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The map label for this gene is tatD [H]

Identifier: 238892437

GI number: 238892437

Start: 200508

End: 201299

Strand: Direct

Name: tatD [H]

Synonym: KP1_0198

Alternate gene names: 238892437

Gene position: 200508-201299 (Clockwise)

Preceding gene: 238892436

Following gene: 238892439

Centisome position: 3.82

GC content: 63.51

Gene sequence:

>792_bases
ATGTTTGATATCGGCGTTAATCTGACCAGTTCGCAGTTTTCCCGCGATCATGATGAGGTAGTGGCGCGCGCCCTGGCGGC
GGGGGTTAACGGCATGCTGCTGACCGGCACAAATTTGGCGGAGAGCCAGCAGGCGCAGAAACTGGCGAGCCGCTATTCCG
GCTGCTGGTCCACGGCGGGGGTTCATCCCCATGACGGTAGCAGCTGGACGCCAGCGGTCGCCGAGGCGATTTATACCCTC
GCCGGCGAGCCGCAGGTGGTGGCGATAGGCGAGTGCGGTCTGGATTTTAACCGGAATTTTTCCACGCCGCACGAGCAGGA
GGTAGCGTTCAGCGCCCAGTTGGCGCTGGCCGCTGAGCTGTCGATGCCGGTGTTTTTGCACTGCCGCGACGCCCACGATC
GGTTTCTGACGCTGCTTAAACCCTGGCTTGAGAAGATCCCGGGCGCGGTGCTGCACTGCTTTACCGGCAGCCGCAGCGAG
GTGCAGGAATGCCTGGATCTGGGCCTGTTTATCGGTATTACCGGTTGGGTTTGCGATGAGCGGCGGGGACTGGAGCTGCG
CGAGCTGCTGCCGGCGATCCCGGCGGAACGTCTGCTGCTGGAGACCGATGCGCCTTATCTGCTGCCGCGCGACCTCAAGC
CGAAACCGGCCTCGCGGCGTAACGAGCCCGCGTATTTGCCGCATATCCTGGGCTGCGTCGCGGCCTGGCGCGGCGAGGAG
GCGCAATGGCTGGAGGCGCAAACGGACGCAAACGTCAGGGCGCTGTTTGGCGTTGACATTAACGGCGTTTAG

Upstream 100 bases:

>100_bases
CGCGCGATGACGACGCCGCGGCCGAAGCTGAAGCCGCAGAGCACAGAGAAGAGTAATACCGCCAACCGCCCGTCAGGGCG
GTTGGCATATGGGAGCGATT

Downstream 100 bases:

>100_bases
ATTTTCTGGAAGTCGGTATTTTTAACGCTCTGCAGGACTTGCTTATTCAGCAGGTTTAACAGCAACATAGAGCGCGCTTC
GCCGTCGGGCTCGGTGAAGA

Product: DNase TatD

Products: NA

Alternate protein names: DNase tatD [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MFDIGVNLTSSQFSRDHDEVVARALAAGVNGMLLTGTNLAESQQAQKLASRYSGCWSTAGVHPHDGSSWTPAVAEAIYTL
AGEPQVVAIGECGLDFNRNFSTPHEQEVAFSAQLALAAELSMPVFLHCRDAHDRFLTLLKPWLEKIPGAVLHCFTGSRSE
VQECLDLGLFIGITGWVCDERRGLELRELLPAIPAERLLLETDAPYLLPRDLKPKPASRRNEPAYLPHILGCVAAWRGEE
AQWLEAQTDANVRALFGVDINGV

Sequences:

>Translated_263_residues
MFDIGVNLTSSQFSRDHDEVVARALAAGVNGMLLTGTNLAESQQAQKLASRYSGCWSTAGVHPHDGSSWTPAVAEAIYTL
AGEPQVVAIGECGLDFNRNFSTPHEQEVAFSAQLALAAELSMPVFLHCRDAHDRFLTLLKPWLEKIPGAVLHCFTGSRSE
VQECLDLGLFIGITGWVCDERRGLELRELLPAIPAERLLLETDAPYLLPRDLKPKPASRRNEPAYLPHILGCVAAWRGEE
AQWLEAQTDANVRALFGVDINGV
>Mature_263_residues
MFDIGVNLTSSQFSRDHDEVVARALAAGVNGMLLTGTNLAESQQAQKLASRYSGCWSTAGVHPHDGSSWTPAVAEAIYTL
AGEPQVVAIGECGLDFNRNFSTPHEQEVAFSAQLALAAELSMPVFLHCRDAHDRFLTLLKPWLEKIPGAVLHCFTGSRSE
VQECLDLGLFIGITGWVCDERRGLELRELLPAIPAERLLLETDAPYLLPRDLKPKPASRRNEPAYLPHILGCVAAWRGEE
AQWLEAQTDANVRALFGVDINGV

Specific function: Shows DNase activity [H]

COG id: COG0084

COG function: function code L; Mg-dependent DNase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tatD DNase family [H]

Homologues:

Organism=Homo sapiens, GI14042943, Length=291, Percent_Identity=31.6151202749141, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI225903439, Length=249, Percent_Identity=31.7269076305221, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI225903424, Length=206, Percent_Identity=31.5533980582524, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI110349730, Length=273, Percent_Identity=27.8388278388278, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI226061853, Length=277, Percent_Identity=27.7978339350181, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI110349734, Length=273, Percent_Identity=28.2051282051282, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI226061595, Length=230, Percent_Identity=29.1304347826087, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI226061614, Length=262, Percent_Identity=27.4809160305344, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI48994985, Length=258, Percent_Identity=75.5813953488372, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1787342, Length=252, Percent_Identity=32.9365079365079, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI87082439, Length=249, Percent_Identity=28.9156626506024, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17559024, Length=281, Percent_Identity=35.9430604982206, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71980746, Length=266, Percent_Identity=25.187969924812, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565396, Length=168, Percent_Identity=32.1428571428571, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17543026, Length=171, Percent_Identity=32.1637426900585, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319416, Length=295, Percent_Identity=28.8135593220339, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24648690, Length=283, Percent_Identity=35.3356890459364, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI221330018, Length=249, Percent_Identity=32.1285140562249, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24586117, Length=221, Percent_Identity=32.579185520362, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015992
- InterPro:   IPR001130
- InterPro:   IPR018228
- InterPro:   IPR012278 [H]

Pfam domain/function: PF01026 TatD_DNase [H]

EC number: 3.1.21.-

Molecular weight: Translated: 28757; Mature: 28757

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS01090 TATD_2 ; PS01091 TATD_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDIGVNLTSSQFSRDHDEVVARALAAGVNGMLLTGTNLAESQQAQKLASRYSGCWSTAG
CEEECCCCCHHHHCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHCCC
VHPHDGSSWTPAVAEAIYTLAGEPQVVAIGECGLDFNRNFSTPHEQEVAFSAQLALAAEL
CCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
SMPVFLHCRDAHDRFLTLLKPWLEKIPGAVLHCFTGSRSEVQECLDLGLFIGITGWVCDE
CCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEECC
RRGLELRELLPAIPAERLLLETDAPYLLPRDLKPKPASRRNEPAYLPHILGCVAAWRGEE
CCCCHHHHHHCCCCHHHEEEECCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
AQWLEAQTDANVRALFGVDINGV
CHHHHHCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MFDIGVNLTSSQFSRDHDEVVARALAAGVNGMLLTGTNLAESQQAQKLASRYSGCWSTAG
CEEECCCCCHHHHCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHCCC
VHPHDGSSWTPAVAEAIYTLAGEPQVVAIGECGLDFNRNFSTPHEQEVAFSAQLALAAEL
CCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
SMPVFLHCRDAHDRFLTLLKPWLEKIPGAVLHCFTGSRSEVQECLDLGLFIGITGWVCDE
CCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEECC
RRGLELRELLPAIPAERLLLETDAPYLLPRDLKPKPASRRNEPAYLPHILGCVAAWRGEE
CCCCHHHHHHCCCCHHHEEEECCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
AQWLEAQTDANVRALFGVDINGV
CHHHHHCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Mg [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1584020; 9649434; 1379743; 9278503; 10747959 [H]