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The map label for this gene is rmlA1 [H]

Identifier: 238026392

GI number: 238026392

Start: 785451

End: 786344

Strand: Direct

Name: rmlA1 [H]

Synonym: bglu_1g07270

Alternate gene names: 238026392

Gene position: 785451-786344 (Clockwise)

Preceding gene: 238026391

Following gene: 238026393

Centisome position: 20.11

GC content: 63.76

Gene sequence:

>894_bases
ATGGCACGCAAGGGCATCATTCTGGCCGGCGGTTCCGGCACCCGTCTGTACCCGATCACGCATGCGGTGTCGAAGCAGCT
GCTGCCGGTGTACGACAAGCCGATGATCTACTATCCGCTGTCGACGCTGATGATCGCGGGAATCCGCGACGTGCTGATCA
TCTCGACGCCGCAGGACACGCCGCGCTTCGAGGCCATGCTCGGCGACGGCGCGCAGTGGGGCATGAACATTTCCTACGCG
GTGCAGCCGTCTCCGGACGGGCTCGCGCAGGCGTTCATCATCGGCCGCGAGTTCATCGGCCGCGATCCGTCGACGCTGAT
TCTCGGTGACAACATTTTCTACGGCCACGATCTCGCCGGGCAGCTCGAGCGGGCCAACGCCCAGCAGAGCGGCGCGACGG
TGTTCGCCTATCACGTTCAGGACCCGGAACGCTACGGCGTGGTCGAGTTCGACGCGTCGTTCCGCGCGTTGTCGATCGAG
GAAAAGCCCGCCAAGCCGCGCTCGAACTATGCCGTGACCGGGCTGTACTTCTACGACAACCGCGTGTGCGACATTGCCGC
CGACATCAAGCCGTCCGCGCGCGGCGAGCTGGAAATCACCGACGTGAACTCGCGCTATCTCGAAGACGACGCGCTCGACG
TCGAGATCATGGGACGCGGCTACGCGTGGCTCGACACCGGCACGCATGACTCGCTGATCGAGGCCGCGACCTTCATCGCC
ACGCTGCAGAAGCGCCAGGGGCTGATGGTGGCGTGTCCTGAAGAAATCGCCTATCGCAGGCAGTGGATCGACGCCGAGCA
ACTGACGCGACTGGCCGAGCCGCTCGCGAAGAACGGCTACGGCCGCTATCTCAAAAACCTTCTCATGGATCAAGTGGTAT
GGCCATCCAGGTAA

Upstream 100 bases:

>100_bases
TGGTATCTCGATAACCAGCCGTGGGCCGCCGAGGTTGCCTCGGGCGAATATCGTAACTGGGTCGAGATGAACTACGCGCG
GCGCGCGTGACGGAGGCGAG

Downstream 100 bases:

>100_bases
CCGCCACGGCGCTTCCCGAAGTCAAGCTCATCGAGCCGAAGGTGTTCGGCGACGCGCGCGGGTTCTTCTACGAGAGCTTC
ACCGCGCGCGAGTTCGCGGC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MARKGIILAGGSGTRLYPITHAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDTPRFEAMLGDGAQWGMNISYA
VQPSPDGLAQAFIIGREFIGRDPSTLILGDNIFYGHDLAGQLERANAQQSGATVFAYHVQDPERYGVVEFDASFRALSIE
EKPAKPRSNYAVTGLYFYDNRVCDIAADIKPSARGELEITDVNSRYLEDDALDVEIMGRGYAWLDTGTHDSLIEAATFIA
TLQKRQGLMVACPEEIAYRRQWIDAEQLTRLAEPLAKNGYGRYLKNLLMDQVVWPSR

Sequences:

>Translated_297_residues
MARKGIILAGGSGTRLYPITHAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDTPRFEAMLGDGAQWGMNISYA
VQPSPDGLAQAFIIGREFIGRDPSTLILGDNIFYGHDLAGQLERANAQQSGATVFAYHVQDPERYGVVEFDASFRALSIE
EKPAKPRSNYAVTGLYFYDNRVCDIAADIKPSARGELEITDVNSRYLEDDALDVEIMGRGYAWLDTGTHDSLIEAATFIA
TLQKRQGLMVACPEEIAYRRQWIDAEQLTRLAEPLAKNGYGRYLKNLLMDQVVWPSR
>Mature_296_residues
ARKGIILAGGSGTRLYPITHAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDTPRFEAMLGDGAQWGMNISYAV
QPSPDGLAQAFIIGREFIGRDPSTLILGDNIFYGHDLAGQLERANAQQSGATVFAYHVQDPERYGVVEFDASFRALSIEE
KPAKPRSNYAVTGLYFYDNRVCDIAADIKPSARGELEITDVNSRYLEDDALDVEIMGRGYAWLDTGTHDSLIEAATFIAT
LQKRQGLMVACPEEIAYRRQWIDAEQLTRLAEPLAKNGYGRYLKNLLMDQVVWPSR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=248, Percent_Identity=25.4032258064516, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI11761619, Length=248, Percent_Identity=25.4032258064516, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=72.5694444444444, Blast_Score=446, Evalue=1e-127,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=64.2105263157895, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1787488, Length=247, Percent_Identity=25.5060728744939, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=182, Percent_Identity=24.7252747252747, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=247, Percent_Identity=27.5303643724696, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21355443, Length=245, Percent_Identity=23.265306122449, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24644084, Length=245, Percent_Identity=23.265306122449, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33076; Mature: 32945

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKGIILAGGSGTRLYPITHAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDT
CCCCCEEEECCCCCEEEEEHHHHHHCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFEAMLGDGAQWGMNISYAVQPSPDGLAQAFIIGREFIGRDPSTLILGDNIFYGHDLAG
CCHHHEECCCCHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCHH
QLERANAQQSGATVFAYHVQDPERYGVVEFDASFRALSIEEKPAKPRSNYAVTGLYFYDN
HHHHCCCCCCCCEEEEEEECCCCCCCEEEECCCEEEEEECCCCCCCCCCEEEEEEEEECC
RVCDIAADIKPSARGELEITDVNSRYLEDDALDVEIMGRGYAWLDTGTHDSLIEAATFIA
EEEEEEECCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHH
TLQKRQGLMVACPEEIAYRRQWIDAEQLTRLAEPLAKNGYGRYLKNLLMDQVVWPSR
HHHHHCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ARKGIILAGGSGTRLYPITHAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDT
CCCCEEEECCCCCEEEEEHHHHHHCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFEAMLGDGAQWGMNISYAVQPSPDGLAQAFIIGREFIGRDPSTLILGDNIFYGHDLAG
CCHHHEECCCCHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCHH
QLERANAQQSGATVFAYHVQDPERYGVVEFDASFRALSIEEKPAKPRSNYAVTGLYFYDN
HHHHCCCCCCCCEEEEEEECCCCCCCEEEECCCEEEEEECCCCCCCCCCEEEEEEEEECC
RVCDIAADIKPSARGELEITDVNSRYLEDDALDVEIMGRGYAWLDTGTHDSLIEAATFIA
EEEEEEECCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHH
TLQKRQGLMVACPEEIAYRRQWIDAEQLTRLAEPLAKNGYGRYLKNLLMDQVVWPSR
HHHHHCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]