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The map label for this gene is metR [H]

Identifier: 238026498

GI number: 238026498

Start: 907177

End: 908109

Strand: Reverse

Name: metR [H]

Synonym: bglu_1g08420

Alternate gene names: 238026498

Gene position: 908109-907177 (Counterclockwise)

Preceding gene: 238026500

Following gene: 238026497

Centisome position: 23.25

GC content: 69.24

Gene sequence:

>933_bases
ATGAATCGCTCGCCGCTTGAGCTGCGCCATCTGCAGACCCTCACGGCGCTGCGCGATACCGGCAACCTGTCGCGCGCGGC
TCAGGTGCTCTGCGTCACGCAGTCGGCGCTCTCGCATCAGTTGAAGGCGCTCGAGACCCACTACGGGCTGCCGCTATTCG
TGCGCAAGTCCTCGCCGCTCGCGTTCACGGCGGCCGGCAAGCGGCTGCTCGCGCTGGCCGACCAGTTGGTGCCGGTAGTC
GACGAGGCCGAGCGCGATCTCGCGCGGCTCGCGCAGGGCACGGGCGGCGCGCTGCGCATCGCGGTGGAGTGCCATACCTG
CTTCGACTGGCTGATGCCGGCCATGGATGCATTCCGGCAGCGCTGGCCGGAGGTGGAGTTGGATATCGTTTCCGGTTTCC
ATGCCGATCCGGTCGGCCTGCTGCACCAGGACCGCGCCGATCTCGCGATCGTCGCCGAGACCGAGCCCGAGGACGGCGTC
GAATTCCACCCGCTGTTCCGCTTCCAGATCGTCGGCCTGGTCGGCAACGACCACGCGCTCGCCAGGCGCGCCGCGCTCGT
TGCCGACGATTTCCGCGACGAGACGCTGATCACCTACCCGGTGCCCGACGACATGCTCGACATCGTCCGCCAGGTGCTGC
GCCCGGCCGGCATCGAGCCGAAGCGGCGCACCTCGGAACTGACCGTGGCGATCCTGCAACTGGTGGCGAGCCGGCGCGGC
GTGGCCGCGCTGCCGCTGTGGGCCGTCGCCACCTATCTCGACAAGCATTACGTCACCTCGCGGCCGGTGCTGCGCGCAAG
CGGCGCCACGCTGTCGGGCGAGCTGTATGCCGCCACGCTGCCGGCCTTCTCGCGGCGCCCCTATCTCGTCGATTTCGTGC
GCACCATGCGTGCGACCAGCGTCGCGTCGCTACCCGAAATCGAGCTGTTGTGA

Upstream 100 bases:

>100_bases
ATGGGCTGCAGTATCGGATCTCGCTTATCATTACTCAAACGAAATTTTCTTGAGTTGAACATGAAAAATATTCAGGTTCA
CGCTGCTACTGAACGCCGCC

Downstream 100 bases:

>100_bases
CCGGGCCGTCACGCCCGTGGCCGTGATACGGAACAAAAAGGCGGCGGTGCGTCAGGGCGGCGCGGGTAAAATTGCGAAAA
ACAGCTATTTTCCCGCCTCT

Product: transcriptional activator MetR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MNRSPLELRHLQTLTALRDTGNLSRAAQVLCVTQSALSHQLKALETHYGLPLFVRKSSPLAFTAAGKRLLALADQLVPVV
DEAERDLARLAQGTGGALRIAVECHTCFDWLMPAMDAFRQRWPEVELDIVSGFHADPVGLLHQDRADLAIVAETEPEDGV
EFHPLFRFQIVGLVGNDHALARRAALVADDFRDETLITYPVPDDMLDIVRQVLRPAGIEPKRRTSELTVAILQLVASRRG
VAALPLWAVATYLDKHYVTSRPVLRASGATLSGELYAATLPAFSRRPYLVDFVRTMRATSVASLPEIELL

Sequences:

>Translated_310_residues
MNRSPLELRHLQTLTALRDTGNLSRAAQVLCVTQSALSHQLKALETHYGLPLFVRKSSPLAFTAAGKRLLALADQLVPVV
DEAERDLARLAQGTGGALRIAVECHTCFDWLMPAMDAFRQRWPEVELDIVSGFHADPVGLLHQDRADLAIVAETEPEDGV
EFHPLFRFQIVGLVGNDHALARRAALVADDFRDETLITYPVPDDMLDIVRQVLRPAGIEPKRRTSELTVAILQLVASRRG
VAALPLWAVATYLDKHYVTSRPVLRASGATLSGELYAATLPAFSRRPYLVDFVRTMRATSVASLPEIELL
>Mature_310_residues
MNRSPLELRHLQTLTALRDTGNLSRAAQVLCVTQSALSHQLKALETHYGLPLFVRKSSPLAFTAAGKRLLALADQLVPVV
DEAERDLARLAQGTGGALRIAVECHTCFDWLMPAMDAFRQRWPEVELDIVSGFHADPVGLLHQDRADLAIVAETEPEDGV
EFHPLFRFQIVGLVGNDHALARRAALVADDFRDETLITYPVPDDMLDIVRQVLRPAGIEPKRRTSELTVAILQLVASRRG
VAALPLWAVATYLDKHYVTSRPVLRASGATLSGELYAATLPAFSRRPYLVDFVRTMRATSVASLPEIELL

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=303, Percent_Identity=38.9438943894389, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI1787879, Length=249, Percent_Identity=27.3092369477912, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788296, Length=188, Percent_Identity=32.4468085106383, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI157672245, Length=247, Percent_Identity=26.7206477732794, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082132, Length=270, Percent_Identity=28.5185185185185, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786401, Length=157, Percent_Identity=29.9363057324841, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790208, Length=150, Percent_Identity=30.6666666666667, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI145693105, Length=241, Percent_Identity=23.2365145228216, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI87082024, Length=152, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI2367136, Length=215, Percent_Identity=24.6511627906977, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789173, Length=108, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34212; Mature: 34212

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSPLELRHLQTLTALRDTGNLSRAAQVLCVTQSALSHQLKALETHYGLPLFVRKSSPL
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCE
AFTAAGKRLLALADQLVPVVDEAERDLARLAQGTGGALRIAVECHTCFDWLMPAMDAFRQ
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHH
RWPEVELDIVSGFHADPVGLLHQDRADLAIVAETEPEDGVEFHPLFRFQIVGLVGNDHAL
HCCCCEEEEECCCCCCCCCHHCCCCCCEEEEEECCCCCCCEECEEEEEEEEEEECCCHHH
ARRAALVADDFRDETLITYPVPDDMLDIVRQVLRPAGIEPKRRTSELTVAILQLVASRRG
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
VAALPLWAVATYLDKHYVTSRPVLRASGATLSGELYAATLPAFSRRPYLVDFVRTMRATS
CCHHHHHHHHHHHHHHHCCCCCEEEECCCEECCCEEEEECCCCCCCCHHHHHHHHHHHHH
VASLPEIELL
HCCCCCEECC
>Mature Secondary Structure
MNRSPLELRHLQTLTALRDTGNLSRAAQVLCVTQSALSHQLKALETHYGLPLFVRKSSPL
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCE
AFTAAGKRLLALADQLVPVVDEAERDLARLAQGTGGALRIAVECHTCFDWLMPAMDAFRQ
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHH
RWPEVELDIVSGFHADPVGLLHQDRADLAIVAETEPEDGVEFHPLFRFQIVGLVGNDHAL
HCCCCEEEEECCCCCCCCCHHCCCCCCEEEEEECCCCCCCEECEEEEEEEEEEECCCHHH
ARRAALVADDFRDETLITYPVPDDMLDIVRQVLRPAGIEPKRRTSELTVAILQLVASRRG
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
VAALPLWAVATYLDKHYVTSRPVLRASGATLSGELYAATLPAFSRRPYLVDFVRTMRATS
CCHHHHHHHHHHHHHHHCCCCCEEEECCCEECCCEEEEECCCCCCCCHHHHHHHHHHHHH
VASLPEIELL
HCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]