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The map label for this gene is kefC [H]

Identifier: 238893020

GI number: 238893020

Start: 833161

End: 835026

Strand: Direct

Name: kefC [H]

Synonym: KP1_0857

Alternate gene names: 238893020

Gene position: 833161-835026 (Clockwise)

Preceding gene: 238893019

Following gene: 238893021

Centisome position: 15.87

GC content: 62.17

Gene sequence:

>1866_bases
ATGGATAGCCATACGCTGATACAGGCGTTGATTTACCTCGGCGCCGCGGCGCTGATTGTGCCCATCGCCGTCCGTCTGGG
GCTGGGGTCAGTGCTGGGCTATCTCATCGCCGGCTGTATTATCGGCCCGTGGGCGCTGCGGCTGGTGACCGATGCCGAGG
CGATTCTGCACTTTGCCGAGATTGGCGTGGTGCTGATGTTGTTCGTCATTGGTCTGGAGCTCGATCCGCAGCGCTTATGG
AAGCTGCGCGCCTCGGTGTTTGGCGGCGGCGCACTACAGATGGTGGCCTGCGGGGTGTTGATCGGCCTGTTCTGCATGCT
GCTGGGCCTGCGCTGGCAGGTGGCCGAGCTGATTGGTATGACTCTGGCGCTTTCCTCAACCGCGATCGCTATGCAGGCGA
TGAATGAGCGCAATCTGACGGTGTCGCAGATGGGGCGCAGCGCCTTTGCGGTGCTGCTGTTCCAGGATATCGCCGCGATC
CCGCTGGTGGCGATGATCCCGCTGCTGGCGGCCAGCGGCGGCGCCACTTCGCTGATGGCTTTTGCCCTCTCCGCGCTGAA
AGTGGCCGCAGCGCTGGCGCTGGTGGTGGTCCTTGGGCGCTATCTGACCCGGCCGCTGCTGCGCTTTGTCGCCCGTTCCG
GCCTGCGCGAAGTGTTCAGCGCCGTGGCCCTGTTCCTGGTCTTCGGCTTTGGCTTATTGCTGGAAGAGGTGGGGCTGTCG
ATGGCGATGGGGGCGTTTCTCGCCGGGGTGCTGCTGGCCAGTTCCGAATATCGTCATGCGCTGGAGAGTGATATTGAGCC
GTTTAAAGGACTGCTGTTGGGGCTGTTCTTTATCGGCGTCGGCATGTCGATTGATTTCGGCACCCTGGTCACCCATCCGC
TGCGTATTGTGATTTTGCTGGTCGGTTTCCTGGCGATAAAAATGCTGATGCTGTGGCTTATCGCCAGGCCGCTTGGCGTA
CCGCGCGCCCAGCGCCGCTGGTTTGCGGTGCTGCTGGGGCAGGGGAGTGAGTTCGCGTTTGTGGTGTTTGGCGCCGCGCG
GATGGCGGATGTACTGGACGGCGAATGGGCAAAAGCGTTGACCCTGGCGGTGGCCCTGTCGATGGCGGCAACCCCCATTC
TGCTGGTGCTGCTGACCCGTCTGGAGAAATCGTCCAGCGGCCAGGCGCGTGATGCTGACGAGATTGATGAAGAGCAGCCG
CGGGTGATTGTCGCCGGCTTTGGCCGCTTCGGGCAGATTGCCGGGCGATTGCTGCTCTCGAGCGGGGTGAAGATGGTGAT
CCTCGATCATGACCCGGACCATGTCGATACCCTGCGCAAATTTGATATGAAGGTTTTCTACGGCGATGCCACCCGGGTCG
ATCTGCTGGAGTCGGCCGGGGCCGAAAAGGCGGAAGTGCTGATCAATGCCATTGACGATCCGCACGTCAGCCTGGAGCTG
GTGGCGAGGGTAAAAGAGCATTTTCCGCATCTGCAGATCATCTCCCGCGCCCGCGATGTCGATCATTACATTCAGCTGCG
CCAGGCTGGCGTCGAGGCCCCGGAGCGTGAAACCTTCGAGGCGGCGCTGAAGTCCGGCCGAATGACGCTGGAGGCGCTGG
GGCTCGGCGCCTATGAAGCGCGCGAGCGGGCCGATCTGTTTCGACGATTCAACCTGCAGATGGTCGAAGAGATGGTGGCG
ATGGCGGAAAACGATGCCGCGTCGCGGGTGGCGGTCTTCAAGCGGACCAGCGATATGCTGACCGGCATCATCAACGAAGA
TCGTCATCATCTGTCGCTGGTGCAGCGTCATGGCTGGCAGGGTACGGAAGAGGGCAGGCACACCGGGGATATCGCCGATG
AGCCGGAAAATAAGCCCTCAGCCTGA

Upstream 100 bases:

>100_bases
TTCGCTATGCACTGCACCTTTATCTGCGATGATGAAACGCTGCAGGCGCAGGCCCGCCGCTATCGTCAACGCTTAATCGA
CTGGCAGGAGGCACACCAGA

Downstream 100 bases:

>100_bases
GGCTGACCAGTAACATTTTGTTTTCGTTTGGATCCTCTTCTGGCGGCCCACGGTGTGAACGTGGGCTTGCCAGCAAATCA
GAAAATTTTCTTATTCTTTA

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MDSHTLIQALIYLGAAALIVPIAVRLGLGSVLGYLIAGCIIGPWALRLVTDAEAILHFAEIGVVLMLFVIGLELDPQRLW
KLRASVFGGGALQMVACGVLIGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQMGRSAFAVLLFQDIAAI
PLVAMIPLLAASGGATSLMAFALSALKVAAALALVVVLGRYLTRPLLRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVTHPLRIVILLVGFLAIKMLMLWLIARPLGV
PRAQRRWFAVLLGQGSEFAFVVFGAARMADVLDGEWAKALTLAVALSMAATPILLVLLTRLEKSSSGQARDADEIDEEQP
RVIVAGFGRFGQIAGRLLLSSGVKMVILDHDPDHVDTLRKFDMKVFYGDATRVDLLESAGAEKAEVLINAIDDPHVSLEL
VARVKEHFPHLQIISRARDVDHYIQLRQAGVEAPERETFEAALKSGRMTLEALGLGAYEARERADLFRRFNLQMVEEMVA
MAENDAASRVAVFKRTSDMLTGIINEDRHHLSLVQRHGWQGTEEGRHTGDIADEPENKPSA

Sequences:

>Translated_621_residues
MDSHTLIQALIYLGAAALIVPIAVRLGLGSVLGYLIAGCIIGPWALRLVTDAEAILHFAEIGVVLMLFVIGLELDPQRLW
KLRASVFGGGALQMVACGVLIGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQMGRSAFAVLLFQDIAAI
PLVAMIPLLAASGGATSLMAFALSALKVAAALALVVVLGRYLTRPLLRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVTHPLRIVILLVGFLAIKMLMLWLIARPLGV
PRAQRRWFAVLLGQGSEFAFVVFGAARMADVLDGEWAKALTLAVALSMAATPILLVLLTRLEKSSSGQARDADEIDEEQP
RVIVAGFGRFGQIAGRLLLSSGVKMVILDHDPDHVDTLRKFDMKVFYGDATRVDLLESAGAEKAEVLINAIDDPHVSLEL
VARVKEHFPHLQIISRARDVDHYIQLRQAGVEAPERETFEAALKSGRMTLEALGLGAYEARERADLFRRFNLQMVEEMVA
MAENDAASRVAVFKRTSDMLTGIINEDRHHLSLVQRHGWQGTEEGRHTGDIADEPENKPSA
>Mature_621_residues
MDSHTLIQALIYLGAAALIVPIAVRLGLGSVLGYLIAGCIIGPWALRLVTDAEAILHFAEIGVVLMLFVIGLELDPQRLW
KLRASVFGGGALQMVACGVLIGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQMGRSAFAVLLFQDIAAI
PLVAMIPLLAASGGATSLMAFALSALKVAAALALVVVLGRYLTRPLLRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVTHPLRIVILLVGFLAIKMLMLWLIARPLGV
PRAQRRWFAVLLGQGSEFAFVVFGAARMADVLDGEWAKALTLAVALSMAATPILLVLLTRLEKSSSGQARDADEIDEEQP
RVIVAGFGRFGQIAGRLLLSSGVKMVILDHDPDHVDTLRKFDMKVFYGDATRVDLLESAGAEKAEVLINAIDDPHVSLEL
VARVKEHFPHLQIISRARDVDHYIQLRQAGVEAPERETFEAALKSGRMTLEALGLGAYEARERADLFRRFNLQMVEEMVA
MAENDAASRVAVFKRTSDMLTGIINEDRHHLSLVQRHGWQGTEEGRHTGDIADEPENKPSA

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=381, Percent_Identity=26.246719160105, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1786232, Length=621, Percent_Identity=85.6682769726248, Blast_Score=1074, Evalue=0.0,
Organism=Escherichia coli, GI1789749, Length=607, Percent_Identity=45.3047775947282, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1786685, Length=518, Percent_Identity=30.3088803088803, Blast_Score=170, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67350; Mature: 67350

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSHTLIQALIYLGAAALIVPIAVRLGLGSVLGYLIAGCIIGPWALRLVTDAEAILHFAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVVLMLFVIGLELDPQRLWKLRASVFGGGALQMVACGVLIGLFCMLLGLRWQVAELIGM
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TLALSSTAIAMQAMNERNLTVSQMGRSAFAVLLFQDIAAIPLVAMIPLLAASGGATSLMA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
FALSALKVAAALALVVVLGRYLTRPLLRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVTHPLRIVILL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VGFLAIKMLMLWLIARPLGVPRAQRRWFAVLLGQGSEFAFVVFGAARMADVLDGEWAKAL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEECCCCCEEEEEECHHHHHHHHCCHHHHHH
TLAVALSMAATPILLVLLTRLEKSSSGQARDADEIDEEQPRVIVAGFGRFGQIAGRLLLS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCEEEEECCCHHHHHHHHHHHH
SGVKMVILDHDPDHVDTLRKFDMKVFYGDATRVDLLESAGAEKAEVLINAIDDPHVSLEL
CCCEEEEECCCCCHHHHHHHHCCCEEECCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHH
VARVKEHFPHLQIISRARDVDHYIQLRQAGVEAPERETFEAALKSGRMTLEALGLGAYEA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHCCCHHHH
RERADLFRRFNLQMVEEMVAMAENDAASRVAVFKRTSDMLTGIINEDRHHLSLVQRHGWQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
GTEEGRHTGDIADEPENKPSA
CCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDSHTLIQALIYLGAAALIVPIAVRLGLGSVLGYLIAGCIIGPWALRLVTDAEAILHFAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVVLMLFVIGLELDPQRLWKLRASVFGGGALQMVACGVLIGLFCMLLGLRWQVAELIGM
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TLALSSTAIAMQAMNERNLTVSQMGRSAFAVLLFQDIAAIPLVAMIPLLAASGGATSLMA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
FALSALKVAAALALVVVLGRYLTRPLLRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVTHPLRIVILL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VGFLAIKMLMLWLIARPLGVPRAQRRWFAVLLGQGSEFAFVVFGAARMADVLDGEWAKAL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEECCCCCEEEEEECHHHHHHHHCCHHHHHH
TLAVALSMAATPILLVLLTRLEKSSSGQARDADEIDEEQPRVIVAGFGRFGQIAGRLLLS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCEEEEECCCHHHHHHHHHHHH
SGVKMVILDHDPDHVDTLRKFDMKVFYGDATRVDLLESAGAEKAEVLINAIDDPHVSLEL
CCCEEEEECCCCCHHHHHHHHCCCEEECCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHH
VARVKEHFPHLQIISRARDVDHYIQLRQAGVEAPERETFEAALKSGRMTLEALGLGAYEA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHCCCHHHH
RERADLFRRFNLQMVEEMVAMAENDAASRVAVFKRTSDMLTGIINEDRHHLSLVQRHGWQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
GTEEGRHTGDIADEPENKPSA
CCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11053405 [H]