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The map label for this gene is fadE [H]

Identifier: 238893212

GI number: 238893212

Start: 1053435

End: 1055942

Strand: Reverse

Name: fadE [H]

Synonym: KP1_1078

Alternate gene names: 238893212

Gene position: 1055942-1053435 (Counterclockwise)

Preceding gene: 238893215

Following gene: 238893211

Centisome position: 20.12

GC content: 59.21

Gene sequence:

>2508_bases
ATGCACTACAACCAATACATCACAAGTGGTCAGACCTCCTACAAGCTCAGGGAGCATTTCTCTATGATGATTTTGAGTAT
TGTTGCAACCGTCGTTTTACTCGGCGCGCTCTTCTATCACCGGGTCAGCCTGCTGCTCAGCAGCGTGATTTTGCTCGCCT
GGACCGCGGCGCTCGGCGCGGCCGGAGTGTGGAATATCTGGCTGCTGCTGCCGCTGGCGATCATACTGTTGCCGTTTAAC
TTTGCGCCTATGCGTAAATCCATGATTTCCGCACCGGCGTTTCGCACATTCCGCAAGGTGATGCCGCCGATGTCGCGCAC
GGAAAAAGAAGCCATCGACGCCGGCACCACCTGGTGGGAAGGCGATCTGTTTCGCGGCAATCCTGACTGGCAAAAGTTAC
ATAACTATCCGCAGCCGCGGCTGACCGCCGAAGAGCAAGCTTTCCTCGACGGCCCAGTTGAAGAAGCCTGCCGGATGGCT
AACGACTTCGCCATCACTCACGAAATGGCCGATCTGCCGCCGGAGCTGTGGGCCTATCTGAAAGAGCACCGCTTCTTCGC
GATGATCATTAAGAAAGAGTATGGCGGACTTGAGTTCTCCGCTTACGCTCAGGCACGAGTACTGCAGAAACTCTCTGGCG
TCTCCGGCATCCTGGCGATCACCGTCGGCGTCCCGAACTCGCTGGGCCCGGGCGAACTGCTGCAGCATTACGGTACCGAA
GAACAGAAGAATCATTATCTGCCGCGTCTGGCACGCGGCCTGGAAATCCCTTGCTTCGCTCTCACCAGCCCGGAAGCGGG
CTCTGACGCCGGCGCCATCCCGGATACCGGCGTGGTGTGCATGGGCGACTGGCAGGGTCAACAGGTGCTGGGGATGCGCC
TGACCTGGAACAAACGTTATATCACGCTGGCGCCTATCGCCACCGTGCTGGGGCTGGCTTTCAAACTCTCTGACCCGGAT
CGTTTGCTGGGCGGAGAAGAAGAGCTGGGTATCACCTGCGCGCTGATCCCCACCTCCACCCCGGGCGTGGAAATCGGCCG
TCGCCACTTCCCGCTGAATGTGCCGTTCCAGAACGGTCCAACCCGCGGCAAAGATATCTTCGTGCCTATCGATTACATCA
TCGGCGGCCCAAGCATGGCCGGTCAGGGCTGGCGCATGTTGGTTGAATGTCTATCGGTCGGCCGCGGTATTACTCTGCCG
TCCAACGCCACCGGTGGTCTGAAATCCGTTGCCATGGCGACTGGCGCTTACGCCCATATTCGCCGCCAGTTCAAAATCTC
CATCGGCAAAATGGAAGGGATTGAAGAGGCGCTGGCGCGTATCGCCGGTAACGCCTATGTGATGGACGCTGCGGCGTCGC
TGATCACCTACGGCATCATGCTCGGCGAGAAACCTGCAGTGCTGTCCGCTATCGTGAAATATCACTGCACCCACCGCGGC
CAGCGCTCCATTATCGACGCGATGGATATTACCGGCGGGAAAGGCATTATGCTGGGCGAAGGCAACTTCCTCGCCCGGGC
ATATCAGGGCGCGCCTATCGCCATCACCGTGGAAGGCGCAAACATTTTGACCCGCAGCATGATGATCTTCGGTCAGGGGG
CGATTCGCTGCCATCCGTACGTACTGGAGGAGATGGCCGCCGCGCAGAATAATGACCTGAACGCCTATGACAAGCTGCTG
TTCAAACACATCGGCCATGTCGGCAGTAATAAAGTGCGGAGTTTCTGGCTGGGCCTGACCGGCGGGCGCACCAGCAGCGC
GCCGACCCGTGACGCCACCCGTCGCTACTATCAGCAAATGAATCGTCTGAGCGCCAACCTGGCACTGCTGTCAGACGTCT
CAATGGCGGTGCTCGGCGGCAGCCTCAAGCGACGCGAACGTATCTCCGCCCGTCTGGGGGATGTGTTAAGCCAGCTGTAC
CTGGCCTCGGCGGTGCTGAAACGCTATGACGATGAAGGACGCAATGAAGCCGATCTGCCGCTGGTTCACTGGGGGGTACA
GGACGCGCTGCACCAGGCCGAGCAAGCCATTGACGATCTGTTGGACAATTTCCCGAACCGTCTGGTGGCAGGCGTAATGC
GCCTGGTCATCTTCCCGACCGGCCGTCATCATCATGCGCCGTCGGATAGGCTGGACCACCAGGTCGCCAAAATTCTGCAG
GTGCCCAGCGCCACGCGCTCCCGCATCGGCCGCGGTCAGTATCTGACGCCGAGCGAGCATAACCCGGTAGGCCTGCTGGA
AGAGGCCCTGCTGGAAGTGATGGCGGCCGATCCTATCCACCAGCGGATCTGCAAAGAGTTGGGTAAAAATCTGCCGTTCA
CCCGTCTGGATGAGCTGGCCCACAACGCGCTGGCCAAAGGATTAATCAGTCAGGATGAGGCCGCCATTCTTACCCGTGCA
GAGCATAGCCGTCTGCGCAGCATTAACGTCGACGACTTTGCGCCAGAGGAGCTGGCGACAAAGCCGGTAAAGCTGCCGGA
AAAAGTTCGTAAAGTTGAAGCTGCATAA

