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The map label for this gene is udhA [H]

Identifier: 238892359

GI number: 238892359

Start: 113265

End: 114665

Strand: Reverse

Name: udhA [H]

Synonym: KP1_0116

Alternate gene names: 238892359

Gene position: 114665-113265 (Counterclockwise)

Preceding gene: 238892362

Following gene: 238892354

Centisome position: 2.18

GC content: 57.1

Gene sequence:

>1401_bases
ATGTCACACTCTTGGGATTATGATGCAATAGTGATTGGTTCCGGTCCTGGCGGGGAAGGCGCCGCCATGGGACTGGTGAA
ACAGGGAGCACGCGTTGCCGTCATCGAGCGCTACCATAATGTCGGCGGCGGTTGCACCCACTGGGGCACCATCCCGTCGA
AAGCCCTCCGCCATGCCGTCAGCCGTATTATCGAGTTTAACCAAAACCCCCTCTACAGCGACCACTCCCGCCTTCTTCGC
TCTTCTTTCGCCGACATCCTTAACCATGCCGACAGCGTCATCAACCAGCAGACTCATATGCGCCAGGGATTCTATGAGCG
CAACCACTGTGAAATTCTGCAGGGCAATGCCCACTTCGTGGATGAGCATACTCTGGCGCTGGAGTGCCATGACGGCACGG
TCGAGACTGTGACCGCGGAGAAATTCGTTATCGCCTGCGGATCGCGCCCCTACCATCCGGCGGATGTCGATTTCCACCAC
CCGCGCATCTATGACAGCGATTCGATTCTCAGCCTGCAGCATGAGCCGCGCCATGTGATCATTTACGGCGCCGGGGTGAT
CGGTTGTGAATATGCGTCGATCTTCCGCGGCATGGAGGTGAAGGTCGATCTGATCAACACCCGCGATCGTCTGCTGGCCT
TCCTCGATCAGGAGATGTCAGACTCGCTCTCTTATCACTTCTGGAACAGCGGCGTGGTTATTCGCCACAACGAGGAGTAT
GAGAAAATTGAAGGGGTGGATGACGGGGTGATCATGCACCTGAAGTCCGGCAAAAAGCTGAAGGCCGATTGCCTGCTGTA
CGCTAACGGCCGCACCGGCAACACCGACACCCTGGCGCTGGAAAATATCGGTCTGCAGACCGACAGCCGCGGTCAGCTGA
AGGTCAACAGCATGTATCAGACCGCCCTCCCGCACATCTATGCGGTTGGCGATGTCATCGGCTATCCAAGCCTGGCTTCT
GCCGCTTACGATCAAGGACGCATTGCCGCCCAGGCGCTGGTGAAAGGCGAAGCCTCAGCGCATCTGATTGAAGATATCCC
GACCGGGATCTATACCATTCCGGAAATCAGCTCCGTCGGGAAAACCGAGCAGCAGCTGACGGCGATGAAAGTGCCGTATG
AGGTGGGCCGCGCCCAGTTTAAACACCTGGCGCGGGCGCAAATCGTCGGTATGAGCGTTGGTACGCTGAAGATCCTGTTC
CATCGTGAAACCAAGGAGATCCTTGGCATTCACTGCTTTGGCGAGCGCGCGGCCGAAATTATTCATATCGGCCAGGCGAT
CATGGAGCAGAAAGGCGGTGGCAACACCATTGAGTACTTCGTCAACACCACCTTTAACTACCCGACCATGGCGGAAGCGT
ACCGGGTTGCCGCGCTGAACGGCTTAAACCGCCTGTTTTAA

Upstream 100 bases:

>100_bases
TCTGCTTTTATGCTGCAAAAAAGCACAACGATAATTGGGTTAAAGCGCAGCGAATGTTATCATCGTGTTTATTTTATGTA
TAAAACAGGTGAGTAATGCC

Downstream 100 bases:

>100_bases
CGCCTTGTCGAAATGGCCATCCATCGTGCCGCGGATGGCCTCCGCCAGATGTTCATAGCGGCTGCGCAGCGGGGAGCCCG
GACGATAAACCAGACCGATG

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSHSWDYDAIVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLR
SSFADILNHADSVINQQTHMRQGFYERNHCEILQGNAHFVDEHTLALECHDGTVETVTAEKFVIACGSRPYHPADVDFHH
PRIYDSDSILSLQHEPRHVIIYGAGVIGCEYASIFRGMEVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEY
EKIEGVDDGVIMHLKSGKKLKADCLLYANGRTGNTDTLALENIGLQTDSRGQLKVNSMYQTALPHIYAVGDVIGYPSLAS
AAYDQGRIAAQALVKGEASAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMSVGTLKILF
HRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Sequences:

>Translated_466_residues
MSHSWDYDAIVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLR
SSFADILNHADSVINQQTHMRQGFYERNHCEILQGNAHFVDEHTLALECHDGTVETVTAEKFVIACGSRPYHPADVDFHH
PRIYDSDSILSLQHEPRHVIIYGAGVIGCEYASIFRGMEVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEY
EKIEGVDDGVIMHLKSGKKLKADCLLYANGRTGNTDTLALENIGLQTDSRGQLKVNSMYQTALPHIYAVGDVIGYPSLAS
AAYDQGRIAAQALVKGEASAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMSVGTLKILF
HRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
>Mature_465_residues
SHSWDYDAIVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRS
SFADILNHADSVINQQTHMRQGFYERNHCEILQGNAHFVDEHTLALECHDGTVETVTAEKFVIACGSRPYHPADVDFHHP
RIYDSDSILSLQHEPRHVIIYGAGVIGCEYASIFRGMEVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYE
KIEGVDDGVIMHLKSGKKLKADCLLYANGRTGNTDTLALENIGLQTDSRGQLKVNSMYQTALPHIYAVGDVIGYPSLASA
AYDQGRIAAQALVKGEASAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMSVGTLKILFH
RETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=474, Percent_Identity=28.9029535864979, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=27.0152505446623, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI22035672, Length=485, Percent_Identity=26.5979381443299, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI33519430, Length=350, Percent_Identity=24.5714285714286, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI33519428, Length=350, Percent_Identity=24.5714285714286, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI33519426, Length=350, Percent_Identity=24.5714285714286, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI148277065, Length=350, Percent_Identity=24.5714285714286, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI148277071, Length=350, Percent_Identity=24.5714285714286, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI291045266, Length=440, Percent_Identity=25, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI291045268, Length=359, Percent_Identity=26.7409470752089, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI226437568, Length=202, Percent_Identity=28.7128712871287, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI65787454, Length=202, Percent_Identity=28.7128712871287, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI21389617, Length=202, Percent_Identity=28.7128712871287, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=94.8497854077253, Blast_Score=926, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=467, Percent_Identity=27.8372591006424, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI87081717, Length=464, Percent_Identity=27.5862068965517, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=27.8422273781903, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI32565766, Length=472, Percent_Identity=29.4491525423729, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=24.4725738396624, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71983419, Length=355, Percent_Identity=26.4788732394366, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71983429, Length=355, Percent_Identity=26.4788732394366, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17559934, Length=286, Percent_Identity=25.1748251748252, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=482, Percent_Identity=28.0082987551867, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=26.6949152542373, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=25.3796095444685, Blast_Score=136, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21358499, Length=475, Percent_Identity=30.3157894736842, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24640553, Length=489, Percent_Identity=30.6748466257669, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24640549, Length=489, Percent_Identity=30.6748466257669, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24640551, Length=489, Percent_Identity=30.6748466257669, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI17737741, Length=493, Percent_Identity=26.369168356998, Blast_Score=132, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 51533; Mature: 51402

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSWDYDAIVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKALRHAV
CCCCCCCCEEEEECCCCCCCHHHHHHHCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHH
SRIIEFNQNPLYSDHSRLLRSSFADILNHADSVINQQTHMRQGFYERNHCEILQGNAHFV
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEE
DEHTLALECHDGTVETVTAEKFVIACGSRPYHPADVDFHHPRIYDSDSILSLQHEPRHVI
ECEEEEEEECCCCEEEEEECEEEEEECCCCCCCCCCCCCCCEEECCCCEEEEECCCCEEE
IYGAGVIGCEYASIFRGMEVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEY
EEECCCHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCEEEEECCHH
EKIEGVDDGVIMHLKSGKKLKADCLLYANGRTGNTDTLALENIGLQTDSRGQLKVNSMYQ
HHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCEEECHHHH
TALPHIYAVGDVIGYPSLASAAYDQGRIAAQALVKGEASAHLIEDIPTGIYTIPEISSVG
HHCCHHEEHHHHHCCCCHHHHHHCCCHHHHHHHHCCCCCHHHHHHCCCCEEECCCCHHCC
KTEQQLTAMKVPYEVGRAQFKHLARAQIVGMSVGTLKILFHRETKEILGIHCFGERAAEI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCEEEEEEECCCHHHEEEEECCHHHHHH
IHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
HHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHSWDYDAIVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKALRHAV
CCCCCCCEEEEECCCCCCCHHHHHHHCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHH
SRIIEFNQNPLYSDHSRLLRSSFADILNHADSVINQQTHMRQGFYERNHCEILQGNAHFV
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEE
DEHTLALECHDGTVETVTAEKFVIACGSRPYHPADVDFHHPRIYDSDSILSLQHEPRHVI
ECEEEEEEECCCCEEEEEECEEEEEECCCCCCCCCCCCCCCEEECCCCEEEEECCCCEEE
IYGAGVIGCEYASIFRGMEVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEY
EEECCCHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCEEEEECCHH
EKIEGVDDGVIMHLKSGKKLKADCLLYANGRTGNTDTLALENIGLQTDSRGQLKVNSMYQ
HHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCEEECHHHH
TALPHIYAVGDVIGYPSLASAAYDQGRIAAQALVKGEASAHLIEDIPTGIYTIPEISSVG
HHCCHHEEHHHHHCCCCHHHHHHCCCHHHHHHHHCCCCCHHHHHHCCCCEEECCCCHHCC
KTEQQLTAMKVPYEVGRAQFKHLARAQIVGMSVGTLKILFHRETKEILGIHCFGERAAEI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCEEEEEEECCCHHHEEEEECCHHHHHH
IHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
HHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA