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The map label for this gene is serA [H]

Identifier: 238893240

GI number: 238893240

Start: 1082676

End: 1083671

Strand: Reverse

Name: serA [H]

Synonym: KP1_1109

Alternate gene names: 238893240

Gene position: 1083671-1082676 (Counterclockwise)

Preceding gene: 238893241

Following gene: 238893239

Centisome position: 20.65

GC content: 51.41

Gene sequence:

>996_bases
ATGAAATGTCTGGCAATTGCCGATCTGTTTATCAATGCAGCGATGATGGAATCAGGACTGAAAGCGCTCAGGGATAACGG
GATTGAAGTAGAAGTACGCGAGTGGTCACATGGCTCCGTTGAGAAACTTCAGGAAGATAATCTGCGGGTTGAACAGGAAG
GAGCAGAAGCCGTGGCCTTACCGGAAGCGCTGCTTCAGGGAACGGATGATATTGACATCCTGATCACTCAGTTTGCCCCG
GTCAATACTGCGGTGTTCGATAAACTACCAAAGCTGAAATATGTAGGCGTGCTCCGCGGTGGTGTGGAAAACGTGAATCT
TCAGGTGGCGAACGCCCGGGGCGTTGAGGTGATGAACACCCCGGGGCGTAACGCTCGCAGCGTCGCCGAATTCACGGTCG
GCATGATCCTGGCGGAAATGCGCAATATTGCCCGTTCACACGATGCCCTGCGTGACAAATACTGGCGTAAAGACAGCCCG
AACCATCAGGCAATCCCTGAGCTTGGCGGAAAAGTCGTGGGGCTGGTTGGCCTCGGTCATATTGCCCAACTGGTCGCGGG
ATTTCTCAGCGGCTTTGGCACGGAGATTATCTTTTACGATAAGTACGTTGCAGGCCATGAACGTTATGAGAAAGTCGATT
CTCTGGACGAACTGGTACAACGCGCCGACGTTATCTCGTTACATGCTCGCCTGACGCCGGAAACCGAAAATCTGATTAAC
GCACACCATTTCGCGCTGATGAAGCGCAGTGCCATCATTGTTAACACAGCACGCTCCGGGTTAATCAATGAAAAAGAGAT
GATTGATGCGCTCAGATCCGGGCAAATCATGGGCGCCGCGCTTGATACCTTTGATGACGAGCCGCTTCCTGACGACAGTG
CATTCTATACTCTGAATAACGTGACTATTACGCCGCATATTGCCGGGAGTACCATTGACGCATTCAGTAATTCGCCCAAA
CTCTTCGCTGAGATCCTTTTAAAGAAACTCAGTTAA

Upstream 100 bases:

>100_bases
ATCGGTGTCTTCATGGTTTCTCCTAAGACCAGCTATATGACGGGAGCAACTCTGGACGTTACCGGCGGTATGTTGATGCG
TTAATCTAGGGAGAATCATT

Downstream 100 bases:

>100_bases
ATATTAAAAGAACCATTAAAGGTATTAACAGGGCCCAATGGGCACGGGTTTACTCGTGCCCAATTCGCCCGCCTTTTAAG
GAATCATTATGGATATTATC

Product: putative oxidoreductase protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKCLAIADLFINAAMMESGLKALRDNGIEVEVREWSHGSVEKLQEDNLRVEQEGAEAVALPEALLQGTDDIDILITQFAP
VNTAVFDKLPKLKYVGVLRGGVENVNLQVANARGVEVMNTPGRNARSVAEFTVGMILAEMRNIARSHDALRDKYWRKDSP
NHQAIPELGGKVVGLVGLGHIAQLVAGFLSGFGTEIIFYDKYVAGHERYEKVDSLDELVQRADVISLHARLTPETENLIN
AHHFALMKRSAIIVNTARSGLINEKEMIDALRSGQIMGAALDTFDDEPLPDDSAFYTLNNVTITPHIAGSTIDAFSNSPK
LFAEILLKKLS

Sequences:

>Translated_331_residues
MKCLAIADLFINAAMMESGLKALRDNGIEVEVREWSHGSVEKLQEDNLRVEQEGAEAVALPEALLQGTDDIDILITQFAP
VNTAVFDKLPKLKYVGVLRGGVENVNLQVANARGVEVMNTPGRNARSVAEFTVGMILAEMRNIARSHDALRDKYWRKDSP
NHQAIPELGGKVVGLVGLGHIAQLVAGFLSGFGTEIIFYDKYVAGHERYEKVDSLDELVQRADVISLHARLTPETENLIN
AHHFALMKRSAIIVNTARSGLINEKEMIDALRSGQIMGAALDTFDDEPLPDDSAFYTLNNVTITPHIAGSTIDAFSNSPK
LFAEILLKKLS
>Mature_331_residues
MKCLAIADLFINAAMMESGLKALRDNGIEVEVREWSHGSVEKLQEDNLRVEQEGAEAVALPEALLQGTDDIDILITQFAP
VNTAVFDKLPKLKYVGVLRGGVENVNLQVANARGVEVMNTPGRNARSVAEFTVGMILAEMRNIARSHDALRDKYWRKDSP
NHQAIPELGGKVVGLVGLGHIAQLVAGFLSGFGTEIIFYDKYVAGHERYEKVDSLDELVQRADVISLHARLTPETENLIN
AHHFALMKRSAIIVNTARSGLINEKEMIDALRSGQIMGAALDTFDDEPLPDDSAFYTLNNVTITPHIAGSTIDAFSNSPK
LFAEILLKKLS

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=261, Percent_Identity=36.7816091954023, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI6912396, Length=315, Percent_Identity=27.9365079365079, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI4557497, Length=232, Percent_Identity=31.0344827586207, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI61743967, Length=232, Percent_Identity=31.0344827586207, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI145580578, Length=232, Percent_Identity=31.4655172413793, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4557499, Length=232, Percent_Identity=31.4655172413793, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI145580575, Length=232, Percent_Identity=31.4655172413793, Blast_Score=108, Evalue=5e-24,
Organism=Escherichia coli, GI1789279, Length=240, Percent_Identity=32.9166666666667, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI87082289, Length=295, Percent_Identity=28.8135593220339, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787645, Length=250, Percent_Identity=30.4, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87081824, Length=190, Percent_Identity=28.4210526315789, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788660, Length=260, Percent_Identity=26.1538461538462, Blast_Score=61, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17532191, Length=228, Percent_Identity=36.8421052631579, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=247, Percent_Identity=32.7935222672065, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=276, Percent_Identity=31.1594202898551, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=241, Percent_Identity=32.3651452282158, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324055, Length=231, Percent_Identity=29.4372294372294, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=330, Percent_Identity=26.0606060606061, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=171, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=172, Percent_Identity=31.9767441860465, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28574286, Length=248, Percent_Identity=32.6612903225806, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI19921140, Length=230, Percent_Identity=35.6521739130435, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24585516, Length=289, Percent_Identity=30.4498269896194, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI45552429, Length=259, Percent_Identity=28.5714285714286, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24585514, Length=259, Percent_Identity=28.5714285714286, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574282, Length=259, Percent_Identity=28.5714285714286, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574284, Length=326, Percent_Identity=27.3006134969325, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45551003, Length=259, Percent_Identity=28.5714285714286, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28571528, Length=247, Percent_Identity=31.5789473684211, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646446, Length=232, Percent_Identity=31.4655172413793, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24646448, Length=232, Percent_Identity=31.4655172413793, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24646452, Length=232, Percent_Identity=31.4655172413793, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24646450, Length=232, Percent_Identity=31.4655172413793, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI62472511, Length=232, Percent_Identity=31.4655172413793, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36287; Mature: 36287

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCLAIADLFINAAMMESGLKALRDNGIEVEVREWSHGSVEKLQEDNLRVEQEGAEAVAL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCEEECCCCCHHHH
PEALLQGTDDIDILITQFAPVNTAVFDKLPKLKYVGVLRGGVENVNLQVANARGVEVMNT
HHHHHCCCCCCEEEEECCCCCCHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCEEEECC
PGRNARSVAEFTVGMILAEMRNIARSHDALRDKYWRKDSPNHQAIPELGGKVVGLVGLGH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEHHHHHH
IAQLVAGFLSGFGTEIIFYDKYVAGHERYEKVDSLDELVQRADVISLHARLTPETENLIN
HHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHH
AHHFALMKRSAIIVNTARSGLINEKEMIDALRSGQIMGAALDTFDDEPLPDDSAFYTLNN
HHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHCCCEEEHHHHCCCCCCCCCCCCEEEEEC
VTITPHIAGSTIDAFSNSPKLFAEILLKKLS
EEEECCCCCCCHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKCLAIADLFINAAMMESGLKALRDNGIEVEVREWSHGSVEKLQEDNLRVEQEGAEAVAL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCEEECCCCCHHHH
PEALLQGTDDIDILITQFAPVNTAVFDKLPKLKYVGVLRGGVENVNLQVANARGVEVMNT
HHHHHCCCCCCEEEEECCCCCCHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCEEEECC
PGRNARSVAEFTVGMILAEMRNIARSHDALRDKYWRKDSPNHQAIPELGGKVVGLVGLGH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEHHHHHH
IAQLVAGFLSGFGTEIIFYDKYVAGHERYEKVDSLDELVQRADVISLHARLTPETENLIN
HHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHH
AHHFALMKRSAIIVNTARSGLINEKEMIDALRSGQIMGAALDTFDDEPLPDDSAFYTLNN
HHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHCCCEEEHHHHCCCCCCCCCCCCEEEEEC
VTITPHIAGSTIDAFSNSPKLFAEILLKKLS
EEEECCCCCCCHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]