Upstream 100 bases:

>100_bases
GCGTTATCCCTCGCTCTTTTGATTTTATGTGCCGCTTTTGCATACAACAATGTGAGCAAGGTTGTAATTATTTTGTAAAC
ACATTGCTAAATAAAAACGC

Downstream 100 bases:

>100_bases
TAAAACCACTACCACATCACGCGCCGGGCGGGGAACTTTCCCCGCCTTTTTTTCGCCCTCTCCTCCCCTTTCGTTTCCAT
CAGTAGCATTTTTTTAACAA

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 835; Mature: 835

Protein sequence:

>835_residues
MHYNQYITSGQTSYKLREHFSMMILSIVATVVLLGALFYHRVSLLLSSVILLAWTAALGAAGVWNIWLLLPLAIILLPFN
FAPMRKSMISAPAFRTFRKVMPPMSRTEKEAIDAGTTWWEGDLFRGNPDWQKLHNYPQPRLTAEEQAFLDGPVEEACRMA
NDFAITHEMADLPPELWAYLKEHRFFAMIIKKEYGGLEFSAYAQARVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTE
EQKNHYLPRLARGLEIPCFALTSPEAGSDAGAIPDTGVVCMGDWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPD
RLLGGEEELGITCALIPTSTPGVEIGRRHFPLNVPFQNGPTRGKDIFVPIDYIIGGPSMAGQGWRMLVECLSVGRGITLP
SNATGGLKSVAMATGAYAHIRRQFKISIGKMEGIEEALARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRG
QRSIIDAMDITGGKGIMLGEGNFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMAAAQNNDLNAYDKLL
FKHIGHVGSNKVRSFWLGLTGGRTSSAPTRDATRRYYQQMNRLSANLALLSDVSMAVLGGSLKRRERISARLGDVLSQLY
LASAVLKRYDDEGRNEADLPLVHWGVQDALHQAEQAIDDLLDNFPNRLVAGVMRLVIFPTGRHHHAPSDRLDHQVAKILQ
VPSATRSRIGRGQYLTPSEHNPVGLLEEALLEVMAADPIHQRICKELGKNLPFTRLDELAHNALAKGLISQDEAAILTRA
EHSRLRSINVDDFAPEELATKPVKLPEKVRKVEAA

Sequences:

>Translated_835_residues
MHYNQYITSGQTSYKLREHFSMMILSIVATVVLLGALFYHRVSLLLSSVILLAWTAALGAAGVWNIWLLLPLAIILLPFN
FAPMRKSMISAPAFRTFRKVMPPMSRTEKEAIDAGTTWWEGDLFRGNPDWQKLHNYPQPRLTAEEQAFLDGPVEEACRMA
NDFAITHEMADLPPELWAYLKEHRFFAMIIKKEYGGLEFSAYAQARVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTE
EQKNHYLPRLARGLEIPCFALTSPEAGSDAGAIPDTGVVCMGDWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPD
RLLGGEEELGITCALIPTSTPGVEIGRRHFPLNVPFQNGPTRGKDIFVPIDYIIGGPSMAGQGWRMLVECLSVGRGITLP
SNATGGLKSVAMATGAYAHIRRQFKISIGKMEGIEEALARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRG
QRSIIDAMDITGGKGIMLGEGNFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMAAAQNNDLNAYDKLL
FKHIGHVGSNKVRSFWLGLTGGRTSSAPTRDATRRYYQQMNRLSANLALLSDVSMAVLGGSLKRRERISARLGDVLSQLY
LASAVLKRYDDEGRNEADLPLVHWGVQDALHQAEQAIDDLLDNFPNRLVAGVMRLVIFPTGRHHHAPSDRLDHQVAKILQ
VPSATRSRIGRGQYLTPSEHNPVGLLEEALLEVMAADPIHQRICKELGKNLPFTRLDELAHNALAKGLISQDEAAILTRA
EHSRLRSINVDDFAPEELATKPVKLPEKVRKVEAA
>Mature_835_residues
MHYNQYITSGQTSYKLREHFSMMILSIVATVVLLGALFYHRVSLLLSSVILLAWTAALGAAGVWNIWLLLPLAIILLPFN
FAPMRKSMISAPAFRTFRKVMPPMSRTEKEAIDAGTTWWEGDLFRGNPDWQKLHNYPQPRLTAEEQAFLDGPVEEACRMA
NDFAITHEMADLPPELWAYLKEHRFFAMIIKKEYGGLEFSAYAQARVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTE
EQKNHYLPRLARGLEIPCFALTSPEAGSDAGAIPDTGVVCMGDWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPD
RLLGGEEELGITCALIPTSTPGVEIGRRHFPLNVPFQNGPTRGKDIFVPIDYIIGGPSMAGQGWRMLVECLSVGRGITLP
SNATGGLKSVAMATGAYAHIRRQFKISIGKMEGIEEALARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRG
QRSIIDAMDITGGKGIMLGEGNFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMAAAQNNDLNAYDKLL
FKHIGHVGSNKVRSFWLGLTGGRTSSAPTRDATRRYYQQMNRLSANLALLSDVSMAVLGGSLKRRERISARLGDVLSQLY
LASAVLKRYDDEGRNEADLPLVHWGVQDALHQAEQAIDDLLDNFPNRLVAGVMRLVIFPTGRHHHAPSDRLDHQVAKILQ
VPSATRSRIGRGQYLTPSEHNPVGLLEEALLEVMAADPIHQRICKELGKNLPFTRLDELAHNALAKGLISQDEAAILTRA
EHSRLRSINVDDFAPEELATKPVKLPEKVRKVEAA

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=581, Percent_Identity=25.6454388984509, Blast_Score=117, Evalue=6e-26,
Organism=Homo sapiens, GI4557233, Length=422, Percent_Identity=28.6729857819905, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI4557235, Length=431, Percent_Identity=25.2900232018561, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI76496475, Length=410, Percent_Identity=25.609756097561, Blast_Score=88, Evalue=4e-17,
Organism=Homo sapiens, GI4501859, Length=337, Percent_Identity=26.1127596439169, Blast_Score=74, Evalue=8e-13,
Organism=Escherichia coli, GI87081702, Length=814, Percent_Identity=91.031941031941, Blast_Score=1554, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985184, Length=410, Percent_Identity=24.6341463414634, Blast_Score=93, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71985192, Length=356, Percent_Identity=23.5955056179775, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17538396, Length=329, Percent_Identity=24.0121580547112, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17506239, Length=283, Percent_Identity=26.1484098939929, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=27.5423728813559, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508101, Length=277, Percent_Identity=27.0758122743682, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281363737, Length=411, Percent_Identity=27.4939172749392, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24646207, Length=280, Percent_Identity=27.1428571428571, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356377, Length=277, Percent_Identity=28.5198555956679, Blast_Score=73, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24666513, Length=330, Percent_Identity=26.3636363636364, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 91792; Mature: 91792

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYNQYITSGQTSYKLREHFSMMILSIVATVVLLGALFYHRVSLLLSSVILLAWTAALGA
CCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGVWNIWLLLPLAIILLPFNFAPMRKSMISAPAFRTFRKVMPPMSRTEKEAIDAGTTWWE
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHCCCCCEEC
GDLFRGNPDWQKLHNYPQPRLTAEEQAFLDGPVEEACRMANDFAITHEMADLPPELWAYL
CCCCCCCCCHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
KEHRFFAMIIKKEYGGLEFSAYAQARVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTE
HHCCCEEEEEEHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCC
EQKNHYLPRLARGLEIPCFALTSPEAGSDAGAIPDTGVVCMGDWQGQQVLGMRLTWNKRY
HHHCCCHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCE
ITLAPIATVLGLAFKLSDPDRLLGGEEELGITCALIPTSTPGVEIGRRHFPLNVPFQNGP
EEHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCC
TRGKDIFVPIDYIIGGPSMAGQGWRMLVECLSVGRGITLPSNATGGLKSVAMATGAYAHI
CCCCEEEEEHHHEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RRQFKISIGKMEGIEEALARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRG
HHHHHEEHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
QRSIIDAMDITGGKGIMLGEGNFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPY
HHHHHHHHHCCCCCEEEEECCCEEEHEECCCCEEEEECCCHHHHHHHHHHCCCCCEECHH
VLEEMAAAQNNDLNAYDKLLFKHIGHVGSNKVRSFWLGLTGGRTSSAPTRDATRRYYQQM
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHEEEECCCCCCCCCCCHHHHHHHHHHH
NRLSANLALLSDVSMAVLGGSLKRRERISARLGDVLSQLYLASAVLKRYDDEGRNEADLP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LVHWGVQDALHQAEQAIDDLLDNFPNRLVAGVMRLVIFPTGRHHHAPSDRLDHQVAKILQ
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
VPSATRSRIGRGQYLTPSEHNPVGLLEEALLEVMAADPIHQRICKELGKNLPFTRLDELA
CCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHH
HNALAKGLISQDEAAILTRAEHSRLRSINVDDFAPEELATKPVKLPEKVRKVEAA
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MHYNQYITSGQTSYKLREHFSMMILSIVATVVLLGALFYHRVSLLLSSVILLAWTAALGA
CCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGVWNIWLLLPLAIILLPFNFAPMRKSMISAPAFRTFRKVMPPMSRTEKEAIDAGTTWWE
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHCCCCCEEC
GDLFRGNPDWQKLHNYPQPRLTAEEQAFLDGPVEEACRMANDFAITHEMADLPPELWAYL
CCCCCCCCCHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
KEHRFFAMIIKKEYGGLEFSAYAQARVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTE
HHCCCEEEEEEHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCC
EQKNHYLPRLARGLEIPCFALTSPEAGSDAGAIPDTGVVCMGDWQGQQVLGMRLTWNKRY
HHHCCCHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCE
ITLAPIATVLGLAFKLSDPDRLLGGEEELGITCALIPTSTPGVEIGRRHFPLNVPFQNGP
EEHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCC
TRGKDIFVPIDYIIGGPSMAGQGWRMLVECLSVGRGITLPSNATGGLKSVAMATGAYAHI
CCCCEEEEEHHHEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RRQFKISIGKMEGIEEALARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRG
HHHHHEEHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
QRSIIDAMDITGGKGIMLGEGNFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPY
HHHHHHHHHCCCCCEEEEECCCEEEHEECCCCEEEEECCCHHHHHHHHHHCCCCCEECHH
VLEEMAAAQNNDLNAYDKLLFKHIGHVGSNKVRSFWLGLTGGRTSSAPTRDATRRYYQQM
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHEEEECCCCCCCCCCCHHHHHHHHHHH
NRLSANLALLSDVSMAVLGGSLKRRERISARLGDVLSQLYLASAVLKRYDDEGRNEADLP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LVHWGVQDALHQAEQAIDDLLDNFPNRLVAGVMRLVIFPTGRHHHAPSDRLDHQVAKILQ
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
VPSATRSRIGRGQYLTPSEHNPVGLLEEALLEVMAADPIHQRICKELGKNLPFTRLDELA
CCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHH
HNALAKGLISQDEAAILTRAEHSRLRSINVDDFAPEELATKPVKLPEKVRKVEAA
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]