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The map label for this gene is gabP [H]

Identifier: 238893231

GI number: 238893231

Start: 1072324

End: 1073724

Strand: Reverse

Name: gabP [H]

Synonym: KP1_1100

Alternate gene names: 238893231

Gene position: 1073724-1072324 (Counterclockwise)

Preceding gene: 238893232

Following gene: 238893230

Centisome position: 20.46

GC content: 57.96

Gene sequence:

>1401_bases
ATGGGGCAACTGTCGCAATCACAGGATTTAGGGGCGGGGCTGAAGTCGCGCCACGTCACGATGTTATCTATCGCCGGGGT
GATCGGCGCGAGTTTATTTGTCGGATCCAGCGTCGCCATTGCCGAGGCAGGCCCGGCGGTGCTGCTGGCCTATCTGTTTG
CCGGGCTGCTGGTGGTGATGATTATGCGTATGCTGGCCGAAATGGCGGTCGCCACGCCGGATACCGGCTCCTTTTCCACC
TACGCCGATAAAGCCATCGGCCGCTGGGCGGGGTATACCATCGGCTGGCTGTACTGGTGGTTCTGGGTCCTGGTTATTCC
GCTGGAAGCCAATATCGCGGCGATTATTCTGCATTCGTGGGTGCCGGGCGTCCCGGTGTGGTTGTTCTCCCTGGTCATCA
CTCTCGCCCTCACCGGCAGTAACCTGCTGAGCGTCAAGAACTACGGCGAATTCGAGTTCTGGCTGGCGCTGTGCAAAGTG
ATCGCTATTCTGGCGTTTATCGTACTGGGCGCGGTCGCCATTACCGGCTTTTATCCCTATGCCGAAGTGAGCGGCATTTC
GCGGCTGTGGGATCACGGCGGCTTTATGCCTAACGGCTTCGGCGCGGTGCTGAGCGCGATGCTGATCACCATGTTCTCGT
TTATGGGCGCGGAGATCGTCACCATTGCCGCCGCCGAATCGGATACCCCGGATAAACATATCGTGCGCGCCACCAACTCG
GTGATCTGGCGTATCTCTATTTTTTATCTGTGCTCGATCTTTATCGTCGTCGCCCTCATCCCATGGAATATGCCGGGGCT
GAAGAGCATCGGCTCCTACCGCTCGGTGCTCGAGCTGCTGCATATTCCCTATGCCAAGCTGATTATGGACGGCGTGATCC
TCCTGTCGGTCACCAGCTGTCTGAACTCGGCGCTGTATACCGCCTCGCGGATGCTCTACTCCCTGAGCCGTCGTGGCGAT
GCGCCGGCCATTATGGGCCGGACCAACCGCAGCAAAACGCCATACGTGGCGGTGCTGCTCTCTACCGGCGCGGCGTTCCT
CACCGTAGTGGTGAACTACTATGCCCCCGCCAAGGTGTTTAAATTTCTCATCGACAGCTCTGGCGCCATCGCCCTGCTGG
TCTATCTGGTGATCGCCGTTTCACAACTGCGGATGCGCAAAATCCTTCAGGCGCAAGGCGGCGAGATCCGTCTCAGAATG
TGGCTCTATCCGTACCTGACCTGGCTGGTGATCGCCTTTATCACCTTCGTGCTGGTGGTGATGCTGTTTCGTCCGGCGCA
GCAGCTGGAGGTGATCTCTACCGGCCTGTTAGCTCTGGGAATTATTTGTACGGTACCGATTATGTCACGCTGGAAAAAGC
TGGTATTGTGGCAAAAACTGCCGCTGCAAAATACGCGTTAA

Upstream 100 bases:

>100_bases
GGGAATGAAGACGAGACCTGCAAAACAACAATAATACGCGTGCCCCGGCGCGGGAACGTCGGGGCGCTCTCCCAGGTGAC
ACACTTCGAGAGGGTAAATG

Downstream 100 bases:

>100_bases
CCCTGTTCCCGGCGCCCGCCGGGAAGAGTATTCAGGAGTAAGAACATGACCGCCATTCCCCAGGCGACGGCCATTGACGG
ATACCGTTGGTTAAAAAACG

Product: gamma-aminobutyrate transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MGQLSQSQDLGAGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFST
YADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAIILHSWVPGVPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKV
IAILAFIVLGAVAITGFYPYAEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNS
VIWRISIFYLCSIFIVVALIPWNMPGLKSIGSYRSVLELLHIPYAKLIMDGVILLSVTSCLNSALYTASRMLYSLSRRGD
APAIMGRTNRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILQAQGGEIRLRM
WLYPYLTWLVIAFITFVLVVMLFRPAQQLEVISTGLLALGIICTVPIMSRWKKLVLWQKLPLQNTR

Sequences:

>Translated_466_residues
MGQLSQSQDLGAGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFST
YADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAIILHSWVPGVPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKV
IAILAFIVLGAVAITGFYPYAEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNS
VIWRISIFYLCSIFIVVALIPWNMPGLKSIGSYRSVLELLHIPYAKLIMDGVILLSVTSCLNSALYTASRMLYSLSRRGD
APAIMGRTNRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILQAQGGEIRLRM
WLYPYLTWLVIAFITFVLVVMLFRPAQQLEVISTGLLALGIICTVPIMSRWKKLVLWQKLPLQNTR
>Mature_465_residues
GQLSQSQDLGAGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFSTY
ADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAIILHSWVPGVPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVI
AILAFIVLGAVAITGFYPYAEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNSV
IWRISIFYLCSIFIVVALIPWNMPGLKSIGSYRSVLELLHIPYAKLIMDGVILLSVTSCLNSALYTASRMLYSLSRRGDA
PAIMGRTNRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILQAQGGEIRLRMW
LYPYLTWLVIAFITFVLVVMLFRPAQQLEVISTGLLALGIICTVPIMSRWKKLVLWQKLPLQNTR

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=466, Percent_Identity=93.3476394849785, Blast_Score=876, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=446, Percent_Identity=36.0986547085202, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=37.0629370629371, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI87081708, Length=436, Percent_Identity=36.0091743119266, Blast_Score=248, Evalue=8e-67,
Organism=Escherichia coli, GI48994972, Length=455, Percent_Identity=33.4065934065934, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1788480, Length=403, Percent_Identity=33.9950372208437, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=32.5980392156863, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1786602, Length=390, Percent_Identity=35.1282051282051, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1790653, Length=447, Percent_Identity=30.4250559284116, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17532491, Length=364, Percent_Identity=22.8021978021978, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=441, Percent_Identity=30.8390022675737, Blast_Score=210, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6324061, Length=439, Percent_Identity=28.9293849658314, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324059, Length=439, Percent_Identity=29.6127562642369, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=394, Percent_Identity=31.7258883248731, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=417, Percent_Identity=30.9352517985612, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6324924, Length=462, Percent_Identity=29.004329004329, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6322892, Length=394, Percent_Identity=32.994923857868, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6320717, Length=413, Percent_Identity=28.8135593220339, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=415, Percent_Identity=27.710843373494, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=419, Percent_Identity=27.2076372315036, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6321629, Length=403, Percent_Identity=27.5434243176179, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6319543, Length=440, Percent_Identity=25.4545454545455, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320251, Length=409, Percent_Identity=27.6283618581907, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=403, Percent_Identity=27.0471464019851, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322967, Length=394, Percent_Identity=26.9035532994924, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324981, Length=402, Percent_Identity=30.3482587064677, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=421, Percent_Identity=26.603325415677, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=468, Percent_Identity=23.5042735042735, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24667468, Length=400, Percent_Identity=22.75, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51086; Mature: 50955

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQLSQSQDLGAGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVM
CCCCCCCCHHCCCHHHCCHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
IMRMLAEMAVATPDTGSFSTYADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAIILHSW
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
VPGVPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIVLGAVAITGFYPY
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
VIWRISIFYLCSIFIVVALIPWNMPGLKSIGSYRSVLELLHIPYAKLIMDGVILLSVTSC
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LNSALYTASRMLYSLSRRGDAPAIMGRTNRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVF
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEHHCCHHHHHHHHHHCCHHHHH
KFLIDSSGAIALLVYLVIAVSQLRMRKILQAQGGEIRLRMWLYPYLTWLVIAFITFVLVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
MLFRPAQQLEVISTGLLALGIICTVPIMSRWKKLVLWQKLPLQNTR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GQLSQSQDLGAGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVM
CCCCCCCHHCCCHHHCCHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
IMRMLAEMAVATPDTGSFSTYADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAIILHSW
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
VPGVPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIVLGAVAITGFYPY
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
VIWRISIFYLCSIFIVVALIPWNMPGLKSIGSYRSVLELLHIPYAKLIMDGVILLSVTSC
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LNSALYTASRMLYSLSRRGDAPAIMGRTNRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVF
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEHHCCHHHHHHHHHHCCHHHHH
KFLIDSSGAIALLVYLVIAVSQLRMRKILQAQGGEIRLRMWLYPYLTWLVIAFITFVLVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
MLFRPAQQLEVISTGLLALGIICTVPIMSRWKKLVLWQKLPLQNTR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]