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The map label for this gene is acoB [H]

Identifier: 238893248

GI number: 238893248

Start: 1091247

End: 1092275

Strand: Reverse

Name: acoB [H]

Synonym: KP1_1118

Alternate gene names: 238893248

Gene position: 1092275-1091247 (Counterclockwise)

Preceding gene: 238893249

Following gene: 238893247

Centisome position: 20.81

GC content: 58.02

Gene sequence:

>1029_bases
GTGATAACCATGACAATAAAAACCTATCGTGAAGCGGTCAAGGAAGCCCTGGCTCAGGAAATGGAACGCGATGAACGCGT
GGTGCTCATCGGTGAAGACTTGCGTGGCGGTCATGGCGGAAATGCGCCCGAAGAGGCGAAAATAGAAGCCTTTGGCGGTG
TGCTGGGTGTCACTAAAGGGCTGTGGACGCAGTTCGGCTCCGATCGGGTGATCGACACGCCCATTACCGAGTCGGCCATC
ATCGGTATGGCGGCCGGCGCCGCAGCGACGGGTTTGCGGCCGGTCGCGGAATTGATGTTCATGGATTTTTTTGGCGTGAG
TCACGATGCGCTGTACAACCAGGCGGCTAAGTTCCGCTACATGTTTGGTGGCAAAGCCAGAGCTCCGCTGGTGATGCGAG
GGATGATCGGCGCGGGGTTTTCTGCCGCAGCCCAGCATTCACAGTCACCCTATAATATCTTTGCCACCACGCCTGGACTG
AAGGTGGTGGTGCCCTCGACGCCTTATGACGTCAAAGGTCTGTTAATCCAGTCCATTCGCGACGACGACCCGGTGGTATT
CTGCGAGCATAAAATGCTGTACGACCTCAAGGGCGAGGTACCGGACGAGATCTATACCATCCCGCTAGGTGTAGCCAACT
ACACGCGCGAAGGAGAGGACGTCACCATCATTGCGCTGTCGGCAATGGTGCATAAAGCCAACCAGGTGGCGGACAAGCTG
GCGAAAGAGGGGATCTCGGTCGAGGTGGTCGACCCGCGAACCATTTCGCCGCTGGATGAGGAAGGGATTCTGGAATCGGT
GGCGTCCACGGGGCGGGTCGTGATTGTCGACGAATCCGCGGCACGCTTCGGTTTTGCTCATGATGTCGCAGCGCTGATTG
CGTCCCAGGCATTCCATTTCCTCAAAGCGCCCGTTCTGCTGGTGACGCCGCCACACACGCCGGTCCCGTTCTCCCCTGCT
CTCGAAAAACTCTGGATCCCTGGCGTAGAACGTATCGAAGCCGCCGTCCGTCAAGTGCTGGAGGATTAA

Upstream 100 bases:

>100_bases
AAGTAGAAGCCCTGGTCAACGATGCCGTATTGAAGGCCCGCGCCGCTGCCTACCCGGCTCCGGAAGACCTGCTGACAGAC
GTGTACGTCTCATACTGAGG

Downstream 100 bases:

>100_bases
CCTATGAGCGAAATCAAGACGCTTGAAATGCCAAAGTGGGGGCTTTCCATGGAGGAAGGCTTGCTCGCTCGGTGGGCAAT
CCAGGAGGGTGACAGCTTCA

Product: acetoin:DCPIP oxidoreductase beta subunit

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-beta; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit beta [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MITMTIKTYREAVKEALAQEMERDERVVLIGEDLRGGHGGNAPEEAKIEAFGGVLGVTKGLWTQFGSDRVIDTPITESAI
IGMAAGAAATGLRPVAELMFMDFFGVSHDALYNQAAKFRYMFGGKARAPLVMRGMIGAGFSAAAQHSQSPYNIFATTPGL
KVVVPSTPYDVKGLLIQSIRDDDPVVFCEHKMLYDLKGEVPDEIYTIPLGVANYTREGEDVTIIALSAMVHKANQVADKL
AKEGISVEVVDPRTISPLDEEGILESVASTGRVVIVDESAARFGFAHDVAALIASQAFHFLKAPVLLVTPPHTPVPFSPA
LEKLWIPGVERIEAAVRQVLED

Sequences:

>Translated_342_residues
MITMTIKTYREAVKEALAQEMERDERVVLIGEDLRGGHGGNAPEEAKIEAFGGVLGVTKGLWTQFGSDRVIDTPITESAI
IGMAAGAAATGLRPVAELMFMDFFGVSHDALYNQAAKFRYMFGGKARAPLVMRGMIGAGFSAAAQHSQSPYNIFATTPGL
KVVVPSTPYDVKGLLIQSIRDDDPVVFCEHKMLYDLKGEVPDEIYTIPLGVANYTREGEDVTIIALSAMVHKANQVADKL
AKEGISVEVVDPRTISPLDEEGILESVASTGRVVIVDESAARFGFAHDVAALIASQAFHFLKAPVLLVTPPHTPVPFSPA
LEKLWIPGVERIEAAVRQVLED
>Mature_342_residues
MITMTIKTYREAVKEALAQEMERDERVVLIGEDLRGGHGGNAPEEAKIEAFGGVLGVTKGLWTQFGSDRVIDTPITESAI
IGMAAGAAATGLRPVAELMFMDFFGVSHDALYNQAAKFRYMFGGKARAPLVMRGMIGAGFSAAAQHSQSPYNIFATTPGL
KVVVPSTPYDVKGLLIQSIRDDDPVVFCEHKMLYDLKGEVPDEIYTIPLGVANYTREGEDVTIIALSAMVHKANQVADKL
AKEGISVEVVDPRTISPLDEEGILESVASTGRVVIVDESAARFGFAHDVAALIASQAFHFLKAPVLLVTPPHTPVPFSPA
LEKLWIPGVERIEAAVRQVLED

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde, in vitro. The beta subunit is probably not the catalytic subunit of the enzyme [H]

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=339, Percent_Identity=38.0530973451327, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI4557353, Length=335, Percent_Identity=37.910447761194, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI34101272, Length=335, Percent_Identity=37.910447761194, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI291084858, Length=339, Percent_Identity=35.9882005899705, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17538422, Length=344, Percent_Identity=38.6627906976744, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17506935, Length=332, Percent_Identity=40.0602409638554, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319698, Length=344, Percent_Identity=38.6627906976744, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI21358145, Length=338, Percent_Identity=38.1656804733728, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24650940, Length=338, Percent_Identity=38.1656804733728, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI160714828, Length=335, Percent_Identity=37.0149253731343, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI160714832, Length=335, Percent_Identity=37.0149253731343, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24650943, Length=96, Percent_Identity=41.6666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650945, Length=96, Percent_Identity=41.6666666666667, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 1.2.4.1

Molecular weight: Translated: 36876; Mature: 36876

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITMTIKTYREAVKEALAQEMERDERVVLIGEDLRGGHGGNAPEEAKIEAFGGVLGVTKG
CEEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LWTQFGSDRVIDTPITESAIIGMAAGAAATGLRPVAELMFMDFFGVSHDALYNQAAKFRY
HHHHCCCCCEEECCCCHHHHHHHHCCHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHEEE
MFGGKARAPLVMRGMIGAGFSAAAQHSQSPYNIFATTPGLKVVVPSTPYDVKGLLIQSIR
EECCCCCCCCHHHHHHCCCHHHHHHCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHCC
DDDPVVFCEHKMLYDLKGEVPDEIYTIPLGVANYTREGEDVTIIALSAMVHKANQVADKL
CCCCEEEECCEEEEECCCCCCCCEEEEEECHHHCCCCCCCEEEEEHHHHHHHHHHHHHHH
AKEGISVEVVDPRTISPLDEEGILESVASTGRVVIVDESAARFGFAHDVAALIASQAFHF
HHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHCHHHHHHHHHHHHHHHH
LKAPVLLVTPPHTPVPFSPALEKLWIPGVERIEAAVRQVLED
HHCCEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MITMTIKTYREAVKEALAQEMERDERVVLIGEDLRGGHGGNAPEEAKIEAFGGVLGVTKG
CEEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LWTQFGSDRVIDTPITESAIIGMAAGAAATGLRPVAELMFMDFFGVSHDALYNQAAKFRY
HHHHCCCCCEEECCCCHHHHHHHHCCHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHEEE
MFGGKARAPLVMRGMIGAGFSAAAQHSQSPYNIFATTPGLKVVVPSTPYDVKGLLIQSIR
EECCCCCCCCHHHHHHCCCHHHHHHCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHCC
DDDPVVFCEHKMLYDLKGEVPDEIYTIPLGVANYTREGEDVTIIALSAMVHKANQVADKL
CCCCEEEECCEEEEECCCCCCCCEEEEEECHHHCCCCCCCEEEEEHHHHHHHHHHHHHHH
AKEGISVEVVDPRTISPLDEEGILESVASTGRVVIVDESAARFGFAHDVAALIASQAFHF
HHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHCHHHHHHHHHHHHHHHH
LKAPVLLVTPPHTPVPFSPALEKLWIPGVERIEAAVRQVLED
HHCCEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2061286 [H]