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The map label for this gene is dctA [H]

Identifier: 238028731

GI number: 238028731

Start: 3628998

End: 3630395

Strand: Reverse

Name: dctA [H]

Synonym: bglu_1g31950

Alternate gene names: 238028731

Gene position: 3630395-3628998 (Counterclockwise)

Preceding gene: 238028732

Following gene: 238028730

Centisome position: 92.93

GC content: 65.24

Gene sequence:

>1398_bases
TTGTTGCGGCACGGCAGCCGCGCGGGCGAATGGCGCTCCCCCCTGACATTCGCCCGCGTGCGTGACGCCGACACTTCGAC
TCCCTTCACCCTTCTGGAATCTGGACCCATCGTGAAGAAGAAACCGTTCTACAAAGTGCTCTACGTGCAGGTGATCTGCG
CCATCATCGTCGGCGTGATCCTCGGCCATTACTACCCGTCGCTCGCCGTCGACATGAAGCCGCTCGGCGACGGCTTCATC
AAGCTGATCAAGATGGTGATCGGCCCGATCATCTTCTGCACGGTCGTGACCGGCATCGCCGGCATGCAGGACATGAAGAA
GGTGGGCCGCGTCGGCGGCAAGGCGCTGCTCTACTTCGAGATCGTCTCGACGTTCGCGCTGGTGCTGGGCCTCGCGGCCA
CCCACCTGCTGCGTCCGGGCGCGGGCTTCAACATCGATCCGGCCACGCTCAACGGCAAGGAAGTGGCGTCGTATGCCGCC
AAGGCGCATGGCCAGTCGACGGTCGACTTCCTGATGCACATCATCCCGAACACGATGTTCGACGCGTTCGGCCAGGGCGA
GATCCTGCAGATCCTGCTGATCGCGCTGCTGTTCGGCAGCGTGCTCGCGCATATCGGCGAGCGCGGCAAGGTGGTGACCG
ACTTCATCGAGGGCATCAGCCGCGTGCTGTTCGGCATCGTCCACATCATCACCAAGCTCGCCCCGATCGGCGCGTTCGGC
GCGATGGCGTTCACCATCGGCAAGTACGGCGTGGGCTCGCTGGTGCCGCTGCTCAAGCTGATCGGCACGTTCTACCTGAC
CTCGGTGGTGTTCGTGGTGGTGGTGCTCGGCGCGGTGGCGCGCTACACCGGCTTCTCGATCCTGCGCTTCGTGGCCTACA
TCAAGGAAGAGATGCTGATCGTGCTCGGCACCAGCTCGTCGGAGGCGGCGCTGCCGCAGCTGATGGAGAAGCTCGAGAAG
GCGGGCTGCTCGCGTTCGGTGGTGGGCCTGGTGGTGCCCACCGGCTACTCGTTCAACCTGGACGGCACCAACATCTACAT
GACGATGGCGGTGCTGTTCATCGCCCAGGCCACCAACATCGAGCTGAGCTGGATGCAGCAGCTCACGCTGCTGGCCGTCG
CGATGCTGACCTCGAAGGGCGCGAGCGGCGTGACGGGCGCGGGCTTCATCACGCTGGCCGCGACGCTGGCCGTGGTGCCG
ACCATTCCGCTCACCGGCATGGTGCTGATCCTCGGCATCGACCGCTTCATGAGCGAGTGCCGCGCGCTGACCAACATCGT
CGGCAACGGCGTGGCGACGATCGTCGTCTCGGCATGGGAGAAGGAACTCGACCGCAGCAAGCTGCGCGCCGCGCTGAACG
GCGAGGCCACGGTCGACGGCAGCCCCGCGCAGGTCTGA

Upstream 100 bases:

>100_bases
GTCGCAAGGCCGGTCTTCCGGCTGGACAACGACAGCAGCAAGGAGACAATCGATGACGCCCCACCCGTATCCTTCCCCCC
GGATGGCTTGAGGCCGTCGC

Downstream 100 bases:

>100_bases
CGTGAGGCCTCCTGCAGCGGTGCGCGATACGCCGCCGCTGCCGGGCGGGGCCGGCCCCGCCCCGTTTCGGGCGGGCGGCT
ATGCCACAATGAGCGATTCC

Product: C4-dicarboxylate transporter DctA

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MLRHGSRAGEWRSPLTFARVRDADTSTPFTLLESGPIVKKKPFYKVLYVQVICAIIVGVILGHYYPSLAVDMKPLGDGFI
KLIKMVIGPIIFCTVVTGIAGMQDMKKVGRVGGKALLYFEIVSTFALVLGLAATHLLRPGAGFNIDPATLNGKEVASYAA
KAHGQSTVDFLMHIIPNTMFDAFGQGEILQILLIALLFGSVLAHIGERGKVVTDFIEGISRVLFGIVHIITKLAPIGAFG
AMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVVVVLGAVARYTGFSILRFVAYIKEEMLIVLGTSSSEAALPQLMEKLEK
AGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQATNIELSWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVP
TIPLTGMVLILGIDRFMSECRALTNIVGNGVATIVVSAWEKELDRSKLRAALNGEATVDGSPAQV

Sequences:

>Translated_465_residues
MLRHGSRAGEWRSPLTFARVRDADTSTPFTLLESGPIVKKKPFYKVLYVQVICAIIVGVILGHYYPSLAVDMKPLGDGFI
KLIKMVIGPIIFCTVVTGIAGMQDMKKVGRVGGKALLYFEIVSTFALVLGLAATHLLRPGAGFNIDPATLNGKEVASYAA
KAHGQSTVDFLMHIIPNTMFDAFGQGEILQILLIALLFGSVLAHIGERGKVVTDFIEGISRVLFGIVHIITKLAPIGAFG
AMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVVVVLGAVARYTGFSILRFVAYIKEEMLIVLGTSSSEAALPQLMEKLEK
AGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQATNIELSWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVP
TIPLTGMVLILGIDRFMSECRALTNIVGNGVATIVVSAWEKELDRSKLRAALNGEATVDGSPAQV
>Mature_465_residues
MLRHGSRAGEWRSPLTFARVRDADTSTPFTLLESGPIVKKKPFYKVLYVQVICAIIVGVILGHYYPSLAVDMKPLGDGFI
KLIKMVIGPIIFCTVVTGIAGMQDMKKVGRVGGKALLYFEIVSTFALVLGLAATHLLRPGAGFNIDPATLNGKEVASYAA
KAHGQSTVDFLMHIIPNTMFDAFGQGEILQILLIALLFGSVLAHIGERGKVVTDFIEGISRVLFGIVHIITKLAPIGAFG
AMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVVVVLGAVARYTGFSILRFVAYIKEEMLIVLGTSSSEAALPQLMEKLEK
AGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQATNIELSWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVP
TIPLTGMVLILGIDRFMSECRALTNIVGNGVATIVVSAWEKELDRSKLRAALNGEATVDGSPAQV

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=484, Percent_Identity=24.1735537190083, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI21314632, Length=436, Percent_Identity=24.3119266055046, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4827012, Length=274, Percent_Identity=28.8321167883212, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI40254478, Length=430, Percent_Identity=25.5813953488372, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI66773030, Length=418, Percent_Identity=24.1626794258373, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI194239697, Length=480, Percent_Identity=23.125, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI5032093, Length=393, Percent_Identity=26.4631043256997, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI223468564, Length=268, Percent_Identity=27.6119402985075, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI223468566, Length=268, Percent_Identity=27.6119402985075, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI262359914, Length=425, Percent_Identity=23.0588235294118, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI301601644, Length=188, Percent_Identity=27.6595744680851, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789947, Length=426, Percent_Identity=61.2676056338028, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1790514, Length=413, Percent_Identity=38.0145278450363, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1788024, Length=403, Percent_Identity=21.8362282878412, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789473, Length=322, Percent_Identity=25.1552795031056, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=439, Percent_Identity=26.879271070615, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI193206505, Length=463, Percent_Identity=23.9740820734341, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71996953, Length=465, Percent_Identity=24.5161290322581, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71983099, Length=473, Percent_Identity=23.6786469344609, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71983106, Length=473, Percent_Identity=23.6786469344609, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI193206654, Length=413, Percent_Identity=22.5181598062954, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17541374, Length=438, Percent_Identity=21.0045662100457, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583025, Length=412, Percent_Identity=23.0582524271845, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17137668, Length=412, Percent_Identity=23.0582524271845, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24583023, Length=412, Percent_Identity=23.0582524271845, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281360483, Length=478, Percent_Identity=24.8953974895398, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17137666, Length=478, Percent_Identity=24.8953974895398, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI281360481, Length=478, Percent_Identity=24.8953974895398, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 49511; Mature: 49511

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
>Mature Secondary Structure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HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA