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The map label for this gene is hemL [H]

Identifier: 238026458

GI number: 238026458

Start: 861686

End: 862969

Strand: Reverse

Name: hemL [H]

Synonym: bglu_1g08010

Alternate gene names: 238026458

Gene position: 862969-861686 (Counterclockwise)

Preceding gene: 238026460

Following gene: 238026457

Centisome position: 22.09

GC content: 70.56

Gene sequence:

>1284_bases
ATGTCGAACAATCAAACGCTCTTCGAACGCGCCCAGCGAACCATTCCCGGCGGCGTCAACTCGCCCGTGCGCGCCTTTCG
CTCGGTGGGCGGCACGCCGCGCTTCGTGTCGCGCGCGCAAGGCCCGTACTTCTGGGACGCCGACGGGCAGCGCTATATCG
ACTACATCGGCTCGTGGGGGCCGATGATCGTCGGCCATGTTCATCCCGAGGTGCTGGCCGCCGTGCAGGCCGTGCTCGCC
GACGGCTTCTCGTTCGGCGCGCCCACCGAGGCCGAGATCGAGATCGCCGAGGAGATCTGCAAGCTGGTGCCCTCGATCGA
GCAGGTGCGGATGGTATCGAGCGGCACCGAGGCCACCATGAGCGCGCTGCGCCTGGCGCGCGGCTTCACCGGCCGCAGCC
GGATCGTGAAGTTCGAGGGCTGCTACCACGGCCACGCCGACAGCCTGCTCGTGAAGGCCGGCTCGGGCCTGCTGACGTTC
GGCAACCCGACCTCGGCCGGCGTGCCCGCCGACATCGCCAAGCACACCACCGTGCTCGAGTACAACAACGTGGCCGAGCT
CGAAGCAGCGTTCGGCGCGTTCGGCGACGAGATCGCCGCCGTGATCGTCGAGCCCGTGGCCGGCAACATGAACCTCGTGC
GCGGCACCGCCGAATTCCTGAACGCGCTGCGCGCGCTCTGCACGAAGCACGGCGCCGTGCTGATCTTCGACGAGGTGATG
TGCGGCTTCCGCGTCGCGCTCGGCGGCGCGCAACAGCACTACGGCATCCAGGCCGACCTGACCTGCCTGGGCAAGGTGAT
CGGCGGCGGCATGCCCGCCGCGGCGTTCGGCGGGCGCCGCGACATCATGGCGCAGCTCGCGCCGCTCGGCGGCGTCTATC
AGGCCGGCACGCTGTCGGGCAACCCGATCGCCGTGGCCGCGGGCCTGAAGACGCTGCAGCTGATCCAGGCGCCCGGCTTC
TACGACGCGCTCGCCGCGCAGACGAGGCGCCTCGCCGACGGCCTCGCCGCCGAGGCGCGCGCGGCCGGCGTCGCGTTCAG
CGCCGATGCGATCGGCGCGATGTTCGGCCTCTACTTCACCGAGGCCGTGCCGACCAGCTTCGCCGACGTGACCCAGAGCG
ACATCGCGCGCTTCAACCGCTTCTTCCACCTGATGCTCGACGAAGGCGTCTATTTCGCACCGTCCGCGTATGAGGCCGGC
TTCGTCTCCAGCACCCACGACGACGCCGTGATCGACGCGACGCTCGCCGCCGCGCGCCGCGCCTTCGCCGCGCTGGCCGC
CTGA

Upstream 100 bases:

>100_bases
TGCCCATTGTGTTCGCACGGTTTCGTGCGTTCGCGGCTGGGACGACGCGGCGGTCGTCGCGCCCCGCCCGGCCGCCGCCT
CTCACCGCGGGTCCTTATCC

Downstream 100 bases:

>100_bases
CCTACCACGGAGCACCGGATGTTCTCGGATACCGATTTCGCGCACATGCAACGCGCGCTCGACCTGTCGTCGCGCGGGAT
GTATACGACCACGCCGAATC

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSNNQTLFERAQRTIPGGVNSPVRAFRSVGGTPRFVSRAQGPYFWDADGQRYIDYIGSWGPMIVGHVHPEVLAAVQAVLA
DGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTF
GNPTSAGVPADIAKHTTVLEYNNVAELEAAFGAFGDEIAAVIVEPVAGNMNLVRGTAEFLNALRALCTKHGAVLIFDEVM
CGFRVALGGAQQHYGIQADLTCLGKVIGGGMPAAAFGGRRDIMAQLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGF
YDALAAQTRRLADGLAAEARAAGVAFSADAIGAMFGLYFTEAVPTSFADVTQSDIARFNRFFHLMLDEGVYFAPSAYEAG
FVSSTHDDAVIDATLAAARRAFAALAA

Sequences:

>Translated_427_residues
MSNNQTLFERAQRTIPGGVNSPVRAFRSVGGTPRFVSRAQGPYFWDADGQRYIDYIGSWGPMIVGHVHPEVLAAVQAVLA
DGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTF
GNPTSAGVPADIAKHTTVLEYNNVAELEAAFGAFGDEIAAVIVEPVAGNMNLVRGTAEFLNALRALCTKHGAVLIFDEVM
CGFRVALGGAQQHYGIQADLTCLGKVIGGGMPAAAFGGRRDIMAQLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGF
YDALAAQTRRLADGLAAEARAAGVAFSADAIGAMFGLYFTEAVPTSFADVTQSDIARFNRFFHLMLDEGVYFAPSAYEAG
FVSSTHDDAVIDATLAAARRAFAALAA
>Mature_426_residues
SNNQTLFERAQRTIPGGVNSPVRAFRSVGGTPRFVSRAQGPYFWDADGQRYIDYIGSWGPMIVGHVHPEVLAAVQAVLAD
GFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFG
NPTSAGVPADIAKHTTVLEYNNVAELEAAFGAFGDEIAAVIVEPVAGNMNLVRGTAEFLNALRALCTKHGAVLIFDEVMC
GFRVALGGAQQHYGIQADLTCLGKVIGGGMPAAAFGGRRDIMAQLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGFY
DALAAQTRRLADGLAAEARAAGVAFSADAIGAMFGLYFTEAVPTSFADVTQSDIARFNRFFHLMLDEGVYFAPSAYEAGF
VSSTHDDAVIDATLAAARRAFAALAA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=331, Percent_Identity=26.5861027190332, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI284507298, Length=256, Percent_Identity=25.390625, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=60.093896713615, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1789016, Length=412, Percent_Identity=31.0679611650485, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788044, Length=335, Percent_Identity=30.7462686567164, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1789759, Length=311, Percent_Identity=28.9389067524116, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI1787560, Length=359, Percent_Identity=29.8050139275766, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI145693181, Length=337, Percent_Identity=30.2670623145401, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786991, Length=385, Percent_Identity=27.5324675324675, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=363, Percent_Identity=24.7933884297521, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=344, Percent_Identity=27.6162790697674, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=364, Percent_Identity=23.3516483516484, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=340, Percent_Identity=26.7647058823529, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324432, Length=355, Percent_Identity=25.3521126760563, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357415, Length=320, Percent_Identity=25.625, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21356575, Length=348, Percent_Identity=27.0114942528736, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 44793; Mature: 44662

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNQTLFERAQRTIPGGVNSPVRAFRSVGGTPRFVSRAQGPYFWDADGQRYIDYIGSWG
CCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEECCCCCHHHHHHCCCC
PMIVGHVHPEVLAAVQAVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADIAKHTTVLE
HHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHCCEEEE
YNNVAELEAAFGAFGDEIAAVIVEPVAGNMNLVRGTAEFLNALRALCTKHGAVLIFDEVM
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHH
CGFRVALGGAQQHYGIQADLTCLGKVIGGGMPAAAFGGRRDIMAQLAPLGGVYQAGTLSG
HHHHHHHCCCHHHCCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCEECCCCCC
NPIAVAAGLKTLQLIQAPGFYDALAAQTRRLADGLAAEARAAGVAFSADAIGAMFGLYFT
CCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHH
EAVPTSFADVTQSDIARFNRFFHLMLDEGVYFAPSAYEAGFVSSTHDDAVIDATLAAARR
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AFAALAA
HHHHHCC
>Mature Secondary Structure 
SNNQTLFERAQRTIPGGVNSPVRAFRSVGGTPRFVSRAQGPYFWDADGQRYIDYIGSWG
CCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEECCCCCHHHHHHCCCC
PMIVGHVHPEVLAAVQAVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADIAKHTTVLE
HHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHCCEEEE
YNNVAELEAAFGAFGDEIAAVIVEPVAGNMNLVRGTAEFLNALRALCTKHGAVLIFDEVM
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHH
CGFRVALGGAQQHYGIQADLTCLGKVIGGGMPAAAFGGRRDIMAQLAPLGGVYQAGTLSG
HHHHHHHCCCHHHCCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCEECCCCCC
NPIAVAAGLKTLQLIQAPGFYDALAAQTRRLADGLAAEARAAGVAFSADAIGAMFGLYFT
CCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHH
EAVPTSFADVTQSDIARFNRFFHLMLDEGVYFAPSAYEAGFVSSTHDDAVIDATLAAARR
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AFAALAA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA