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The map label for this gene is purH [H]

Identifier: 238026248

GI number: 238026248

Start: 609790

End: 611355

Strand: Reverse

Name: purH [H]

Synonym: bglu_1g05810

Alternate gene names: 238026248

Gene position: 611355-609790 (Counterclockwise)

Preceding gene: 238026249

Following gene: 238026247

Centisome position: 15.65

GC content: 67.94

Gene sequence:

>1566_bases
ATGATCAAGCAAGCGCTCCTCTCCGTTTCCGATAAAACCGGCATCGTCGAATTCGCGACGGCGTTGTCGCAGCAAGGCGT
CAAGCTGCTGTCGACGGGCGGCACCGCGAAACTGCTCGCCGAGGCCGGCCTTCCGGTCACGGAAGTCGCCGACTACACCG
GCTTTCCGGAAATGCTCGACGGGCGCGTGAAGACGCTGCACCCGAAGGTCCACGGCGGCATCCTCGCGCGGCGCGACCTG
CCCGAGCACATGCAGGCGCTCGACGCGCACGGCATCCCGACCATCGACCTGCTGGTGGTGAACCTCTACCCGTTCGTCGC
GACCATCGCGAAGGACGACTGCACGCTCGCCGACGCGATCGAGAACATCGACATCGGCGGCCCGACCATGCTGCGCTCGG
CCGCCAAGAACCATCGCGACGTGACGGTGATCGTCGATCCGGCCGACTACGCGGTGGTGCTGGACGAGATGAAGGCCAAC
GGCAACACGGTCGGCTACGCCACCAATTTCCGCCTCGCCACCAAGGTGTTCGCGCACACCGCGCAGTACGACGGCGCGAT
CACGAACTACCTGACGAGCCTGACCGACGAGTTGCAGCACGCCACGCGCAGCGCCTACCCGGCCACGCTGAACCTCGCGT
TCGACAAGGTGCAGGACCTGCGCTACGGCGAGAACCCGCACCAGAGCGCCGCGTTCTACCGCGACCTCGCGGCGCCGGCC
GGCGCGCTCGCGAACTATCGCCAGCTGCAGGGCAAGGAACTGTCGTACAACAACATCGCCGATTCGGACGCCGCCTGGGA
ATGCGTGAAGACGTTCGACGCGCCGGCCTGCGTGATCATCAAGCACGCCAACCCGTGCGGGGTGGCGGTGGGCGCGAATC
CGGCCGAAGCCTACGCCAAGGCGTTCCAGACCGATCCGACCTCGGCGTTCGGCGGCATCATCGCGTTCAACCGCGAACTC
GACGAGGCCGGCGCGCAGGCGGTGGCCAAGCAGTTCGTCGAGGTGCTGATCGCGCCGTCGTTCTCCGCAGCGGCGCGCCA
GGTGTTCGCCGCCAAGCAGAACGTGCGTCTGCTCGAGATCGCGCTCGGCGACGGCTTCAACGCGTTCGACCTGAAGCGCG
TGGGCGGCGGCCTGCTGGTGCAGTCGCTCGATTCGCGCAACGTGCAGCCCGACGAGCTGCGCGTCGTGACCAAGCGCCAG
CCGACGCCGAAGGAACTCGACGACCTGCTGTTCGCCTGGCGCGTCGCGAAGTTCGTGAAATCGAACGCGATCGTGTTCTG
CGGCAACGGCATGACGCTCGGCGTCGGCGCGGGCCAGATGAGCCGCGTCGATTCGGCCCGCATCGCCGGCATCAAGGCGC
AGAACGCGGGCCTCACGCTGGCCGGCTCGGCGGTGGCCTCGGACGCATTCTTCCCGTTCCGCGACGGCCTCGACGTGGTG
GTGGCGGCGGGCGCGACGGCCGTGATCCATCCGGGCGGCTCGATGCGCGACGAGGAAGTGATCGCCGCGGCCGACGAGCA
CGGCATCGCGATGGTGCTCACGGGCATCCGCCACTTCCGTCACTGA

Upstream 100 bases:

>100_bases
GGGCATCAATCGCAATACGCTGCGCAAGAAGCTGCAGCAGCACGGTCTGCTGTAGGCGGCCTCTTCTTCCCCGTTCTCCT
GGCTATTGGTGCCCCCGATC

Downstream 100 bases:

>100_bases
CCGGCCCGGCCGGACGAGCCGGCGGCCCCGGCCGGCCCGGCCGCGCCGCGCGAGGCACCCGGCGGCGAAGGCATCGCCCT
CGCCGCCGGGTTTTGGCTTG

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MIKQALLSVSDKTGIVEFATALSQQGVKLLSTGGTAKLLAEAGLPVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRDL
PEHMQALDAHGIPTIDLLVVNLYPFVATIAKDDCTLADAIENIDIGGPTMLRSAAKNHRDVTVIVDPADYAVVLDEMKAN
GNTVGYATNFRLATKVFAHTAQYDGAITNYLTSLTDELQHATRSAYPATLNLAFDKVQDLRYGENPHQSAAFYRDLAAPA
GALANYRQLQGKELSYNNIADSDAAWECVKTFDAPACVIIKHANPCGVAVGANPAEAYAKAFQTDPTSAFGGIIAFNREL
DEAGAQAVAKQFVEVLIAPSFSAAARQVFAAKQNVRLLEIALGDGFNAFDLKRVGGGLLVQSLDSRNVQPDELRVVTKRQ
PTPKELDDLLFAWRVAKFVKSNAIVFCGNGMTLGVGAGQMSRVDSARIAGIKAQNAGLTLAGSAVASDAFFPFRDGLDVV
VAAGATAVIHPGGSMRDEEVIAAADEHGIAMVLTGIRHFRH

Sequences:

>Translated_521_residues
MIKQALLSVSDKTGIVEFATALSQQGVKLLSTGGTAKLLAEAGLPVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRDL
PEHMQALDAHGIPTIDLLVVNLYPFVATIAKDDCTLADAIENIDIGGPTMLRSAAKNHRDVTVIVDPADYAVVLDEMKAN
GNTVGYATNFRLATKVFAHTAQYDGAITNYLTSLTDELQHATRSAYPATLNLAFDKVQDLRYGENPHQSAAFYRDLAAPA
GALANYRQLQGKELSYNNIADSDAAWECVKTFDAPACVIIKHANPCGVAVGANPAEAYAKAFQTDPTSAFGGIIAFNREL
DEAGAQAVAKQFVEVLIAPSFSAAARQVFAAKQNVRLLEIALGDGFNAFDLKRVGGGLLVQSLDSRNVQPDELRVVTKRQ
PTPKELDDLLFAWRVAKFVKSNAIVFCGNGMTLGVGAGQMSRVDSARIAGIKAQNAGLTLAGSAVASDAFFPFRDGLDVV
VAAGATAVIHPGGSMRDEEVIAAADEHGIAMVLTGIRHFRH
>Mature_521_residues
MIKQALLSVSDKTGIVEFATALSQQGVKLLSTGGTAKLLAEAGLPVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRDL
PEHMQALDAHGIPTIDLLVVNLYPFVATIAKDDCTLADAIENIDIGGPTMLRSAAKNHRDVTVIVDPADYAVVLDEMKAN
GNTVGYATNFRLATKVFAHTAQYDGAITNYLTSLTDELQHATRSAYPATLNLAFDKVQDLRYGENPHQSAAFYRDLAAPA
GALANYRQLQGKELSYNNIADSDAAWECVKTFDAPACVIIKHANPCGVAVGANPAEAYAKAFQTDPTSAFGGIIAFNREL
DEAGAQAVAKQFVEVLIAPSFSAAARQVFAAKQNVRLLEIALGDGFNAFDLKRVGGGLLVQSLDSRNVQPDELRVVTKRQ
PTPKELDDLLFAWRVAKFVKSNAIVFCGNGMTLGVGAGQMSRVDSARIAGIKAQNAGLTLAGSAVASDAFFPFRDGLDVV
VAAGATAVIHPGGSMRDEEVIAAADEHGIAMVLTGIRHFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=478, Percent_Identity=37.2384937238494, Blast_Score=267, Evalue=2e-71,
Organism=Escherichia coli, GI1790439, Length=525, Percent_Identity=62.4761904761905, Blast_Score=657, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985564, Length=612, Percent_Identity=32.6797385620915, Blast_Score=290, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI71985574, Length=352, Percent_Identity=24.7159090909091, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71985556, Length=119, Percent_Identity=34.453781512605, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323768, Length=480, Percent_Identity=35.8333333333333, Blast_Score=262, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6323056, Length=488, Percent_Identity=36.0655737704918, Blast_Score=262, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24649832, Length=485, Percent_Identity=37.7319587628866, Blast_Score=271, Evalue=8e-73,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 55401; Mature: 55401

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQALLSVSDKTGIVEFATALSQQGVKLLSTGGTAKLLAEAGLPVTEVADYTGFPEMLD
CCHHHHHHCCCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCHHHHHHCCCCHHHHC
GRVKTLHPKVHGGILARRDLPEHMQALDAHGIPTIDLLVVNLYPFVATIAKDDCTLADAI
CCCEEECCHHHCCEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
ENIDIGGPTMLRSAAKNHRDVTVIVDPADYAVVLDEMKANGNTVGYATNFRLATKVFAHT
HHCCCCCHHHHHHHHCCCCCEEEEECCCCEEEEEEHHCCCCCEEEEEECHHHHHHHHHHH
AQYDGAITNYLTSLTDELQHATRSAYPATLNLAFDKVQDLRYGENPHQSAAFYRDLAAPA
HHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHCCCH
GALANYRQLQGKELSYNNIADSDAAWECVKTFDAPACVIIKHANPCGVAVGANPAEAYAK
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCCHHHHHHH
AFQTDPTSAFGGIIAFNRELDEAGAQAVAKQFVEVLIAPSFSAAARQVFAAKQNVRLLEI
HHCCCCCHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEE
ALGDGFNAFDLKRVGGGLLVQSLDSRNVQPDELRVVTKRQPTPKELDDLLFAWRVAKFVK
EECCCCCCHHHHHCCCCCEEEECCCCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHH
SNAIVFCGNGMTLGVGAGQMSRVDSARIAGIKAQNAGLTLAGSAVASDAFFPFRDGLDVV
CCEEEEECCCEEEEECCCHHHHCCCHHEEEEEECCCCEEEECCHHHCCCCCCCCCCCCEE
VAAGATAVIHPGGSMRDEEVIAAADEHGIAMVLTGIRHFRH
EECCCEEEECCCCCCCCCHHEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIKQALLSVSDKTGIVEFATALSQQGVKLLSTGGTAKLLAEAGLPVTEVADYTGFPEMLD
CCHHHHHHCCCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCHHHHHHCCCCHHHHC
GRVKTLHPKVHGGILARRDLPEHMQALDAHGIPTIDLLVVNLYPFVATIAKDDCTLADAI
CCCEEECCHHHCCEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
ENIDIGGPTMLRSAAKNHRDVTVIVDPADYAVVLDEMKANGNTVGYATNFRLATKVFAHT
HHCCCCCHHHHHHHHCCCCCEEEEECCCCEEEEEEHHCCCCCEEEEEECHHHHHHHHHHH
AQYDGAITNYLTSLTDELQHATRSAYPATLNLAFDKVQDLRYGENPHQSAAFYRDLAAPA
HHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHCCCH
GALANYRQLQGKELSYNNIADSDAAWECVKTFDAPACVIIKHANPCGVAVGANPAEAYAK
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCCHHHHHHH
AFQTDPTSAFGGIIAFNRELDEAGAQAVAKQFVEVLIAPSFSAAARQVFAAKQNVRLLEI
HHCCCCCHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEE
ALGDGFNAFDLKRVGGGLLVQSLDSRNVQPDELRVVTKRQPTPKELDDLLFAWRVAKFVK
EECCCCCCHHHHHCCCCCEEEECCCCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHH
SNAIVFCGNGMTLGVGAGQMSRVDSARIAGIKAQNAGLTLAGSAVASDAFFPFRDGLDVV
CCEEEEECCCEEEEECCCHHHHCCCHHEEEEEECCCCEEEECCHHHCCCCCCCCCCCCEE
VAAGATAVIHPGGSMRDEEVIAAADEHGIAMVLTGIRHFRH
EECCCEEEECCCCCCCCCHHEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA