Click here to switch to the map view.

The map label for this gene is wecG

Identifier: 238892399

GI number: 238892399

Start: 161373

End: 162113

Strand: Direct

Name: wecG

Synonym: KP1_0157

Alternate gene names: 238892399

Gene position: 161373-162113 (Clockwise)

Preceding gene: 238892398

Following gene: 238892400

Centisome position: 3.07

GC content: 59.65

Gene sequence:

>741_bases
ATGACTGGGACCATTTCCGCGCCGTTGTACCTGTTAAGAGGGCTGCAGCTCATAGGCTGGCGCGATATGCCGCACGCTCT
GGATTATTTGTTTGCCGACGGCGCGCTCCGGGAGGGGACGCTGGTGGCCATTAATGCTGAGAAAATGCTGGCCGTAGAAG
ATAACCCGGAGGTACGGGCGCTGATTGAGGCGGCGGAGTTTAAATATGCCGATGGCATCAGCGTGGTGCGTTCGCTGCGC
AAAAAATACCCGCAGGCCCAGGTATCCCGCGTCGCCGGGGCCGATCTCTGGGAAGCGTTAATGCAGCGCGCTGGCGCTGA
AGGGACACCGGTGTTTTTGGTTGGTGGTAAACCTGAGGTCCTGGCGCAGACAGAATCCAGGCTGCGTCAGCGCTGGCAGG
TGAACATCGTCGGCAGCCAGGACGGTTATTTCACCCCTGAGCAACGCCAGGCATTGTTCGAACGCATTCGCGACAGCGGG
GCGAAAATCGTCACCGTCGCGATGGGGTCGCCGCGCCAGGAGATCTTCATGCGCGACTGCCGGCGCCTGTATCCGCACGC
GCTGTATATGGGCGTCGGCGGCACTTACGATGTTTTTACCGGGCACGTCCATCGGGCGCCGAAGTTCTGGCAGGATCTGG
GGCTGGAGTGGTTCTATCGTCTGCTTTTGCAGCCGAGCCGCATCAAGAGACAGTTCCGCCTACTGCGCTATTTACGTTGG
CATTATTCCGGTAAGCTCTGA

Upstream 100 bases:

>100_bases
TGCTGGCGGCGAAACTGCTGTACTGGTTCCTGGATAGCGTGGGACTGATTCATAAGCGCGTAAAACCGCTTTCGCAACCG
CAAGTCTGAGAAGGATGGAC

Downstream 100 bases:

>100_bases
TATTCCACTGCAACCAGGCGAGTTTGCATACATATTCTGTGTAATCTCTTCACTCGCCTGATACTTTATTTGCCATTTCC
GCAAAATTAATTAACCATTC

Product: putative UDP-N-acetyl-D-mannosaminuronic acid transferase

Products: C55-PP-GlcNAc-ManNAcA; UDP [C]

Alternate protein names: UDP-ManNAcA transferase

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MTGTISAPLYLLRGLQLIGWRDMPHALDYLFADGALREGTLVAINAEKMLAVEDNPEVRALIEAAEFKYADGISVVRSLR
KKYPQAQVSRVAGADLWEALMQRAGAEGTPVFLVGGKPEVLAQTESRLRQRWQVNIVGSQDGYFTPEQRQALFERIRDSG
AKIVTVAMGSPRQEIFMRDCRRLYPHALYMGVGGTYDVFTGHVHRAPKFWQDLGLEWFYRLLLQPSRIKRQFRLLRYLRW
HYSGKL

Sequences:

>Translated_246_residues
MTGTISAPLYLLRGLQLIGWRDMPHALDYLFADGALREGTLVAINAEKMLAVEDNPEVRALIEAAEFKYADGISVVRSLR
KKYPQAQVSRVAGADLWEALMQRAGAEGTPVFLVGGKPEVLAQTESRLRQRWQVNIVGSQDGYFTPEQRQALFERIRDSG
AKIVTVAMGSPRQEIFMRDCRRLYPHALYMGVGGTYDVFTGHVHRAPKFWQDLGLEWFYRLLLQPSRIKRQFRLLRYLRW
HYSGKL
>Mature_245_residues
TGTISAPLYLLRGLQLIGWRDMPHALDYLFADGALREGTLVAINAEKMLAVEDNPEVRALIEAAEFKYADGISVVRSLRK
KYPQAQVSRVAGADLWEALMQRAGAEGTPVFLVGGKPEVLAQTESRLRQRWQVNIVGSQDGYFTPEQRQALFERIRDSGA
KIVTVAMGSPRQEIFMRDCRRLYPHALYMGVGGTYDVFTGHVHRAPKFWQDLGLEWFYRLLLQPSRIKRQFRLLRYLRWH
YSGKL

Specific function: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in ECA synthesis

COG id: COG1922

COG function: function code M; Teichoic acid biosynthesis proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 26 family

Homologues:

Organism=Escherichia coli, GI2367289, Length=246, Percent_Identity=82.520325203252, Blast_Score=405, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): WECG_KLEP7 (A6TGI3)

Other databases:

- EMBL:   CP000647
- RefSeq:   YP_001337934.1
- STRING:   A6TGI3
- GeneID:   5339149
- GenomeReviews:   CP000647_GR
- KEGG:   kpn:KPN_04295
- eggNOG:   COG1922
- HOGENOM:   HBG685240
- OMA:   YGPDLML
- ProtClustDB:   PRK03692
- HAMAP:   MF_01001
- InterPro:   IPR023085
- InterPro:   IPR004629
- TIGRFAMs:   TIGR00696

Pfam domain/function: PF03808 Glyco_tran_WecB

EC number: 2.4.1.- [C]

Molecular weight: Translated: 28158; Mature: 28027

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGTISAPLYLLRGLQLIGWRDMPHALDYLFADGALREGTLVAINAEKMLAVEDNPEVRA
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCEEEEECCCCHHHH
LIEAAEFKYADGISVVRSLRKKYPQAQVSRVAGADLWEALMQRAGAEGTPVFLVGGKPEV
HHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCHH
LAQTESRLRQRWQVNIVGSQDGYFTPEQRQALFERIRDSGAKIVTVAMGSPRQEIFMRDC
HHHHHHHHHHCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
RRLYPHALYMGVGGTYDVFTGHVHRAPKFWQDLGLEWFYRLLLQPSRIKRQFRLLRYLRW
HHHCCHHEEECCCCCHHHHCCCHHCCHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHH
HYSGKL
HHCCCC
>Mature Secondary Structure 
TGTISAPLYLLRGLQLIGWRDMPHALDYLFADGALREGTLVAINAEKMLAVEDNPEVRA
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCEEEEECCCCHHHH
LIEAAEFKYADGISVVRSLRKKYPQAQVSRVAGADLWEALMQRAGAEGTPVFLVGGKPEV
HHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCHH
LAQTESRLRQRWQVNIVGSQDGYFTPEQRQALFERIRDSGAKIVTVAMGSPRQEIFMRDC
HHHHHHHHHHCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
RRLYPHALYMGVGGTYDVFTGHVHRAPKFWQDLGLEWFYRLLLQPSRIKRQFRLLRYLRW
HHHCCHHEEECCCCCHHHHCCCHHCCHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHH
HYSGKL
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosaminuronic-acid; undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate [C]

Specific reaction: UDP-N-acetyl-D-mannosaminuronic-acid + undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate = C55-PP-GlcNAc-ManNAcA + UDP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA