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The map label for this gene is clpA [H]

Identifier: 238028417

GI number: 238028417

Start: 3264761

End: 3267058

Strand: Reverse

Name: clpA [H]

Synonym: bglu_1g28810

Alternate gene names: 238028417

Gene position: 3267058-3264761 (Counterclockwise)

Preceding gene: 238028418

Following gene: 238028411

Centisome position: 83.63

GC content: 64.32

Gene sequence:

>2298_bases
ATGATTGCCCAGGAATTGGAAGTCAGCCTGCACATGGCGTTCATGGAAGCGCGCCAGGCGCGGCACGAATTCATAACGGT
CGAACACCTGTTGCTCGCGCTGCTGGACAACCCGACGGCGGCCGAAGTGTTGCGCGCATGCGCGGCCAACATCGAGGATC
TGCGCCAGAACCTGCGCAACTTCATCCACGACAACACACCGACAGTGCCGGGTACCGACGACGTCGACACGCAGCCGACG
CTCGGTTTCCAGCGCGTGATCCAGCGCGCGATCATGCACGTGCAGTCGACCTCGAACGGCAAGAAGGAAGTCACGGGCGC
GAACGTGCTGGTGGCGATCTTCGGCGAGAAGGATTCGCATGCTGTCTACTATTTGCAACAGCAGGGCGTGACGCGGCTCG
ACGTCGTGAACTTCATTTCGCATGGCATCGCCAAGACGGGCAGCTCCGACGCGGCGAAGGCCGGTGACGGCACGCCGGAG
TCGGAGGACGCGAACGCGCAGAAGGAAACGCCGCTCGCGCAGTTCACGCAGAACCTGAACCAGATGGCCAAGGACGGCCG
CATCGATCCGCTCATCGGTCGCGAGACCGAGGTCGAGCGCGTCGTGCAGGTGCTCTGCCGCCGTCGCAAGAACAACCCGC
TGCTGGTCGGCGAGGCCGGAGTGGGCAAGACCGCGATCGCCGAGGGCCTGGCATGGCGCATCACGCGCGGCGAGGTGCCC
GACATCCTCGCGAACGCACAGGTGTTCTCGCTCGACATGGGCGCATTGCTCGCGGGCACGAAATATCGGGGCGATTTCGA
GCAGCGTCTGAAGACGGTGCTGAAGGAACTGAAGGAGCGTCCGCACGCGATCCTCTTCATCGACGAGATCCACACGCTGA
TCGGCGCGGGCGCGGCCTCGGGCGGTACGCTCGACGCCTCCAACCTGCTCAAGCCGGCGCTCTCGTCGGGCAATCTGAAG
TGCATCGGCGCGACCACCTTCACCGAATATCGCGGCATATTCGAGAAGGATGCGGCGCTGTCGCGGCGCTTCCAGAAGGT
CGACGTGAACGAGCCGAGCGTCGAGCAGACGGTGGCGATCCTGCGCGGGCTGAAGTCGCGCTTCGAGGAGCACCACGGCG
TCAAGTATTCGTCTGGCGCGCTGTCGGCGGCCGCCGAGCTGTCGTCACGCTTCATCACCGACCGGCACCTGCCGGACAAG
GCGATCGACGTGATCGACGAGGCCGGCGCGGCGCAGCGGATCCTGCCGAAGTCGAAGCAGAAGAAGACGATCGGCAAGGC
CGAGATCGAGGAAATCATCTCGAAGATCGCGCGCGTCCCGCCGCAAAGCGTGTCGCAGGACGATCGCAGCAAGCTGCAGA
CGCTCGATCGCGACCTCAAGAGCGTGGTGTTCGGCCAGGATCCGGCGATCGACGCGCTGGCGGCCTCGATCAAGATGGCG
CGGGCCGGCCTCGGCAAGCTCGACAAGCCGATCGGCGCGTTCCTGTTCTCCGGCCCGACCGGCGTCGGCAAGACCGAAGT
GGCGCGTCAGCTCGCGTTCACGCTGGGCATCGAGCTGATCCGCTTCGACATGTCGGAGTACATGGAGCGTCACGCGGTGA
GCCGGCTGATCGGCGCGCCGCCGGGCTATGTCGGTTTCGACCAGGGCGGGCTGCTGACCGAGGCCGTCACCAAGAAGCCG
CACTGCGTGCTGCTGCTCGACGAAATCGAAAAGGCGCATCCGGACATCTTCAACGTGCTGCTGCAGGTGATGGACCACGG
CACGCTGACCGACAACAACGGTCGCAAGGCCGATTTCCGCAACGTCATCATCATCATGACGACCAACGCGGGCGCCGAGT
CGATGCAAAAGGGCACGATCGGGTTCACGACGCGCCGCGAAACCGGCGACGAAATGGCCGAGATCAAGCGCCTGTTCACG
CCGGAATTCCGCAACCGACTCGACTCGACCATCAGCTTCCGCTCGCTCGATGAGGAAATCATCATGCGCGTGGTCGACAA
GTTCCTGATCCAGCTGGAAGATCAGCTGCACGAGAAGAAGGTGGATGCGCTCTTCACCGACGCGCTGCGCAAGTATCTGT
CGAAGCACGGCTTCGATCCGCTGATGGGTGCGCGGCCGATGCAGCGTCTGATCCAGGACACGATCCGCCGTGCGCTGGCC
GACGAACTGCTGTTCGGCAAGCTCGTCAGCGGTGGCCGCGTGACGGTGGACGTCGACGAGAACGACGCGGTCCAACTGTC
GTTCGACAACTCGGCCGAGCCGCCGAAGCCGAGCGAAGAGACGGTCGAAGTCGAGTAA

Upstream 100 bases:

>100_bases
GTGGGGTCTATACGCGGGACATCGCGTCGACCAAAGTTGAGCAAGTCGTTACCCATGCGCGGCAGGCAGGGCATCCGCTG
CAGTGCGTGATGGAGGAAGC

Downstream 100 bases:

>100_bases
TCGATCGGATCCGGCGATCCGGTCCGCTCGCGCGCGGTGCGTGTGAGCCCAACGGCGCGGAGTTCACTCCGCGCCGTTTT
TCTTTTTCGTCAGGGGTGCC

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTGSSDAAKAGDGTPE
SEDANAQKETPLAQFTQNLNQMAKDGRIDPLIGRETEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITRGEVP
DILANAQVFSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGNLK
CIGATTFTEYRGIFEKDAALSRRFQKVDVNEPSVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSSRFITDRHLPDK
AIDVIDEAGAAQRILPKSKQKKTIGKAEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
RAGLGKLDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKGTIGFTTRRETGDEMAEIKRLFT
PEFRNRLDSTISFRSLDEEIIMRVVDKFLIQLEDQLHEKKVDALFTDALRKYLSKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVSGGRVTVDVDENDAVQLSFDNSAEPPKPSEETVEVE

Sequences:

>Translated_765_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTGSSDAAKAGDGTPE
SEDANAQKETPLAQFTQNLNQMAKDGRIDPLIGRETEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITRGEVP
DILANAQVFSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGNLK
CIGATTFTEYRGIFEKDAALSRRFQKVDVNEPSVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSSRFITDRHLPDK
AIDVIDEAGAAQRILPKSKQKKTIGKAEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
RAGLGKLDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKGTIGFTTRRETGDEMAEIKRLFT
PEFRNRLDSTISFRSLDEEIIMRVVDKFLIQLEDQLHEKKVDALFTDALRKYLSKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVSGGRVTVDVDENDAVQLSFDNSAEPPKPSEETVEVE
>Mature_765_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTGSSDAAKAGDGTPE
SEDANAQKETPLAQFTQNLNQMAKDGRIDPLIGRETEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITRGEVP
DILANAQVFSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGNLK
CIGATTFTEYRGIFEKDAALSRRFQKVDVNEPSVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSSRFITDRHLPDK
AIDVIDEAGAAQRILPKSKQKKTIGKAEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
RAGLGKLDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKGTIGFTTRRETGDEMAEIKRLFT
PEFRNRLDSTISFRSLDEEIIMRVVDKFLIQLEDQLHEKKVDALFTDALRKYLSKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVSGGRVTVDVDENDAVQLSFDNSAEPPKPSEETVEVE

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=338, Percent_Identity=28.4023668639053, Blast_Score=148, Evalue=2e-35,
Organism=Escherichia coli, GI1787109, Length=741, Percent_Identity=62.0782726045884, Blast_Score=961, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=401, Percent_Identity=45.1371571072319, Blast_Score=305, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6320464, Length=259, Percent_Identity=56.7567567567568, Blast_Score=293, Evalue=6e-80,
Organism=Saccharomyces cerevisiae, GI6323002, Length=296, Percent_Identity=47.972972972973, Blast_Score=265, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84121; Mature: 84121

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIHDNTPTVPGTDDVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIAKTGSSDAAKAGDGTPESEDANAQKETPLAQFTQNLN
EEEEEHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHH
QMAKDGRIDPLIGRETEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITRGEVP
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEEECCCCC
DILANAQVFSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAAS
HHHHCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCC
GGTLDASNLLKPALSSGNLKCIGATTFTEYRGIFEKDAALSRRFQKVDVNEPSVEQTVAI
CCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LRGLKSRFEEHHGVKYSSGALSAAAELSSRFITDRHLPDKAIDVIDEAGAAQRILPKSKQ
HHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHH
KKTIGKAEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
HHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RAGLGKLDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAP
HHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFR
CCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVIIIMTTNAGAESMQKGTIGFTTRRETGDEMAEIKRLFTPEFRNRLDSTISFRSLDEEI
CEEEEEECCCCHHHHHCCCCCEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHH
IMRVVDKFLIQLEDQLHEKKVDALFTDALRKYLSKHGFDPLMGARPMQRLIQDTIRRALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
DELLFGKLVSGGRVTVDVDENDAVQLSFDNSAEPPKPSEETVEVE
HHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCEECC
>Mature Secondary Structure
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIHDNTPTVPGTDDVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIAKTGSSDAAKAGDGTPESEDANAQKETPLAQFTQNLN
EEEEEHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHH
QMAKDGRIDPLIGRETEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRITRGEVP
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEEECCCCC
DILANAQVFSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAAS
HHHHCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCC
GGTLDASNLLKPALSSGNLKCIGATTFTEYRGIFEKDAALSRRFQKVDVNEPSVEQTVAI
CCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LRGLKSRFEEHHGVKYSSGALSAAAELSSRFITDRHLPDKAIDVIDEAGAAQRILPKSKQ
HHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHH
KKTIGKAEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
HHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RAGLGKLDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAP
HHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFR
CCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVIIIMTTNAGAESMQKGTIGFTTRRETGDEMAEIKRLFTPEFRNRLDSTISFRSLDEEI
CEEEEEECCCCHHHHHCCCCCEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHH
IMRVVDKFLIQLEDQLHEKKVDALFTDALRKYLSKHGFDPLMGARPMQRLIQDTIRRALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
DELLFGKLVSGGRVTVDVDENDAVQLSFDNSAEPPKPSEETVEVE
HHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]