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The map label for this gene is pyrD [H]

Identifier: 238027536

GI number: 238027536

Start: 2133935

End: 2134963

Strand: Direct

Name: pyrD [H]

Synonym: bglu_1g19540

Alternate gene names: 238027536

Gene position: 2133935-2134963 (Clockwise)

Preceding gene: 238027535

Following gene: 238027537

Centisome position: 54.63

GC content: 69.87

Gene sequence:

>1029_bases
GTGTTCAGTTCCCTTTATCCGCTTGCCCGCGCGTCCCTGTTCCGGATGGACGCGGAAGACGCCCACCACCTGACGCTGCG
CCTGCTCGGCGCCGCCGGCCGCGCCGGCGTGGCGGGGCTGCTCGCGCCGAGCGTGCCGGACGCGCCGCGCACGGTGATGG
GCCTCACGTTCCGCAACCCGGTCGGGCTCGCGGCCGGGCTCGACAAGGACGGCGCCTGCATCGACGGGCTCGCCGCGCTC
GGCTTCGGCTTCATCGAAGTCGGCACGGTCACGCCGCGCCCACAGCCGGGCAACCCGCGTCCGCGCATCTTCCGCCTGCC
GCAGGCCGAGGCGGTGATCAACCGGATGGGCTTCAACAACCACGGCGTCGAGCAGTTCGTGAAGAACGTGCAGGCCGCGC
GCTATCGTGGCGTGCTGGGCCTGAACATCGGCAAGAACGCCGACACGCCGATCGAGCGCGCGGCCGACGATTACCTCTAT
TGCCTCGAACGCGTCTATCCGTTTGCGAGCTACGTGACGATCAACATCTCGTCGCCGAACACGAAGAACCTGCGACAGCT
TCAGGGTTCGAACGAGCTCGACGCGCTGCTCGCCGCGCTGAAGGACAAGCAGGCGCGCCTGGCCGACCTGCACGGCAAGC
TGGTGCCGCTCGCGCTGAAGATCGCGCCCGACCTCGACGACGAACAGATCAAGGAAATCGCCGCGCTGCTGCTGCGCCAT
CGCATCGAGGCCGTGATCGCCACCAACACCACGCTCTCGCGCGCGGCCGTGCAGGGCCTGCCGCACGCCGAGGAAGCGGG
CGGCCTGTCGGGGCGGCCGGTGCTCGACGCGTCCAACCAGGTGATCCGCAAGCTGCACGCCGAACTGGGCGGCGCGGTGC
CGATCATCGGGGTGGGCGGTATTTTTTCGGGCGATGACGCGCGGGCGAAACTCGCCGCGGGCGCGTCGCTGGTGCAGCTG
TACACGGGCTTCATCTATCGCGGGCCGCCGCTCGTCGCCGATTGCGTGCGCGCCATCGCGCGCGGCTGA

Upstream 100 bases:

>100_bases
GGCCGGCCACGGCGGCACGCGCTGACGCTGCGGCGGCCGGGTCCGGCCGCCGTTCGGTTAAAATACCGGGTTATCAATTT
TCGGCGCCGCCCTTCCCTTC

Downstream 100 bases:

>100_bases
TGCCGCGGTTATATGGAAATGAGCAAACGATAGTTAGGCGTGTCCCGCCGCTTCGCTATGATGCGCGGCTATCGTCAACG
CCCGCTGCGGGCATTACAGG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MFSSLYPLARASLFRMDAEDAHHLTLRLLGAAGRAGVAGLLAPSVPDAPRTVMGLTFRNPVGLAAGLDKDGACIDGLAAL
GFGFIEVGTVTPRPQPGNPRPRIFRLPQAEAVINRMGFNNHGVEQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTINISSPNTKNLRQLQGSNELDALLAALKDKQARLADLHGKLVPLALKIAPDLDDEQIKEIAALLLRH
RIEAVIATNTTLSRAAVQGLPHAEEAGGLSGRPVLDASNQVIRKLHAELGGAVPIIGVGGIFSGDDARAKLAAGASLVQL
YTGFIYRGPPLVADCVRAIARG

Sequences:

>Translated_342_residues
MFSSLYPLARASLFRMDAEDAHHLTLRLLGAAGRAGVAGLLAPSVPDAPRTVMGLTFRNPVGLAAGLDKDGACIDGLAAL
GFGFIEVGTVTPRPQPGNPRPRIFRLPQAEAVINRMGFNNHGVEQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTINISSPNTKNLRQLQGSNELDALLAALKDKQARLADLHGKLVPLALKIAPDLDDEQIKEIAALLLRH
RIEAVIATNTTLSRAAVQGLPHAEEAGGLSGRPVLDASNQVIRKLHAELGGAVPIIGVGGIFSGDDARAKLAAGASLVQL
YTGFIYRGPPLVADCVRAIARG
>Mature_342_residues
MFSSLYPLARASLFRMDAEDAHHLTLRLLGAAGRAGVAGLLAPSVPDAPRTVMGLTFRNPVGLAAGLDKDGACIDGLAAL
GFGFIEVGTVTPRPQPGNPRPRIFRLPQAEAVINRMGFNNHGVEQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTINISSPNTKNLRQLQGSNELDALLAALKDKQARLADLHGKLVPLALKIAPDLDDEQIKEIAALLLRH
RIEAVIATNTTLSRAAVQGLPHAEEAGGLSGRPVLDASNQVIRKLHAELGGAVPIIGVGGIFSGDDARAKLAAGASLVQL
YTGFIYRGPPLVADCVRAIARG

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=335, Percent_Identity=45.6716417910448, Blast_Score=259, Evalue=2e-69,
Organism=Escherichia coli, GI1787177, Length=334, Percent_Identity=57.185628742515, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17509475, Length=333, Percent_Identity=42.042042042042, Blast_Score=239, Evalue=1e-63,
Organism=Drosophila melanogaster, GI281361352, Length=293, Percent_Identity=44.0273037542662, Blast_Score=242, Evalue=2e-64,
Organism=Drosophila melanogaster, GI17137316, Length=293, Percent_Identity=44.0273037542662, Blast_Score=242, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36296; Mature: 36296

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSSLYPLARASLFRMDAEDAHHLTLRLLGAAGRAGVAGLLAPSVPDAPRTVMGLTFRNP
CCCCHHHHHHHHHHHCCCCCHHHHHHHEECCCCCCCCHHHHCCCCCCCCCCEEEEEECCC
VGLAAGLDKDGACIDGLAALGFGFIEVGTVTPRPQPGNPRPRIFRLPQAEAVINRMGFNN
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCC
HGVEQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLYCLERVYPFASYVTINISSPN
CCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
TKNLRQLQGSNELDALLAALKDKQARLADLHGKLVPLALKIAPDLDDEQIKEIAALLLRH
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
RIEAVIATNTTLSRAAVQGLPHAEEAGGLSGRPVLDASNQVIRKLHAELGGAVPIIGVGG
HHHHHHCCCCHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
IFSGDDARAKLAAGASLVQLYTGFIYRGPPLVADCVRAIARG
EECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MFSSLYPLARASLFRMDAEDAHHLTLRLLGAAGRAGVAGLLAPSVPDAPRTVMGLTFRNP
CCCCHHHHHHHHHHHCCCCCHHHHHHHEECCCCCCCCHHHHCCCCCCCCCCEEEEEECCC
VGLAAGLDKDGACIDGLAALGFGFIEVGTVTPRPQPGNPRPRIFRLPQAEAVINRMGFNN
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCC
HGVEQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLYCLERVYPFASYVTINISSPN
CCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
TKNLRQLQGSNELDALLAALKDKQARLADLHGKLVPLALKIAPDLDDEQIKEIAALLLRH
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
RIEAVIATNTTLSRAAVQGLPHAEEAGGLSGRPVLDASNQVIRKLHAELGGAVPIIGVGG
HHHHHHCCCCHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
IFSGDDARAKLAAGASLVQLYTGFIYRGPPLVADCVRAIARG
EECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA