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The map label for this gene is fepA [H]

Identifier: 238893633

GI number: 238893633

Start: 1489016

End: 1491244

Strand: Reverse

Name: fepA [H]

Synonym: KP1_1547

Alternate gene names: 238893633

Gene position: 1491244-1489016 (Counterclockwise)

Preceding gene: 238893637

Following gene: 238893632

Centisome position: 28.41

GC content: 59.94

Gene sequence:

>2229_bases
ATGAATAACAGGATCAAATCCCTGGCCTTGCTGGTCAATCTGGGAATTTACGGGGTTGCTTTTCCGTTAAGCGCAGCGGA
AACCGCCACCGACGATAAAAACAGCGCCGCTGAAGAGACCATGGTGGTCACCGCCGCCGAGCAGAACCTGCAGGCGCCGG
GCGTCTCCACCATCACCGCCGATGAGATCCGCAAACGCCCCCCGGCGCGCGACGTCTCGGAGATCATTCGCACCATGCCG
GGGGTCAACCTGACCGGCAACTCCACCAGCGGCCAGCGCGGCAACAACCGCCAGATTGATATCCGCGGCATGGGCCCGGA
AAATACCCTGATCCTGATCGACGGCAAGCCGGTCACCAGCCGCAACTCCGTGCGCCTTGGCTGGCGCGGCGAGCGCGACA
CCCGCGGCGATACCAGCTGGGTGCCGCCGGAGATGATCGAACGTATCGAAGTGATTCGCGGCCCGGCCGCCGCCCGCTAC
GGCAACGGCGCCGCCGGCGGCGTGGTGAATATCATCACCAAAAAAACCGGCGATGAGTGGCACGGCTCATGGAACACCTA
TATGAACGCCCCGGAGCACAAGGATGAAGGCTCCACCAAACGCACTAACTTCAGCCTCAGCGGCCCGCTGGGCGGCGATT
TTAGCTTCCGCCTGTTCGGTAACCTCGACAAAACGCAGGCTGACGCCTGGGATATCAACCAGGGCCATCAGTCCGAGCGT
ACCGGGATCTATGCCGATACTCTGCCGGCCGGGCGCGAAGGGGTGAAAAACAAAAACATCGATGGTCTGGTGCGCTGGGA
ATTCGCTCCGATGCAGTCGCTGGAGTTTGAGGCCGGCTACAGCCGCCAGGGCAACCTCTACGCCGGCGATACCCAGAACA
CCAACTCCAACGACCTGGTAAAAGAGAACTACGGCAAAGAGACCAACCGTCTGTATCGCAACACCTACTCGGTTACCTGG
AACGGCGCCTGGGACAACGGGGTGACCACCAGCAACTGGGCGCAGTACGAACGCACCCGCAACTCGCGCAAAGGCGAAGG
CCTGGCCGGCGGCACCGAGGGGATCTTTAACAGCAACCAGTTCACGGATATCGATCTGGCGGATGTGATGCTGCACAGCG
AAGTCAGCATTCCCTTCGACTATCTGGTTAATCAGAACCTGACGCTGGGCAGCGAGTGGAACCAGCAGCGGATGAAGGAT
AACGCCTCCAATACCCAGGCGCTGTCGGGCGGCAGCATCCCGGGCTACGACAGCACCGGCCGCAGCCCGTACTCGCAGGC
GGAAATCTTCTCGCTGTTCGCTGAGAACAACATGGAGCTGACCGACACCACCATGCTGACCCCGGCGCTGCGTTTCGATC
ATCACAGCATCGTGGGCAATAACTGGAGCCCGTCCCTCAACCTGTCGCAGGGCCTGTGGGATGACTTCACGCTGAAGATG
GGCATCGCCCGCGCCTATAAAGCGCCGAGCCTGTATCAGACCAACCCGAACTACATTCTCTACAGTAAAGGCCAGGGCTG
CTATGCCAGTAAAGACGGCTGCTATCTGCAGGGTAACGACGACTTAAAAGCCGAGACCAGCATCAACAAAGAGATTGGCC
TCGAGTTTAAACGCGACGGCTGGCTGGCTGGCGTCACCTGGTTCCGCAACGACTACCGCAACAAGATTGAAGCGGGCTAT
GCCCCGGTCTATCAAAACAATAAAGGTACCGATCTCTACCAGTGGGAAAACGTGCCGAAAGCGGTGGTGGAAGGTCTGGA
GGGGACGTTGAACGTTCCGGTGAGCGAGACCGTCAACTGGACCAACAACATCACCTATATGCTGCAGAGTAAGAACAAAA
AGACCGGCGATCGTCTGTCGATTATCCCGGAATACACGCTGAACTCCACCCTGAGCTGGCAGGTTCGCGATGACGTTTCG
CTGCAGTCGACCTTCACCTGGTACGGCAAGCAGGAGCCGAAGAAGTACAACTACAAGGGTCAACCGGTCACCGGCAGCGA
GAAGAACGAGGTTAGCCCCTACAGCATCCTCGGCCTGAGCGCGACCTGGGACGTCACCAAATACGTCAGTCTGACCGGCG
GCGTGGATAACGTCTTCGATAAGCGCCACTGGCGCGCGGGCAACGCCCAGACCACCGGGGGCGCCACCGGCACGATGTAC
GGCGCCGGCGCCGAGACCTACAATGAATCGGGCCGCACCTGGTACCTGAGCGTCAACACCCACTTCTGA

Upstream 100 bases:

>100_bases
GACGGAGTGCCTTTGCCCGCTTTTGGCAACATTTATGCCGCCTCCCCTCCCGGTGGGAAGGGGCGTTTGGGGAACGTGGC
GACAAAAAGCAGGAATAACA

Downstream 100 bases:

>100_bases
TAGCGGGTTCTCCCTCCCCTGCCCTTGCTGGACAAAGGGCGGGGGCAACCGCGGTAACCTTATCCTATGCGCCACCATCG
CACCGTTTTGCCTCTGGCCG

Product: outer membrane receptor FepA

Products: NA

Alternate protein names: Enterobactin outer-membrane receptor [H]

Number of amino acids: Translated: 742; Mature: 742

Protein sequence:

>742_residues
MNNRIKSLALLVNLGIYGVAFPLSAAETATDDKNSAAEETMVVTAAEQNLQAPGVSTITADEIRKRPPARDVSEIIRTMP
GVNLTGNSTSGQRGNNRQIDIRGMGPENTLILIDGKPVTSRNSVRLGWRGERDTRGDTSWVPPEMIERIEVIRGPAAARY
GNGAAGGVVNIITKKTGDEWHGSWNTYMNAPEHKDEGSTKRTNFSLSGPLGGDFSFRLFGNLDKTQADAWDINQGHQSER
TGIYADTLPAGREGVKNKNIDGLVRWEFAPMQSLEFEAGYSRQGNLYAGDTQNTNSNDLVKENYGKETNRLYRNTYSVTW
NGAWDNGVTTSNWAQYERTRNSRKGEGLAGGTEGIFNSNQFTDIDLADVMLHSEVSIPFDYLVNQNLTLGSEWNQQRMKD
NASNTQALSGGSIPGYDSTGRSPYSQAEIFSLFAENNMELTDTTMLTPALRFDHHSIVGNNWSPSLNLSQGLWDDFTLKM
GIARAYKAPSLYQTNPNYILYSKGQGCYASKDGCYLQGNDDLKAETSINKEIGLEFKRDGWLAGVTWFRNDYRNKIEAGY
APVYQNNKGTDLYQWENVPKAVVEGLEGTLNVPVSETVNWTNNITYMLQSKNKKTGDRLSIIPEYTLNSTLSWQVRDDVS
LQSTFTWYGKQEPKKYNYKGQPVTGSEKNEVSPYSILGLSATWDVTKYVSLTGGVDNVFDKRHWRAGNAQTTGGATGTMY
GAGAETYNESGRTWYLSVNTHF

Sequences:

>Translated_742_residues
MNNRIKSLALLVNLGIYGVAFPLSAAETATDDKNSAAEETMVVTAAEQNLQAPGVSTITADEIRKRPPARDVSEIIRTMP
GVNLTGNSTSGQRGNNRQIDIRGMGPENTLILIDGKPVTSRNSVRLGWRGERDTRGDTSWVPPEMIERIEVIRGPAAARY
GNGAAGGVVNIITKKTGDEWHGSWNTYMNAPEHKDEGSTKRTNFSLSGPLGGDFSFRLFGNLDKTQADAWDINQGHQSER
TGIYADTLPAGREGVKNKNIDGLVRWEFAPMQSLEFEAGYSRQGNLYAGDTQNTNSNDLVKENYGKETNRLYRNTYSVTW
NGAWDNGVTTSNWAQYERTRNSRKGEGLAGGTEGIFNSNQFTDIDLADVMLHSEVSIPFDYLVNQNLTLGSEWNQQRMKD
NASNTQALSGGSIPGYDSTGRSPYSQAEIFSLFAENNMELTDTTMLTPALRFDHHSIVGNNWSPSLNLSQGLWDDFTLKM
GIARAYKAPSLYQTNPNYILYSKGQGCYASKDGCYLQGNDDLKAETSINKEIGLEFKRDGWLAGVTWFRNDYRNKIEAGY
APVYQNNKGTDLYQWENVPKAVVEGLEGTLNVPVSETVNWTNNITYMLQSKNKKTGDRLSIIPEYTLNSTLSWQVRDDVS
LQSTFTWYGKQEPKKYNYKGQPVTGSEKNEVSPYSILGLSATWDVTKYVSLTGGVDNVFDKRHWRAGNAQTTGGATGTMY
GAGAETYNESGRTWYLSVNTHF
>Mature_742_residues
MNNRIKSLALLVNLGIYGVAFPLSAAETATDDKNSAAEETMVVTAAEQNLQAPGVSTITADEIRKRPPARDVSEIIRTMP
GVNLTGNSTSGQRGNNRQIDIRGMGPENTLILIDGKPVTSRNSVRLGWRGERDTRGDTSWVPPEMIERIEVIRGPAAARY
GNGAAGGVVNIITKKTGDEWHGSWNTYMNAPEHKDEGSTKRTNFSLSGPLGGDFSFRLFGNLDKTQADAWDINQGHQSER
TGIYADTLPAGREGVKNKNIDGLVRWEFAPMQSLEFEAGYSRQGNLYAGDTQNTNSNDLVKENYGKETNRLYRNTYSVTW
NGAWDNGVTTSNWAQYERTRNSRKGEGLAGGTEGIFNSNQFTDIDLADVMLHSEVSIPFDYLVNQNLTLGSEWNQQRMKD
NASNTQALSGGSIPGYDSTGRSPYSQAEIFSLFAENNMELTDTTMLTPALRFDHHSIVGNNWSPSLNLSQGLWDDFTLKM
GIARAYKAPSLYQTNPNYILYSKGQGCYASKDGCYLQGNDDLKAETSINKEIGLEFKRDGWLAGVTWFRNDYRNKIEAGY
APVYQNNKGTDLYQWENVPKAVVEGLEGTLNVPVSETVNWTNNITYMLQSKNKKTGDRLSIIPEYTLNSTLSWQVRDDVS
LQSTFTWYGKQEPKKYNYKGQPVTGSEKNEVSPYSILGLSATWDVTKYVSLTGGVDNVFDKRHWRAGNAQTTGGATGTMY
GAGAETYNESGRTWYLSVNTHF

Specific function: This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1786798, Length=751, Percent_Identity=81.358189081225, Blast_Score=1243, Evalue=0.0,
Organism=Escherichia coli, GI1788478, Length=766, Percent_Identity=32.3759791122715, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1790405, Length=257, Percent_Identity=30.7392996108949, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1787723, Length=150, Percent_Identity=32.6666666666667, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917
- InterPro:   IPR010105 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 82298; Mature: 82298

