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The map label for this gene is mutY [H]

Identifier: 238028663

GI number: 238028663

Start: 3554790

End: 3555899

Strand: Reverse

Name: mutY [H]

Synonym: bglu_1g31270

Alternate gene names: 238028663

Gene position: 3555899-3554790 (Counterclockwise)

Preceding gene: 238028664

Following gene: 238028651

Centisome position: 91.03

GC content: 72.07

Gene sequence:

>1110_bases
TTGAAACCTCCCCGTACCCGAGCGGCGCCGGTCGCGCCGCCCACCCCGCTGCACGCGAGCTTCGCGCGCCGCCTGATCGC
CTGGCAGCGCGAACACGGCCGTCACGACCTGCCGTGGCAGAACACGCGCGATCCGTACCGGATCTGGCTGTCGGAAATCA
TGCTGCAGCAGACCCAGGTTTCGACCGTGGTGCCGTATTACCAACGGTTTCTCGCGCGCTTTCCCGAGGTCGCCGCGCTG
GCCGCCGCGCCGGCCGACGACGTGATGGCGCTGTGGGCCGGGCTCGGCTATTACACGCGCGCGCGTAACCTGCATCGCTG
CGCGCAGGTGGTGGTCGAGCAGCATGGCGGGCGCTTTCCGCAAACGCCCGACGCACTCGCCGAGTTGCCCGGCATCGGAC
GCTCGACCGCGGCCGCGATCGCCTCGTTCGCGTTCGGTGCGCGCGCGCCGATCCTTGACGGCAACGTCAAGCGCGTGCTC
GCGCGCGTGTTCGGCGTGGAGGGGTTTCCGGGCGAGAAGCGCGTCGAGAACGACATGTGGGTGCTGGCCGAAACGCTGTT
TCCGCGCGACGAGGACGATGCCGGCATCAGCGCCTACACGCAGGGCCTGATGGATCTCGGCGCGACGCTGTGCGGGCGCG
GCAAGCCCGACTGCCAGCGCTGCCCGTTCGCGCCCGACTGCGTGGCCAATGCGACCGGCCGCCAGCGCGAGCTGCCGGCG
GCACGGCCGAAGAAGGCGGTGCCGACGCGGCGCACCTGGATGCTGGTGCTGCGCGACGGGGATGCCGTGCTGCTCGAACG
GCGCCCGCCCGCCGGCGTCTGGGGCGGTCTCTGGAGCCTGCCCGAGGCGGACGGCGACGCGGCGGCGCTGCAGCGCGTGC
GCGCATTCGGCGCCGATTCGGTGATCTCGCTCGCGCCGTTTACGCACACGTTCACGCATTTCCGGCTCGAGATCGAGCCG
CGCATCGCCGAGGTCGGCAGGGCATCGGGCGGCCAAGCCGGCGCGGCCGATGCCGACACCGAATGGGTGCCGCTCGCGCG
GCTCGACGCGTACGGCGTGCCGGCGCCCGTGCGCAAGCTGCTCGACAGCCTGAGCGGGACGCTGCTCTGA

Upstream 100 bases:

>100_bases
CGTGCCGGCGAGCCGTGCCGCGTCTGCGGTACGCCGATCCGCCAGATCGTGCAGGGCCAGCGGTCCACCTATTTCTGTCC
GAATTGTCAGCGTTGATATC

Downstream 100 bases:

>100_bases
CCGATGCTCAGGGGCGGCAGGGGGGCGGCCCGGGCCGCCCCGCCCGTGCGCTCACAGCCAGTCGTGGCGCTTGAGCACCT
GATGCACGGCGTCGATCCGC

Product: A/G-specific adenine glycosylase MutY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKPPRTRAAPVAPPTPLHASFARRLIAWQREHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVVPYYQRFLARFPEVAAL
AAAPADDVMALWAGLGYYTRARNLHRCAQVVVEQHGGRFPQTPDALAELPGIGRSTAAAIASFAFGARAPILDGNVKRVL
ARVFGVEGFPGEKRVENDMWVLAETLFPRDEDDAGISAYTQGLMDLGATLCGRGKPDCQRCPFAPDCVANATGRQRELPA
ARPKKAVPTRRTWMLVLRDGDAVLLERRPPAGVWGGLWSLPEADGDAAALQRVRAFGADSVISLAPFTHTFTHFRLEIEP
RIAEVGRASGGQAGAADADTEWVPLARLDAYGVPAPVRKLLDSLSGTLL

Sequences:

>Translated_369_residues
MKPPRTRAAPVAPPTPLHASFARRLIAWQREHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVVPYYQRFLARFPEVAAL
AAAPADDVMALWAGLGYYTRARNLHRCAQVVVEQHGGRFPQTPDALAELPGIGRSTAAAIASFAFGARAPILDGNVKRVL
ARVFGVEGFPGEKRVENDMWVLAETLFPRDEDDAGISAYTQGLMDLGATLCGRGKPDCQRCPFAPDCVANATGRQRELPA
ARPKKAVPTRRTWMLVLRDGDAVLLERRPPAGVWGGLWSLPEADGDAAALQRVRAFGADSVISLAPFTHTFTHFRLEIEP
RIAEVGRASGGQAGAADADTEWVPLARLDAYGVPAPVRKLLDSLSGTLL
>Mature_369_residues
MKPPRTRAAPVAPPTPLHASFARRLIAWQREHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVVPYYQRFLARFPEVAAL
AAAPADDVMALWAGLGYYTRARNLHRCAQVVVEQHGGRFPQTPDALAELPGIGRSTAAAIASFAFGARAPILDGNVKRVL
ARVFGVEGFPGEKRVENDMWVLAETLFPRDEDDAGISAYTQGLMDLGATLCGRGKPDCQRCPFAPDCVANATGRQRELPA
ARPKKAVPTRRTWMLVLRDGDAVLLERRPPAGVWGGLWSLPEADGDAAALQRVRAFGADSVISLAPFTHTFTHFRLEIEP
RIAEVGRASGGQAGAADADTEWVPLARLDAYGVPAPVRKLLDSLSGTLL

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=365, Percent_Identity=33.6986301369863, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI6912520, Length=365, Percent_Identity=33.6986301369863, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI115298650, Length=365, Percent_Identity=33.6986301369863, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI190358497, Length=365, Percent_Identity=33.6986301369863, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI115298654, Length=365, Percent_Identity=33.6986301369863, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI115298652, Length=365, Percent_Identity=33.6986301369863, Blast_Score=175, Evalue=6e-44,
Organism=Escherichia coli, GI1789331, Length=348, Percent_Identity=46.264367816092, Blast_Score=334, Evalue=5e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40307; Mature: 40307

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPPRTRAAPVAPPTPLHASFARRLIAWQREHGRHDLPWQNTRDPYRIWLSEIMLQQTQV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
STVVPYYQRFLARFPEVAALAAAPADDVMALWAGLGYYTRARNLHRCAQVVVEQHGGRFP
HHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QTPDALAELPGIGRSTAAAIASFAFGARAPILDGNVKRVLARVFGVEGFPGEKRVENDMW
CCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCHHH
VLAETLFPRDEDDAGISAYTQGLMDLGATLCGRGKPDCQRCPFAPDCVANATGRQRELPA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHCCCCCCCCCCC
ARPKKAVPTRRTWMLVLRDGDAVLLERRPPAGVWGGLWSLPEADGDAAALQRVRAFGADS
CCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
VISLAPFTHTFTHFRLEIEPRIAEVGRASGGQAGAADADTEWVPLARLDAYGVPAPVRKL
CEECCCCHHEEEEEEEEECCHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHH
LDSLSGTLL
HHHHCCCCC
>Mature Secondary Structure
MKPPRTRAAPVAPPTPLHASFARRLIAWQREHGRHDLPWQNTRDPYRIWLSEIMLQQTQV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
STVVPYYQRFLARFPEVAALAAAPADDVMALWAGLGYYTRARNLHRCAQVVVEQHGGRFP
HHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QTPDALAELPGIGRSTAAAIASFAFGARAPILDGNVKRVLARVFGVEGFPGEKRVENDMW
CCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCHHH
VLAETLFPRDEDDAGISAYTQGLMDLGATLCGRGKPDCQRCPFAPDCVANATGRQRELPA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHCCCCCCCCCCC
ARPKKAVPTRRTWMLVLRDGDAVLLERRPPAGVWGGLWSLPEADGDAAALQRVRAFGADS
CCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
VISLAPFTHTFTHFRLEIEPRIAEVGRASGGQAGAADADTEWVPLARLDAYGVPAPVRKL
CEECCCCHHEEEEEEEEECCHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHH
LDSLSGTLL
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]