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The map label for this gene is fadA [H]

Identifier: 238028606

GI number: 238028606

Start: 3488607

End: 3489806

Strand: Reverse

Name: fadA [H]

Synonym: bglu_1g30700

Alternate gene names: 238028606

Gene position: 3489806-3488607 (Counterclockwise)

Preceding gene: 238028607

Following gene: 238028605

Centisome position: 89.33

GC content: 69.92

Gene sequence:

>1200_bases
ATGAGCAAACAGCTGCAAGACGCATACATCGTCGCCGCGAGCCGCACGCCGATCGGCAAGGCGCCGCGCGGCGTGTTCAA
GAACACGCGCCCGGACGAACTGCTGGTCCACGCGATCCGCGCCGCGGTCGCGCAGGTGCCGGGCTTCGACACCAAGCTGA
TCGAGGACGCGATCATCGGCTGCGCGATCCCCGAGGCCGAGCAGGGCCTGAACGTGGCGCGCATCAGCGCGCTGCTGGCC
GGGCTGCCGAACACGGTCGGCGGCGTGACCGTCAACCGCTTCTGCGCGTCGGGCCTGACCGCGCTCGCGTTCGCGGCCGA
CCGGATTCGCGTGGGCGAATCGGAGGCCCTGATCGCGGGCGGCACCGAGTCGATGAGCATGGTGCCGATGATGGGCAACA
AGCCGTCGATGTCGCCGCACATCTTCGACCGCAGCGAGGACGTCGGCATCGCCTACGGCATGGGCCTGACGGCCGAGCGC
GTGGCCGAGCGGTGGCAGGTGAGCCGCGAGGACCAGGACGCGTTCTCGGTCGAGTCGCATCGCAAGGCGCTGGCTGCGCA
GCAGGCCGGCGAGTTCGCCGACGAGATCGCGCCGTACACCATCAGCGAGCATTTTCCGAATCTCGCGACCGGCGAGATCG
ACGTGAAGAGGCGCGAGATCAAGCTCGACGAAGGCCCGCGCGCCGATACCTCGCCGGAAGGGCTCGCCAAGCTGCGCGCG
GTGTTCGCGAACAAGGGCTCGGTGACGGCCGGCAACAGCTCGCAGACCTCGGACGGCGCCGGCGCGCTGCTGGTGGTCTC
GGAGAAGGTGCTGAAGGAGTTCAACCTGACGCCGCTCGCGCGCTTCGTCAGCTTCGCCGTGCGCGGCGTGCCGCCCGAGA
TCATGGGGATCGGCCCGAAGGAGGCGATCCCGGCCGCGCTGAAGGCCGCCGGCCTCAAGCAGGACGATCTCGACTGGATC
GAGCTGAACGAGGCATTCGCCGCGCAGTCGCTGGCCGTGATCCGCGATCTCGGCCTCGATCCGGCCAAGGTCAACCCGCT
TGGCGGCGCGATCGCGCTCGGCCACCCGCTCGGCGCGACCGGCGCGATCCGTGCCGCGACGGTGGTGCATGGCCTGCGCC
GCCGCAACCTGAAGTACGGGATGGTGACGATGTGCGTCGGCACCGGGATGGGCGCCGCGGGCATCTTCGAACGGCTGTAG

Upstream 100 bases:

>100_bases
CAGACCGGCAAGCCGGTGCGCAACTGAGCGGGCCGCGGGACACTTTGGATCGGACCCGTTGCGGCGCGAGCGCGCCGTGC
CGGGTCGACAGGAGCCACAA

Downstream 100 bases:

>100_bases
GCGGGCAGCGTGCCCGATCATGGCGGTGCGCGGGCGGCTCGCTCGCGCACCGCTTTTTTATCGCTCGGATTTGAGGAGAC
GGTGAGATGGACATCCAGAC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIRAAVAQVPGFDTKLIEDAIIGCAIPEAEQGLNVARISALLA
GLPNTVGGVTVNRFCASGLTALAFAADRIRVGESEALIAGGTESMSMVPMMGNKPSMSPHIFDRSEDVGIAYGMGLTAER
VAERWQVSREDQDAFSVESHRKALAAQQAGEFADEIAPYTISEHFPNLATGEIDVKRREIKLDEGPRADTSPEGLAKLRA
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDLDWI
ELNEAFAAQSLAVIRDLGLDPAKVNPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIFERL

Sequences:

>Translated_399_residues
MSKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIRAAVAQVPGFDTKLIEDAIIGCAIPEAEQGLNVARISALLA
GLPNTVGGVTVNRFCASGLTALAFAADRIRVGESEALIAGGTESMSMVPMMGNKPSMSPHIFDRSEDVGIAYGMGLTAER
VAERWQVSREDQDAFSVESHRKALAAQQAGEFADEIAPYTISEHFPNLATGEIDVKRREIKLDEGPRADTSPEGLAKLRA
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDLDWI
ELNEAFAAQSLAVIRDLGLDPAKVNPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIFERL
>Mature_398_residues
SKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIRAAVAQVPGFDTKLIEDAIIGCAIPEAEQGLNVARISALLAG
LPNTVGGVTVNRFCASGLTALAFAADRIRVGESEALIAGGTESMSMVPMMGNKPSMSPHIFDRSEDVGIAYGMGLTAERV
AERWQVSREDQDAFSVESHRKALAAQQAGEFADEIAPYTISEHFPNLATGEIDVKRREIKLDEGPRADTSPEGLAKLRAV
FANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDLDWIE
LNEAFAAQSLAVIRDLGLDPAKVNPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIFERL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=45.4081632653061, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI167614485, Length=405, Percent_Identity=38.7654320987654, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI148539872, Length=341, Percent_Identity=41.0557184750733, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=35.3086419753086, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=35.7142857142857, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI4504327, Length=447, Percent_Identity=30.2013422818792, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=43.5835351089588, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=43.5323383084577, Blast_Score=284, Evalue=5e-78,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=39.8514851485149, Blast_Score=257, Evalue=9e-70,
Organism=Escherichia coli, GI1788554, Length=409, Percent_Identity=40.0977995110024, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1788683, Length=379, Percent_Identity=32.4538258575198, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=41.7910447761194, Blast_Score=270, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=35.5555555555556, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=33.0845771144279, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=29.2191435768262, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17551802, Length=444, Percent_Identity=29.5045045045045, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6322031, Length=407, Percent_Identity=40.7862407862408, Blast_Score=280, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=37.8378378378378, Blast_Score=226, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24655093, Length=406, Percent_Identity=39.6551724137931, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17648125, Length=410, Percent_Identity=38.780487804878, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=34.2298288508557, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI17137578, Length=441, Percent_Identity=30.8390022675737, Blast_Score=158, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41987; Mature: 41855

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIRAAVAQVPGFDTKLIEDAIIG
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARISALLAGLPNTVGGVTVNRFCASGLTALAFAADRIRVGESEALIAG
CCCCCHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
GTESMSMVPMMGNKPSMSPHIFDRSEDVGIAYGMGLTAERVAERWQVSREDQDAFSVESH
CCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCHHHHHHHH
RKALAAQQAGEFADEIAPYTISEHFPNLATGEIDVKRREIKLDEGPRADTSPEGLAKLRA
HHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEHEEEECCCCCCCCCCHHHHHHHHH
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALKAAGLKQDDLDWIELNEAFAAQSLAVIRDLGLDPAKVNPLGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIFERL
HHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHHHHCC
>Mature Secondary Structure 
SKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHAIRAAVAQVPGFDTKLIEDAIIG
CCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARISALLAGLPNTVGGVTVNRFCASGLTALAFAADRIRVGESEALIAG
CCCCCHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
GTESMSMVPMMGNKPSMSPHIFDRSEDVGIAYGMGLTAERVAERWQVSREDQDAFSVESH
CCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCHHHHHHHH
RKALAAQQAGEFADEIAPYTISEHFPNLATGEIDVKRREIKLDEGPRADTSPEGLAKLRA
HHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEHEEEECCCCCCCCCCHHHHHHHHH
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALKAAGLKQDDLDWIELNEAFAAQSLAVIRDLGLDPAKVNPLGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIFERL
HHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]