Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 238893170

GI number: 238893170

Start: 1007329

End: 1008087

Strand: Direct

Name: uppS [H]

Synonym: KP1_1028

Alternate gene names: 238893170

Gene position: 1007329-1008087 (Clockwise)

Preceding gene: 238893169

Following gene: 238893171

Centisome position: 19.19

GC content: 54.15

Gene sequence:

>759_bases
ATGTTGTCTGCTAATCAAACTGTCAGCGAAATATCGCCCACCCATGGCTGCCGTCATGTCGCCATTATTATGGATGGCAA
CGGCCGTTGGGCGAAACGGCAAGGTAAAATTCGCGCTTTCGGGCATAAGGCCGGTGCGAAATCCGTGCGTCGCGCGGTCT
CCTTCGCGGCGAATAATGGGATTGAGGCGTTAACGTTATACGCGTTCAGCAGCGAAAACTGGAACCGTCCGGCTCAGGAA
GTCAGTGCGCTGATGGAACTGTTCGTCTGGGCGCTGGATAGCGAAGTCAAAAGCCTGCACCGACACAATGTGCGTCTGCG
GATTATTGGCGACACCACGCGCTTCAATGCGCGCCTGCAGGAGCGGATCCGCAAAGCGGAAGCGCTAACCGCAAACAATA
CCGGCTTAACGCTGAATATTGCAGCCAATTACGGCGGTCGCTGGGATATTACCCAGGGCGTTCGTTTGCTGGCGAAACAG
GTACAGGACGGGACGCTGCTGCCTGAGCAGATCACGGAAGACATGCTGAGTCAGCAGGTCTGCATGCATGAACTGGCTCC
CGTTGATTTAGTTATTAGGACCGGGGGAGAGCACCGAATAAGTAACTTTCTGATTTGGCAAATTGCCTATGCCGAACTTT
ACTTTACGGATGTTCTTTGGCCCGATTTTGCTGAACAGGACTTTGAAGGTGCACTCCATGCCTTTGTTAATCGAGAGCGT
CGTTTCGGCGGCACTGAGCCGGGTGGCAGTCATGCCTGA

Upstream 100 bases:

>100_bases
TGGCTGCAGCCCCGGCACCGGATAAAAATGCGTATCCAGCGCGGCCCGGTGGCCTCTGTTTGGTGGCTAGTTAATCCTTA
TTATGGACTTAAAACGCGTG

Downstream 100 bases:

>100_bases
TGGGGGTCACTTTTGCTGAAGTATCGCCTGATATCTGCTTTCGTCTTAATCCCCATCGTCATTGCGGCATTGTTTTTATT
GCCGCCGATGGGCTTTGCTA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MLSANQTVSEISPTHGCRHVAIIMDGNGRWAKRQGKIRAFGHKAGAKSVRRAVSFAANNGIEALTLYAFSSENWNRPAQE
VSALMELFVWALDSEVKSLHRHNVRLRIIGDTTRFNARLQERIRKAEALTANNTGLTLNIAANYGGRWDITQGVRLLAKQ
VQDGTLLPEQITEDMLSQQVCMHELAPVDLVIRTGGEHRISNFLIWQIAYAELYFTDVLWPDFAEQDFEGALHAFVNRER
RFGGTEPGGSHA

Sequences:

>Translated_252_residues
MLSANQTVSEISPTHGCRHVAIIMDGNGRWAKRQGKIRAFGHKAGAKSVRRAVSFAANNGIEALTLYAFSSENWNRPAQE
VSALMELFVWALDSEVKSLHRHNVRLRIIGDTTRFNARLQERIRKAEALTANNTGLTLNIAANYGGRWDITQGVRLLAKQ
VQDGTLLPEQITEDMLSQQVCMHELAPVDLVIRTGGEHRISNFLIWQIAYAELYFTDVLWPDFAEQDFEGALHAFVNRER
RFGGTEPGGSHA
>Mature_252_residues
MLSANQTVSEISPTHGCRHVAIIMDGNGRWAKRQGKIRAFGHKAGAKSVRRAVSFAANNGIEALTLYAFSSENWNRPAQE
VSALMELFVWALDSEVKSLHRHNVRLRIIGDTTRFNARLQERIRKAEALTANNTGLTLNIAANYGGRWDITQGVRLLAKQ
VQDGTLLPEQITEDMLSQQVCMHELAPVDLVIRTGGEHRISNFLIWQIAYAELYFTDVLWPDFAEQDFEGALHAFVNRER
RFGGTEPGGSHA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=209, Percent_Identity=37.3205741626794, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI45580738, Length=209, Percent_Identity=37.3205741626794, Blast_Score=137, Evalue=9e-33,
Organism=Escherichia coli, GI1786371, Length=252, Percent_Identity=88.0952380952381, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71993029, Length=216, Percent_Identity=36.1111111111111, Blast_Score=130, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=236, Percent_Identity=33.4745762711864, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323748, Length=214, Percent_Identity=31.3084112149533, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI18857969, Length=222, Percent_Identity=35.1351351351351, Blast_Score=127, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28210; Mature: 28210

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSANQTVSEISPTHGCRHVAIIMDGNGRWAKRQGKIRAFGHKAGAKSVRRAVSFAANNG
CCCCCCCHHHCCCCCCCEEEEEEECCCCCEECCCCCEEEECCHHHHHHHHHHHHHHHCCC
IEALTLYAFSSENWNRPAQEVSALMELFVWALDSEVKSLHRHNVRLRIIGDTTRFNARLQ
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
ERIRKAEALTANNTGLTLNIAANYGGRWDITQGVRLLAKQVQDGTLLPEQITEDMLSQQV
HHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
CMHELAPVDLVIRTGGEHRISNFLIWQIAYAELYFTDVLWPDFAEQDFEGALHAFVNRER
HHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RFGGTEPGGSHA
HCCCCCCCCCCC
>Mature Secondary Structure
MLSANQTVSEISPTHGCRHVAIIMDGNGRWAKRQGKIRAFGHKAGAKSVRRAVSFAANNG
CCCCCCCHHHCCCCCCCEEEEEEECCCCCEECCCCCEEEECCHHHHHHHHHHHHHHHCCC
IEALTLYAFSSENWNRPAQEVSALMELFVWALDSEVKSLHRHNVRLRIIGDTTRFNARLQ
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
ERIRKAEALTANNTGLTLNIAANYGGRWDITQGVRLLAKQVQDGTLLPEQITEDMLSQQV
HHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
CMHELAPVDLVIRTGGEHRISNFLIWQIAYAELYFTDVLWPDFAEQDFEGALHAFVNRER
HHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RFGGTEPGGSHA
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]