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The map label for this gene is ilvI [H]

Identifier: 238893058

GI number: 238893058

Start: 882717

End: 884441

Strand: Direct

Name: ilvI [H]

Synonym: KP1_0898

Alternate gene names: 238893058

Gene position: 882717-884441 (Clockwise)

Preceding gene: 238893057

Following gene: 238893059

Centisome position: 16.82

GC content: 59.48

Gene sequence:

>1725_bases
ATGGAGATGTTGTCAGGAGCCGAGATGGTCGTCCAATCGCTTGTCGATCAGGGCGTCAAGCAAGTATTCGGCTATCCCGG
AGGCGCAGTCCTCGATATCTATGATGCGTTACATACCCTTGGCGGTATCGATCATGTGCTGGTTCGTCACGAGCAGGCGG
CGGTGCATATGGCGGATGGCCTGGCGCGGGCGACCGGGGAGGTCGGCGTGGTGCTGGTGACCTCTGGGCCTGGGGCGACG
AACGCCATCACTGGCATTGCGACAGCCTATATGGACTCTATTCCGTTGGTGATCCTCTCGGGGCAGGTAGCCACCTCGCT
TATCGGCTACGATGCCTTCCAGGAGTGCGACATGGTGGGGATTTCCCGTCCGGTGGTGAAGCACAGTTTCCTGGTGAAGC
AGACCGAAGATATTCCCGGCGTGCTGAAGAAAGCCTTCTGGCTGGCGGCCAGCGGTCGCCCCGGTCCGGTAGTGGTCGAT
CTGCCGAAGGATATTCTCAATCCGGCGAAGAAGCTGCCTTACGTCTGGCCGGACGCGGTGAGCATGCGCTCGTATAACCC
AACCACCAGTGGCCATAAAGGGCAGATTAAACGCGCGCTACAGACTCTGGTGGCCGCAAGTAAGCCGGTCGTCTACGTCG
GCGGCGGGGCGATCAATGCGCATTGCGAACCTCAGCTGCGCGAGCTGGTGGAAAAACTGAAGCTGCCGGTGGCCTCATCC
TTGATGGGACTTGGCGCTTTCCCGGCGACACACTCGCAGGCGCTGGGGATGCTGGGGATGCACGGCACCTATGAAGCCAA
CATGACCATGCACCACTCGGACGTGATTTTTGCCGTCGGCGTTCGCTTTGACGACCGGACCACCAATAACCTGGCCAAGT
ATTGTCCGAACGCGACGGTACTGCATATTGATATCGATCCGACTTCAATCTCGAAAACCGTGCCGGCAGATGTGCCGATC
GTCGGCGATGCCCGGCTGGTGCTGGAGCAGATGCTGGAGCTGCTGGAGCAGGAGGAAGCGCAGCAGCCGCTGGACGACAT
TCGCGACTGGTGGCAACAGATCGAGCAGTGGCGTGCCCGTCATTGTCTGCGCTACGACGACCAGAGCGATAAAATCAAAC
CGCAGGCGGTAATTGAAACTATCTGGCGGCTGACCCAGGGCGATGCCTACGTCACTTCCGATGTGGGTCAGCATCAGATG
TTCGCCGCCCTGTATTACCCCTTCGATAAACCGCGGCGCTGGATTAACTCCGGTGGTCTCGGCACCATGGGCTTTGGCCT
ACCGGCTGCGCTGGGGGTCAAAATGGCTCTGCCGGACGAAATGGTGGTCTGCGTGACCGGTGACGGCAGTATCCAGATGA
ACATTCAGGAACTCTCCACTGCGCTGCAGTATGAGCTGCCGGTCCTGGTGCTTAACCTCAACAACCGCTATCTCGGGATG
GTGAAGCAGTGGCAGGATATGCTCTATTCCGGGCGTCACTCGCAGTCCTATATGGAATCGCTACCGGACTTTGTCCGTCT
GGCGGAAGCCTATGGCCACGTCGGGATCCGCATCAGCGAGCCGCAGGAGCTGGAGACGAAGCTTGCTGAAGCTCTGGAGC
AGGTGCGCCAGCGTCGGCTGGTGTTTGTCGATGTGACCGTCGACGGCAGTGAGCATGTGTACCCCATGCAGATCCGCGGC
GGCGGCATGGATGAAATGTGGTTGAGCAAAACGGAGAGGACCTGA

Upstream 100 bases:

>100_bases
CAGTACATTCACCTCAATGCGGAGGACCACTCCTTCGCATCGTGCGAGCGCGCGGAAATTGAGTTCCGCTGTCGTAAAAC
AATAAGCCTGGAGGCAAACC

Downstream 100 bases:

>100_bases
TTATGCGCCGGATATTATCGGTATTACTGGAAAACGAATCGGGTGCATTGTCCCGCGTTATCGGCCTCTTTTCCCAGCGT
GGCTATAATATAGAAAGCCT

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: AHAS-III; ALS-III; Acetohydroxy-acid synthase III large subunit [H]

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MEMLSGAEMVVQSLVDQGVKQVFGYPGGAVLDIYDALHTLGGIDHVLVRHEQAAVHMADGLARATGEVGVVLVTSGPGAT
NAITGIATAYMDSIPLVILSGQVATSLIGYDAFQECDMVGISRPVVKHSFLVKQTEDIPGVLKKAFWLAASGRPGPVVVD
LPKDILNPAKKLPYVWPDAVSMRSYNPTTSGHKGQIKRALQTLVAASKPVVYVGGGAINAHCEPQLRELVEKLKLPVASS
LMGLGAFPATHSQALGMLGMHGTYEANMTMHHSDVIFAVGVRFDDRTTNNLAKYCPNATVLHIDIDPTSISKTVPADVPI
VGDARLVLEQMLELLEQEEAQQPLDDIRDWWQQIEQWRARHCLRYDDQSDKIKPQAVIETIWRLTQGDAYVTSDVGQHQM
FAALYYPFDKPRRWINSGGLGTMGFGLPAALGVKMALPDEMVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNNRYLGM
VKQWQDMLYSGRHSQSYMESLPDFVRLAEAYGHVGIRISEPQELETKLAEALEQVRQRRLVFVDVTVDGSEHVYPMQIRG
GGMDEMWLSKTERT

Sequences:

>Translated_574_residues
MEMLSGAEMVVQSLVDQGVKQVFGYPGGAVLDIYDALHTLGGIDHVLVRHEQAAVHMADGLARATGEVGVVLVTSGPGAT
NAITGIATAYMDSIPLVILSGQVATSLIGYDAFQECDMVGISRPVVKHSFLVKQTEDIPGVLKKAFWLAASGRPGPVVVD
LPKDILNPAKKLPYVWPDAVSMRSYNPTTSGHKGQIKRALQTLVAASKPVVYVGGGAINAHCEPQLRELVEKLKLPVASS
LMGLGAFPATHSQALGMLGMHGTYEANMTMHHSDVIFAVGVRFDDRTTNNLAKYCPNATVLHIDIDPTSISKTVPADVPI
VGDARLVLEQMLELLEQEEAQQPLDDIRDWWQQIEQWRARHCLRYDDQSDKIKPQAVIETIWRLTQGDAYVTSDVGQHQM
FAALYYPFDKPRRWINSGGLGTMGFGLPAALGVKMALPDEMVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNNRYLGM
VKQWQDMLYSGRHSQSYMESLPDFVRLAEAYGHVGIRISEPQELETKLAEALEQVRQRRLVFVDVTVDGSEHVYPMQIRG
GGMDEMWLSKTERT
>Mature_574_residues
MEMLSGAEMVVQSLVDQGVKQVFGYPGGAVLDIYDALHTLGGIDHVLVRHEQAAVHMADGLARATGEVGVVLVTSGPGAT
NAITGIATAYMDSIPLVILSGQVATSLIGYDAFQECDMVGISRPVVKHSFLVKQTEDIPGVLKKAFWLAASGRPGPVVVD
LPKDILNPAKKLPYVWPDAVSMRSYNPTTSGHKGQIKRALQTLVAASKPVVYVGGGAINAHCEPQLRELVEKLKLPVASS
LMGLGAFPATHSQALGMLGMHGTYEANMTMHHSDVIFAVGVRFDDRTTNNLAKYCPNATVLHIDIDPTSISKTVPADVPI
VGDARLVLEQMLELLEQEEAQQPLDDIRDWWQQIEQWRARHCLRYDDQSDKIKPQAVIETIWRLTQGDAYVTSDVGQHQM
FAALYYPFDKPRRWINSGGLGTMGFGLPAALGVKMALPDEMVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNNRYLGM
VKQWQDMLYSGRHSQSYMESLPDFVRLAEAYGHVGIRISEPQELETKLAEALEQVRQRRLVFVDVTVDGSEHVYPMQIRG
GGMDEMWLSKTERT

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=562, Percent_Identity=28.2918149466192, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI21361361, Length=581, Percent_Identity=25.9896729776248, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI87081685, Length=574, Percent_Identity=91.4634146341463, Blast_Score=1097, Evalue=0.0,
Organism=Escherichia coli, GI1790104, Length=564, Percent_Identity=39.7163120567376, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1786717, Length=562, Percent_Identity=34.5195729537367, Blast_Score=317, Evalue=9e-88,
Organism=Escherichia coli, GI1787096, Length=562, Percent_Identity=29.8932384341637, Blast_Score=205, Evalue=7e-54,
Organism=Escherichia coli, GI1788716, Length=556, Percent_Identity=25.1798561151079, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17531299, Length=548, Percent_Identity=27.3722627737226, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17531301, Length=548, Percent_Identity=27.3722627737226, Blast_Score=169, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17542570, Length=503, Percent_Identity=26.0437375745527, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323755, Length=583, Percent_Identity=41.852487135506, Blast_Score=448, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6320816, Length=489, Percent_Identity=24.5398773006135, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI19922626, Length=494, Percent_Identity=27.9352226720648, Blast_Score=189, Evalue=6e-48,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 63072; Mature: 63072

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMLSGAEMVVQSLVDQGVKQVFGYPGGAVLDIYDALHTLGGIDHVLVRHEQAAVHMADG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LARATGEVGVVLVTSGPGATNAITGIATAYMDSIPLVILSGQVATSLIGYDAFQECDMVG
HHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCC
ISRPVVKHSFLVKQTEDIPGVLKKAFWLAASGRPGPVVVDLPKDILNPAKKLPYVWPDAV
CCCHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCEEEECCHHHCCHHHHCCCCCCCCC
SMRSYNPTTSGHKGQIKRALQTLVAASKPVVYVGGGAINAHCEPQLRELVEKLKLPVASS
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCCCCHHHHHHHHHHCCCHHHH
LMGLGAFPATHSQALGMLGMHGTYEANMTMHHSDVIFAVGVRFDDRTTNNLAKYCPNATV
HHHCCCCCCCHHHHHHCCCCCCEEECCEEEEECCEEEEEEEEECCCCHHHHHHHCCCCEE
LHIDIDPTSISKTVPADVPIVGDARLVLEQMLELLEQEEAQQPLDDIRDWWQQIEQWRAR
EEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
HCLRYDDQSDKIKPQAVIETIWRLTQGDAYVTSDVGQHQMFAALYYPFDKPRRWINSGGL
HHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHEECCCHHHHHHHCCCCC
GTMGFGLPAALGVKMALPDEMVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNNRYLGM
CCCCCCCHHHHCEEEECCCCEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEECCCCHHHH
VKQWQDMLYSGRHSQSYMESLPDFVRLAEAYGHVGIRISEPQELETKLAEALEQVRQRRL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCE
VFVDVTVDGSEHVYPMQIRGGGMDEMWLSKTERT
EEEEEEECCCCCEEEEEECCCCCCHHHHHHCCCC
>Mature Secondary Structure
MEMLSGAEMVVQSLVDQGVKQVFGYPGGAVLDIYDALHTLGGIDHVLVRHEQAAVHMADG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LARATGEVGVVLVTSGPGATNAITGIATAYMDSIPLVILSGQVATSLIGYDAFQECDMVG
HHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCC
ISRPVVKHSFLVKQTEDIPGVLKKAFWLAASGRPGPVVVDLPKDILNPAKKLPYVWPDAV
CCCHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCEEEECCHHHCCHHHHCCCCCCCCC
SMRSYNPTTSGHKGQIKRALQTLVAASKPVVYVGGGAINAHCEPQLRELVEKLKLPVASS
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCCCCHHHHHHHHHHCCCHHHH
LMGLGAFPATHSQALGMLGMHGTYEANMTMHHSDVIFAVGVRFDDRTTNNLAKYCPNATV
HHHCCCCCCCHHHHHHCCCCCCEEECCEEEEECCEEEEEEEEECCCCHHHHHHHCCCCEE
LHIDIDPTSISKTVPADVPIVGDARLVLEQMLELLEQEEAQQPLDDIRDWWQQIEQWRAR
EEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
HCLRYDDQSDKIKPQAVIETIWRLTQGDAYVTSDVGQHQMFAALYYPFDKPRRWINSGGL
HHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHEECCCHHHHHHHCCCCC
GTMGFGLPAALGVKMALPDEMVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNNRYLGM
CCCCCCCHHHHCEEEECCCCEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEECCCCHHHH
VKQWQDMLYSGRHSQSYMESLPDFVRLAEAYGHVGIRISEPQELETKLAEALEQVRQRRL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCE
VFVDVTVDGSEHVYPMQIRGGGMDEMWLSKTERT
EEEEEEECCCCCEEEEEECCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6308579; 1630901; 9278503; 3891724; 9298646 [H]