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The map label for this gene is mutM [H]

Identifier: 238028664

GI number: 238028664

Start: 3555904

End: 3556731

Strand: Reverse

Name: mutM [H]

Synonym: bglu_1g31280

Alternate gene names: 238028664

Gene position: 3556731-3555904 (Counterclockwise)

Preceding gene: 238028672

Following gene: 238028663

Centisome position: 91.05

GC content: 70.05

Gene sequence:

>828_bases
ATGCCAGAGTTGCCGGAAGTCGAGGTTACCCGCCGCGGAATCGAACCCTTCGTCACCGGACGGCGCGTCAGGCGCGTCGA
CGTGCGCACCGCCACGCTGCGCTGGCCGGTGCCCGACAACCTCGCCGCCGCGCTCGAGGCGCGCGAGGTGCTGCGTGTCG
AGCGGCGCGGCAAGTATCTGCTGTTCGAGGTGGATGCCGGCTGGTTCATCGTCCATCTCGGCATGACCGGTACGCTGCGC
GTGCTGCCCGGGGGCGAGCCGCCCGAGGCCAGGAAGCACGACCACATCGACTGGGTGTTCGACGAATGCGTGCTGCGCTT
TCGCGATCCGCGCCGGTTCGGCGCCGTGCTCTGGCACGCGCGCGAGTCCGGCGACATCCACCGGCATCCGCTCCTCACGA
GCCTCGGCGTCGAGCCGTTCTCGCCGCTCTTCACGCCCGAGCTCCTGTTCCGGCGCACGCGGGGGCGCACCGTTTCGGTG
AAGCAGGCGCTGCTGGCGGGCGACATCGTGGTGGGCGTCGGCAATATTTACGCCTCCGAAAGCCTGTTCCGCGCCGGCAT
CCGGCCGACCACGGCCGCCGGCCGCGTGTCGCTGCCGCGCTACCAGCGGCTCGCCGAGGCGGTGCGCGCGACGCTGGCCG
ACGCGATCGAGCGCGGCGGCAGCACCTTGCGCGATTTCGTCGGCAGCAACGGCGAAAGCGGCTACTTCCAGCTCGACTGC
TTCGTCTACGATCGTGCCGGCGAGCCGTGCCGCGTCTGCGGTACGCCGATCCGCCAGATCGTGCAGGGCCAGCGGTCCAC
CTATTTCTGTCCGAATTGTCAGCGTTGA

Upstream 100 bases:

>100_bases
AGGGCAAGGTCATGGAAATCCGTTCGAGGTTTCGGTCGATTGTAACGCGCTCGCTACAATACGCGCACCATCGCACCAGC
CACACACAGACCACAAAACC

Downstream 100 bases:

>100_bases
TATCTTGAAACCTCCCCGTACCCGAGCGGCGCCGGTCGCGCCGCCCACCCCGCTGCACGCGAGCTTCGCGCGCCGCCTGA
TCGCCTGGCAGCGCGAACAC

Product: formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MPELPEVEVTRRGIEPFVTGRRVRRVDVRTATLRWPVPDNLAAALEAREVLRVERRGKYLLFEVDAGWFIVHLGMTGTLR
VLPGGEPPEARKHDHIDWVFDECVLRFRDPRRFGAVLWHARESGDIHRHPLLTSLGVEPFSPLFTPELLFRRTRGRTVSV
KQALLAGDIVVGVGNIYASESLFRAGIRPTTAAGRVSLPRYQRLAEAVRATLADAIERGGSTLRDFVGSNGESGYFQLDC
FVYDRAGEPCRVCGTPIRQIVQGQRSTYFCPNCQR

Sequences:

>Translated_275_residues
MPELPEVEVTRRGIEPFVTGRRVRRVDVRTATLRWPVPDNLAAALEAREVLRVERRGKYLLFEVDAGWFIVHLGMTGTLR
VLPGGEPPEARKHDHIDWVFDECVLRFRDPRRFGAVLWHARESGDIHRHPLLTSLGVEPFSPLFTPELLFRRTRGRTVSV
KQALLAGDIVVGVGNIYASESLFRAGIRPTTAAGRVSLPRYQRLAEAVRATLADAIERGGSTLRDFVGSNGESGYFQLDC
FVYDRAGEPCRVCGTPIRQIVQGQRSTYFCPNCQR
>Mature_274_residues
PELPEVEVTRRGIEPFVTGRRVRRVDVRTATLRWPVPDNLAAALEAREVLRVERRGKYLLFEVDAGWFIVHLGMTGTLRV
LPGGEPPEARKHDHIDWVFDECVLRFRDPRRFGAVLWHARESGDIHRHPLLTSLGVEPFSPLFTPELLFRRTRGRTVSVK
QALLAGDIVVGVGNIYASESLFRAGIRPTTAAGRVSLPRYQRLAEAVRATLADAIERGGSTLRDFVGSNGESGYFQLDCF
VYDRAGEPCRVCGTPIRQIVQGQRSTYFCPNCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=276, Percent_Identity=49.6376811594203, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1786932, Length=288, Percent_Identity=27.4305555555556, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30966; Mature: 30835

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVTRRGIEPFVTGRRVRRVDVRTATLRWPVPDNLAAALEAREVLRVERRGKYL
CCCCCCCHHHHCCCCHHHCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEE
LFEVDAGWFIVHLGMTGTLRVLPGGEPPEARKHDHIDWVFDECVLRFRDPRRFGAVLWHA
EEEECCCEEEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHEEEC
RESGDIHRHPLLTSLGVEPFSPLFTPELLFRRTRGRTVSVKQALLAGDIVVGVGNIYASE
CCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHCCCEEHHHHHHHHCCEEEECCCHHHHH
SLFRAGIRPTTAAGRVSLPRYQRLAEAVRATLADAIERGGSTLRDFVGSNGESGYFQLDC
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEE
FVYDRAGEPCRVCGTPIRQIVQGQRSTYFCPNCQR
EEEECCCCCHHHCCHHHHHHHCCCCCEECCCCCCC
>Mature Secondary Structure 
PELPEVEVTRRGIEPFVTGRRVRRVDVRTATLRWPVPDNLAAALEAREVLRVERRGKYL
CCCCCCHHHHCCCCHHHCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEE
LFEVDAGWFIVHLGMTGTLRVLPGGEPPEARKHDHIDWVFDECVLRFRDPRRFGAVLWHA
EEEECCCEEEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHEEEC
RESGDIHRHPLLTSLGVEPFSPLFTPELLFRRTRGRTVSVKQALLAGDIVVGVGNIYASE
CCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHCCCEEHHHHHHHHCCEEEECCCHHHHH
SLFRAGIRPTTAAGRVSLPRYQRLAEAVRATLADAIERGGSTLRDFVGSNGESGYFQLDC
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEE
FVYDRAGEPCRVCGTPIRQIVQGQRSTYFCPNCQR
EEEECCCCCHHHCCHHHHHHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA