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The map label for this gene is nadC [H]

Identifier: 238028407

GI number: 238028407

Start: 3252346

End: 3253224

Strand: Reverse

Name: nadC [H]

Synonym: bglu_1g28710

Alternate gene names: 238028407

Gene position: 3253224-3252346 (Counterclockwise)

Preceding gene: 238028408

Following gene: 238028402

Centisome position: 83.28

GC content: 70.08

Gene sequence:

>879_bases
ATGACGGCGGTCTCCGCGATCTACGGCGAGATCGTCGCCGAATACGGCGCGGCCTTCGAGGCCGCGATCGCGCGCAATGT
CGCCGATGCGATTGCCGAGGACGTCGGCAGCGGCGACCAGACCGGCCGGCTGATACCCGACGGCCTTGCGCGGCGCGCGC
GCGTCATCGTGCGCGAGCGTGCGGTGCTATGCGGCGTGCCGTGGTTCGAGGCGGTGATGCGCGCGATCGATCCGTCGATC
GAAGTCGACTGGCGCTATCGCGAAGGCGAACTGATGGAGGCCGACGCCACCGTCTGCGAGCTGCGCGGCCCGGCCCGGGC
GCTGCTGACGGCCGAGCGCAACGGCCTGAATTTCCTGCAACTGCTCTCCGGCGTGGCGAGCGCGACGCGCCGCTACGTCG
ATCTGATCGACGGGCATCGCGGGCGCATCCTCGATACGCGCAAGACGCTGCCGGGGCTGCGGCTCGCGCAGAAATACGCG
GTGCGCGTGGGCGGCGGGGCCAACCAGCGGCTCGCGCTGTACGACGGCATCCTGATCAAGGAGAACCACATCGCGGCCGC
GGGCGGCGTCGGCGCGGCACTCGACGCGGCGTTCGCGCTGCAGTCGGGCGTGCCGGTGCAGATCGAGGTGGAGACGCTCG
CGCAGCTCGATACCGCGCTCGCGCATGGCGCGAAGTCGGTGCTGCTCGACAACTTCACGTTCGAGATGATGCGCGAGGCG
GTGCGGATCGCGAGCGGCCGGGCCGTGCTCGAGGTGTCGGGCGGCGTCAATGCCGATACCGTCGTCGAGATCGCGTCGAC
GGGCGTTGACCGGATCTCGATCGGCGCGCTGACGAAGGACGTGCGCGCCACCGATTTCTCGATGCGCATCGTCGACTGA

Upstream 100 bases:

>100_bases
TCGACCGCATGCTCGCGTTCGCCGCCGAGCACAAGCGGCGCGTGCAGGCCAGCGGCGACCTGCAGCGCGATGCGAGCCTG
TTCTCGAACGTGGGGGCGGC

Downstream 100 bases:

>100_bases
ATCACGAGGCGCGATCAAAGCGAAGCCGCGCGCGGAAGGGTCCGCGCGCGGCTTCGTCGTTTTTCGAGCCGATTCGCCGG
TTCGCCGGCCCGCTGCATTA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTAVSAIYGEIVAEYGAAFEAAIARNVADAIAEDVGSGDQTGRLIPDGLARRARVIVRERAVLCGVPWFEAVMRAIDPSI
EVDWRYREGELMEADATVCELRGPARALLTAERNGLNFLQLLSGVASATRRYVDLIDGHRGRILDTRKTLPGLRLAQKYA
VRVGGGANQRLALYDGILIKENHIAAAGGVGAALDAAFALQSGVPVQIEVETLAQLDTALAHGAKSVLLDNFTFEMMREA
VRIASGRAVLEVSGGVNADTVVEIASTGVDRISIGALTKDVRATDFSMRIVD

Sequences:

>Translated_292_residues
MTAVSAIYGEIVAEYGAAFEAAIARNVADAIAEDVGSGDQTGRLIPDGLARRARVIVRERAVLCGVPWFEAVMRAIDPSI
EVDWRYREGELMEADATVCELRGPARALLTAERNGLNFLQLLSGVASATRRYVDLIDGHRGRILDTRKTLPGLRLAQKYA
VRVGGGANQRLALYDGILIKENHIAAAGGVGAALDAAFALQSGVPVQIEVETLAQLDTALAHGAKSVLLDNFTFEMMREA
VRIASGRAVLEVSGGVNADTVVEIASTGVDRISIGALTKDVRATDFSMRIVD
>Mature_291_residues
TAVSAIYGEIVAEYGAAFEAAIARNVADAIAEDVGSGDQTGRLIPDGLARRARVIVRERAVLCGVPWFEAVMRAIDPSIE
VDWRYREGELMEADATVCELRGPARALLTAERNGLNFLQLLSGVASATRRYVDLIDGHRGRILDTRKTLPGLRLAQKYAV
RVGGGANQRLALYDGILIKENHIAAAGGVGAALDAAFALQSGVPVQIEVETLAQLDTALAHGAKSVLLDNFTFEMMREAV
RIASGRAVLEVSGGVNADTVVEIASTGVDRISIGALTKDVRATDFSMRIVD

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=249, Percent_Identity=36.5461847389558, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=50.7407407407407, Blast_Score=239, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6321162, Length=295, Percent_Identity=32.2033898305085, Blast_Score=148, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31102; Mature: 30971

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVSAIYGEIVAEYGAAFEAAIARNVADAIAEDVGSGDQTGRLIPDGLARRARVIVRER
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
AVLCGVPWFEAVMRAIDPSIEVDWRYREGELMEADATVCELRGPARALLTAERNGLNFLQ
HHHCCCHHHHHHHHHCCCCEEEEEEECCCCEEECCCHHHHCCCCHHHHEEECCCCCHHHH
LLSGVASATRRYVDLIDGHRGRILDTRKTLPGLRLAQKYAVRVGGGANQRLALYDGILIK
HHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCHHHHHHHHEEECCCCCCEEEEECCEEEE
ENHIAAAGGVGAALDAAFALQSGVPVQIEVETLAQLDTALAHGAKSVLLDNFTFEMMREA
CCCEEECCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
VRIASGRAVLEVSGGVNADTVVEIASTGVDRISIGALTKDVRATDFSMRIVD
HHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHCCCCCCCEEEEECC
>Mature Secondary Structure 
TAVSAIYGEIVAEYGAAFEAAIARNVADAIAEDVGSGDQTGRLIPDGLARRARVIVRER
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
AVLCGVPWFEAVMRAIDPSIEVDWRYREGELMEADATVCELRGPARALLTAERNGLNFLQ
HHHCCCHHHHHHHHHCCCCEEEEEEECCCCEEECCCHHHHCCCCHHHHEEECCCCCHHHH
LLSGVASATRRYVDLIDGHRGRILDTRKTLPGLRLAQKYAVRVGGGANQRLALYDGILIK
HHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCHHHHHHHHEEECCCCCCEEEEECCEEEE
ENHIAAAGGVGAALDAAFALQSGVPVQIEVETLAQLDTALAHGAKSVLLDNFTFEMMREA
CCCEEECCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
VRIASGRAVLEVSGGVNADTVVEIASTGVDRISIGALTKDVRATDFSMRIVD
HHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]