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The map label for this gene is hemH [H]

Identifier: 238026296

GI number: 238026296

Start: 671398

End: 672465

Strand: Direct

Name: hemH [H]

Synonym: bglu_1g06300

Alternate gene names: 238026296

Gene position: 671398-672465 (Clockwise)

Preceding gene: 238026295

Following gene: 238026297

Centisome position: 17.19

GC content: 70.51

Gene sequence:

>1068_bases
ATGCGTTTTGATCTCGAACCACCGTCGCAACACGCCGCGGCGCATCGCGTCGCCGTCCTGCTCGTCAATCTCGGTACGCC
CGACGCGCCCACTCCGGGCGCGGTGCGGCGCTACCTCGCGCAGTTCCTGTCGGACCCGCGCGTGGTCGAAATCCCGGCCA
TCGCCTGGCAGCCGATCCTGCGCGGGCTGATCCTGCCGCTGCGTTCGCGCGCCTCGGCGAAGAAATACCGGTCGGTGTGG
ATGCCCGAGGGCTCGCCGCTGCGCGTGTATACCGAACGGCAGGTCGAGGGCCTGCGCCCGCTGTTCGCCGCGAACGGCTA
CCAGGTGCTGATCGACTACGCGATGCGCTACGGCACGCCCGACATCGGCACGGTGCTCGGCCAGCTGAAGCGCGCCGGCA
CCGAGCGCGTGTTGCTGGTGCCGATGTATCCGCAGTACTCGTCGTCGACCACGGCCACCGCGTTCGACGCTGCGTTCGCC
GCGCTCGGCCGCATGCGCAACCAGCTCGAGGTCCGCACGCTGCGCCACTACGCCGATCATCCCGCCTACATCCACGCGCT
CGCCGAGCAGGTCCGCCAATACTGGGCCGAGCACGGGCGCCCCGATTTCGCGGCCGGCGACAAGCTGGTGCTGAGCTTCC
ACGGCGTGCCCAAGCGCACGCTCGACCTCGGCGACCCCTATCATGACCAGTGCCAGCAGACGGGCGCGTTGCTGATGGCC
GCACTCGAACTGACCCCGCTCGAATGCCGCGTCACGTTCCAGTCGCGCTTCGGCAAGGCCGAATGGCTGCAGCCCTACAC
GGCGCCGACGCTGCGCGAGCTCGGCGCGGCCGGCGTCAGGCGCGCCGACGTGTTCTGCCCGGGCTTCACGGCCGACTGCC
TCGAAACGATCGAGGAGATCGGCATGGAGGTGCGCGACGAGTTTCTGCACGGCGGCGGCGGGACGTTCCACCGGATTCCG
TGCCTGAACGCGTCGCCGGCCTGGATCGACGCGCTCGGCCAGATCGTGGCCGAGAACCTGCAGGGCTGGCCGGTGCGCGC
GCCGGCGCCGGCCGACGCGGCGGCATGA

Upstream 100 bases:

>100_bases
GATACGTGCGCCGGAGGCATTGGGGCGGCATCGGTCGCGCCGCGGCGGCCTCGCTATAATGAGGCTCGTTCGATCCGGTG
CCCAGGCCCACCTTCCGTTC

Downstream 100 bases:

>100_bases
CGGCGAACCGGCCGCGCGACGGCCACTGAGACGGGAAAGATCCGATGAATCACCGAATTTCGACCGAACCGGGCGCGAAG
CTGCGCATCGACAAATGGCT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MRFDLEPPSQHAAAHRVAVLLVNLGTPDAPTPGAVRRYLAQFLSDPRVVEIPAIAWQPILRGLILPLRSRASAKKYRSVW
MPEGSPLRVYTERQVEGLRPLFAANGYQVLIDYAMRYGTPDIGTVLGQLKRAGTERVLLVPMYPQYSSSTTATAFDAAFA
ALGRMRNQLEVRTLRHYADHPAYIHALAEQVRQYWAEHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
ALELTPLECRVTFQSRFGKAEWLQPYTAPTLRELGAAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLHGGGGTFHRIP
CLNASPAWIDALGQIVAENLQGWPVRAPAPADAAA

Sequences:

>Translated_355_residues
MRFDLEPPSQHAAAHRVAVLLVNLGTPDAPTPGAVRRYLAQFLSDPRVVEIPAIAWQPILRGLILPLRSRASAKKYRSVW
MPEGSPLRVYTERQVEGLRPLFAANGYQVLIDYAMRYGTPDIGTVLGQLKRAGTERVLLVPMYPQYSSSTTATAFDAAFA
ALGRMRNQLEVRTLRHYADHPAYIHALAEQVRQYWAEHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
ALELTPLECRVTFQSRFGKAEWLQPYTAPTLRELGAAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLHGGGGTFHRIP
CLNASPAWIDALGQIVAENLQGWPVRAPAPADAAA
>Mature_355_residues
MRFDLEPPSQHAAAHRVAVLLVNLGTPDAPTPGAVRRYLAQFLSDPRVVEIPAIAWQPILRGLILPLRSRASAKKYRSVW
MPEGSPLRVYTERQVEGLRPLFAANGYQVLIDYAMRYGTPDIGTVLGQLKRAGTERVLLVPMYPQYSSSTTATAFDAAFA
ALGRMRNQLEVRTLRHYADHPAYIHALAEQVRQYWAEHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
ALELTPLECRVTFQSRFGKAEWLQPYTAPTLRELGAAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLHGGGGTFHRIP
CLNASPAWIDALGQIVAENLQGWPVRAPAPADAAA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=338, Percent_Identity=25.4437869822485, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI60499025, Length=338, Percent_Identity=25.4437869822485, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=45.3416149068323, Blast_Score=275, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6324750, Length=336, Percent_Identity=24.1071428571429, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17864156, Length=341, Percent_Identity=24.9266862170088, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24651774, Length=269, Percent_Identity=24.5353159851301, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39206; Mature: 39206

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDLEPPSQHAAAHRVAVLLVNLGTPDAPTPGAVRRYLAQFLSDPRVVEIPAIAWQPIL
CCCCCCCCHHHHHHHEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHH
RGLILPLRSRASAKKYRSVWMPEGSPLRVYTERQVEGLRPLFAANGYQVLIDYAMRYGTP
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCHHHHCCCHHHHHHHHHHCCCC
DIGTVLGQLKRAGTERVLLVPMYPQYSSSTTATAFDAAFAALGRMRNQLEVRTLRHYADH
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PAYIHALAEQVRQYWAEHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALELTPLECRVTFQSRFGKAEWLQPYTAPTLRELGAAGVRRADVFCPGFTADCLETIEEI
HHHCCCCEEEEEHHHHCCCHHHCCCCCCHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHH
GMEVRDEFLHGGGGTFHRIPCLNASPAWIDALGQIVAENLQGWPVRAPAPADAAA
HHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRFDLEPPSQHAAAHRVAVLLVNLGTPDAPTPGAVRRYLAQFLSDPRVVEIPAIAWQPIL
CCCCCCCCHHHHHHHEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHH
RGLILPLRSRASAKKYRSVWMPEGSPLRVYTERQVEGLRPLFAANGYQVLIDYAMRYGTP
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCHHHHCCCHHHHHHHHHHCCCC
DIGTVLGQLKRAGTERVLLVPMYPQYSSSTTATAFDAAFAALGRMRNQLEVRTLRHYADH
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PAYIHALAEQVRQYWAEHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALELTPLECRVTFQSRFGKAEWLQPYTAPTLRELGAAGVRRADVFCPGFTADCLETIEEI
HHHCCCCEEEEEHHHHCCCHHHCCCCCCHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHH
GMEVRDEFLHGGGGTFHRIPCLNASPAWIDALGQIVAENLQGWPVRAPAPADAAA
HHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA