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The map label for this gene is coaBC [H]

Identifier: 238028415

GI number: 238028415

Start: 3262743

End: 3263954

Strand: Direct

Name: coaBC [H]

Synonym: bglu_1g28790

Alternate gene names: 238028415

Gene position: 3262743-3263954 (Clockwise)

Preceding gene: 238028414

Following gene: 238028416

Centisome position: 83.52

GC content: 69.8

Gene sequence:

>1212_bases
TTGGAACACCAGGAACTGGCAGGAAAACATCTCGTGATCGGCATGACGGGCGGCATCGCCTGCTACAAGATCGCCGAACT
CACGCGCCTGCTGACCAAGGCCGGCGCGACCGTGCAGGTGGTGATGACCGAGGCCGCCACGCAGTTCATCACGCCGGTCA
CGATGCAGGCGCTGTCGGGGCGGCCCGTGTTCACGAGCCAGTGGGACGCGCGCGTCGACAACAACATGGCGCACATCGAC
CTGTCGCGCCACGCCGACGCGATCGTGATCGCGCCGGCCTCGACCGACTTCCTCGCGAAGCTCGCGCACGGCTTCGCCGA
CGATCTGCTCGCGACGCTGTGCATCGCGCGCGACTGCCCGCTGCTGGTGGTGCCGGCCATGAACCGCCAGATGTGGCAGA
ACCCGGCCACGCAGCGCAACGCAGCGCAGTTGCGCGCCGACGGCGTGGCCGTGCTCGGCCCCGATTCGGGCGCGCAGGCC
TGCGGCGAAGTCGGCGACGGGCGCATGCTCGAGCCGGGCGCCATCTACGAGGCAATCGTCTCGCATTTCCGGCCGAAGCG
GCTCGCCCACAAGCGCGTGCTGATCACGGCCGGCCCGACCTTCGAACCGCTCGATCCGGTGCGCGGGCTCACCAACCGCT
CCAGCGGCAAGATGGGCTTCGCGCTCGCACGCGCCGCGCAGCAGGCCGGTGCCGAGGTTCACCTGGTGGCGGGCCCGGTG
CCGCTCGCCACGCCGTGGGGCGTCTACCGCGAGGACGTGCAGACCGCGCAGCAGATGCACGACGCCGTGATGCATGCGGT
GCCCGACGCGGATCTGTTCATCGCGGTGGCGGCCGTGGCCGACTGGCGCGTCGACCAGCCCGCCGAGCACAAGATCAAGA
AGACCGCCGATCGCCGGATGCCGGTGCTGAACTTCGTCGAGAATCCCGACATCCTGGCCGCGGTCGCGGCACTGCCCGAC
GCGCCCTACTGCGTCGGCTTCGCGGCCGAAAGCGGCGACCTCGACGTACACGGCGAGGAAAAGCGCCTGCGCAAAGGGGT
GCCCCTGTTGATCGGCAACCTCGGCCCGCTGACGTTCGGCCTCGACGACAATGAGGTCGTGCTGTTCGAAGCCGGCGGCA
CGACGCGGCTGCCGCGCGCGCCGAAGGCCACGCTCGCGCACACGCTGATCGACGAAATCGCGAAGCGTCTGCCCGACACG
CGCCTGATCTGA

Upstream 100 bases:

>100_bases
TGCGCGGCACGCGCTGAGCCTCACCGTCGCGCCCGAGCGGCGCGGCGCGTGACAGGGCCGGGCCGCGTGGCGCCGGCCCG
TTTCGTTACCGGAGGTCCAG

Downstream 100 bases:

>100_bases
TCCATCCAAGCCGCCGGGCCGCAACGCATGGCGCGGCCCGGTGCATGTTGCAATTTCACGACTCCTGCCAGCAGACCCGC
CGCATGAAACTCGACCTCAA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MEHQELAGKHLVIGMTGGIACYKIAELTRLLTKAGATVQVVMTEAATQFITPVTMQALSGRPVFTSQWDARVDNNMAHID
LSRHADAIVIAPASTDFLAKLAHGFADDLLATLCIARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVAVLGPDSGAQA
CGEVGDGRMLEPGAIYEAIVSHFRPKRLAHKRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGAEVHLVAGPV
PLATPWGVYREDVQTAQQMHDAVMHAVPDADLFIAVAAVADWRVDQPAEHKIKKTADRRMPVLNFVENPDILAAVAALPD
APYCVGFAAESGDLDVHGEEKRLRKGVPLLIGNLGPLTFGLDDNEVVLFEAGGTTRLPRAPKATLAHTLIDEIAKRLPDT
RLI

Sequences:

>Translated_403_residues
MEHQELAGKHLVIGMTGGIACYKIAELTRLLTKAGATVQVVMTEAATQFITPVTMQALSGRPVFTSQWDARVDNNMAHID
LSRHADAIVIAPASTDFLAKLAHGFADDLLATLCIARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVAVLGPDSGAQA
CGEVGDGRMLEPGAIYEAIVSHFRPKRLAHKRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGAEVHLVAGPV
PLATPWGVYREDVQTAQQMHDAVMHAVPDADLFIAVAAVADWRVDQPAEHKIKKTADRRMPVLNFVENPDILAAVAALPD
APYCVGFAAESGDLDVHGEEKRLRKGVPLLIGNLGPLTFGLDDNEVVLFEAGGTTRLPRAPKATLAHTLIDEIAKRLPDT
RLI
>Mature_403_residues
MEHQELAGKHLVIGMTGGIACYKIAELTRLLTKAGATVQVVMTEAATQFITPVTMQALSGRPVFTSQWDARVDNNMAHID
LSRHADAIVIAPASTDFLAKLAHGFADDLLATLCIARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVAVLGPDSGAQA
CGEVGDGRMLEPGAIYEAIVSHFRPKRLAHKRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGAEVHLVAGPV
PLATPWGVYREDVQTAQQMHDAVMHAVPDADLFIAVAAVADWRVDQPAEHKIKKTADRRMPVLNFVENPDILAAVAALPD
APYCVGFAAESGDLDVHGEEKRLRKGVPLLIGNLGPLTFGLDDNEVVLFEAGGTTRLPRAPKATLAHTLIDEIAKRLPDT
RLI

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=177, Percent_Identity=36.1581920903955, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI87082301, Length=398, Percent_Identity=48.4924623115578, Blast_Score=333, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17560194, Length=195, Percent_Identity=30.7692307692308, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322762, Length=189, Percent_Identity=31.2169312169312, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24657262, Length=190, Percent_Identity=33.1578947368421, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43206; Mature: 43206

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHQELAGKHLVIGMTGGIACYKIAELTRLLTKAGATVQVVMTEAATQFITPVTMQALSG
CCCHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHCC
RPVFTSQWDARVDNNMAHIDLSRHADAIVIAPASTDFLAKLAHGFADDLLATLCIARDCP
CCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
LLVVPAMNRQMWQNPATQRNAAQLRADGVAVLGPDSGAQACGEVGDGRMLEPGAIYEAIV
EEEEECCCHHHHCCCCCCHHHHHHHHCCEEEECCCCCHHHHHHCCCCCEECCHHHHHHHH
SHFRPKRLAHKRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGAEVHLVAGPV
HHCCHHHHCCCEEEEEECCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCC
PLATPWGVYREDVQTAQQMHDAVMHAVPDADLFIAVAAVADWRVDQPAEHKIKKTADRRM
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
PVLNFVENPDILAAVAALPDAPYCVGFAAESGDLDVHGEEKRLRKGVPLLIGNLGPLTFG
CHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCEEEECCCCEEEC
LDDNEVVLFEAGGTTRLPRAPKATLAHTLIDEIAKRLPDTRLI
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEHQELAGKHLVIGMTGGIACYKIAELTRLLTKAGATVQVVMTEAATQFITPVTMQALSG
CCCHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHCC
RPVFTSQWDARVDNNMAHIDLSRHADAIVIAPASTDFLAKLAHGFADDLLATLCIARDCP
CCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
LLVVPAMNRQMWQNPATQRNAAQLRADGVAVLGPDSGAQACGEVGDGRMLEPGAIYEAIV
EEEEECCCHHHHCCCCCCHHHHHHHHCCEEEECCCCCHHHHHHCCCCCEECCHHHHHHHH
SHFRPKRLAHKRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGAEVHLVAGPV
HHCCHHHHCCCEEEEEECCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCC
PLATPWGVYREDVQTAQQMHDAVMHAVPDADLFIAVAAVADWRVDQPAEHKIKKTADRRM
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
PVLNFVENPDILAAVAALPDAPYCVGFAAESGDLDVHGEEKRLRKGVPLLIGNLGPLTFG
CHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCEEEECCCCEEEC
LDDNEVVLFEAGGTTRLPRAPKATLAHTLIDEIAKRLPDTRLI
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]