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The map label for this gene is prs [H]

Identifier: 238028668

GI number: 238028668

Start: 3560392

End: 3561351

Strand: Direct

Name: prs [H]

Synonym: bglu_1g31320

Alternate gene names: 238028668

Gene position: 3560392-3561351 (Clockwise)

Preceding gene: 238028667

Following gene: 238028669

Centisome position: 91.14

GC content: 63.85

Gene sequence:

>960_bases
ATGATGAGCAGCCATGACGGCCTGATGGTTTTCACTGGCAACGCAAACCCCGCGCTTGCACAGAAAGTCGTCGACAATCT
CGGAATTCCTCTTGGCAAGGCCATGGTCAGCCGTTTCTCGGACGGTGAAATCCAGGTCGAAATCCAGGAAAACGTGCGCG
GCAAGGACATCTTCGTCCTGCAATCGACCTGCGCGCCAGCGAACGACAACCTGATGGAACTGATGATCATGGTCGATGCG
CTCAAGCGCGCATCCGCAGGCCGGATCACCGCTGCCATCCCCTACTTCGGCTACGCACGCCAGGATCGCCGCCCGCGTTC
GGCGCGCGTCGCGATTTCGGCGAAGATCGTCGCGAACATGCTGGAAATCGCCGGCGTCGAGCGAATCATCACGATGGATC
TGCATGCCGACCAGATCCAGGGCTTCTTCGACATTCCCGTCGACAACATCTACGCCACGCCGATCCTGCTGGGCGACCTG
CGCAAGCAGAACCACCAGGATCTGCTGGTGGTGTCGCCGGACGTCGGCGGCGTGGTGCGCGCGCGTGCGCTCGCCAAGCA
GCTGAACTGCGATCTCGCGATCATCGACAAGCGTCGCCCGAAGGCGAACGTCGCCGAGGTGATGAACATCATCGGTGAAG
TCGAAGGCCGCACCTGCGTGATCATGGACGACATGGTCGATACGGCCGGCACGCTCTGCAAGGCCGCGCAAGTGCTGAAG
GAACGCGGCGCGAAGCGCGTGTTCGCCTATGCCACGCACCCGGTGCTGTCGGGCGGCGCGGCCGCGCGCATCGACGCGTC
GGAGCTCGACGAGCTCGTCGTCACCGACACCATCCCGCTGTCGGCCGAGTCGCTCGGCTGCGCGAAGATCCGGGCGCTGT
CGAGCGCCGATCTGCTCGCCGAAACGTTCGCGCGGATCCGCCGCGGCGATTCGGTGATGTCGCTGTTCGCCGAGTCCTGA

Upstream 100 bases:

>100_bases
TCAAGGCACCGGATTTTGATTCCGGCATGCGAGGGTTCGAGTCCTTCCTCCCCTGCCAAAGTTTCTTCTGTCATTCCCGC
CCCCAGCCCGAAGCAGGTTC

Downstream 100 bases:

>100_bases
TCGCGGCACAGCGGTTCGCGTGGCGGCTCACGCCGGCGCGCGAATCCAAGGTATTCGGTTGTACGTGAAAAGCGAAGCGT
CCGCGCTTCGCTTTTTGCAC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MMSSHDGLMVFTGNANPALAQKVVDNLGIPLGKAMVSRFSDGEIQVEIQENVRGKDIFVLQSTCAPANDNLMELMIMVDA
LKRASAGRITAAIPYFGYARQDRRPRSARVAISAKIVANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDL
RKQNHQDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVLK
ERGAKRVFAYATHPVLSGGAAARIDASELDELVVTDTIPLSAESLGCAKIRALSSADLLAETFARIRRGDSVMSLFAES

Sequences:

>Translated_319_residues
MMSSHDGLMVFTGNANPALAQKVVDNLGIPLGKAMVSRFSDGEIQVEIQENVRGKDIFVLQSTCAPANDNLMELMIMVDA
LKRASAGRITAAIPYFGYARQDRRPRSARVAISAKIVANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDL
RKQNHQDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVLK
ERGAKRVFAYATHPVLSGGAAARIDASELDELVVTDTIPLSAESLGCAKIRALSSADLLAETFARIRRGDSVMSLFAES
>Mature_319_residues
MMSSHDGLMVFTGNANPALAQKVVDNLGIPLGKAMVSRFSDGEIQVEIQENVRGKDIFVLQSTCAPANDNLMELMIMVDA
LKRASAGRITAAIPYFGYARQDRRPRSARVAISAKIVANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDL
RKQNHQDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVLK
ERGAKRVFAYATHPVLSGGAAARIDASELDELVVTDTIPLSAESLGCAKIRALSSADLLAETFARIRRGDSVMSLFAES

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=48.0891719745223, Blast_Score=303, Evalue=1e-82,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=48.0891719745223, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=47.1337579617834, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI84875539, Length=315, Percent_Identity=46.6666666666667, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI194018537, Length=351, Percent_Identity=37.037037037037, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=36.1271676300578, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=36.9127516778523, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=36.9127516778523, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=36.9127516778523, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=36.9127516778523, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1787458, Length=310, Percent_Identity=63.2258064516129, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=46.4968152866242, Blast_Score=300, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=46.9453376205788, Blast_Score=300, Evalue=5e-82,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=46.4968152866242, Blast_Score=300, Evalue=6e-82,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=46.4968152866242, Blast_Score=299, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=33.0383480825959, Blast_Score=205, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6321776, Length=300, Percent_Identity=45.6666666666667, Blast_Score=259, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6320946, Length=319, Percent_Identity=42.3197492163009, Blast_Score=258, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6319403, Length=318, Percent_Identity=42.4528301886792, Blast_Score=256, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=42.3469387755102, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=108, Percent_Identity=40.7407407407407, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21355239, Length=313, Percent_Identity=47.6038338658147, Blast_Score=294, Evalue=6e-80,
Organism=Drosophila melanogaster, GI45551540, Length=335, Percent_Identity=44.4776119402985, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24651458, Length=359, Percent_Identity=33.983286908078, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24651456, Length=359, Percent_Identity=33.983286908078, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI281362873, Length=359, Percent_Identity=33.983286908078, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24651454, Length=359, Percent_Identity=33.983286908078, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24651462, Length=207, Percent_Identity=38.1642512077295, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24651464, Length=207, Percent_Identity=38.1642512077295, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI45552010, Length=207, Percent_Identity=38.1642512077295, Blast_Score=144, Evalue=6e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34420; Mature: 34420

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSSHDGLMVFTGNANPALAQKVVDNLGIPLGKAMVSRFSDGEIQVEIQENVRGKDIFVL
CCCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEEE
QSTCAPANDNLMELMIMVDALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKIVANM
ECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHEEEEHHHHHHHH
LEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDLRKQNHQDLLVVSPDVGGVVR
HHHCCCCEEEEEECCHHHHCCEEECCCCCEEECHHHHHHHHCCCCCCEEEECCCCCHHHH
ARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVLK
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
ERGAKRVFAYATHPVLSGGAAARIDASELDELVVTDTIPLSAESLGCAKIRALSSADLLA
HCCCCEEEEEECCCHHCCCCEEEECHHHHCCEEEECCCCCCCCCCCHHHHHHCCHHHHHH
ETFARIRRGDSVMSLFAES
HHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure
MMSSHDGLMVFTGNANPALAQKVVDNLGIPLGKAMVSRFSDGEIQVEIQENVRGKDIFVL
CCCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEEE
QSTCAPANDNLMELMIMVDALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKIVANM
ECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHEEEEHHHHHHHH
LEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDLRKQNHQDLLVVSPDVGGVVR
HHHCCCCEEEEEECCHHHHCCEEECCCCCEEECHHHHHHHHCCCCCCEEEECCCCCHHHH
ARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVLK
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
ERGAKRVFAYATHPVLSGGAAARIDASELDELVVTDTIPLSAESLGCAKIRALSSADLLA
HCCCCEEEEEECCCHHCCCCEEEECHHHHCCEEEECCCCCCCCCCCHHHHHHCCHHHHHH
ETFARIRRGDSVMSLFAES
HHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]