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The map label for this gene is uvrB [H]

Identifier: 238028103

GI number: 238028103

Start: 2911779

End: 2913869

Strand: Reverse

Name: uvrB [H]

Synonym: bglu_1g25540

Alternate gene names: 238028103

Gene position: 2913869-2911779 (Counterclockwise)

Preceding gene: 238028107

Following gene: 238028102

Centisome position: 74.59

GC content: 64.32

Gene sequence:

>2091_bases
ATGTCCGAACATTCCCCCGAAGTTGCCGAGGAACTCGATGAATCGAAGTTCGTCGAGTTCGATGGCTCCCCGTTCCAGCT
CTACCAGCCATATCCGCCGGCAGGCGACCAGCCTACTGCGATCGACACGCTCGTCGAGGGCGTCGAGGACGGCCTGTCGT
TCCAGACGCTGCTCGGCGTGACCGGGTCCGGCAAGACCTTCACGATGGCGAACACGATCGCGCGCCTCGGCCGCCCGGCC
ATCGTGTTCGCGCCGAACAAGACGCTCGCCGCCCAGCTCTATTCCGAGTTTCGCGAGTTCTTCCCGCGCAACGCGGTCGA
GTACTTCGTCTCGTATTACGACTACTACCAGCCGGAAGCCTATGTGCCGCAGCGCGACCTGTTCATCGAGAAGGACTCGT
CGATCAACGAGCACATCGAGCAGATGCGGCTGTCGGCCACCAAGAGCCTGATGGAGCGGCGCGACGTCGTGATCGTCGCG
ACCGTTTCGGCGATCTACGGTATCGGCAACCCGTCCGAGTACCACCAGATGATCCTGACGCTGCGCAATGGCGACCGGAT
CGGCCAGCGCGACGTGATCGCGCGTCTGATCGCGATGCAATACACGCGCAACGAGCAGGACTTCCAGCGCGGCACGTTCC
GCGTGCGCGGCGACACGATCGACATCTTCCCGGCCGAGCACGCCGAGATGGCGGTGCGCGTCGAACTGTTCGACGACGAG
GTCGAGACGCTGCAACTGTTCGATCCGCTGACGGGCCGGGTGCGCCAGAAGATCGCGCGCTTTACCGTCTATCCTTCGTC
GCACTACGTGACGCCGCGCGACACCGTGATGCGCGCGGTCGAGACGATCAAGGAGGAGTTGCGCGAGCGGCTCGAGTTCT
TCCATCGCGAAAACCGCCTCGTCGAGGCGCAGCGGCTCGAGCAGCGCACGCGCTTCGATCTCGAGATGCTGCAGGAACTC
GGCTTCTGCAAGGGCATCGAGAACTACTCGCGGCACTTCTCGGGCGCGGCGCCCGGTGAGCCGCCGCCGACGCTGGTCGA
CTATCTGCCGTCCGACGCGCTGATGCTGCTCGACGAATCGCATGTGCTGATCGGCCAGCTGAACGGCATGTACAACGGTG
ACCGCGCACGCAAGGAGAATCTCGTCAACTACGGCTTTCGCCTGCCGTCCGCGCTCGACAACCGGCCGCTGAAGTTTCCC
GAGTTCGAACGCAAGATGCGGCAGGTCGTGTTCGTGTCGGCGACGCCCGCCGACTACGAGCAGCGCGTGTCCGGCCAGGT
GGCCGAACAGGTGGTGCGGCCGACCGGGCTCGTCGATCCCGAGATCGAGGTGCGTCCCGCGAGTTCGCAGGTCGACGACG
TGCTGGCCGAAATCAACGAGCGCGTGAAAGCCGGCGAACGTGTGCTGATCACGGTGCTGACCAAGCGCATGGCCGAACAG
CTCACCGAGTTCCTGGCCGATCACGGTGTCAAGGTTCGCTATCTGCACAGCGATATCGATACCGTCGAGCGTGTCGAGAT
CATTCGCGACCTGCGGCTCGGCACCTTCGACGTGCTGGTCGGGATCAACCTGCTGCGCGAGGGGCTCGACATTCCGGAGG
TGTCGCTCGTCGCGATCCTCGACGCCGACAAGGAAGGTTTCCTGCGCGCCGAACGCTCGCTGATCCAGACCATCGGCCGC
GCGGCGCGCAACGTGAACGGCAAGGCCATCCTCTATGCCGACCACATGACCGATTCGATGCGGCGCGCGATCGACGAGAC
CGAGCGGCGCCGTGCCAAGCAGATCGCGCACAACGAGAAGCTCGGCATCACGCCGCGCGGCGTGGTGAAACGGATCAAGG
ACATCATCGACGGCGTCTACAACGTCGACGAGGCGCGCGCCGAGCTGAAGGAGGCGCAGCAGCGCGCGAAATTCGAGGAC
ATGTCCGAGAAGCAGTTGGCGAAGGAAATCAAGCGGCTCGAAAAACAGATGACCGACTACGCGAAGAACCTCGAATTCGA
GAAGGCGGCCCAGACCCGCGACCAGCTCGCGCTGCTGCGCGAGCGAGTGTTCGGCGCCAATGTCGGCGATCACGTGAGCG
GCGCCGGCTGA

Upstream 100 bases:

>100_bases
GTTGCAGGTATCGGGGCGCGAACCGGGCGATGCGGGCGCTCGGCCCGCCCGTCACCGAAGCGCTAGAATGCTTGTTTGCA
CGCGGCCCGGTTTCCGACTC

Downstream 100 bases:

>100_bases
GCACGCCGATTCCGCCATGCCGGCCTCGCAGGCCGGCACGGCGGAGCACCCCACGAAACTTCCGAAAACCTTTCTACATC
AATGGCTTGAATTTCTTTCC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MSEHSPEVAEELDESKFVEFDGSPFQLYQPYPPAGDQPTAIDTLVEGVEDGLSFQTLLGVTGSGKTFTMANTIARLGRPA
IVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVA
TVSAIYGIGNPSEYHQMILTLRNGDRIGQRDVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDE
VETLQLFDPLTGRVRQKIARFTVYPSSHYVTPRDTVMRAVETIKEELRERLEFFHRENRLVEAQRLEQRTRFDLEMLQEL
GFCKGIENYSRHFSGAAPGEPPPTLVDYLPSDALMLLDESHVLIGQLNGMYNGDRARKENLVNYGFRLPSALDNRPLKFP
EFERKMRQVVFVSATPADYEQRVSGQVAEQVVRPTGLVDPEIEVRPASSQVDDVLAEINERVKAGERVLITVLTKRMAEQ
LTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNVNGKAILYADHMTDSMRRAIDETERRRAKQIAHNEKLGITPRGVVKRIKDIIDGVYNVDEARAELKEAQQRAKFED
MSEKQLAKEIKRLEKQMTDYAKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGAG

Sequences:

>Translated_696_residues
MSEHSPEVAEELDESKFVEFDGSPFQLYQPYPPAGDQPTAIDTLVEGVEDGLSFQTLLGVTGSGKTFTMANTIARLGRPA
IVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVA
TVSAIYGIGNPSEYHQMILTLRNGDRIGQRDVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDE
VETLQLFDPLTGRVRQKIARFTVYPSSHYVTPRDTVMRAVETIKEELRERLEFFHRENRLVEAQRLEQRTRFDLEMLQEL
GFCKGIENYSRHFSGAAPGEPPPTLVDYLPSDALMLLDESHVLIGQLNGMYNGDRARKENLVNYGFRLPSALDNRPLKFP
EFERKMRQVVFVSATPADYEQRVSGQVAEQVVRPTGLVDPEIEVRPASSQVDDVLAEINERVKAGERVLITVLTKRMAEQ
LTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNVNGKAILYADHMTDSMRRAIDETERRRAKQIAHNEKLGITPRGVVKRIKDIIDGVYNVDEARAELKEAQQRAKFED
MSEKQLAKEIKRLEKQMTDYAKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGAG
>Mature_695_residues
SEHSPEVAEELDESKFVEFDGSPFQLYQPYPPAGDQPTAIDTLVEGVEDGLSFQTLLGVTGSGKTFTMANTIARLGRPAI
VFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVAT
VSAIYGIGNPSEYHQMILTLRNGDRIGQRDVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDEV
ETLQLFDPLTGRVRQKIARFTVYPSSHYVTPRDTVMRAVETIKEELRERLEFFHRENRLVEAQRLEQRTRFDLEMLQELG
FCKGIENYSRHFSGAAPGEPPPTLVDYLPSDALMLLDESHVLIGQLNGMYNGDRARKENLVNYGFRLPSALDNRPLKFPE
FERKMRQVVFVSATPADYEQRVSGQVAEQVVRPTGLVDPEIEVRPASSQVDDVLAEINERVKAGERVLITVLTKRMAEQL
TEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRA
ARNVNGKAILYADHMTDSMRRAIDETERRRAKQIAHNEKLGITPRGVVKRIKDIIDGVYNVDEARAELKEAQQRAKFEDM
SEKQLAKEIKRLEKQMTDYAKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGAG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=65.8718330849478, Blast_Score=870, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=23.1270358306189, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 79360; Mature: 79229

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHSPEVAEELDESKFVEFDGSPFQLYQPYPPAGDQPTAIDTLVEGVEDGLSFQTLLGV
CCCCCCHHHHHCCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCC
TGSGKTFTMANTIARLGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEA
CCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
YVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIGNPSEYHQMILT
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHH
LRNGDRIGQRDVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDE
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCEEEECCEEEECCCCCCCEEEEEEEECCH
VETLQLFDPLTGRVRQKIARFTVYPSSHYVTPRDTVMRAVETIKEELRERLEFFHRENRL
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPSDALMLLDES
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCEEEEECC
HVLIGQLNGMYNGDRARKENLVNYGFRLPSALDNRPLKFPEFERKMRQVVFVSATPADYE
CEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHEEEEECCCCCHH
QRVSGQVAEQVVRPTGLVDPEIEVRPASSQVDDVLAEINERVKAGERVLITVLTKRMAEQ
HHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAIL
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEE
DADKEGFLRAERSLIQTIGRAARNVNGKAILYADHMTDSMRRAIDETERRRAKQIAHNEK
ECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
LGITPRGVVKRIKDIIDGVYNVDEARAELKEAQQRAKFEDMSEKQLAKEIKRLEKQMTDY
CCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGAG
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SEHSPEVAEELDESKFVEFDGSPFQLYQPYPPAGDQPTAIDTLVEGVEDGLSFQTLLGV
CCCCCHHHHHCCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCC
TGSGKTFTMANTIARLGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEA
CCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
YVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIGNPSEYHQMILT
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHH
LRNGDRIGQRDVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDE
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCEEEECCEEEECCCCCCCEEEEEEEECCH
VETLQLFDPLTGRVRQKIARFTVYPSSHYVTPRDTVMRAVETIKEELRERLEFFHRENRL
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPSDALMLLDES
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCEEEEECC
HVLIGQLNGMYNGDRARKENLVNYGFRLPSALDNRPLKFPEFERKMRQVVFVSATPADYE
CEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHEEEEECCCCCHH
QRVSGQVAEQVVRPTGLVDPEIEVRPASSQVDDVLAEINERVKAGERVLITVLTKRMAEQ
HHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAIL
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEE
DADKEGFLRAERSLIQTIGRAARNVNGKAILYADHMTDSMRRAIDETERRRAKQIAHNEK
ECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
LGITPRGVVKRIKDIIDGVYNVDEARAELKEAQQRAKFEDMSEKQLAKEIKRLEKQMTDY
CCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGAG
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA