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The map label for this gene is icd [H]

Identifier: 238028428

GI number: 238028428

Start: 3278411

End: 3279667

Strand: Reverse

Name: icd [H]

Synonym: bglu_1g28920

Alternate gene names: 238028428

Gene position: 3279667-3278411 (Counterclockwise)

Preceding gene: 238028433

Following gene: 238028427

Centisome position: 83.95

GC content: 64.68

Gene sequence:

>1257_bases
ATGCCGTATCAGCACATCGTGGTGCCGGACGGCGGTGACAAGATCACCGTCAACAAGGACTTTACGCTCAACGTCTCGGA
CCAGCCCATCATCCCGTACATCGAGGGCGACGGCACGGGGGCCGACATCACGCCGGTGATGCTGAAAGTGGTCGACGCGG
CCGTCGAGAAGGCCTACGGCGGCCGGCGCCGGATCCACTGGATGGAGATCTTCGCCGGCGAGAAGGCCACGCGCGTCTAC
GGCCCCGACGTCTGGCTGCCCGACGAGACGCTGCAGGCGGTGAAGGACTACGTCGTGTCGATCAAGGGGCCGCTGACCAC
CCCGGTCGGCGGCGGCATCCGCTCGCTCAACGTTACGCTGCGCCAGGAACTCGATCTCTACGTCTGCCTGCGCCCGGTGC
GCTATTTCAAGGGCGTGCCTTCGCCGGTGCGTGCGCCGGAGAAGACCGACATGGTGATCTTCCGAGAGAACTCCGAAGAC
ATCTATGCCGGCATCGAGTGGCCTGCCGGCTCGGAGAAGGCCAAGCGCGTGATCCGCTTCCTGCAGGAAGAGATGGGCGT
GAAGTCGATCCGCTTTCCCGACAGCTCGGCGCTCGGCGTCAAGCCGGTGTCGCGCGAAGGCACCGAGCGCCTGGTGCGCA
AGGCGATCCAGTACGCGCTCGATCACGAGCGCAAGTCGGTCACGCTGGTCCACAAGGGCAACATCATGAAGTACACCGAG
GGCGCGTTCCGTGACTACGGCTACGCGCTCGCGCAGAAGGAATTCGGCGCCGAGCTGATCGACGGCGGCCCATGGATGCG
CGTGAAGAACCCGAAGACGGGCGGCGAGATCGTCATCAAGGATTCGATCGCCGACGCGTTCCTGCAGCAGATCCTGCTGC
GGCCCGCCGAATACGACGTGATCGCCACGCTGAACCTGAACGGCGACTACATCTCCGATGCGCTCGCCGCGCAGGTCGGC
GGGATCGGCATCGCGCCGGGCGCCAACCAGTCCGATTCGGTCGCGATGTTCGAGGCGACCCACGGTACGGCGCCGAAGTA
CGCGGGCAAGGATTACGTGAACCCCGGTTCCGAAATCCTGTCTGCCGAGATGATGCTGCGCCACCTCGGCTGGACCGAGG
CGGCCGACCTCATCATTTCGTCGATGGAGAAATCGATCCAGCAGAAGCGCGTGACGTATGACTTCGCGCGGCTGATGGAG
GGCGCGACGCAGGTGTCGTGCTCGGGTTTCGGCAACGTGCTGATCGAGAACATGTAG

Upstream 100 bases:

>100_bases
GCACGGCCGTTACGGGCGCTAGAATAGCGGCAACGTTTCTGTGCATCAGCCAGGCAAGCCCCCGCTTTCCATCAGCCCAG
CCATATCACTGGAGTCGACC

Downstream 100 bases:

>100_bases
GCACGATGCGGTAATGCCGGATCCGTTCCGGCCACCCCGGCGCCAGGCCGATGTCGCCGGGGTGGGAGCTAAGGTTCGTC
GGCGCTTGTTCGCGGTCGGT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MPYQHIVVPDGGDKITVNKDFTLNVSDQPIIPYIEGDGTGADITPVMLKVVDAAVEKAYGGRRRIHWMEIFAGEKATRVY
GPDVWLPDETLQAVKDYVVSIKGPLTTPVGGGIRSLNVTLRQELDLYVCLRPVRYFKGVPSPVRAPEKTDMVIFRENSED
IYAGIEWPAGSEKAKRVIRFLQEEMGVKSIRFPDSSALGVKPVSREGTERLVRKAIQYALDHERKSVTLVHKGNIMKYTE
GAFRDYGYALAQKEFGAELIDGGPWMRVKNPKTGGEIVIKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVG
GIGIAPGANQSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADLIISSMEKSIQQKRVTYDFARLME
GATQVSCSGFGNVLIENM

Sequences:

>Translated_418_residues
MPYQHIVVPDGGDKITVNKDFTLNVSDQPIIPYIEGDGTGADITPVMLKVVDAAVEKAYGGRRRIHWMEIFAGEKATRVY
GPDVWLPDETLQAVKDYVVSIKGPLTTPVGGGIRSLNVTLRQELDLYVCLRPVRYFKGVPSPVRAPEKTDMVIFRENSED
IYAGIEWPAGSEKAKRVIRFLQEEMGVKSIRFPDSSALGVKPVSREGTERLVRKAIQYALDHERKSVTLVHKGNIMKYTE
GAFRDYGYALAQKEFGAELIDGGPWMRVKNPKTGGEIVIKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVG
GIGIAPGANQSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADLIISSMEKSIQQKRVTYDFARLME
GATQVSCSGFGNVLIENM
>Mature_417_residues
PYQHIVVPDGGDKITVNKDFTLNVSDQPIIPYIEGDGTGADITPVMLKVVDAAVEKAYGGRRRIHWMEIFAGEKATRVYG
PDVWLPDETLQAVKDYVVSIKGPLTTPVGGGIRSLNVTLRQELDLYVCLRPVRYFKGVPSPVRAPEKTDMVIFRENSEDI
YAGIEWPAGSEKAKRVIRFLQEEMGVKSIRFPDSSALGVKPVSREGTERLVRKAIQYALDHERKSVTLVHKGNIMKYTEG
AFRDYGYALAQKEFGAELIDGGPWMRVKNPKTGGEIVIKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVGG
IGIAPGANQSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADLIISSMEKSIQQKRVTYDFARLMEG
ATQVSCSGFGNVLIENM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=398, Percent_Identity=30.4020100502513, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=28.9772727272727, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=28.9772727272727, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI28178838, Length=306, Percent_Identity=27.7777777777778, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI4758582, Length=282, Percent_Identity=28.7234042553192, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=34.8066298342541, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1787381, Length=413, Percent_Identity=73.8498789346247, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=378, Percent_Identity=28.3068783068783, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI87081683, Length=398, Percent_Identity=25.6281407035176, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71986051, Length=377, Percent_Identity=30.5039787798408, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=32.1311475409836, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17505779, Length=310, Percent_Identity=30.3225806451613, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17550882, Length=260, Percent_Identity=28.8461538461538, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324709, Length=366, Percent_Identity=30.6010928961749, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6322097, Length=365, Percent_Identity=29.041095890411, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324291, Length=392, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6319830, Length=358, Percent_Identity=26.8156424581006, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24643270, Length=385, Percent_Identity=32.7272727272727, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24643268, Length=385, Percent_Identity=32.7272727272727, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24661184, Length=391, Percent_Identity=31.2020460358056, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI161078635, Length=301, Percent_Identity=28.9036544850498, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI161078639, Length=301, Percent_Identity=28.9036544850498, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI161078633, Length=301, Percent_Identity=28.9036544850498, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24650122, Length=301, Percent_Identity=28.9036544850498, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI161078637, Length=301, Percent_Identity=28.9036544850498, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20130355, Length=296, Percent_Identity=25, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281362242, Length=336, Percent_Identity=27.3809523809524, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24648872, Length=336, Percent_Identity=27.3809523809524, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46008; Mature: 45877

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYQHIVVPDGGDKITVNKDFTLNVSDQPIIPYIEGDGTGADITPVMLKVVDAAVEKAYG
CCCCEEEEECCCCEEEECCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
GRRRIHWMEIFAGEKATRVYGPDVWLPDETLQAVKDYVVSIKGPLTTPVGGGIRSLNVTL
CCCEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHEECCCCCCCCCCCCEEEEEEEE
RQELDLYVCLRPVRYFKGVPSPVRAPEKTDMVIFRENSEDIYAGIEWPAGSEKAKRVIRF
HHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHH
LQEEMGVKSIRFPDSSALGVKPVSREGTERLVRKAIQYALDHERKSVTLVHKGNIMKYTE
HHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECC
GAFRDYGYALAQKEFGAELIDGGPWMRVKNPKTGGEIVIKDSIADAFLQQILLRPAEYDV
CHHHHHHHHHHHHHHCCCEECCCCEEEECCCCCCCEEEEECHHHHHHHHHHHCCCCCCCE
IATLNLNGDYISDALAAQVGGIGIAPGANQSDSVAMFEATHGTAPKYAGKDYVNPGSEIL
EEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHH
SAEMMLRHLGWTEAADLIISSMEKSIQQKRVTYDFARLMEGATQVSCSGFGNVLIENM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEECC
>Mature Secondary Structure 
PYQHIVVPDGGDKITVNKDFTLNVSDQPIIPYIEGDGTGADITPVMLKVVDAAVEKAYG
CCCEEEEECCCCEEEECCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
GRRRIHWMEIFAGEKATRVYGPDVWLPDETLQAVKDYVVSIKGPLTTPVGGGIRSLNVTL
CCCEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHEECCCCCCCCCCCCEEEEEEEE
RQELDLYVCLRPVRYFKGVPSPVRAPEKTDMVIFRENSEDIYAGIEWPAGSEKAKRVIRF
HHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHH
LQEEMGVKSIRFPDSSALGVKPVSREGTERLVRKAIQYALDHERKSVTLVHKGNIMKYTE
HHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECC
GAFRDYGYALAQKEFGAELIDGGPWMRVKNPKTGGEIVIKDSIADAFLQQILLRPAEYDV
CHHHHHHHHHHHHHHCCCEECCCCEEEECCCCCCCEEEEECHHHHHHHHHHHCCCCCCCE
IATLNLNGDYISDALAAQVGGIGIAPGANQSDSVAMFEATHGTAPKYAGKDYVNPGSEIL
EEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHH
SAEMMLRHLGWTEAADLIISSMEKSIQQKRVTYDFARLMEGATQVSCSGFGNVLIENM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]