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The map label for this gene is rmlA [H]

Identifier: 238892393

GI number: 238892393

Start: 155024

End: 155905

Strand: Direct

Name: rmlA [H]

Synonym: KP1_0151

Alternate gene names: 238892393

Gene position: 155024-155905 (Clockwise)

Preceding gene: 238892392

Following gene: 238892394

Centisome position: 2.95

GC content: 58.05

Gene sequence:

>882_bases
ATGAAAGGTATTATTCTGGCGGGCGGTTCCGGAACGCGGCTACATCCCATCACCCGCGGCGTATCGAAGCAGCTGTTGCC
GATCTACGATAAGCCGATGATCTACTACCCGCTGTCGGTATTAATGCTGGCCGGGATCCGTGAGATCCTGATTATCACCA
CGCCGGACGACCTACGTGATTTCCAGCGCCTGCTCGGCGATGGCTCAGAGTTTGGCATTGCGCTGCACTATGCCGTACAG
CCGACGCCGGATGGTTTAGCCCAGGCGTTTATCATCGGCGAAGCCTTTCTTAACGGCGAACCGGCGTGTCTGGTGTTAGG
CGACAATATCTTCTTCGGCCAAAGCTTTAGCCCGAAGCTGCGCAGCGTCGCTGCCCGCACGGAAGGGGCGACGATTTTTG
GCTATCAGGTGATGGATCCTGAGCGCTTTGGCGTGGTGGAGTTTGATGATAACTTCCGTGCGCTATCGCTGGAAGAGAAG
CCGAAGCAGCCGAAGTCGAACTGGGCGGTCACCGGTCTCTATTTCTACGATGGCAAGGTGACGGAGTATGCCAAACGGGT
CAAACCATCCGAGCGCGGCGAGCTGGAAATCACCTCCATCAACCAGATGTATCTGGAGGATGGCGCATTGACCGTCGAAC
TGCTTGGACGCGGCTTTGCCTGGCTGGACACCGGCACCCACGATAGCCTGATCGAGGCCAGCATGTTCGTGCAGACCGTC
GAGAAGCGCCAGGGCTTTAAAATCGCCTGTCTGGAAGAGATCGGCTGGCGTAACGGCTGGCTGGACGACGACGGCGTCAA
ACGTGCGGCGAAGCGGCTGGAAAAAACCGGCTACGGCCAATATCTGCTGGATCTGCTCCGTGCCCGTCCGCGCCAGTATT
GA

Upstream 100 bases:

>100_bases
GTGGTATCTGGCGAACGAGGCCTGGTGGCGTCGGGTTCAGGACGGAAGCTATCAGGGCGAGCGTCTTGGGCTGCAAAGCT
AATCATCTCTGGGGGGAATG

Downstream 100 bases:

>100_bases
CCCCCTGGAGTGGGAGAACCGCTTCTTTGCCGTGAACAGCGCGATCGTGCGCTTTGACGAGCACGCGCCGCGGCTGACGC
CTGAGGCGCTGGCGGGGTGG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 2; dTDP-glucose pyrophosphorylase 2; dTDP-glucose synthase 2 [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIREILIITTPDDLRDFQRLLGDGSEFGIALHYAVQ
PTPDGLAQAFIIGEAFLNGEPACLVLGDNIFFGQSFSPKLRSVAARTEGATIFGYQVMDPERFGVVEFDDNFRALSLEEK
PKQPKSNWAVTGLYFYDGKVTEYAKRVKPSERGELEITSINQMYLEDGALTVELLGRGFAWLDTGTHDSLIEASMFVQTV
EKRQGFKIACLEEIGWRNGWLDDDGVKRAAKRLEKTGYGQYLLDLLRARPRQY

Sequences:

>Translated_293_residues
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIREILIITTPDDLRDFQRLLGDGSEFGIALHYAVQ
PTPDGLAQAFIIGEAFLNGEPACLVLGDNIFFGQSFSPKLRSVAARTEGATIFGYQVMDPERFGVVEFDDNFRALSLEEK
PKQPKSNWAVTGLYFYDGKVTEYAKRVKPSERGELEITSINQMYLEDGALTVELLGRGFAWLDTGTHDSLIEASMFVQTV
EKRQGFKIACLEEIGWRNGWLDDDGVKRAAKRLEKTGYGQYLLDLLRARPRQY
>Mature_293_residues
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIREILIITTPDDLRDFQRLLGDGSEFGIALHYAVQ
PTPDGLAQAFIIGEAFLNGEPACLVLGDNIFFGQSFSPKLRSVAARTEGATIFGYQVMDPERFGVVEFDDNFRALSLEEK
PKQPKSNWAVTGLYFYDGKVTEYAKRVKPSERGELEITSINQMYLEDGALTVELLGRGFAWLDTGTHDSLIEASMFVQTV
EKRQGFKIACLEEIGWRNGWLDDDGVKRAAKRLEKTGYGQYLLDLLRARPRQY

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790224, Length=293, Percent_Identity=91.1262798634812, Blast_Score=549, Evalue=1e-158,
Organism=Escherichia coli, GI1788351, Length=287, Percent_Identity=65.5052264808362, Blast_Score=386, Evalue=1e-109,
Organism=Escherichia coli, GI1787488, Length=241, Percent_Identity=24.4813278008299, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788355, Length=236, Percent_Identity=24.1525423728814, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=253, Percent_Identity=25.6916996047431, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=27.6679841897233, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355443, Length=252, Percent_Identity=25.7936507936508, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24644084, Length=252, Percent_Identity=25.7936507936508, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32797; Mature: 32797

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIREILIITTPDDLRD
CCCEEEECCCCCEECHHHHCCHHCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCHHHHH
FQRLLGDGSEFGIALHYAVQPTPDGLAQAFIIGEAFLNGEPACLVLGDNIFFGQSFSPKL
HHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCCHHH
RSVAARTEGATIFGYQVMDPERFGVVEFDDNFRALSLEEKPKQPKSNWAVTGLYFYDGKV
HHHHHHCCCCEEEEEEEECCCCCEEEEECCCEEEEECCCCCCCCCCCEEEEEEEEECCCH
TEYAKRVKPSERGELEITSINQMYLEDGALTVELLGRGFAWLDTGTHDSLIEASMFVQTV
HHHHHHCCCCCCCCEEEEECCEEEECCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHH
EKRQGFKIACLEEIGWRNGWLDDDGVKRAAKRLEKTGYGQYLLDLLRARPRQY
HHHCCCEEEEHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIREILIITTPDDLRD
CCCEEEECCCCCEECHHHHCCHHCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCHHHHH
FQRLLGDGSEFGIALHYAVQPTPDGLAQAFIIGEAFLNGEPACLVLGDNIFFGQSFSPKL
HHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCCHHH
RSVAARTEGATIFGYQVMDPERFGVVEFDDNFRALSLEEKPKQPKSNWAVTGLYFYDGKV
HHHHHHCCCCEEEEEEEECCCCCEEEEECCCEEEEECCCCCCCCCCCEEEEEEEEECCCH
TEYAKRVKPSERGELEITSINQMYLEDGALTVELLGRGFAWLDTGTHDSLIEASMFVQTV
HHHHHHCCCCCCCCEEEEECCEEEECCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHH
EKRQGFKIACLEEIGWRNGWLDDDGVKRAAKRLEKTGYGQYLLDLLRARPRQY
HHHCCCEEEEHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]