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The map label for this gene is nhaA [H]

Identifier: 238893003

GI number: 238893003

Start: 814494

End: 815681

Strand: Direct

Name: nhaA [H]

Synonym: KP1_0837

Alternate gene names: 238893003

Gene position: 814494-815681 (Clockwise)

Preceding gene: 238893002

Following gene: 238893004

Centisome position: 15.52

GC content: 59.93

Gene sequence:

>1188_bases
ATGAAAGTAAAAGTGAAACATCTGCAACGATTCTTTAGTAGCGATGCTTCCGGCGGCATTGTCTTAATTATCGCCGCCGC
GCTGGCGATGGTGATGGCCAATACCAGCGTGACCAGCGGTCTGTATCACTCCTTCCTTGAGACGCCAGTACAGCTGCGTG
TGGGCGCGCTGGAGATCAACAAGAACATGCTGTTATGGATCAATGATGCCCTGATGGCGGTGTTCTTTTTGCTGATTGGC
CTGGAGGTCAAGCGTGAGCTGATTCAAGGGTCGCTGGCGAGCCGCCGTCAGGCGGTCTTCCCGGTGATAGCCGCGCTGGG
CGGGATGATCGTCCCGGCCCTGGTCTACCTGGCCTTTAACGCCCAGGATCCTGTCGCCAGAGAAGGGTGGGCGATCCCGG
CGGCGACGGATATTGCCTTTGCCCTCGGCGTGCTGGCGCTGTTAGGTAGCCGGGTCCCGACGGCGCTGAAGATTTTCCTG
ATGGCGCTGGCGATTATTGATGACCTCGGGGCTATCGTGATTATCGCGCTGTTTTATACCCACGACCTGTCCATGCTCTC
GCTGGGCGTGGCGGCGGCGGCGATTGCGGTGCTGGTGGCCCTGAATCTGAGCGGCGTGCGGCGTACCGGGATCTATATTC
TGGTTGGCGCGGTGCTGTGGACGGCGGTGCTGAAGTCTGGCGTTCACGCGACCCTTGCCGGGGTGATTGTCGGCTTTATG
ATCCCGCTCGAGGAAAAGCATGGCAAGTCGCCGGCCAAAGCGCTTGAGCATGTCCTGCACCCGTGGGTGGCGTTTATGAT
CCTGCCGCTGTTTGCCTTCGCGAACGCGGGGGTCTCACTGCAGGGGGTCACCCTTGCCGGGCTGACGTCGCTCCTGCCGC
TGGGCATTATGGCTGGCCTGTTTATCGGTAAGCCGCTGGGGATTAGCCTGTTCTGCTGGCTGGCCCTGAAGCTGAAGTGG
GCTTCGCTGCCGGAGGGTACCACCTGCAAGCAAATTATGGCGGTGGGGATCCTGTGCGGGATTGGCTTTACGATGTCGAT
TTTCATCGCCACCCTGGCCTTTGGCAGCGTGGATCCCGCGTTGATCAACTGGGCCAAGCTTGGCATTCTGATCGGCTCAG
TGCTATCAGCGGTCGTCGGCTACCTCATACTGCGTCAGCGCGTGACGGATACTCGCCTCGCGGTATAA

Upstream 100 bases:

>100_bases
CCTTTAGCTCGTAAAAAGCGAATATTAGCGCAACTTAAATCTGATTTTTTCGAGTTATCAGTATGTGTATTATGCTTTTA
TCGAGTTATTCACCAACAGG

Downstream 100 bases:

>100_bases
CCTTTCTGCAGGAGAGCCCGCCAGGCTCTCCTGGACATTATCAGGGAGAGAAGCATGTCACATATTAACTACAATCATCT
GTACTACTTCTGGCACGTGT

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1 [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MKVKVKHLQRFFSSDASGGIVLIIAAALAMVMANTSVTSGLYHSFLETPVQLRVGALEINKNMLLWINDALMAVFFLLIG
LEVKRELIQGSLASRRQAVFPVIAALGGMIVPALVYLAFNAQDPVAREGWAIPAATDIAFALGVLALLGSRVPTALKIFL
MALAIIDDLGAIVIIALFYTHDLSMLSLGVAAAAIAVLVALNLSGVRRTGIYILVGAVLWTAVLKSGVHATLAGVIVGFM
IPLEEKHGKSPAKALEHVLHPWVAFMILPLFAFANAGVSLQGVTLAGLTSLLPLGIMAGLFIGKPLGISLFCWLALKLKW
ASLPEGTTCKQIMAVGILCGIGFTMSIFIATLAFGSVDPALINWAKLGILIGSVLSAVVGYLILRQRVTDTRLAV

Sequences:

>Translated_395_residues
MKVKVKHLQRFFSSDASGGIVLIIAAALAMVMANTSVTSGLYHSFLETPVQLRVGALEINKNMLLWINDALMAVFFLLIG
LEVKRELIQGSLASRRQAVFPVIAALGGMIVPALVYLAFNAQDPVAREGWAIPAATDIAFALGVLALLGSRVPTALKIFL
MALAIIDDLGAIVIIALFYTHDLSMLSLGVAAAAIAVLVALNLSGVRRTGIYILVGAVLWTAVLKSGVHATLAGVIVGFM
IPLEEKHGKSPAKALEHVLHPWVAFMILPLFAFANAGVSLQGVTLAGLTSLLPLGIMAGLFIGKPLGISLFCWLALKLKW
ASLPEGTTCKQIMAVGILCGIGFTMSIFIATLAFGSVDPALINWAKLGILIGSVLSAVVGYLILRQRVTDTRLAV
>Mature_395_residues
MKVKVKHLQRFFSSDASGGIVLIIAAALAMVMANTSVTSGLYHSFLETPVQLRVGALEINKNMLLWINDALMAVFFLLIG
LEVKRELIQGSLASRRQAVFPVIAALGGMIVPALVYLAFNAQDPVAREGWAIPAATDIAFALGVLALLGSRVPTALKIFL
MALAIIDDLGAIVIIALFYTHDLSMLSLGVAAAAIAVLVALNLSGVRRTGIYILVGAVLWTAVLKSGVHATLAGVIVGFM
IPLEEKHGKSPAKALEHVLHPWVAFMILPLFAFANAGVSLQGVTLAGLTSLLPLGIMAGLFIGKPLGISLFCWLALKLKW
ASLPEGTTCKQIMAVGILCGIGFTMSIFIATLAFGSVDPALINWAKLGILIGSVLSAVVGYLILRQRVTDTRLAV

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=387, Percent_Identity=84.2377260981912, Blast_Score=608, Evalue=1e-175,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 41712; Mature: 41712

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKVKHLQRFFSSDASGGIVLIIAAALAMVMANTSVTSGLYHSFLETPVQLRVGALEIN
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHEEEEEEEC
KNMLLWINDALMAVFFLLIGLEVKRELIQGSLASRRQAVFPVIAALGGMIVPALVYLAFN
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AQDPVAREGWAIPAATDIAFALGVLALLGSRVPTALKIFLMALAIIDDLGAIVIIALFYT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDLSMLSLGVAAAAIAVLVALNLSGVRRTGIYILVGAVLWTAVLKSGVHATLAGVIVGFM
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IPLEEKHGKSPAKALEHVLHPWVAFMILPLFAFANAGVSLQGVTLAGLTSLLPLGIMAGL
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHH
FIGKPLGISLFCWLALKLKWASLPEGTTCKQIMAVGILCGIGFTMSIFIATLAFGSVDPA
HHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LINWAKLGILIGSVLSAVVGYLILRQRVTDTRLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVKVKHLQRFFSSDASGGIVLIIAAALAMVMANTSVTSGLYHSFLETPVQLRVGALEIN
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHEEEEEEEC
KNMLLWINDALMAVFFLLIGLEVKRELIQGSLASRRQAVFPVIAALGGMIVPALVYLAFN
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AQDPVAREGWAIPAATDIAFALGVLALLGSRVPTALKIFLMALAIIDDLGAIVIIALFYT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDLSMLSLGVAAAAIAVLVALNLSGVRRTGIYILVGAVLWTAVLKSGVHATLAGVIVGFM
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IPLEEKHGKSPAKALEHVLHPWVAFMILPLFAFANAGVSLQGVTLAGLTSLLPLGIMAGL
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHH
FIGKPLGISLFCWLALKLKWASLPEGTTCKQIMAVGILCGIGFTMSIFIATLAFGSVDPA
HHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LINWAKLGILIGSVLSAVVGYLILRQRVTDTRLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA