Click here to switch to the map view.

The map label for this gene is yeiG [C]

Identifier: 238028493

GI number: 238028493

Start: 3345751

End: 3346605

Strand: Reverse

Name: yeiG [C]

Synonym: bglu_1g29570

Alternate gene names: 238028493

Gene position: 3346605-3345751 (Counterclockwise)

Preceding gene: 238028494

Following gene: 238028488

Centisome position: 85.67

GC content: 70.29

Gene sequence:

>855_bases
ATGCTTGAACTGACTGCGTCGCATGCATGCTTCGGCGGCGAGCAGCGTTTCTATCGCCACGAATCGTCGATCATCGGCCT
GCCGATGAAGTTCTCGGTGTTCCTGCCGCGGCAGGCGGTGCAGGGCGGCACGCGCGTGCCCGCGCTGTTCTTCCTGGCGG
GGCTGACCTGCACCGAGGAAACCTTCATGATCAAGGCCGGCGCGCAGCGCTTCGCGGCCGAGCACGGCATCGCGCTGATC
GCGCCCGACACGAGCCCGCGCGGCGCCGGCGTGCCGGGCGAGGCCGATGCCTGGGATTTCGGGGTGGGCGCGGGCTTCTA
TCTCGACGCCACCCAGGCGCCGTGGGCCACGCATTACCGGATGGAGTCGTACCTGATGGACGAGCTGCGCGCGCTGGTGC
TCGGCGCGCTGCCGGTCGAGGGCACGCGGCTGGGCATCTTCGGCCATTCGATGGGCGGCCATGGCGCGCTGACGCTCGCG
CTGCGGCACCCGGGCGTGTTCCGCTCGGTCTCGGCGTTCGCGCCGATCGCCGCGCCGATGCGCTGCGCGTGGGGCGAGAA
GGCGTTCAGCGGCTATCTCGGCGAGGATCGCGAGGCCTGGAAGGCGCACGACGCGAGCGAGCTGGTCGCGCGCAGCGATG
CGCCGCGCTATGCCGACGGGATCCTCATCGATCAGGGGCTGGCCGACCAGTTCCTGCCGACCCAGCTCAACCCCGAGGTG
TTCGAGGCCGCCTGCCGCGAGGCCGGCCAGCCGCTCACGCTGCGCCGCCACGAAGGCTACGACCACGGCTATTATTTCAT
CTCGACGTTCATCGCCGACCACCTCGCGCATCACGCGCGCACGCTGCTCGCGTGA

Upstream 100 bases:

>100_bases
CACCGTCTGCCGCTCGAGCAGATCAACGACGGCTTCGACCTGATGAAGAAGGGCGAGTCGATCCGCTCGGTCGTGCTCTA
CTGATCCGGAGGCAGCGATC

Downstream 100 bases:

>100_bases
CGGAGCGGGCGGCTGGCGCTGCCCGGCCCCGCCCGATGGCTCGGGCCAGGAAACGACGAAGCCCGCCGCCGCGCCCGCCA
GCGCGCCGGCGGGCTTTTTC

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MLELTASHACFGGEQRFYRHESSIIGLPMKFSVFLPRQAVQGGTRVPALFFLAGLTCTEETFMIKAGAQRFAAEHGIALI
APDTSPRGAGVPGEADAWDFGVGAGFYLDATQAPWATHYRMESYLMDELRALVLGALPVEGTRLGIFGHSMGGHGALTLA
LRHPGVFRSVSAFAPIAAPMRCAWGEKAFSGYLGEDREAWKAHDASELVARSDAPRYADGILIDQGLADQFLPTQLNPEV
FEAACREAGQPLTLRRHEGYDHGYYFISTFIADHLAHHARTLLA

Sequences:

>Translated_284_residues
MLELTASHACFGGEQRFYRHESSIIGLPMKFSVFLPRQAVQGGTRVPALFFLAGLTCTEETFMIKAGAQRFAAEHGIALI
APDTSPRGAGVPGEADAWDFGVGAGFYLDATQAPWATHYRMESYLMDELRALVLGALPVEGTRLGIFGHSMGGHGALTLA
LRHPGVFRSVSAFAPIAAPMRCAWGEKAFSGYLGEDREAWKAHDASELVARSDAPRYADGILIDQGLADQFLPTQLNPEV
FEAACREAGQPLTLRRHEGYDHGYYFISTFIADHLAHHARTLLA
>Mature_284_residues
MLELTASHACFGGEQRFYRHESSIIGLPMKFSVFLPRQAVQGGTRVPALFFLAGLTCTEETFMIKAGAQRFAAEHGIALI
APDTSPRGAGVPGEADAWDFGVGAGFYLDATQAPWATHYRMESYLMDELRALVLGALPVEGTRLGIFGHSMGGHGALTLA
LRHPGVFRSVSAFAPIAAPMRCAWGEKAFSGYLGEDREAWKAHDASELVARSDAPRYADGILIDQGLADQFLPTQLNPEV
FEAACREAGQPLTLRRHEGYDHGYYFISTFIADHLAHHARTLLA

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=284, Percent_Identity=54.5774647887324, Blast_Score=325, Evalue=3e-89,
Organism=Escherichia coli, GI1788477, Length=282, Percent_Identity=54.6099290780142, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI1786551, Length=281, Percent_Identity=48.0427046263345, Blast_Score=278, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17510185, Length=281, Percent_Identity=46.2633451957295, Blast_Score=269, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6322393, Length=299, Percent_Identity=37.7926421404682, Blast_Score=195, Evalue=6e-51,
Organism=Drosophila melanogaster, GI45551932, Length=285, Percent_Identity=50.5263157894737, Blast_Score=287, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24648347, Length=285, Percent_Identity=50.5263157894737, Blast_Score=286, Evalue=9e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30880; Mature: 30880

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELTASHACFGGEQRFYRHESSIIGLPMKFSVFLPRQAVQGGTRVPALFFLAGLTCTEE
CCEECCCCCCCCCHHHHHHCCCCEEECCEEEEEECCHHHHCCCCCCHHHHHHHCCCCCCC
TFMIKAGAQRFAAEHGIALIAPDTSPRGAGVPGEADAWDFGVGAGFYLDATQAPWATHYR
EEEEEHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHH
MESYLMDELRALVLGALPVEGTRLGIFGHSMGGHGALTLALRHPGVFRSVSAFAPIAAPM
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCHHHHHHHHCCCCCCH
RCAWGEKAFSGYLGEDREAWKAHDASELVARSDAPRYADGILIDQGLADQFLPTQLNPEV
HHHCCCHHHHCCCCCCHHHHHHCCHHHHHHCCCCCCCCCCEEEECCCCHHCCCCCCCHHH
FEAACREAGQPLTLRRHEGYDHGYYFISTFIADHLAHHARTLLA
HHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLELTASHACFGGEQRFYRHESSIIGLPMKFSVFLPRQAVQGGTRVPALFFLAGLTCTEE
CCEECCCCCCCCCHHHHHHCCCCEEECCEEEEEECCHHHHCCCCCCHHHHHHHCCCCCCC
TFMIKAGAQRFAAEHGIALIAPDTSPRGAGVPGEADAWDFGVGAGFYLDATQAPWATHYR
EEEEEHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHH
MESYLMDELRALVLGALPVEGTRLGIFGHSMGGHGALTLALRHPGVFRSVSAFAPIAAPM
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCHHHHHHHHCCCCCCH
RCAWGEKAFSGYLGEDREAWKAHDASELVARSDAPRYADGILIDQGLADQFLPTQLNPEV
HHHCCCHHHHCCCCCCHHHHHHCCHHHHHHCCCCCCCCCCEEEECCCCHHCCCCCCCHHH
FEAACREAGQPLTLRRHEGYDHGYYFISTFIADHLAHHARTLLA
HHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]