Click here to switch to the map view.

The map label for this gene is ilvD [H]

Identifier: 238027391

GI number: 238027391

Start: 1962902

End: 1964653

Strand: Reverse

Name: ilvD [H]

Synonym: bglu_1g17870

Alternate gene names: 238027391

Gene position: 1964653-1962902 (Counterclockwise)

Preceding gene: 238027393

Following gene: 238027390

Centisome position: 50.29

GC content: 69.18

Gene sequence:

>1752_bases
ATGTCGGCAAGCAAACCGAAGCTGCGATCCCAACAATGGTTCGGCACCACGGACAAGAACGGCTTCATGTATCGAAGCTG
GATGAAGAATCAGGGTATTCCCGACCATGAGTTCGACGGCAGGCCGATCATCGGCATCTGCAACACCTGGTCGGAGCTGA
CGCCCTGCAACGCGCACTTCCGCAAGCTCGCCGAGCACGTCAAGCGCGGCGTGTACGAGGCCGGCGGCTTCCCGGTCGAA
TTCCCGGTGTTCTCGAACGGCGAGTCGAACCTGCGCCCGACCGCGATGCTCACGCGCAACCTGGCGAGCATGGACGTGGA
AGAGGCGATCCGCGGCAACCCGGTGGACGCGGTGGTGCTGCTGGCCGGTTGCGACAAGACCACCCCGGCGCTGCTGATGG
GCGCGGCCAGCTGCGACGTGCCGGCCATCGTGGTGAGCGGCGGCCCGATGCTGAACGGCAAGCTCGAGGGCAAGGACATC
GGCTCGGGCACGGCGGTGTGGCGCCTGCACGAATCGCTGAAGGCCGGCGAGATCGATCTGCATCATTTCCTGTCGGCGGA
GGCGGGCATGTCGCGCTCGGCCGGCACCTGCAACACCATGGGCACGGCCTCGACGATGGCCTGCATGGCCGAGGCGCTCG
GCGTGACGCTGCCGCACAACGCGGCGATTCCGGCCGTGGACGCGCGCCGCTACGTGCTCGCCCATCTGTCGGGCAGCCGC
ATCGTGCAGATGGCGCTGGAGGATCTGAAGCTCTCGAAGGTGCTCACGCGCGCCGCGTTCGAGAACGCGATCCGCACCAA
CGCGGCGATCGGCGGCTCGACCAACGCGGTGATCCACCTGAAGGCGATCGCGGGCCGCATCGGCGTGCCGCTGGAACTGG
AAGACTGGATGCGCATCGGCCGCAACACGCCGACGCTGGTGGACCTGCAGCCGTCGGGCCGCTTCCTGATGGAGGAGTTC
TACTACGCGGGCGGCCTGCCGGCGGTGCTGCGCCGCCTCGGCGAGGCGCAGCTGCTGCCGCATCCGGACGCGCTGACGGT
GAACGGCAAATCGATCTGGGACAACGTGCGCGAGGCGCCGAACTACGACGAGGAAGTGATCCGGCCGCTGGACCGGCCGC
TGATCGCCGACGGCGGCATCTGCATCCTGCGCGGCAACCTCGCGCCGCGCGGCGCCGTGCTCAAGCCCTCGGCCGCCACG
CCGGAGCTGCTCAAGCACCGCGGCCGCGCGGTGGTGTTCGAGAACTTCGATCACTACAAGGCGACCATCGGCGACGAGTC
GCTGGAGGTGGACAAGGATTCGATCCTGGTGATGAAGAACTGCGGCCCGCGCGGCTACCCCGGCATGGCCGAGGTCGGCA
ACATGGGCCTGCCGCCGAAGCTGTTGCGCCAGGGCGTGAAGGACATGGTGCGGATCTCCGACGCACGCATGAGCGGCACG
GCCTACGGCACGGTGGTGCTGCACGTGGCGCCGGAAGCGGCCGCGGGCGGACCGCTCGCGGCGGTGCGCAACGGCGACTG
GATCGAGCTCGACTGCGAGGCGGGACGGCTGCATCTGGACATCAGCGACGAGGAACTGGCTCGGCGCCTGCGCGACGTCG
ATCCGAGCGCCGCGCCGGGCGTGGCCGAGCAGGCCGGCCGCGGCGGCTACGCCCGGCTCTATGTCGATCACGTGCTGCAG
GCCGACGAGGGGTGCGACCTCGACTTCCTGGTCGGCATGCGCGGCGCCGAGGTGCCGCGCCACTCGCACTGA

