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The map label for this gene is fadD11 [H]

Identifier: 238027276

GI number: 238027276

Start: 1831314

End: 1832873

Strand: Direct

Name: fadD11 [H]

Synonym: bglu_1g16630

Alternate gene names: 238027276

Gene position: 1831314-1832873 (Clockwise)

Preceding gene: 238027275

Following gene: 238027277

Centisome position: 46.88

GC content: 70.71

Gene sequence:

>1560_bases
ATGACGCGCCCGCCATCGGTGATCAACGCGGTGGCCGCGAACGGCGGCAAGCACGCCACGCAGCGCGTGACGTTCTTCCA
GCAGGGCGGCCGCATCGACCTCACGCACGCACAGCTCGACGCGCTGGCCGCGCGGCTCGCGCTGCGCCTGCGCGAGGCGG
GCCTGAAGCGCGGCGCGCGGATCGGCATCGTCGCGCGCAACGGGCTGGCCTGGGTGCTGCTCGACCTGGCCGCGCTGAAG
GCCGGCTATGTCACGGCCGGCTTCGAGTTCGGCAAGTTCGAGGCCAACCGCGAGCTGGTCGAGCGCTATGCCCTCGACGC
GATCCTGGCCGACGGCGGCGCGCCGTTCGCCGCGCGCGGCGTCCACGACCTGCGCGAGCTCGTCGAGGCGGTGGTGGCGC
AGGCCGGCGACGGCCGCGAGGTCGATCCGGTCGCGCCGGCGTTCGACACGGCCGTCTATGGCGAGGACGACGTCACCACC
ATCAAGTTCACCTCGGGCAGCTCGGGCGAGCCGAAGGGGCTGGCCGCGCGCGTCGGCAGCATCGACGCCTCGCTCGCGGC
GGTCCAGCAGATCTACGCGCACGGCCCCGACGACGACCTGCTGGTGTTCCTGCCGCTGTCGCTGCTGCAACAGCGCTACT
GGATCTACTCGGCGCTGGCGTATGGCCATGCCACCACCGTCACGCGCTTCGAGTACGCGCTCGAGATCGCGCGCCGGCAG
CCGCCCACCGTGGTAATGGGCGTACCGGGCTTCTTCGACGGCGTGAAGAAGCGCATCGAACGGCTCACGCCGGCCGGCGA
GACGGATCCGGCCGCACGGCGCCTGCGCATCGATGCGCTGCTGGGCGGCCGCATCCGCTACCTGTGGACCGGCTCGGCGC
CGGCCAACCCGCAGACGCTGCGTTTCTTCGAGGAGGCCGGCGTGCCGATCTTCGAGGGCTACGGCATGAACGAGACCTGC
ATCGTCAGCAAGAACTATCCGGGCCAGGCGCGCACCGGCAGCGTCGGGCGCCTGCTGCCCGGTAAGCGCGCGCGCATCGA
CGAGCACGGCGTGCTGGTGGTGGGCGCCGAGCAGCCGGTGAACACGCGCTACCTCTACAGCGCGCCCGGCGCGAGCGAAA
AGATCTTCCTGCCGACGGGCGAGGTCAGGACGGGCGACCTCGCGCGCATCGACGAGGACGGCTTCCTCTACATCCTCGGG
CGCGCCGACGATCTGATCGTGCTGGCCAACGGCAAGAACGTCCACGTGCGCAGCCTGGAGGAGCGCGTGAAGGCGCACCA
GGGCGTGGAGGAGTGCGTGCTGTTCGGTTCGGGCAAGCCGTTCCTGGTGGCGGTGGTGTCGCCGCAGGACGCGCGCGCCG
ATCACGCCGCGATCCGCGCGCACCTGAGCGAGCTGAACGCGAGCCTCGCGCCCGACGAGCGGATCGTGCGCGCGTTCATC
ACGCCCGAGCCGTTTCGCGGCCAGACGCGCTTCGTCACCTCGCAGTTCAAGCCGAAGCGCAACGAGATCTTCAACGCGTT
CCGGCAGGAAATCGACCAACTCTATGGAGCTTCAGCGTGA

Upstream 100 bases:

>100_bases
TCCAGGGCTTCGCGGCCGGCAGCTACCGCAACCTTGCCGCCGACCGCCTGCCCGAGCCGGCGGTGGCGCGCGCGGCCACC
ATCGCGGAGGGCTCGGTCTG

Downstream 100 bases:

>100_bases
GCGAAATTGAAACGATCGTGCGGCGCCACCTCGCCGAGGCGGCGGGCAAGGATGCCGCCGGGGCCGCGGCGCTGCCGCTC
GACGCCGACCTCGTCTACGA

Product: AMP-dependent synthetase and ligase

Products: [acyl carrier protein]; L-1-phosphatidyl-ethanolamine; AMP; pyrophosphate; acyl-ACP [C]

Alternate protein names: Acyl-CoA synthetase [H]

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MTRPPSVINAVAANGGKHATQRVTFFQQGGRIDLTHAQLDALAARLALRLREAGLKRGARIGIVARNGLAWVLLDLAALK
AGYVTAGFEFGKFEANRELVERYALDAILADGGAPFAARGVHDLRELVEAVVAQAGDGREVDPVAPAFDTAVYGEDDVTT
IKFTSGSSGEPKGLAARVGSIDASLAAVQQIYAHGPDDDLLVFLPLSLLQQRYWIYSALAYGHATTVTRFEYALEIARRQ
PPTVVMGVPGFFDGVKKRIERLTPAGETDPAARRLRIDALLGGRIRYLWTGSAPANPQTLRFFEEAGVPIFEGYGMNETC
IVSKNYPGQARTGSVGRLLPGKRARIDEHGVLVVGAEQPVNTRYLYSAPGASEKIFLPTGEVRTGDLARIDEDGFLYILG
RADDLIVLANGKNVHVRSLEERVKAHQGVEECVLFGSGKPFLVAVVSPQDARADHAAIRAHLSELNASLAPDERIVRAFI
TPEPFRGQTRFVTSQFKPKRNEIFNAFRQEIDQLYGASA

Sequences:

>Translated_519_residues
MTRPPSVINAVAANGGKHATQRVTFFQQGGRIDLTHAQLDALAARLALRLREAGLKRGARIGIVARNGLAWVLLDLAALK
AGYVTAGFEFGKFEANRELVERYALDAILADGGAPFAARGVHDLRELVEAVVAQAGDGREVDPVAPAFDTAVYGEDDVTT
IKFTSGSSGEPKGLAARVGSIDASLAAVQQIYAHGPDDDLLVFLPLSLLQQRYWIYSALAYGHATTVTRFEYALEIARRQ
PPTVVMGVPGFFDGVKKRIERLTPAGETDPAARRLRIDALLGGRIRYLWTGSAPANPQTLRFFEEAGVPIFEGYGMNETC
IVSKNYPGQARTGSVGRLLPGKRARIDEHGVLVVGAEQPVNTRYLYSAPGASEKIFLPTGEVRTGDLARIDEDGFLYILG
RADDLIVLANGKNVHVRSLEERVKAHQGVEECVLFGSGKPFLVAVVSPQDARADHAAIRAHLSELNASLAPDERIVRAFI
TPEPFRGQTRFVTSQFKPKRNEIFNAFRQEIDQLYGASA
>Mature_518_residues
TRPPSVINAVAANGGKHATQRVTFFQQGGRIDLTHAQLDALAARLALRLREAGLKRGARIGIVARNGLAWVLLDLAALKA
GYVTAGFEFGKFEANRELVERYALDAILADGGAPFAARGVHDLRELVEAVVAQAGDGREVDPVAPAFDTAVYGEDDVTTI
KFTSGSSGEPKGLAARVGSIDASLAAVQQIYAHGPDDDLLVFLPLSLLQQRYWIYSALAYGHATTVTRFEYALEIARRQP
PTVVMGVPGFFDGVKKRIERLTPAGETDPAARRLRIDALLGGRIRYLWTGSAPANPQTLRFFEEAGVPIFEGYGMNETCI
VSKNYPGQARTGSVGRLLPGKRARIDEHGVLVVGAEQPVNTRYLYSAPGASEKIFLPTGEVRTGDLARIDEDGFLYILGR
ADDLIVLANGKNVHVRSLEERVKAHQGVEECVLFGSGKPFLVAVVSPQDARADHAAIRAHLSELNASLAPDERIVRAFIT
PEPFRGQTRFVTSQFKPKRNEIFNAFRQEIDQLYGASA

Specific function: Plays A Role In Lysophospholipid Acylation. Transfers Fatty Acids To The 1-Position VIa An Enzyme-Bound Acyl-Acp Intermediate In The Presence Of ATP And Mg(2+). Its Physiological Function Is To Regenerate Ptdetn From 2-Acyl-Gpe Formed By Transacylation R

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=592, Percent_Identity=23.1418918918919, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI57165412, Length=433, Percent_Identity=25.635103926097, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI57165410, Length=433, Percent_Identity=24.9422632794457, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI27477105, Length=507, Percent_Identity=23.8658777120316, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI42794754, Length=444, Percent_Identity=23.1981981981982, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI42794752, Length=444, Percent_Identity=23.1981981981982, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI38505220, Length=447, Percent_Identity=23.7136465324385, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789201, Length=287, Percent_Identity=30.3135888501742, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788107, Length=148, Percent_Identity=34.4594594594595, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25147511, Length=592, Percent_Identity=25.1689189189189, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17558820, Length=319, Percent_Identity=27.2727272727273, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=318, Percent_Identity=28.6163522012579, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17541856, Length=429, Percent_Identity=25.6410256410256, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17556552, Length=577, Percent_Identity=21.8370883882149, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17510401, Length=604, Percent_Identity=21.523178807947, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193204819, Length=277, Percent_Identity=25.9927797833935, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324893, Length=444, Percent_Identity=24.5495495495495, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6322182, Length=445, Percent_Identity=24.0449438202247, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI62471679, Length=442, Percent_Identity=23.3031674208145, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI62471683, Length=442, Percent_Identity=23.3031674208145, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI62471685, Length=442, Percent_Identity=23.3031674208145, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24586636, Length=442, Percent_Identity=23.3031674208145, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI62471681, Length=442, Percent_Identity=23.3031674208145, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI62471687, Length=442, Percent_Identity=23.3031674208145, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24586634, Length=442, Percent_Identity=23.3031674208145, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI22026970, Length=442, Percent_Identity=23.3031674208145, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI62471689, Length=442, Percent_Identity=23.3031674208145, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 56326; Mature: 56195

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPPSVINAVAANGGKHATQRVTFFQQGGRIDLTHAQLDALAARLALRLREAGLKRGAR
CCCCCHHHHHHHCCCCCHHHHEEHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCE
IGIVARNGLAWVLLDLAALKAGYVTAGFEFGKFEANRELVERYALDAILADGGAPFAARG
EEEEEECCHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHEECCCCCHHHCC
VHDLRELVEAVVAQAGDGREVDPVAPAFDTAVYGEDDVTTIKFTSGSSGEPKGLAARVGS
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCCCCCCHHHHHCC
IDASLAAVQQIYAHGPDDDLLVFLPLSLLQQRYWIYSALAYGHATTVTRFEYALEIARRQ
CHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
PPTVVMGVPGFFDGVKKRIERLTPAGETDPAARRLRIDALLGGRIRYLWTGSAPANPQTL
CCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEEECCEEEEEEECCCCCCCHHH
RFFEEAGVPIFEGYGMNETCIVSKNYPGQARTGSVGRLLPGKRARIDEHGVLVVGAEQPV
HHHHHCCCCEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
NTRYLYSAPGASEKIFLPTGEVRTGDLARIDEDGFLYILGRADDLIVLANGKNVHVRSLE
CCEEEEECCCCCCEEEECCCCCCCCCCEEECCCCEEEEEECCCCEEEEECCCEEEHHHHH
ERVKAHQGVEECVLFGSGKPFLVAVVSPQDARADHAAIRAHLSELNASLAPDERIVRAFI
HHHHHHCCHHHEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHEEEE
TPEPFRGQTRFVTSQFKPKRNEIFNAFRQEIDQLYGASA
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRPPSVINAVAANGGKHATQRVTFFQQGGRIDLTHAQLDALAARLALRLREAGLKRGAR
CCCCHHHHHHHCCCCCHHHHEEHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCE
IGIVARNGLAWVLLDLAALKAGYVTAGFEFGKFEANRELVERYALDAILADGGAPFAARG
EEEEEECCHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHEECCCCCHHHCC
VHDLRELVEAVVAQAGDGREVDPVAPAFDTAVYGEDDVTTIKFTSGSSGEPKGLAARVGS
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCCCCCCHHHHHCC
IDASLAAVQQIYAHGPDDDLLVFLPLSLLQQRYWIYSALAYGHATTVTRFEYALEIARRQ
CHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
PPTVVMGVPGFFDGVKKRIERLTPAGETDPAARRLRIDALLGGRIRYLWTGSAPANPQTL
CCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEEECCEEEEEEECCCCCCCHHH
RFFEEAGVPIFEGYGMNETCIVSKNYPGQARTGSVGRLLPGKRARIDEHGVLVVGAEQPV
HHHHHCCCCEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
NTRYLYSAPGASEKIFLPTGEVRTGDLARIDEDGFLYILGRADDLIVLANGKNVHVRSLE
CCEEEEECCCCCCEEEECCCCCCCCCCEEECCCCEEEEEECCCCEEEEECCCEEEHHHHH
ERVKAHQGVEECVLFGSGKPFLVAVVSPQDARADHAAIRAHLSELNASLAPDERIVRAFI
HHHHHHCCHHHEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHEEEE
TPEPFRGQTRFVTSQFKPKRNEIFNAFRQEIDQLYGASA
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-ACP; 2-acyl-sn-glycero-3-phosphoethanolamine; ATP; a fatty acid [C]

Specific reaction: acyl-ACP + 2-acyl-sn-glycero-3-phosphoethanolamine = [acyl carrier protein] + L-1-phosphatidyl-ethanolamine ATP + a fatty acid + [acyl carrier protein] = AMP + pyrophosphate + acyl-ACP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]