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00430 TONB_DEPENDENT_REC_1 ; PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNRIKSLALLVNLGIYGVAFPLSAAETATDDKNSAAEETMVVTAAEQNLQAPGVSTITA
CCCHHHHHHHHHHHCHHHEEECCCCHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEH
DEIRKRPPARDVSEIIRTMPGVNLTGNSTSGQRGNNRQIDIRGMGPENTLILIDGKPVTS
HHHHCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCC
RNSVRLGWRGERDTRGDTSWVPPEMIERIEVIRGPAAARYGNGAAGGVVNIITKKTGDEW
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCEEEEEEECCCCCC
HGSWNTYMNAPEHKDEGSTKRTNFSLSGPLGGDFSFRLFGNLDKTQADAWDINQGHQSER
CCCCHHCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
TGIYADTLPAGREGVKNKNIDGLVRWEFAPMQSLEFEAGYSRQGNLYAGDTQNTNSNDLV
CCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCCCCCCCEEECCCCCCCCCCCH
KENYGKETNRLYRNTYSVTWNGAWDNGVTTSNWAQYERTRNSRKGEGLAGGTEGIFNSNQ
HHHCCCHHHHHHHEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCC
FTDIDLADVMLHSEVSIPFDYLVNQNLTLGSEWNQQRMKDNASNTQALSGGSIPGYDSTG
CCCCCHHHHHHHCCCCCCHHHHCCCCCEECCCCCHHHHHCCCCCCEEECCCCCCCCCCCC
RSPYSQAEIFSLFAENNMELTDTTMLTPALRFDHHSIVGNNWSPSLNLSQGLWDDFTLKM
CCCCHHHHHHHHHHCCCCEEECCEEECHHHHCCCCEECCCCCCCCCCCCCCCCCCHHHHH
GIARAYKAPSLYQTNPNYILYSKGQGCYASKDGCYLQGNDDLKAETSINKEIGLEFKRDG
HHHHHHCCCCEEECCCCEEEEECCCCCEECCCCCEEECCCCCCCCCCCCHHHCCEECCCC
WLAGVTWFRNDYRNKIEAGYAPVYQNNKGTDLYQWENVPKAVVEGLEGTLNVPVSETVNW
EEEEHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHCCCCHHHHHCCCCEEECCHHHCCCC
TNNITYMLQSKNKKTGDRLSIIPEYTLNSTLSWQVRDDVSLQSTFTWYGKQEPKKYNYKG
CCCEEEEEECCCCCCCCEEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCC
QPVTGSEKNEVSPYSILGLSATWDVTKYVSLTGGVDNVFDKRHWRAGNAQTTGGATGTMY
CCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCEEE
GAGAETYNESGRTWYLSVNTHF
CCCCHHHCCCCCEEEEEEECCC
>Mature Secondary Structure
MNNRIKSLALLVNLGIYGVAFPLSAAETATDDKNSAAEETMVVTAAEQNLQAPGVSTITA
CCCHHHHHHHHHHHCHHHEEECCCCHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEH
DEIRKRPPARDVSEIIRTMPGVNLTGNSTSGQRGNNRQIDIRGMGPENTLILIDGKPVTS
HHHHCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCC
RNSVRLGWRGERDTRGDTSWVPPEMIERIEVIRGPAAARYGNGAAGGVVNIITKKTGDEW
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCEEEEEEECCCCCC
HGSWNTYMNAPEHKDEGSTKRTNFSLSGPLGGDFSFRLFGNLDKTQADAWDINQGHQSER
CCCCHHCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
TGIYADTLPAGREGVKNKNIDGLVRWEFAPMQSLEFEAGYSRQGNLYAGDTQNTNSNDLV
CCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCCCCCCCEEECCCCCCCCCCCH
KENYGKETNRLYRNTYSVTWNGAWDNGVTTSNWAQYERTRNSRKGEGLAGGTEGIFNSNQ
HHHCCCHHHHHHHEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCC
FTDIDLADVMLHSEVSIPFDYLVNQNLTLGSEWNQQRMKDNASNTQALSGGSIPGYDSTG
CCCCCHHHHHHHCCCCCCHHHHCCCCCEECCCCCHHHHHCCCCCCEEECCCCCCCCCCCC
RSPYSQAEIFSLFAENNMELTDTTMLTPALRFDHHSIVGNNWSPSLNLSQGLWDDFTLKM
CCCCHHHHHHHHHHCCCCEEECCEEECHHHHCCCCEECCCCCCCCCCCCCCCCCCHHHHH
GIARAYKAPSLYQTNPNYILYSKGQGCYASKDGCYLQGNDDLKAETSINKEIGLEFKRDG
HHHHHHCCCCEEECCCCEEEEECCCCCEECCCCCEEECCCCCCCCCCCCHHHCCEECCCC
WLAGVTWFRNDYRNKIEAGYAPVYQNNKGTDLYQWENVPKAVVEGLEGTLNVPVSETVNW
EEEEHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHCCCCHHHHHCCCCEEECCHHHCCCC
TNNITYMLQSKNKKTGDRLSIIPEYTLNSTLSWQVRDDVSLQSTFTWYGKQEPKKYNYKG
CCCEEEEEECCCCCCCCEEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCC
QPVTGSEKNEVSPYSILGLSATWDVTKYVSLTGGVDNVFDKRHWRAGNAQTTGGATGTMY
CCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCEEE
GAGAETYNESGRTWYLSVNTHF
CCCCHHHCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3015941; 8905232; 9278503; 2974033; 2526281; 2201687; 9886293 [H]