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The map label for this gene is yaeL [H]

Identifier: 238893172

GI number: 238893172

Start: 1008969

End: 1010321

Strand: Direct

Name: yaeL [H]

Synonym: KP1_1031

Alternate gene names: 238893172

Gene position: 1008969-1010321 (Clockwise)

Preceding gene: 238893171

Following gene: 238893173

Centisome position: 19.22

GC content: 55.28

Gene sequence:

>1353_bases
ATGCTGAGCGTGCTCTGGAATCTGGCGGCTTTTATCATTGCGCTTGGCGTACTGATTACGGTGCATGAGTTTGGCCATTT
TTGGGTGGCGCGCCGCTGCGGTATCCGGGTTGAGCGTTTTTCTATCGGCTTCGGCAAAGCGCTGTGGCGGCGGATGGATA
AGCAGGGCACAGAGTTCGTCATCGCCCTGATCCCACTGGGCGGCTACGTCAAGATGCTGGATGAGCGTGTTGAAGCGGTG
GCGCCGGAGATGCGTCACTACGCCTTCAACAATAAAACCGTCGGTCAGCGTGCGGCGGTGATTGCCGCCGGCCCCATCGC
TAACTTCATTTTCGCTATCTTTGCTTACTGGCTGGTCTTTATCATCGGCGTTCCCGGCGTGCGGCCGGTGGTGGGTGAAA
TAACGCCCAATTCGGTTGCCGCGCAAGCACAAATTGCAAAAGGAACGGAACTTAAAGCGATAGATGGTATCGAAACGCCT
GATTGGGATGCGGTGCGTCTGCAGCTGGTGGCCAAAATCGGCAACCCGCAAACAATAGTTACCGTCGCCCCTTTCGGGAC
CAATCAGCGCCAGGATAAAATCGTCGATCTGCGGCACTGGTCGTTTGAGCCAGACAAGCAAGATCCCGTGACCTCGCTGG
GGATCCAGCCGCGCAGCGCGCAGATTGATACGGTGCTGGCTGAGGTTCAGGCGGGATCGGCAGCCCAGAAAGCGGGTTTG
CAAGCGGGCGACCGGATCGTTAAAGTCGATGGTCAACCGTTAACGCAGTGGATGACGTTTGTTAATCTGGTGCGCGATAA
TCCGGGCAAAGCGCTGGCGCTGGAGATTGAACGGCAGGGGAGTGCGCTGCCGTTAACCCTGACGCCGGATGCGAAAACGG
TGAAAGGTAAGGCGGAAGGGTTCGCAGGGGTGGTGCCAAAGGTCATCCCGCTGCCTGAAGAATACAAGACAGTACGTCAG
TACGGACCGTTTGCCGCCATCGCTGAAGCCACGGATAAAACCTGGCAGCTGATGTCGCTGACGGTCAGGATGCTGGGTAA
ATTGATAACCGGTGATGTCAAACTGAACAACCTCAGTGGGCCGATCTCTATCGCTCAGGGGGCTGGAATGTCAGCGGAGT
TTGGGTTGATTTATTATCTGATGTTCCTGGCGCTGATTAGCGTGAACCTCGGAATCATCAACCTGTTCCCTCTACCCGTA
CTGGATGGGGGACATCTGCTGTTTTTAGCGATTGAAAAGCTGAAGGGCGGGCCGGTATCCGAGCGAGTTCAAGACTTTAG
TTATCGCATTGGCTCAATACTGCTGGTGCTGTTAATGGGGCTTGCACTTTTCAATGATTTCTCTCGGTTATAA

Upstream 100 bases:

>100_bases
ATGGTGGTATTCTCGATCGTATCGACAGCCTGACGGCGGCGGTACCGGTCTTCGCCTGTCTGCTACTGTTGGTCTTCAGG
ACGATTTGACGGAAGGTTAT

Downstream 100 bases:

>100_bases
GAGAGTTTGTTAGGAAGAACGCATAATAACGATGGCGATGAAAAAGTTGCTCATAGCGTCGCTGCTGTTTAGCAGCGCGA
CTGTATACGGTGCTGAAGGG

Product: zinc metallopeptidase RseP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MLSVLWNLAAFIIALGVLITVHEFGHFWVARRCGIRVERFSIGFGKALWRRMDKQGTEFVIALIPLGGYVKMLDERVEAV
APEMRHYAFNNKTVGQRAAVIAAGPIANFIFAIFAYWLVFIIGVPGVRPVVGEITPNSVAAQAQIAKGTELKAIDGIETP
DWDAVRLQLVAKIGNPQTIVTVAPFGTNQRQDKIVDLRHWSFEPDKQDPVTSLGIQPRSAQIDTVLAEVQAGSAAQKAGL
QAGDRIVKVDGQPLTQWMTFVNLVRDNPGKALALEIERQGSALPLTLTPDAKTVKGKAEGFAGVVPKVIPLPEEYKTVRQ
YGPFAAIAEATDKTWQLMSLTVRMLGKLITGDVKLNNLSGPISIAQGAGMSAEFGLIYYLMFLALISVNLGIINLFPLPV
LDGGHLLFLAIEKLKGGPVSERVQDFSYRIGSILLVLLMGLALFNDFSRL

Sequences:

>Translated_450_residues
MLSVLWNLAAFIIALGVLITVHEFGHFWVARRCGIRVERFSIGFGKALWRRMDKQGTEFVIALIPLGGYVKMLDERVEAV
APEMRHYAFNNKTVGQRAAVIAAGPIANFIFAIFAYWLVFIIGVPGVRPVVGEITPNSVAAQAQIAKGTELKAIDGIETP
DWDAVRLQLVAKIGNPQTIVTVAPFGTNQRQDKIVDLRHWSFEPDKQDPVTSLGIQPRSAQIDTVLAEVQAGSAAQKAGL
QAGDRIVKVDGQPLTQWMTFVNLVRDNPGKALALEIERQGSALPLTLTPDAKTVKGKAEGFAGVVPKVIPLPEEYKTVRQ
YGPFAAIAEATDKTWQLMSLTVRMLGKLITGDVKLNNLSGPISIAQGAGMSAEFGLIYYLMFLALISVNLGIINLFPLPV
LDGGHLLFLAIEKLKGGPVSERVQDFSYRIGSILLVLLMGLALFNDFSRL
>Mature_450_residues
MLSVLWNLAAFIIALGVLITVHEFGHFWVARRCGIRVERFSIGFGKALWRRMDKQGTEFVIALIPLGGYVKMLDERVEAV
APEMRHYAFNNKTVGQRAAVIAAGPIANFIFAIFAYWLVFIIGVPGVRPVVGEITPNSVAAQAQIAKGTELKAIDGIETP
DWDAVRLQLVAKIGNPQTIVTVAPFGTNQRQDKIVDLRHWSFEPDKQDPVTSLGIQPRSAQIDTVLAEVQAGSAAQKAGL
QAGDRIVKVDGQPLTQWMTFVNLVRDNPGKALALEIERQGSALPLTLTPDAKTVKGKAEGFAGVVPKVIPLPEEYKTVRQ
YGPFAAIAEATDKTWQLMSLTVRMLGKLITGDVKLNNLSGPISIAQGAGMSAEFGLIYYLMFLALISVNLGIINLFPLPV
LDGGHLLFLAIEKLKGGPVSERVQDFSYRIGSILLVLLMGLALFNDFSRL

Specific function: Cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of rseA. Acts on degS-cleaved rseA to release the cytoplasmic domain of rseA. This provides the cell with sigma E (rpoE) activity through the proteolysis of rseA. In vitr

COG id: COG0750

COG function: function code M; Predicted membrane-associated Zn-dependent proteases 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1786373, Length=450, Percent_Identity=83.1111111111111, Blast_Score=748, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR004387
- InterPro:   IPR008915 [H]

Pfam domain/function: PF00595 PDZ; PF02163 Peptidase_M50 [H]

EC number: NA

Molecular weight: Translated: 49023; Mature: 49023

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS50106 PDZ ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVLWNLAAFIIALGVLITVHEFGHFWVARRCGIRVERFSIGFGKALWRRMDKQGTEFV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCEEE
IALIPLGGYVKMLDERVEAVAPEMRHYAFNNKTVGQRAAVIAAGPIANFIFAIFAYWLVF
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHH
IIGVPGVRPVVGEITPNSVAAQAQIAKGTELKAIDGIETPDWDAVRLQLVAKIGNPQTIV
HHCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEE
TVAPFGTNQRQDKIVDLRHWSFEPDKQDPVTSLGIQPRSAQIDTVLAEVQAGSAAQKAGL
EEECCCCCCCCCCEEEEECCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHCCCHHHHCCC
QAGDRIVKVDGQPLTQWMTFVNLVRDNPGKALALEIERQGSALPLTLTPDAKTVKGKAEG
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCC
FAGVVPKVIPLPEEYKTVRQYGPFAAIAEATDKTWQLMSLTVRMLGKLITGDVKLNNLSG
CCCCCCCCCCCCHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCC
PISIAQGAGMSAEFGLIYYLMFLALISVNLGIINLFPLPVLDGGHLLFLAIEKLKGGPVS
CEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEECCCCEEEEEEEHHCCCCHH
ERVQDFSYRIGSILLVLLMGLALFNDFSRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSVLWNLAAFIIALGVLITVHEFGHFWVARRCGIRVERFSIGFGKALWRRMDKQGTEFV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCEEE
IALIPLGGYVKMLDERVEAVAPEMRHYAFNNKTVGQRAAVIAAGPIANFIFAIFAYWLVF
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHH
IIGVPGVRPVVGEITPNSVAAQAQIAKGTELKAIDGIETPDWDAVRLQLVAKIGNPQTIV
HHCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEE
TVAPFGTNQRQDKIVDLRHWSFEPDKQDPVTSLGIQPRSAQIDTVLAEVQAGSAAQKAGL
EEECCCCCCCCCCEEEEECCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHCCCHHHHCCC
QAGDRIVKVDGQPLTQWMTFVNLVRDNPGKALALEIERQGSALPLTLTPDAKTVKGKAEG
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCC
FAGVVPKVIPLPEEYKTVRQYGPFAAIAEATDKTWQLMSLTVRMLGKLITGDVKLNNLSG
CCCCCCCCCCCCHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCC
PISIAQGAGMSAEFGLIYYLMFLALISVNLGIINLFPLPVLDGGHLLFLAIEKLKGGPVS
CEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEECCCCEEEEEEEHHCCCCHH
ERVQDFSYRIGSILLVLLMGLALFNDFSRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]