Upstream 100 bases:

>100_bases
CCGATACGGAGATCGATATGTGAGACGTCCAACTTTTCATTAGTACGTTATCAACTTTGTTAATAGACTGCACGCAAATC
TAGCCACCGCAAGGCAAACG

Downstream 100 bases:

>100_bases
CGGACCGGCCGCGGCCGCGGCCGCCGCGTGCTTGCCGGCGGTGCCGGCCGCGCGCCGCGGCCACCGGCACCGCCGGCAAG
GTTCAAGGAGACACGATGAC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 583; Mature: 582

Protein sequence:

>583_residues
MSASKPKLRSQQWFGTTDKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHFRKLAEHVKRGVYEAGGFPVE
FPVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPVDAVVLLAGCDKTTPALLMGAASCDVPAIVVSGGPMLNGKLEGKDI
GSGTAVWRLHESLKAGEIDLHHFLSAEAGMSRSAGTCNTMGTASTMACMAEALGVTLPHNAAIPAVDARRYVLAHLSGSR
IVQMALEDLKLSKVLTRAAFENAIRTNAAIGGSTNAVIHLKAIAGRIGVPLELEDWMRIGRNTPTLVDLQPSGRFLMEEF
YYAGGLPAVLRRLGEAQLLPHPDALTVNGKSIWDNVREAPNYDEEVIRPLDRPLIADGGICILRGNLAPRGAVLKPSAAT
PELLKHRGRAVVFENFDHYKATIGDESLEVDKDSILVMKNCGPRGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGT
AYGTVVLHVAPEAAAGGPLAAVRNGDWIELDCEAGRLHLDISDEELARRLRDVDPSAAPGVAEQAGRGGYARLYVDHVLQ
ADEGCDLDFLVGMRGAEVPRHSH

Sequences:

>Translated_583_residues
MSASKPKLRSQQWFGTTDKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHFRKLAEHVKRGVYEAGGFPVE
FPVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPVDAVVLLAGCDKTTPALLMGAASCDVPAIVVSGGPMLNGKLEGKDI
GSGTAVWRLHESLKAGEIDLHHFLSAEAGMSRSAGTCNTMGTASTMACMAEALGVTLPHNAAIPAVDARRYVLAHLSGSR
IVQMALEDLKLSKVLTRAAFENAIRTNAAIGGSTNAVIHLKAIAGRIGVPLELEDWMRIGRNTPTLVDLQPSGRFLMEEF
YYAGGLPAVLRRLGEAQLLPHPDALTVNGKSIWDNVREAPNYDEEVIRPLDRPLIADGGICILRGNLAPRGAVLKPSAAT
PELLKHRGRAVVFENFDHYKATIGDESLEVDKDSILVMKNCGPRGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGT
AYGTVVLHVAPEAAAGGPLAAVRNGDWIELDCEAGRLHLDISDEELARRLRDVDPSAAPGVAEQAGRGGYARLYVDHVLQ
ADEGCDLDFLVGMRGAEVPRHSH
>Mature_582_residues
SASKPKLRSQQWFGTTDKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHFRKLAEHVKRGVYEAGGFPVEF
PVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPVDAVVLLAGCDKTTPALLMGAASCDVPAIVVSGGPMLNGKLEGKDIG
SGTAVWRLHESLKAGEIDLHHFLSAEAGMSRSAGTCNTMGTASTMACMAEALGVTLPHNAAIPAVDARRYVLAHLSGSRI
VQMALEDLKLSKVLTRAAFENAIRTNAAIGGSTNAVIHLKAIAGRIGVPLELEDWMRIGRNTPTLVDLQPSGRFLMEEFY
YAGGLPAVLRRLGEAQLLPHPDALTVNGKSIWDNVREAPNYDEEVIRPLDRPLIADGGICILRGNLAPRGAVLKPSAATP
ELLKHRGRAVVFENFDHYKATIGDESLEVDKDSILVMKNCGPRGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGTA
YGTVVLHVAPEAAAGGPLAAVRNGDWIELDCEAGRLHLDISDEELARRLRDVDPSAAPGVAEQAGRGGYARLYVDHVLQA
DEGCDLDFLVGMRGAEVPRHSH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=579, Percent_Identity=30.0518134715026, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI2367371, Length=467, Percent_Identity=32.5481798715203, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI1788157, Length=516, Percent_Identity=28.8759689922481, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1786464, Length=445, Percent_Identity=33.2584269662921, Blast_Score=172, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=580, Percent_Identity=31.3793103448276, Blast_Score=256, Evalue=9e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62779; Mature: 62647

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASKPKLRSQQWFGTTDKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHF
CCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHH
RKLAEHVKRGVYEAGGFPVEFPVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPVDAVVL
HHHHHHHHHHHHHCCCCCEECCEECCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCEEEE
LAGCDKTTPALLMGAASCDVPAIVVSGGPMLNGKLEGKDIGSGTAVWRLHESLKAGEIDL
EECCCCCCHHHEEECCCCCCCEEEEECCCEECCEECCCCCCCCHHHHHHHHHHCCCCCHH
HHFLSAEAGMSRSAGTCNTMGTASTMACMAEALGVTLPHNAAIPAVDARRYVLAHLSGSR
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCH
IVQMALEDLKLSKVLTRAAFENAIRTNAAIGGSTNAVIHLKAIAGRIGVPLELEDWMRIG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEHHHHHHHC
RNTPTLVDLQPSGRFLMEEFYYAGGLPAVLRRLGEAQLLPHPDALTVNGKSIWDNVREAP
CCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHCC
NYDEEVIRPLDRPLIADGGICILRGNLAPRGAVLKPSAATPELLKHRGRAVVFENFDHYK
CCCHHHHHHCCCCEEECCCEEEEECCCCCCCCEECCCCCCHHHHHHCCCEEEEECCCCEE
ATIGDESLEVDKDSILVMKNCGPRGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGT
EECCCCCEEECCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
AYGTVVLHVAPEAAAGGPLAAVRNGDWIELDCEAGRLHLDISDEELARRLRDVDPSAAPG
EEEEEEEEECCCCCCCCCEEEECCCCEEEEEECCCEEEEECCHHHHHHHHHCCCCCCCCC
VAEQAGRGGYARLYVDHVLQADEGCDLDFLVGMRGAEVPRHSH
CHHHCCCCCEEEEHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SASKPKLRSQQWFGTTDKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHF
CCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHH
RKLAEHVKRGVYEAGGFPVEFPVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPVDAVVL
HHHHHHHHHHHHHCCCCCEECCEECCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCEEEE
LAGCDKTTPALLMGAASCDVPAIVVSGGPMLNGKLEGKDIGSGTAVWRLHESLKAGEIDL
EECCCCCCHHHEEECCCCCCCEEEEECCCEECCEECCCCCCCCHHHHHHHHHHCCCCCHH
HHFLSAEAGMSRSAGTCNTMGTASTMACMAEALGVTLPHNAAIPAVDARRYVLAHLSGSR
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCH
IVQMALEDLKLSKVLTRAAFENAIRTNAAIGGSTNAVIHLKAIAGRIGVPLELEDWMRIG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEHHHHHHHC
RNTPTLVDLQPSGRFLMEEFYYAGGLPAVLRRLGEAQLLPHPDALTVNGKSIWDNVREAP
CCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHCC
NYDEEVIRPLDRPLIADGGICILRGNLAPRGAVLKPSAATPELLKHRGRAVVFENFDHYK
CCCHHHHHHCCCCEEECCCEEEEECCCCCCCCEECCCCCCHHHHHHCCCEEEEECCCCEE
ATIGDESLEVDKDSILVMKNCGPRGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGT
EECCCCCEEECCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
AYGTVVLHVAPEAAAGGPLAAVRNGDWIELDCEAGRLHLDISDEELARRLRDVDPSAAPG
EEEEEEEEECCCCCCCCCEEEECCCCEEEEEECCCEEEEECCHHHHHHHHHCCCCCCCCC
VAEQAGRGGYARLYVDHVLQADEGCDLDFLVGMRGAEVPRHSH
CHHHCCCCCEEEEHHHHHHHCCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA