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The map label for this gene is fba [H]

Identifier: 238893332

GI number: 238893332

Start: 1176434

End: 1177300

Strand: Reverse

Name: fba [H]

Synonym: KP1_1211

Alternate gene names: 238893332

Gene position: 1177300-1176434 (Counterclockwise)

Preceding gene: 238893333

Following gene: 238893328

Centisome position: 22.43

GC content: 57.09

Gene sequence:

>867_bases
GTGAATATGTTAGTGTCGATGAAGGACATGCTTCAGCATGCCCTGCGGGACGGCTACGCCGTCGGTCAGTTCAACATTAA
TAATCTGGAATGGGTCGGCGCCGTATTAAGCACCGCCCAGCAGTGCCGCTCACCGGTTATTTTGGGGGTGTCCGGCGGCA
CGGTTAAGCATATGCTCGGGTTAAAATGTATTCATGACATCGTGGTTAACGCCATGGAGTATTTGCATATTGATGTTCCG
GTGGCGCTGCATCTGGATCATGGCACCTCCCGGGAGGCCTGCGAAGCGGCGATCGCCGCCGGCTTCAGTTCCATTATGTT
TGATGGCTCGCATCTGCCGTTCAGGGAAAACCTGGCCATTACCCGCCACCTGGTGACGCTGGCGCACAGCAAAGGTATCT
CTGTGGAGGCCGAACTGGGGACCATCGCCGGCAGTGAAGACGGCATTGTCAATTCCGAAGTCATCTACGCCGATCCGCAG
GAGTGCTACACCCTGGTGACAGAAACCCAAGTGGATTGCCTCGCCGCCGCGCTGGGCTCCACCCATGGTCTGTATAAAGG
TAAAGCCAGGCTGGGATTTACCGAGATGAAAGCCATTGCCGAGCAGGTGAAGGTTCCGCTGGTGCTGCATGGCGGCACCG
GTATTGCCGATGAGGATATGCGCCGGGCGATTGCCTGCGGCACCGCCAAGATTAACGTTAATACCGAAAATATGTACGCC
TGGTGCCAACAGGTGAAAGCAATTTTCGCCGCCGACACCGGGCACGATGTGAACGATCCGCGGAAAGTCATCGCCCAGGG
ACTGCAGCCGGTACGCGAGATGATTGCCCGCCGCATGGCGCTCTTTGGCTCAGAGCAGCGCTATTGA

Upstream 100 bases:

>100_bases
CGATGCCGGACCTGGCGGTCGTCCACCACTCGTTAAATAGCTACGAGAGAAACTTAACGCAATATTTTGAAGAATAACTG
CATTTAATAAATATCAAGAG

Downstream 100 bases:

>100_bases
CGCCGGGCCAGCGGCTGAAACCACCGCCCCGACGCTGCCGGGGCGGTGGCGTCAGGTATCAAAAGGCAAAGCAGGAACAG
CCCAGCACGCCCCAGAAGGC

Product: putative type II fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNMLVSMKDMLQHALRDGYAVGQFNINNLEWVGAVLSTAQQCRSPVILGVSGGTVKHMLGLKCIHDIVVNAMEYLHIDVP
VALHLDHGTSREACEAAIAAGFSSIMFDGSHLPFRENLAITRHLVTLAHSKGISVEAELGTIAGSEDGIVNSEVIYADPQ
ECYTLVTETQVDCLAAALGSTHGLYKGKARLGFTEMKAIAEQVKVPLVLHGGTGIADEDMRRAIACGTAKINVNTENMYA
WCQQVKAIFAADTGHDVNDPRKVIAQGLQPVREMIARRMALFGSEQRY

Sequences:

>Translated_288_residues
MNMLVSMKDMLQHALRDGYAVGQFNINNLEWVGAVLSTAQQCRSPVILGVSGGTVKHMLGLKCIHDIVVNAMEYLHIDVP
VALHLDHGTSREACEAAIAAGFSSIMFDGSHLPFRENLAITRHLVTLAHSKGISVEAELGTIAGSEDGIVNSEVIYADPQ
ECYTLVTETQVDCLAAALGSTHGLYKGKARLGFTEMKAIAEQVKVPLVLHGGTGIADEDMRRAIACGTAKINVNTENMYA
WCQQVKAIFAADTGHDVNDPRKVIAQGLQPVREMIARRMALFGSEQRY
>Mature_288_residues
MNMLVSMKDMLQHALRDGYAVGQFNINNLEWVGAVLSTAQQCRSPVILGVSGGTVKHMLGLKCIHDIVVNAMEYLHIDVP
VALHLDHGTSREACEAAIAAGFSSIMFDGSHLPFRENLAITRHLVTLAHSKGISVEAELGTIAGSEDGIVNSEVIYADPQ
ECYTLVTETQVDCLAAALGSTHGLYKGKARLGFTEMKAIAEQVKVPLVLHGGTGIADEDMRRAIACGTAKINVNTENMYA
WCQQVKAIFAADTGHDVNDPRKVIAQGLQPVREMIARRMALFGSEQRY

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=287, Percent_Identity=40.418118466899, Blast_Score=199, Evalue=1e-52,
Organism=Escherichia coli, GI87082041, Length=287, Percent_Identity=36.2369337979094, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1788072, Length=292, Percent_Identity=35.2739726027397, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1789293, Length=293, Percent_Identity=25.938566552901, Blast_Score=89, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322790, Length=282, Percent_Identity=26.241134751773, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 31189; Mature: 31189

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMLVSMKDMLQHALRDGYAVGQFNINNLEWVGAVLSTAQQCRSPVILGVSGGTVKHMLG
CCCEEHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
LKCIHDIVVNAMEYLHIDVPVALHLDHGTSREACEAAIAAGFSSIMFDGSHLPFRENLAI
HHHHHHHHHHHHHHEEECCCEEEEECCCCCHHHHHHHHHHCHHHHEECCCCCCCHHHHHH
TRHLVTLAHSKGISVEAELGTIAGSEDGIVNSEVIYADPQECYTLVTETQVDCLAAALGS
HHHHHHHHHCCCCEEEEECCEECCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHC
THGLYKGKARLGFTEMKAIAEQVKVPLVLHGGTGIADEDMRRAIACGTAKINVNTENMYA
CCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCEEEEECHHHHHH
WCQQVKAIFAADTGHDVNDPRKVIAQGLQPVREMIARRMALFGSEQRY
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNMLVSMKDMLQHALRDGYAVGQFNINNLEWVGAVLSTAQQCRSPVILGVSGGTVKHMLG
CCCEEHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
LKCIHDIVVNAMEYLHIDVPVALHLDHGTSREACEAAIAAGFSSIMFDGSHLPFRENLAI
HHHHHHHHHHHHHHEEECCCEEEEECCCCCHHHHHHHHHHCHHHHEECCCCCCCHHHHHH
TRHLVTLAHSKGISVEAELGTIAGSEDGIVNSEVIYADPQECYTLVTETQVDCLAAALGS
HHHHHHHHHCCCCEEEEECCEECCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHC
THGLYKGKARLGFTEMKAIAEQVKVPLVLHGGTGIADEDMRRAIACGTAKINVNTENMYA
CCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCEEEEECHHHHHH
WCQQVKAIFAADTGHDVNDPRKVIAQGLQPVREMIARRMALFGSEQRY
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA