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The map label for this gene is pepQ [H]

Identifier: 238026095

GI number: 238026095

Start: 440304

End: 442130

Strand: Direct

Name: pepQ [H]

Synonym: bglu_1g04240

Alternate gene names: 238026095

Gene position: 440304-442130 (Clockwise)

Preceding gene: 238026094

Following gene: 238026096

Centisome position: 11.27

GC content: 73.02

Gene sequence:

>1827_bases
ATGGAATCCAACATGAACGCCCGTCATCCCGACGTCTCGCCCGTCCCCGCCCGGCTTGCCCTGTTGCGCAGCGCGATGGC
GCGCGAGGGCGTCGCCGCCTGCCTCGTGCCGTCTGCCGATCCGCACCTGTCGGAATACCTGCCGGAGCACTGGCAGTCGC
GCCGCTGGCTGTCCGGCTTCACCGGCTCGGTCGGCACGCTGGTCGTGACGGCCGATTTCGCCGGCCTTTGGGTCGACAGC
CGCTACTGGGTGCAGGCCGCCGCGCAACTCGACGGCACCGGCGTGCAGCTGATGAAGATGATGGGCGGCCAGCAGACCCA
GCCGCACGTCGAATGGCTCGCCGAGCACGTGCCGGCCGGCGCCGCGGTCAGCGTGGACGGCGCGGTGCTCGGCGTGGCCG
CCGCGCGCGCGCTGGCCGCGGCGCTGGCCGCGCGCGGCGTGGTGCTGCGCACCGATCTGGATCTGCTCGAGCGGATCTGG
CCGGAGCGTCCCGCGCTGCCGGCGGCGCCCGTGTTCGAGCACGTCGCGCCGCACGCGCAGATCGCGCGCGCCGCCAAGCT
CGCGCAGGTGCGTGAGGCGATGCGCGCGCAGGGCGCCGGGGTCCATTTCATCTCGACGCTCGACGACATCGCGTGGCTGT
TCAACCTGCGCGGCGCCGACGTCAGCTACAACCCGGTGTTCGTCGCGCATGCGCTGATCACGGCCGACCAGGCGACGTTG
TTCGTCGTCGACGGCAAGCTCGACGCGGCGCTGCAGGCGTCGCTCGCGGCCGACGGCGTGACGGTGCGCGCCTACGAGAC
GGCCGCCGCCGCGCTGGCCGCGCTGCCGGCCGGCAGCACGCTGCTGATCGATCCGCGCCGCGTGACGTTCGGCTCGCTGC
AGGCGGTGCCGGACACGGTGAGGCTGGCCGAGGCCGTCAACCCGTCGACCTTCGCGAAGTCGCGCAAGACGCCGGCCGAG
ATCGCCCACGTGCGCGAGACGATGGCGCGCGACGGCGCGGCGCTGGCCGAATTCTTCGCCTGGTTCGAGGCCGCGCTCGG
CCGCGAGACCGTGACCGAGCTGACCATCGACGAGCAGCTGAACGCCGCGCGCGCGCGACAGCCCGGCTTCGTGTCGCCGA
GCTTCGCGACCATCGCCGGCTTCAACGCGAACGGCGCGATGCCGCATTACCGGGCGACGCCCGAGGCGCACGCGACGATC
GAGGGCGACGGGCTGCTGCTGATCGACTCGGGCGGCCAGTTCGTGGGCGGCACCACCGACATCACGCGCGTGGTGCCGAT
CGGCACGCCGAGCGAGGCGCAGCGGCGCGACTTCACGATCGTGCTGAAGGCGATGATCGCGCTGTCGCGCGCGCGCTTCC
CGCGCGGCATCCGCTCGCCGATGCTCGACGCGATCGCGCGCGCGCCGATGTGGGCCGCCGGGCTCGACTACGGCCACGGC
ACGGGTCACGGCGTCGGCTATTTCCTGAACGTCCACGAAGGCCCGCAGGTGATCGCGCACTACGCGGCGGCCGATCCGCA
GACGGCGATGGAGGAGGGCATGATCACCTCGAACGAGCCGGGCGTGTACCGGCCCGGGCAATGGGGCGTGCGCATCGAGA
ACCTGGTGCTGAACCGCGCGGCGGGACAGACGCCGTTCGGCGACTTCCTCGAGTTCGAGACGCTCACGCTGTGCCCGATC
GACACGCGCTGCGTGCTGGCCGAACTGCTCGACGCGGGCGAGCGCGCCTGGCTCGACGACTATCATGCGACGGTGCGCGA
GCGCGTCGGCCCGCTCGTCACCGGGGCGGCGCGGGCCTGGCTCGAGGCGCGCACGCGGCCGCTCTGA

Upstream 100 bases:

>100_bases
CACGACGGCGGCACGCTCGAATGGCCGGTCTGTGCCGTCACGGCGCTCGTCGCCACCACGTTGACCATGGGCGCGCTCGC
CCGCCGCTGAACCCTCACGG

Downstream 100 bases:

>100_bases
CGCGCCGGGCGGATTCGGAAGGGGGAGGTATGCCAGCCATCCGGGCGGTCGTGTTCGATTTCGGCGGGGTGCTGATCGAC
TGGAACCCCGAGTATCTGTA

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MESNMNARHPDVSPVPARLALLRSAMAREGVAACLVPSADPHLSEYLPEHWQSRRWLSGFTGSVGTLVVTADFAGLWVDS
RYWVQAAAQLDGTGVQLMKMMGGQQTQPHVEWLAEHVPAGAAVSVDGAVLGVAAARALAAALAARGVVLRTDLDLLERIW
PERPALPAAPVFEHVAPHAQIARAAKLAQVREAMRAQGAGVHFISTLDDIAWLFNLRGADVSYNPVFVAHALITADQATL
FVVDGKLDAALQASLAADGVTVRAYETAAAALAALPAGSTLLIDPRRVTFGSLQAVPDTVRLAEAVNPSTFAKSRKTPAE
IAHVRETMARDGAALAEFFAWFEAALGRETVTELTIDEQLNAARARQPGFVSPSFATIAGFNANGAMPHYRATPEAHATI
EGDGLLLIDSGGQFVGGTTDITRVVPIGTPSEAQRRDFTIVLKAMIALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHG
TGHGVGYFLNVHEGPQVIAHYAAADPQTAMEEGMITSNEPGVYRPGQWGVRIENLVLNRAAGQTPFGDFLEFETLTLCPI
DTRCVLAELLDAGERAWLDDYHATVRERVGPLVTGAARAWLEARTRPL

Sequences:

>Translated_608_residues
MESNMNARHPDVSPVPARLALLRSAMAREGVAACLVPSADPHLSEYLPEHWQSRRWLSGFTGSVGTLVVTADFAGLWVDS
RYWVQAAAQLDGTGVQLMKMMGGQQTQPHVEWLAEHVPAGAAVSVDGAVLGVAAARALAAALAARGVVLRTDLDLLERIW
PERPALPAAPVFEHVAPHAQIARAAKLAQVREAMRAQGAGVHFISTLDDIAWLFNLRGADVSYNPVFVAHALITADQATL
FVVDGKLDAALQASLAADGVTVRAYETAAAALAALPAGSTLLIDPRRVTFGSLQAVPDTVRLAEAVNPSTFAKSRKTPAE
IAHVRETMARDGAALAEFFAWFEAALGRETVTELTIDEQLNAARARQPGFVSPSFATIAGFNANGAMPHYRATPEAHATI
EGDGLLLIDSGGQFVGGTTDITRVVPIGTPSEAQRRDFTIVLKAMIALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHG
TGHGVGYFLNVHEGPQVIAHYAAADPQTAMEEGMITSNEPGVYRPGQWGVRIENLVLNRAAGQTPFGDFLEFETLTLCPI
DTRCVLAELLDAGERAWLDDYHATVRERVGPLVTGAARAWLEARTRPL
>Mature_608_residues
MESNMNARHPDVSPVPARLALLRSAMAREGVAACLVPSADPHLSEYLPEHWQSRRWLSGFTGSVGTLVVTADFAGLWVDS
RYWVQAAAQLDGTGVQLMKMMGGQQTQPHVEWLAEHVPAGAAVSVDGAVLGVAAARALAAALAARGVVLRTDLDLLERIW
PERPALPAAPVFEHVAPHAQIARAAKLAQVREAMRAQGAGVHFISTLDDIAWLFNLRGADVSYNPVFVAHALITADQATL
FVVDGKLDAALQASLAADGVTVRAYETAAAALAALPAGSTLLIDPRRVTFGSLQAVPDTVRLAEAVNPSTFAKSRKTPAE
IAHVRETMARDGAALAEFFAWFEAALGRETVTELTIDEQLNAARARQPGFVSPSFATIAGFNANGAMPHYRATPEAHATI
EGDGLLLIDSGGQFVGGTTDITRVVPIGTPSEAQRRDFTIVLKAMIALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHG
TGHGVGYFLNVHEGPQVIAHYAAADPQTAMEEGMITSNEPGVYRPGQWGVRIENLVLNRAAGQTPFGDFLEFETLTLCPI
DTRCVLAELLDAGERAWLDDYHATVRERVGPLVTGAARAWLEARTRPL

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=614, Percent_Identity=36.1563517915309, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI93141226, Length=604, Percent_Identity=33.4437086092715, Blast_Score=345, Evalue=7e-95,
Organism=Homo sapiens, GI264681565, Length=614, Percent_Identity=34.5276872964169, Blast_Score=345, Evalue=9e-95,
Organism=Escherichia coli, GI1788728, Length=230, Percent_Identity=33.0434782608696, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17509539, Length=620, Percent_Identity=31.7741935483871, Blast_Score=306, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI25149105, Length=625, Percent_Identity=26.72, Blast_Score=231, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6322999, Length=653, Percent_Identity=30.3215926493109, Blast_Score=295, Evalue=2e-80,
Organism=Drosophila melanogaster, GI17137632, Length=620, Percent_Identity=33.3870967741935, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI161078230, Length=610, Percent_Identity=27.0491803278689, Blast_Score=236, Evalue=5e-62,
Organism=Drosophila melanogaster, GI21357287, Length=610, Percent_Identity=27.0491803278689, Blast_Score=236, Evalue=5e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 64983; Mature: 64983

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESNMNARHPDVSPVPARLALLRSAMAREGVAACLVPSADPHLSEYLPEHWQSRRWLSGF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCHHCCC
TGSVGTLVVTADFAGLWVDSRYWVQAAAQLDGTGVQLMKMMGGQQTQPHVEWLAEHVPAG
CCCCEEEEEEECCCCEEECCHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCC
AAVSVDGAVLGVAAARALAAALAARGVVLRTDLDLLERIWPERPALPAAPVFEHVAPHAQ
CEEECCCHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCCCCCCCCHHHHHHCCHHH
IARAAKLAQVREAMRAQGAGVHFISTLDDIAWLFNLRGADVSYNPVFVAHALITADQATL
HHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHCCCCEEE
FVVDGKLDAALQASLAADGVTVRAYETAAAALAALPAGSTLLIDPRRVTFGSLQAVPDTV
EEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCEEEECCCCCCCCHHHCCCHHH
RLAEAVNPSTFAKSRKTPAEIAHVRETMARDGAALAEFFAWFEAALGRETVTELTIDEQL
HHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHHHHEEHHHHH
NAARARQPGFVSPSFATIAGFNANGAMPHYRATPEAHATIEGDGLLLIDSGGQFVGGTTD
HHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCEECCCCC
ITRVVPIGTPSEAQRRDFTIVLKAMIALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHG
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCC
TGHGVGYFLNVHEGPQVIAHYAAADPQTAMEEGMITSNEPGVYRPGQWGVRIENLVLNRA
CCCCEEEEEEECCCHHHHHHHHCCCCHHHHHCCCEECCCCCCCCCCCCCCEEHHHHHHHC
AGQTPFGDFLEFETLTLCPIDTRCVLAELLDAGERAWLDDYHATVRERVGPLVTGAARAW
CCCCCCCHHHCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
LEARTRPL
HHHHCCCC
>Mature Secondary Structure
MESNMNARHPDVSPVPARLALLRSAMAREGVAACLVPSADPHLSEYLPEHWQSRRWLSGF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCHHCCC
TGSVGTLVVTADFAGLWVDSRYWVQAAAQLDGTGVQLMKMMGGQQTQPHVEWLAEHVPAG
CCCCEEEEEEECCCCEEECCHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCC
AAVSVDGAVLGVAAARALAAALAARGVVLRTDLDLLERIWPERPALPAAPVFEHVAPHAQ
CEEECCCHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCCCCCCCCHHHHHHCCHHH
IARAAKLAQVREAMRAQGAGVHFISTLDDIAWLFNLRGADVSYNPVFVAHALITADQATL
HHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHCCCCEEE
FVVDGKLDAALQASLAADGVTVRAYETAAAALAALPAGSTLLIDPRRVTFGSLQAVPDTV
EEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCEEEECCCCCCCCHHHCCCHHH
RLAEAVNPSTFAKSRKTPAEIAHVRETMARDGAALAEFFAWFEAALGRETVTELTIDEQL
HHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHHHHEEHHHHH
NAARARQPGFVSPSFATIAGFNANGAMPHYRATPEAHATIEGDGLLLIDSGGQFVGGTTD
HHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCEECCCCC
ITRVVPIGTPSEAQRRDFTIVLKAMIALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHG
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCC
TGHGVGYFLNVHEGPQVIAHYAAADPQTAMEEGMITSNEPGVYRPGQWGVRIENLVLNRA
CCCCEEEEEEECCCHHHHHHHHCCCCHHHHHCCCEECCCCCCCCCCCCCCEEHHHHHHHC
AGQTPFGDFLEFETLTLCPIDTRCVLAELLDAGERAWLDDYHATVRERVGPLVTGAARAW
CCCCCCCHHHCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
LEARTRPL
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]