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The map label for this gene is emrA [H]

Identifier: 238027580

GI number: 238027580

Start: 2188047

End: 2189264

Strand: Direct

Name: emrA [H]

Synonym: bglu_1g19980

Alternate gene names: 238027580

Gene position: 2188047-2189264 (Clockwise)

Preceding gene: 238027579

Following gene: 238027581

Centisome position: 56.01

GC content: 68.97

Gene sequence:

>1218_bases
ATGAGCGACCCTCAACAGAACGCGGCCGGCGCAGCCCGGCCGAACAACACCAAACGCAAGCGGATGATGACGATACTGAT
CGCGCTCATCGTGCTCGCCGCAATCGCCTACGGCGTCTATTACTTCCTCGTCGCGCGCTTCCACGAAACCACCGACGATG
CCTATGTCAACGGCAACGTGGTGCAAATTACGCCGCAGGTGACGGGCACGGTGATCGCTGTCAACGCCGACGACACGCAG
ACCGTGACGGCGGGCGCCCCGCTCGTCGTGCTCGACCCGGCCGATGCGCGCGTCGCGCTGCAGCAGGCCGAGGCCAATCT
CGCGCAGACCGTGCGCCAGGTACGCGGCCTGTTCGTCAACGACGATCAGTACCGCGCGCAGGTCGCGCTGCGCGAAACCG
ACCTGTCGAAGGCGCAGGACGACCTGCGCCGGCGCCTGGCCGTGGCGCAGACGGGCGCGGTCTCGCAGGAAGAGATCGCG
CACGCGCGCGATGCCGTGAAGGCCGCGCAGGCCTCGGTCGATGCCGCACGGCAGCAGCTCGCCTCGAATCGCGCGCTAAC
CGCGAACACCACGGTCGCCGATCACCCCAACGTGCTGGCCGCGGCTGCGAAGGTGCGCGACGCCTATCTGGCCAACGCGC
GCAACATGCTGCCCGCGCCCGTCACCGGCTACGTGGCCAAGCGCTCGGTGCAGGTCGGCCAGCGCGTCGCGCCGGGCACG
CCGCTGATGTCGGTGGTGCCGCTCAACGGCGTATGGGTCGAGGCGAACTTCAAGGAAGTGCAGCTCACGCACATGCGGAT
CGGCCAGCCGGTCGAGCTGACGGCCGACATCTACGGCTCGTCCGTCAAGTATCACGGCAAGGTGGTGGGCTTTTCGGCCG
GCACCGGCTCGGCGTTCTCGCTGCTGCCGGCGCAGAACGCCACCGGCAACTGGATCAAGGTGGTGCAGCGCCTGCCGGTG
CGCATCGCGCTCGACCCGCAACAATTGCAGCAGCATCCGCTGCGCATCGGCCTGTCGATGCAGGTCGACGTCGACATCAA
GGACGACAGCGGCGGCGAGCTCGGCAAGGTGCCGAACACGGTCTACCAGACCGACGTGTTCGCGAAGTACGGCGACGCGG
CCGACGCCGAGATCGCCCGGATCATCGCGCAGAACGCCGGCGGCGCGACGCCGGCCGCCACCAAGCCCGGCGCCGGCGCC
GCGCCGAAGCGGATGTGA

Upstream 100 bases:

>100_bases
CAGGCAGCGGCGGCGCAGCAGGCCGCCAATTGAACGAAGCCCTTGCCCGACACCCCCGTATCACTCGCACCAAGCACAAG
CATCGACGGAGAAATTCGCC

Downstream 100 bases:

>100_bases
GCCCGGAACGGAACGCCCATGGCCAACACCCAACCCGTCATCCACCCTCCGCTGGAGGGCGGTCAGCTACTGCTCGGCAC
CGTCGCCGTGTCGCTTGCGG

Product: efflux pump membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSDPQQNAAGAARPNNTKRKRMMTILIALIVLAAIAYGVYYFLVARFHETTDDAYVNGNVVQITPQVTGTVIAVNADDTQ
TVTAGAPLVVLDPADARVALQQAEANLAQTVRQVRGLFVNDDQYRAQVALRETDLSKAQDDLRRRLAVAQTGAVSQEEIA
HARDAVKAAQASVDAARQQLASNRALTANTTVADHPNVLAAAAKVRDAYLANARNMLPAPVTGYVAKRSVQVGQRVAPGT
PLMSVVPLNGVWVEANFKEVQLTHMRIGQPVELTADIYGSSVKYHGKVVGFSAGTGSAFSLLPAQNATGNWIKVVQRLPV
RIALDPQQLQQHPLRIGLSMQVDVDIKDDSGGELGKVPNTVYQTDVFAKYGDAADAEIARIIAQNAGGATPAATKPGAGA
APKRM

Sequences:

>Translated_405_residues
MSDPQQNAAGAARPNNTKRKRMMTILIALIVLAAIAYGVYYFLVARFHETTDDAYVNGNVVQITPQVTGTVIAVNADDTQ
TVTAGAPLVVLDPADARVALQQAEANLAQTVRQVRGLFVNDDQYRAQVALRETDLSKAQDDLRRRLAVAQTGAVSQEEIA
HARDAVKAAQASVDAARQQLASNRALTANTTVADHPNVLAAAAKVRDAYLANARNMLPAPVTGYVAKRSVQVGQRVAPGT
PLMSVVPLNGVWVEANFKEVQLTHMRIGQPVELTADIYGSSVKYHGKVVGFSAGTGSAFSLLPAQNATGNWIKVVQRLPV
RIALDPQQLQQHPLRIGLSMQVDVDIKDDSGGELGKVPNTVYQTDVFAKYGDAADAEIARIIAQNAGGATPAATKPGAGA
APKRM
>Mature_404_residues
SDPQQNAAGAARPNNTKRKRMMTILIALIVLAAIAYGVYYFLVARFHETTDDAYVNGNVVQITPQVTGTVIAVNADDTQT
VTAGAPLVVLDPADARVALQQAEANLAQTVRQVRGLFVNDDQYRAQVALRETDLSKAQDDLRRRLAVAQTGAVSQEEIAH
ARDAVKAAQASVDAARQQLASNRALTANTTVADHPNVLAAAAKVRDAYLANARNMLPAPVTGYVAKRSVQVGQRVAPGTP
LMSVVPLNGVWVEANFKEVQLTHMRIGQPVELTADIYGSSVKYHGKVVGFSAGTGSAFSLLPAQNATGNWIKVVQRLPVR
IALDPQQLQQHPLRIGLSMQVDVDIKDDSGGELGKVPNTVYQTDVFAKYGDAADAEIARIIAQNAGGATPAATKPGAGAA
PKRM

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=334, Percent_Identity=53.5928143712575, Blast_Score=356, Evalue=1e-99,
Organism=Escherichia coli, GI1788711, Length=375, Percent_Identity=43.2, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI87081951, Length=309, Percent_Identity=28.4789644012945, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790519, Length=317, Percent_Identity=29.3375394321767, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789637, Length=319, Percent_Identity=29.4670846394984, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43025; Mature: 42894

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPQQNAAGAARPNNTKRKRMMTILIALIVLAAIAYGVYYFLVARFHETTDDAYVNGNV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCE
VQITPQVTGTVIAVNADDTQTVTAGAPLVVLDPADARVALQQAEANLAQTVRQVRGLFVN
EEEECCCCEEEEEEECCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCEEEC
DDQYRAQVALRETDLSKAQDDLRRRLAVAQTGAVSQEEIAHARDAVKAAQASVDAARQQL
CCHHEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASNRALTANTTVADHPNVLAAAAKVRDAYLANARNMLPAPVTGYVAKRSVQVGQRVAPGT
HCCCCEEECCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
PLMSVVPLNGVWVEANFKEVQLTHMRIGQPVELTADIYGSSVKYHGKVVGFSAGTGSAFS
CCEEEEECCCEEEECCCCEEEEEEHHCCCCCEEEHHHCCCCEEECCEEEEEECCCCCEEE
LLPAQNATGNWIKVVQRLPVRIALDPQQLQQHPLRIGLSMQVDVDIKDDSGGELGKVPNT
EECCCCCCCHHHHHHHHCCCEEEECHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCCH
VYQTDVFAKYGDAADAEIARIIAQNAGGATPAATKPGAGAAPKRM
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDPQQNAAGAARPNNTKRKRMMTILIALIVLAAIAYGVYYFLVARFHETTDDAYVNGNV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCE
VQITPQVTGTVIAVNADDTQTVTAGAPLVVLDPADARVALQQAEANLAQTVRQVRGLFVN
EEEECCCCEEEEEEECCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCEEEC
DDQYRAQVALRETDLSKAQDDLRRRLAVAQTGAVSQEEIAHARDAVKAAQASVDAARQQL
CCHHEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASNRALTANTTVADHPNVLAAAAKVRDAYLANARNMLPAPVTGYVAKRSVQVGQRVAPGT
HCCCCEEECCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
PLMSVVPLNGVWVEANFKEVQLTHMRIGQPVELTADIYGSSVKYHGKVVGFSAGTGSAFS
CCEEEEECCCEEEECCCCEEEEEEHHCCCCCEEEHHHCCCCEEECCEEEEEECCCCCEEE
LLPAQNATGNWIKVVQRLPVRIALDPQQLQQHPLRIGLSMQVDVDIKDDSGGELGKVPNT
EECCCCCCCHHHHHHHHCCCEEEECHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCCH
VYQTDVFAKYGDAADAEIARIIAQNAGGATPAATKPGAGAAPKRM
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]