDGMSSWWA
CCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEECCCCCCEEEECCCHHHHHHHHHHHH
AIHGYNHPRLNAALKGQIDQMSHVMFGGITHPPAVALCRQLVAMTPASLECVFLADSGSV
HHCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCH
AVEVAMKMALQYWQAKGEPRRRFLTFRNGYHGDTFGAMSVCDPQNSMHSLWQGYLPDNLF
HHHHHHHHHHHHHHCCCCCHHHEEEECCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCC
APAPQSRFDGEWDEMDMVPFARLMAAHRHEIAAVILEPIVQGAGGMRMYHPEWLKRVRKM
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHH
CDREGILLIADEIATGFGRTGKLFACEHAGITADILCLGKALTGGTMTLSAAITTRTVAE
HCCCCEEEEEHHHHHCCCCCCCEEEEECCCCEEEHHHHHHHCCCCCEEEEHHHHHHHHHH
TISNGEAGCFMHGPTFMGNPLACAVAGESLRLLESGEWQPQVAAIEAQLQAELAPARGSA
HHCCCCCCEEEECCCCCCCCEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
LVADVRVLGAIGVVETRRPVNMAALQRFFVEQGVWIRPFGRLIYLMPPYIITPEQLTRLT
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEECCCCEEEECCCEEECHHHHHHHH
RAVNQAVQDETFFSE
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 2971595 [H]