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The map label for this gene is proC [H]

Identifier: 238026280

GI number: 238026280

Start: 646561

End: 647376

Strand: Reverse

Name: proC [H]

Synonym: bglu_1g06130

Alternate gene names: 238026280

Gene position: 647376-646561 (Counterclockwise)

Preceding gene: 238026281

Following gene: 238026275

Centisome position: 16.57

GC content: 73.65

Gene sequence:

>816_bases
ATGAAAATTGCATTCATCGGCGGCGGCAACATGGCCTCCGCTCTGATCGGCGGCATCGTCAAGCGCGGCACGGCCGCGCC
CGACACGCTCTACGTGATCGATCCCAACGACGGCTCGCGCACCAAGCTACGCGAGACGTTCGGCGTGCGTACCGGCGAGA
CGGTCGACGCCGCGCTGGCCGGCTACGACGCGATCGTGCTGGCGGTCAAGCCGCAGGTGCTCGCTGAAGTCGCGAAGACG
CTCGCGCCGCATCTGGGCGGCGCGCTCGTCATCAGCATCGCGGCCGGCGTCCGCGCGACCGACCTGTCGCGCTGGCTCGG
CGGCTACGCGCGCGTCGTGCGCGCCATGCCGAACACGCCGGCGCTGGTCGGCATGGGCGTGACGGGGCTCGCCGCGCTGC
CGGGCGTGGACGCGGCCGGCCGCGAACTCGGCTCGGCCGTGCTCGGCGCGGTCGGCGAGACCGTGTGGTTCGACGACGAA
GCGAAGCTCGACGCCGTCACCGCGATCTCGGGCAGCGGCCCGGCCTACGTGTTCTATTTCATCGAGGCGCTGCAGGAAGC
GGCGCGCCAGCTCGGCCTGAACGACGAGCAGGGCCGCGCGCTGGCGGTGGCGACGTTCACCGGCGCCGCGCAACTGGCCG
CGCAGTCGGGCGAGCCGGCCGGCGTGCTGCGCGAGCGCGTGACCTCGAAGGGCGGCACGACGGCGGCCGCGCTCGCCGCG
TTCGACGCGCAGGACCTGAAGCAGGCGATCGTGCGCGGCGTGCTGGCGGCCGAGGCGCGCGCGCGCGAACTCGGCAACGA
GCTGGGCGGCGCCTGA

Upstream 100 bases:

>100_bases
GAAGGCGCGACGATCGTCCGGATCGGCACCGCGATCTTCGGCGCCCGCGATTATTCGACGCCGAGCGCGTCCTGACCCTT
CGCTTTTCCTCCCAACCATC

Downstream 100 bases:

>100_bases
GCCGGCGCGGCCGGCGCGGCCGGCGCGACGGGCGCCCGGCATCGGCACGCTGCGCCGGAGCGCTTCGGCCGCCTCGCTCG
CCGCCGCCGTCCGGCCGGTA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MKIAFIGGGNMASALIGGIVKRGTAAPDTLYVIDPNDGSRTKLRETFGVRTGETVDAALAGYDAIVLAVKPQVLAEVAKT
LAPHLGGALVISIAAGVRATDLSRWLGGYARVVRAMPNTPALVGMGVTGLAALPGVDAAGRELGSAVLGAVGETVWFDDE
AKLDAVTAISGSGPAYVFYFIEALQEAARQLGLNDEQGRALAVATFTGAAQLAAQSGEPAGVLRERVTSKGGTTAAALAA
FDAQDLKQAIVRGVLAAEARARELGNELGGA

Sequences:

>Translated_271_residues
MKIAFIGGGNMASALIGGIVKRGTAAPDTLYVIDPNDGSRTKLRETFGVRTGETVDAALAGYDAIVLAVKPQVLAEVAKT
LAPHLGGALVISIAAGVRATDLSRWLGGYARVVRAMPNTPALVGMGVTGLAALPGVDAAGRELGSAVLGAVGETVWFDDE
AKLDAVTAISGSGPAYVFYFIEALQEAARQLGLNDEQGRALAVATFTGAAQLAAQSGEPAGVLRERVTSKGGTTAAALAA
FDAQDLKQAIVRGVLAAEARARELGNELGGA
>Mature_271_residues
MKIAFIGGGNMASALIGGIVKRGTAAPDTLYVIDPNDGSRTKLRETFGVRTGETVDAALAGYDAIVLAVKPQVLAEVAKT
LAPHLGGALVISIAAGVRATDLSRWLGGYARVVRAMPNTPALVGMGVTGLAALPGVDAAGRELGSAVLGAVGETVWFDDE
AKLDAVTAISGSGPAYVFYFIEALQEAARQLGLNDEQGRALAVATFTGAAQLAAQSGEPAGVLRERVTSKGGTTAAALAA
FDAQDLKQAIVRGVLAAEARARELGNELGGA

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=267, Percent_Identity=31.0861423220974, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=29.368029739777, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=29.368029739777, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI21361454, Length=274, Percent_Identity=29.1970802919708, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=33.0827067669173, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=32.7137546468402, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=29.2857142857143, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320861, Length=284, Percent_Identity=30.2816901408451, Blast_Score=112, Evalue=7e-26,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=36.7424242424242, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=31.1594202898551, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24647700, Length=172, Percent_Identity=36.6279069767442, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27412; Mature: 27412

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIGGGNMASALIGGIVKRGTAAPDTLYVIDPNDGSRTKLRETFGVRTGETVDAALA
CEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHH
GYDAIVLAVKPQVLAEVAKTLAPHLGGALVISIAAGVRATDLSRWLGGYARVVRAMPNTP
CCCEEEEEECHHHHHHHHHHHHHHCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
ALVGMGVTGLAALPGVDAAGRELGSAVLGAVGETVWFDDEAKLDAVTAISGSGPAYVFYF
CEEECCCHHHHHCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCCCCHHHHH
IEALQEAARQLGLNDEQGRALAVATFTGAAQLAAQSGEPAGVLRERVTSKGGTTAAALAA
HHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHH
FDAQDLKQAIVRGVLAAEARARELGNELGGA
HCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAFIGGGNMASALIGGIVKRGTAAPDTLYVIDPNDGSRTKLRETFGVRTGETVDAALA
CEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHH
GYDAIVLAVKPQVLAEVAKTLAPHLGGALVISIAAGVRATDLSRWLGGYARVVRAMPNTP
CCCEEEEEECHHHHHHHHHHHHHHCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
ALVGMGVTGLAALPGVDAAGRELGSAVLGAVGETVWFDDEAKLDAVTAISGSGPAYVFYF
CEEECCCHHHHHCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCCCCHHHHH
IEALQEAARQLGLNDEQGRALAVATFTGAAQLAAQSGEPAGVLRERVTSKGGTTAAALAA
HHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHH
FDAQDLKQAIVRGVLAAEARARELGNELGGA
HCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]